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1. 发明申请

WO2010065824A3 APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 审中-公开
公开(公告)号：WO2010065824A3
公开(公告)日：2010-10-07
申请号：PCT/US2009066722
申请日：2009-12-04
申请人： ABBOTT LAB , BRUNCKO MILAN , DAI YUJIA , DING HONG , DOHERTY GEORGE A , ELMORE STEVEN W , HASVOLD LISA , HEXAMER LAURA , KUNZER AARON R , MANTEI ROBERT A , MCCLELLAN WILLIAM J , PARK CHANG H , PARK CHEOL-MIN , PETROS ANDREW M , SONG XIAOHONG , SOUERS ANDREW J , SULLIVAN GERARD M , TAO ZHI-FU , WANG GARY T , WANG LE , WANG XILU , WENDT MICHAEL D
发明人： BRUNCKO MILAN , DAI YUJIA , DING HONG , DOHERTY GEORGE A , ELMORE STEVEN W , HASVOLD LISA , HEXAMER LAURA , KUNZER AARON R , MANTEI ROBERT A , MCCLELLAN WILLIAM J , PARK CHANG H , PARK CHEOL-MIN , PETROS ANDREW M , SONG XIAOHONG , SOUERS ANDREW J , SULLIVAN GERARD M , TAO ZHI-FU , WANG GARY T , WANG LE , WANG XILU , WENDT MICHAEL D
IPC分类号： A61P35/00 , A61K31/496 , C07D403/12
CPC分类号： C07D405/12 , C07D209/08 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

2. 发明申请

WO2010065865A3 SULFONAMIDE DERIVATIVES AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES 审中-公开
标题翻译：作为治疗癌症和免疫疾病的BCL-2-选择性病毒诱导剂的磺酰胺衍生物
公开(公告)号：WO2010065865A3
公开(公告)日：2010-09-16
申请号：PCT/US2009066790
申请日：2009-12-04
申请人： ABBOTT LAB , BRUNCKO MILAN , DING HONG , DOHERTY GEORGE A , ELMORE STEVEN W , HASVOLD LISA , HEXAMER LAURA , KUNZER AARON R , MANTEI ROBERT A , MCCLELLAN WILLIAM J , PARK CHANG H , PARK CHEOL-MIN , PETROS ANDREW M , SONG XIAOHONG , SOUERS ANDREW J , SULLIVAN GERARD M , TAO ZHI-FU , WANG GARY T , WANG LE , WANG XILU , WENDT MICHAEL D
发明人： BRUNCKO MILAN , DING HONG , DOHERTY GEORGE A , ELMORE STEVEN W , HASVOLD LISA , HEXAMER LAURA , KUNZER AARON R , MANTEI ROBERT A , MCCLELLAN WILLIAM J , PARK CHANG H , PARK CHEOL-MIN , PETROS ANDREW M , SONG XIAOHONG , SOUERS ANDREW J , SULLIVAN GERARD M , TAO ZHI-FU , WANG GARY T , WANG LE , WANG XILU , WENDT MICHAEL D
IPC分类号： C07D405/12 , A61K31/404 , A61P35/00 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/14 , C07D309/14 , C07D401/12
CPC分类号： C07D405/12 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/14 , C07D309/14 , C07D401/12 , C07D417/12
摘要： Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic BcI -2 or BcI -xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti -aooptotic Bcl-2 protein.
摘要翻译：公开了抑制抗凋亡BcI -2或BcI-xL蛋白活性的式（I）化合物，含有该化合物的组合物和治疗其中表达抗细胞凋亡Bcl-2蛋白的疾病的方法。

3. 发明申请

WO2008131000A3 7-SUBSTITUTED INDOLE MCL-1 INHIBITORS 审中-公开
标题翻译： 7-取代的MCL-1抑制剂
公开(公告)号：WO2008131000A3
公开(公告)日：2008-12-18
申请号：PCT/US2008060472
申请日：2008-04-16
申请人： ABBOTT LAB , ELMORE STEVEN W , SOUERS ANDREW J , BRUNCKO MILAN , SONG XIAOHONG , WANG XILU , HASVOLD LISA A , WANG LE , KUNZER AARON R , PARK CHEOL-MIN , WENDT MICHAEL D , TAO ZHI-FU
发明人： ELMORE STEVEN W , SOUERS ANDREW J , BRUNCKO MILAN , SONG XIAOHONG , WANG XILU , HASVOLD LISA A , WANG LE , KUNZER AARON R , PARK CHEOL-MIN , WENDT MICHAEL D , TAO ZHI-FU
IPC分类号： C07D209/34 , A61K31/404 , A61P35/00 , C07D401/12 , C07D413/06 , C07D417/04
CPC分类号： C07D209/42 , A61K31/5377 , C07D209/34 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D491/113
摘要： Compounds of formula (I) which inhibit the activity of anti-apoptotic McI-I protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated McI-I protein are disclosed.
摘要翻译：公开了抑制抗凋亡McI-1蛋白活性的式（I）化合物，含有该化合物的组合物，以及治疗涉及过表达或未调节的McI-1蛋白的疾病的方法。

