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1. 发明申请

WO2007040650A9 APOPTOSIS PROMOTERS 审中-公开
标题翻译： APOPTOSIS促销者
公开(公告)号：WO2007040650A9
公开(公告)日：2007-07-26
申请号：PCT/US2006018799
申请日：2006-05-12
申请人： ABBOTT LAB , BRUNCKO MILAN , DING HONG , ELMORE STEVEN W , KUNZER AARON R , LYNCH CHRISTOPHER L , MCCELLAN WILLIAM J , PARK CHEOL MIN , SONG XIAHONG , WANG XILU
发明人： BRUNCKO MILAN , DING HONG , ELMORE STEVEN W , KUNZER AARON R , LYNCH CHRISTOPHER L , MCCELLAN WILLIAM J , PARK CHEOL MIN , SONG XIAHONG , WANG XILU
IPC分类号： C07D295/14 , A61K31/496 , A61P35/00 , C07D487/08 , C07D491/08
CPC分类号： C07D295/155 , C07D487/08 , C07D491/08
摘要： Compounds which inhibit the activity of anti-apoptotic family protein members, compositions containing the compounds and methods of treating diseases during which occur expression one or more than one of an anti?apoptotic family protein member are disclosed.
摘要翻译：公开了抑制抗凋亡家族蛋白成员活性的化合物，含有该化合物的组合物和治疗疾病的方法，其中发生表达一种或多种抗β凋亡家族蛋白质成员。

2. 发明申请

WO2005049593A3 N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS 审中-公开
标题翻译： N-氨基磺酰胺疫苗促进剂
公开(公告)号：WO2005049593A3
公开(公告)日：2005-07-07
申请号：PCT/US2004036770
申请日：2004-11-03
申请人： ABBOTT LAB , BRUNCKO MILAN , ELMORE STEVEN , KUNZER AARON R , LYNCH CHRISTOPHER L , WANG XILU , WENDT MICHAEL D
发明人： BRUNCKO MILAN , ELMORE STEVEN , KUNZER AARON R , LYNCH CHRISTOPHER L , WANG XILU , WENDT MICHAEL D
IPC分类号： A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/635 , C07C311/51 , C07C323/25 , C07D205/04 , C07D207/16 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/74 , C07D213/70 , C07D213/75 , C07D233/06 , C07D233/84 , C07D239/06 , C07D263/58 , C07D277/36 , C07D277/74 , C07D295/13 , C07D295/155 , C07D295/192 , C07D307/64 , C07D335/02 , C07D401/12 , C07D403/04 , C07D403/12 , C07D409/12 , C07D413/02 , C07D413/12 , C07D417/02 , C07D487/04 , C07D487/08 , C07D295/14 , A61P35/00
CPC分类号： C07D277/74 , C04B35/632 , C07C323/25 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D211/46 , C07D211/60 , C07D211/74 , C07D213/70 , C07D213/75 , C07D233/06 , C07D233/84 , C07D239/06 , C07D263/58 , C07D277/36 , C07D295/13 , C07D295/192 , C07D307/64 , C07D335/02 , C07D401/12 , C07D403/04 , C07D409/12 , C07D487/04 , C07D487/08
摘要： Disclosed are N-acylsulfonamide compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which are expressed one or more than one of an anti-apoptotic protein family member.
摘要翻译：公开了抑制抗凋亡蛋白家族成员的活性的N-酰基磺酰胺化合物，含有化合物的组合物和该化合物用于制备用于治疗疾病的药物的用途，其中表达一种或多种抗凋亡蛋白家族成员。