4. 发明申请

WO2011119345A2 APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 审中-公开
标题翻译：用于治疗癌症和免疫和自发性疾病的病毒诱导剂
公开(公告)号：WO2011119345A2
公开(公告)日：2011-09-29
申请号：PCT/US2011027895
申请日：2011-03-10
申请人： ABBOTT LAB , DING HONG , ELMORE STEVEN , HEXAMER LAURA , KUNZER AARON R , PARK CHEOL-MIN , SOUERS ANDREW J , SULLIVAN GERARD , WENDT MICHAEL
发明人： DING HONG , ELMORE STEVEN , HEXAMER LAURA , KUNZER AARON R , PARK CHEOL-MIN , SOUERS ANDREW J , SULLIVAN GERARD , WENDT MICHAEL
IPC分类号： C07D295/195 , A61K31/18 , A61K31/451 , A61K31/495 , A61P35/00 , C07C311/51 , C07D211/58
CPC分类号： C07D211/58 , C07C311/51 , C07C2601/14 , C07C2603/74 , C07D295/112 , C07D295/195 , C07D417/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti apoptotic Bcl-2 protein.
摘要翻译：公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有这些化合物的组合物和治疗其中表达抗凋亡Bcl-2蛋白的疾病的方法。

5. 发明申请

WO2005117543A3 N-SULFONYLCARBOXIMIDAMIDE APOPTOSIS PROMOTERS 审中-公开
标题翻译： N-磺酰胆碱酰胺类药物促进剂
公开(公告)号：WO2005117543A3
公开(公告)日：2007-11-22
申请号：PCT/US2005016311
申请日：2005-05-10
申请人： ABBOTT LAB , ELMORE STEVEN W , BRUNCKO MILAN , PARK CHEOL-MIN
发明人： ELMORE STEVEN W , BRUNCKO MILAN , PARK CHEOL-MIN
IPC分类号： C07D211/48 , A61K31/445 , A61K31/495 , A61P35/00 , C07D211/14 , C07D211/18 , C07D211/22 , C07D211/32 , C07D211/46 , C07D211/70 , C07D241/04 , C07D295/06 , C07D295/14 , C07D295/155 , C07D295/205 , C07D409/06
CPC分类号： C07D211/14 , C07D211/18 , C07D211/46 , C07D211/48 , C07D295/155 , C07D295/205 , C07D409/06
摘要： Compounds having the formula (I) are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译：具有式（I）的化合物是凋亡启动子。还公开了制备化合物，含有化合物的组合物和使用该化合物的处理方法的方法。

6. 发明申请

WO2011028000A2 DEVICE, METHOD, AND SYSTEM FOR QUANTITATIVELY MEASURING A SPECIMEN USING A CAMERA 审中-公开
标题翻译：使用摄像机定量测量样本的装置，方法和系统
公开(公告)号：WO2011028000A2
公开(公告)日：2011-03-10
申请号：PCT/KR2010005823
申请日：2010-08-30
申请人： INFOPIA CO LTD , BAE BYEONG-WOO , PARK CHEOL-MIN
发明人： BAE BYEONG-WOO , PARK CHEOL-MIN
IPC分类号： G01N33/50 , G01N33/53
CPC分类号： G01N21/8483
摘要： The present invention relates to a device and method for quantitatively measuring a specimen using a camera. More particularly, to capture the identification code required for obtaining an accurate analysis result for the specimen to be analyzed, to capture the result of the reaction of the specimen using a camera without additional equipment, and to read the identification code and the result of the reaction of the specimen, the device of the present invention comprises: a camera for capturing a camera recognition area of a specimen kit, which contains a specimen reaction result obtained by the reaction of the specimen and an identification code for the specimen kit; an image-processing unit for separating the specimen reaction result image and the identification code image from images of the camera recognition area of the specimen kit captured by the camera; a reading unit for reading the specimen reaction result image and the identification code image; and a control unit for enabling the read result of the specimen reaction result image to be processed using the read result of the identification code image.
摘要翻译：本发明涉及一种使用照相机对样本进行定量测量的装置和方法。更具体地，为了捕获用于获得要分析的样本的准确分析结果所需的识别代码，以使用没有附加设备的相机捕获样本的反应结果，并且读取识别码和本发明的装置包括：照相机，用于拍摄样本套件的相机识别区域，其包含通过样本的反应获得的样本反应结果和样本试剂盒的识别码; 图像处理单元，用于从由照相机捕捉的标本试剂盒的相机识别区域的图像分离样本反应结果图像和识别码图像; 用于读取标本反应结果图像和识别码图像的读取单元; 以及控制单元，其使得能够使用识别码图像的读取结果来处理样本反应结果图像的读取结果。