3. 发明申请

WO2008002956A3 THIAZOLINE AND OXAZOLINE DERIVATIVES AND THEIR METHODS OF USE 审中-公开
标题翻译：噻唑啉和氧杂环丁烷衍生物及其使用方法
公开(公告)号：WO2008002956A3
公开(公告)日：2008-07-03
申请号：PCT/US2007072185
申请日：2007-06-27
申请人： ABBOTT LAB , FAGHIH RAMIN , GFESSER GREGORY A , LYNCH CHRISTOPHER L , GOPALAKRISHNAN MURALI , GOPALAKRISHNAN SUJATHA , MALYSZ JOHN , GUBBINS EARL J , EL KOUHEN RACHID , LI JINHE , SARRIS KATHY A , MICHMERHUIZEN MELISSA J , WANG YING
发明人： FAGHIH RAMIN , GFESSER GREGORY A , LYNCH CHRISTOPHER L , GOPALAKRISHNAN MURALI , GOPALAKRISHNAN SUJATHA , MALYSZ JOHN , GUBBINS EARL J , EL KOUHEN RACHID , LI JINHE , SARRIS KATHY A , MICHMERHUIZEN MELISSA J , WANG YING
IPC分类号： C07D417/04 , A61K31/422 , A61K31/427 , C07D413/04 , C07D417/14
CPC分类号： C07D417/04 , C07D413/04 , C07D417/14
摘要： The invention relates to compounds of formula I selected from compounds. The compounds of formula (I) in treating conditions and disorders that are regulated by the nicotinic acetylcholine receptors.
摘要翻译：本发明涉及选自化合物的式I化合物。式（I）化合物在治疗由烟碱乙酰胆碱受体调节的病症和病症中。

4. 发明申请

WO2007137030A3 CNS ACTIVE FUSED BICYCLOHETEROCYCLE SUBSTITUTED AZABICYCLIC ALKANE DERIVATIVES 审中-公开
标题翻译：中枢神经系统活性融合的双环蛋白取代的亚氨基烷烃衍生物
公开(公告)号：WO2007137030A3
公开(公告)日：2008-07-24
申请号：PCT/US2007068930
申请日：2007-05-15
申请人： ABBOTT LAB , JI JIANGUO , LI TAO , LYNCH CHRISTOPHER L , GOPALAKRISHNAN MURALI
发明人： JI JIANGUO , LI TAO , LYNCH CHRISTOPHER L , GOPALAKRISHNAN MURALI
IPC分类号： C07D451/08 , A61K31/4375 , A61P25/00 , C07D451/14 , C07D519/00
CPC分类号： C07D451/08 , C07D451/14 , C07D519/00
摘要： The invention relates to fused bicycloheterocycle substituted azabicyclic alkane derivatives of formula (I), or a pharmaceutically acceptable salt, ester, amid, or prodrug thereof, wherein n is 1, 2 or 3; A is N or N + -O - ; R is hydrogen, alkyl, cycloalkylalkyl and arylalkyl; L is selected from the group consisting of O, S, and -N(R a )-; Ar 1 is a 6-membered aryl or 6 membered heteroaryl ring; and Ar 2 is a bicyclic heteroaryl; and R a is selected from the group consisting of hydrogen, alkyl and alkylcarbonyl; provided that if Ar 1 is Formula (II), then L is O or S. Compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译：本发明涉及式（I）的稠合双环杂环取代的氮杂双环烷烃衍生物或其药学上可接受的盐，酯，酰胺或前药，其中n为1,2或3; A是N或N + O - - O - R是氢，烷基，环烷基烷基和芳基烷基; L选自O，S和-N（R a）a）。 Ar 1是6元芳基或6元杂芳基环; 且Ar 2是双环杂芳基; 且R a a选自氢，烷基和烷基羰基; 条件是如果Ar 1是式（II），则L是O或S.包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。

5. 发明申请

WO2005032465A3 3,5-ARYL, HETEROARYL OR CYCLOALKYL SUBSTITUTED-1,2,4-OXADIAZOLES AS S1P RECEPTOR AGONISTS 审中-公开
标题翻译： 3,5-ARYL，HETEROARYL或CYCLOALKYL取代的1,2,4-OXADIAZOLES作为S1P受体激动剂
公开(公告)号：WO2005032465A3
公开(公告)日：2005-11-10
申请号：PCT/US2004031675
申请日：2004-09-27
申请人： MERCK & CO INC , DOHERTY GEORGE A , HALE JEFFREY J , LEGIEC IRENE E , LYNCH CHRISTOPHER L , TOTH LESLIE M
发明人： DOHERTY GEORGE A , HALE JEFFREY J , LEGIEC IRENE E , LYNCH CHRISTOPHER L , TOTH LESLIE M
IPC分类号： A61K20060101 , A61K31/4245 , C07D271/06
CPC分类号： C07D413/04 , C07D271/06
摘要： The present invention encompasses compounds of Formula I: (I) as well as the pharmaceutically acceptable salts thereof. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejection. Pharmaceutical compositions and methods of use are included.
摘要翻译：本发明包括式I化合物：（I）及其药学上可接受的盐。该化合物可用于治疗免疫介导的疾病和病症，例如骨髓，器官和组织移植排斥反应。包括药物组合物和使用方法。

6. 发明申请

WO0234716A3 PYRROLIDINE MODULATORS OF CCR5 CHEMOKINE RECEPTOR ACTIVITY 审中-公开
标题翻译： CCR5 CHEMOKINE受体活性的吡咯烷酮调节剂
公开(公告)号：WO0234716A3
公开(公告)日：2002-08-08
申请号：PCT/US0142562
申请日：2001-10-09
申请人： MERCK & CO INC , HALE JEFFREY J , LYNCH CHRISTOPHER L , CALDWELL CHARLES G , WILLOUGHBY CHRISTOPHER A , KIM DOOSEOP , SHEN DONG-MING , MILLS SANDER G , CHAPMAN KEVIN T , CHEN LIYA , GENTRY AMY , MACCOSS MALCOLM
发明人： HALE JEFFREY J , LYNCH CHRISTOPHER L , CALDWELL CHARLES G , WILLOUGHBY CHRISTOPHER A , KIM DOOSEOP , SHEN DONG-MING , MILLS SANDER G , CHAPMAN KEVIN T , CHEN LIYA , GENTRY AMY , MACCOSS MALCOLM
IPC分类号： C07D487/04 , A61K31/4162 , A61K31/454 , A61K31/4545 , A61P1/04 , A61P3/10 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/04 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/08 , A61P21/00 , A61P21/02 , A61P21/04 , A61P25/00 , A61P29/00 , A61P31/18 , A61P33/10 , A61P33/12 , A61P33/14 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07D401/14 , C07D403/14 , C07D405/14 , C07D471/04 , C07D491/052 , C07D495/04 , A61K31/675 , A61K31/40 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/50 , C07D209/44 , C07D209/52 , C07D401/00 , C07D403/00 , C07F9/02 , C07F9/06 , C07F9/28 , C07F9/547
CPC分类号： C07D401/14 , C07D405/14 , C07D471/04 , C07D495/04
摘要： Pyrrolidine compounds of Formula (I), (wherein R , R , R , R , R , R , R , R and R are defined herein) are described. The compounds are modulators of CCR5 chemokine receptor activity. The compounds are useful, for example, in the prevention or treatment of infection by HIV and the treatment of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
摘要翻译：式（I）的吡咯烷化合物（其中R 1，R 2，R 3，R 4，R 5，R 6a，R 6b，R 7和 R 8在本文中定义）。这些化合物是CCR5趋化因子受体活性的调节剂。所述化合物可用于例如预防或治疗HIV感染和治疗AIDS，作为化合物或药学上可接受的盐，或作为药物组合物中的成分，任选地与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合。还描述了治疗艾滋病的方法和预防或治疗HIV感染的方法。

7. 发明专利

RS52062B CNS ACTIVE FUSED BICYCLOHTEROCYCLE SUBSTITUTED AZABICYCLIC ALKANE DERIVATES 未知
公开(公告)号：RS52062B
公开(公告)日：2012-06-30
申请号：RSP20110550
申请日：2007-05-15
申请人： ABBOTT LAB
发明人： JI JIANGUO , LI TAO , LYNCH CHRISTOPHER L , GOPALAKRISHNAN MURALI
IPC分类号： C07D451/08 , A61K31/4375 , A61P25/00 , C07D451/14 , C07D519/00
摘要： The invention relates to fused bicycloheterocycle substituted azabicyclic alkane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