7. 发明专利

CA2744711C BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES 未知
公开(公告)号：CA2744711C
公开(公告)日：2017-06-27
申请号：CA2744711
申请日：2009-12-04
申请人： ABBOTT LAB
发明人： BRUNCKO MILAN , DING HONG , DOHERTY GEORGE A , ELMORE STEVEN W , HASVOLD LISA , HEXAMER LAURA , KUNZER AARON R , MANTEI ROBERT A , MCCLELLAN WILLIAM J , PARK CHANG H , PARK CHEOL-MIN , PETROS ANDREW M , SONG XIAOHONG , SOUERS ANDREW J , SULLIVAN GERARD M , TAO ZHI-FU , WANG GARY T , WANG LE , WANG XILU , WENDT MICHAEL D
IPC分类号： C07D405/12 , A61K31/404 , A61P35/00 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/14 , C07D309/14 , C07D401/12
摘要： Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic BcI -2 or BcI -xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti -aooptotic Bcl-2 protein.

8. 发明专利

CA2682356C 7-SUBSTITUTED INDOLE MCL-1 INHIBITORS 未知
公开(公告)号：CA2682356C
公开(公告)日：2016-06-14
申请号：CA2682356
申请日：2008-04-16
申请人： ABBOTT LAB
发明人： ELMORE STEVEN W , SOUERS ANDREW J , BRUNCKO MILAN , SONG XIAOHONG , WANG XILU , HASVOLD LISA A , WANG LE , KUNZER AARON R , PARK CHEOL-MIN , WENDT MICHAEL D , TAO ZHI-FU , MADAR DAVID
IPC分类号： C07D209/42 , A61K31/404 , A61P35/00 , C07D401/12 , C07D413/06 , C07D417/04
摘要： Compounds of formula (I) which inhibit the activity of anti-apoptotic McI-I protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated McI-I protein are disclosed.

9. 发明专利

ZA201206837B APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 未知
公开(公告)号：ZA201206837B
公开(公告)日：2013-05-29
申请号：ZA201206837
申请日：2012-09-12
申请人： ABBOTT LAB
发明人： DING HONG , HEXAMER LAURA , PARK CHEOL-MIN , SULLIVAN GERARD , ELMORE STEVEN , KUNZER AARON R , SOUERS ANDREW J , WENDT MICHAEL
IPC分类号： A61K20060101 , A61P20060101 , C07C20060101 , C07D20060101
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti apoptotic Bcl-2 protein.

10. 发明专利

CR20120346A DERIVADOS DE SULFONAMIDA COMO AGENTES INDUCTORES DE APOPTOSIS CON SELECTIVIDAD POR Bcl-2 PARA EL TRATAMIENTO DE CÁNCER Y ENFERMEDADES INMUNES 未知
公开(公告)号：CR20120346A
公开(公告)日：2012-09-03
申请号：CR20120346
申请日：2012-06-25
申请人： ABBOTT LAB
发明人： BRUNCKO MILAN , DING HONG , DOHERTY GEORGE A , ELMORE STEVEN W , HASVOLD LISA , HEXAMER LAURA , KUNZER AARON , MANTEI ROBERT A , MCCLELLAN WILLIAM J , PETROS ANDREW M , SOUERS ANDREW J , SULLIVAN GERARD M , TAO ZHI-FU , WANG GARY T , WANG LE , WANG XILU , WENDT MICHAEL D , HANSEN TODD M , SONG XIAOHONG , PARK CHANG H , PARK CHEOL-MIN
IPC分类号： C07D405/12 , A61K31/404 , A61P35/00 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/14 , C07D309/14 , C07D401/12 , C07D405/14
摘要： Compuestos que inhiben la actividad de las proteínas anti-apoptóticas Bcl-2 o Bcl-XL, composiciones que contienen dichos compuestos y métodos para tratar enfermedades durante las cuales se expresa la proteína anti-apoptótica Bcl-2.

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