8. 发明专利

PT2018380E DERIVADOS DE ALCANOS AZABICÍCLICOS SUBSTITUÍDOS COM BICICLO-HETEROCICLO FUNDIDOS ACTIVOS NO CNS 未知
公开(公告)号：PT2018380E
公开(公告)日：2012-01-17
申请号：PT07797473
申请日：2007-05-15
申请人： ABBOTT LAB
发明人： JI JIANGUO , LI TAO , LYNCH CHRISTOPHER L , GOPALAKRISHNAN MURALI
IPC分类号： C07D451/08 , A61K31/4375 , A61P25/00 , C07D451/14 , C07D519/00

9. 发明专利

NZ573735A CNS ACTIVE FUSED BICYCLOHETEROCYCLE SUBSTITUTED AZABICYCLIC ALKANE DERIVATIVES 未知
公开(公告)号：NZ573735A
公开(公告)日：2011-10-28
申请号：NZ57373507
申请日：2007-05-15
申请人： ABBOTT LAB
发明人： JI JIANGUO , LI TAO , LYNCH CHRISTOPHER L , GOPALAKRISHNAN MURALI
IPC分类号： C07D451/08 , A61K31/4375 , A61P25/00 , C07D451/14 , C07D519/00
摘要： Disclosed is the aza-bicyclo[3.2.1]oct-3-yloxy compound of formula (I) or a pharmaceutically acceptable salt, ester or amide thereof, wherein n is 1, 2 or 3; A is N or N+-O-; R is hydrogen, alkyl, cycloalkylalkyl and arylallcyl; L is selected from the group consisting of O, S, and -N(Ra)-; Ar1 is a 6-membered 6 membered ring; and Ar2 is a fused nine-membered bicyclic heteroaryl; and Ra is selected from the group consisting of hydrogen, alkyl and alkylcarbonyl for treating or preventing a condition or disorder selected from the group consisting of attention deficit disorder, attention deficit hyperactivity disorder (ADHD), Alzheimer's disease (AD), mild cognitive impairment, senile dementia, AIDS dementia, Pick's Disease, dementia associated with Lewy bodies, dementia associated with Down's syndrome, arnyotrophic lateral sclerosis, Huntington's disease, diminished CNS function associated with traumatic brain injury, acute pain, post-surgical pain, chronic pain, inflammation, inflammatory pain, neuropathic pain, infertility, need for new blood vessel growth associated with wound healing, need for new blood vessel growth associated with vascularization of skin grafts, and lack of circulation, rheumatoid arthritis, Crohn's disease, ulcerative colitis, inflammatory bowel disease, organ transplant rejection, acute immune disease associated with organ transplantation, chronic immune disease associated with organ transplantation, septic shock, toxic shock syndrome, sepsis syndrome, depression, and rheumatoid spondylitis.

10. 发明专利

CA2606147C APOPTOSIS PROMOTERS 未知
公开(公告)号：CA2606147C
公开(公告)日：2011-07-05
申请号：CA2606147
申请日：2006-05-12
申请人： ABBOTT LAB
发明人： BRUNCKO MILAN , DING HONG , ELMORE STEVEN W , KUNZER AARON R , LYNCH CHRISTOPHER L , MCCELLAN WILLIAM J , PARK CHEOL MIN , SONG XIAOHONG , WANG XILU
IPC分类号： C07D295/14 , A61K31/496 , A61P35/00 , C07D487/08 , C07D491/08
摘要： Compounds which inhibit the activity of anti-apoptotic family protein members, compositions containing the compounds and methods of treating diseases during which occur expression one or more than one of an antiapoptotic family protein member are disclosed.

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