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1. 发明申请

WO2008060766A3 HISTAMINE H4 RECEPTOR LIGANDS FOR USE IN PAIN TREATMENT 审中-公开
标题翻译： HISTAMINE H4受体配体用于治疗疼痛
公开(公告)号：WO2008060766A3
公开(公告)日：2009-02-19
申请号：PCT/US2007080132
申请日：2007-10-02
申请人： ABBOTT LAB , COWART MARLON D , ALTENBACH ROBERT J , LIU HUAQING , DRIZIN IRENE , WISHART NEIL , BABINSKI DAVID J , GREGG ROBERT J , ESBENSHADE TIMOTHY A , HSIEH GIN C , BRIONI JORGE D , HONORE MARIE P , BLACK LAWRENCE A , ZHAO CHEN , WAKEFIELD BRIAN D
发明人： COWART MARLON D , ALTENBACH ROBERT J , LIU HUAQING , DRIZIN IRENE , WISHART NEIL , BABINSKI DAVID J , GREGG ROBERT J , ESBENSHADE TIMOTHY A , HSIEH GIN C , BRIONI JORGE D , HONORE MARIE P , BLACK LAWRENCE A , ZHAO CHEN , WAKEFIELD BRIAN D , HANCOCK ARTHUR A
IPC分类号： A61K31/417 , A61K31/496 , A61K31/506 , A61K45/06 , A61P29/00
CPC分类号： A61K31/506 , A61K31/417 , A61K31/496 , A61K45/06
摘要： This invention discloses histamine H4 receptor ligands for use in a method of treating pain
摘要翻译：本发明公开了用于治疗疼痛的方法中的组胺H 4受体配体

2. 发明申请

WO2008060767A2 MACROCYCLIC BENZOFUSED PYRIMIDINE DERIVATIVES 审中-公开
标题翻译：大环苯并芘嘧啶衍生物
公开(公告)号：WO2008060767A2
公开(公告)日：2008-05-22
申请号：PCT/US2007080133
申请日：2007-10-02
申请人： ABBOTT LAB , ALTENBACH ROBERT J , LIU HUAQING , DRIZIN IRENE , COWART MARLON D , WISHART NEIL , BABINSKI DAVID J , GREGG ROBERT J , ESBENSHADE TIMOTHY A , HSIEH GIN C , BRIONI JORGE D , HONORE MARIE P , BLACK LAWRENCE A , ZHAO CHEN , WAKEFIELD BRIAN D
发明人： ALTENBACH ROBERT J , LIU HUAQING , DRIZIN IRENE , COWART MARLON D , WISHART NEIL , BABINSKI DAVID J , GREGG ROBERT J , ESBENSHADE TIMOTHY A , HSIEH GIN C , BRIONI JORGE D , HONORE MARIE P , BLACK LAWRENCE A , ZHAO CHEN , WAKEFIELD BRIAN D , HANCOCK ARTHUR A
IPC分类号： C07D491/04 , C07D493/04 , C07H17/04
CPC分类号： C07H17/04 , C07D239/70 , C07D403/12 , C07D453/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/04 , C07D495/04 , C07D519/00
摘要： Macrocyclic benzofused pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions and disorders using such compounds and compositions are described herein.
摘要翻译：本文描述了大环苯并稠合的嘧啶化合物，包含此类化合物的组合物，制备所述化合物的方法以及使用此类化合物和组合物治疗和预防疾病，病症和障碍进展的方法。

3. 发明专利

SG182187A1 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS 未知
公开(公告)号：SG182187A1
公开(公告)日：2012-07-30
申请号：SG2012043113
申请日：2008-06-04
申请人： ABBOTT GMBH & CO KG , ABBOTT LAB
发明人： AKRITOPOULOU-ZANZE IRINI , WAKEFIELD BRIAN D , MACK HELMUT , TURNER SEAN C , GASIECKI ALAN F , GRACIAS VIJAYA J , SARRIS KATHY , KALVIN DOUGLAS M , MICHMERHUIZEN MELISSA J , SHUAI QI , PATEL JYOTI R , BAKKER MARGARETHA , TEUSCH NICOLE , KOVAR PETER J , DJURIC STEVAN W , LONG ANDREW J , VASUDEVAN ANIL , HOBSON ADRIAN , ST JOHN MOORE NIGEL , WANG LU , GEORGE DAWN , LI BIQIN , FRANK KRISTINE , JOHNSON ERIC T
摘要： 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORSAbstractThe present invention relates to compounds of formula (1) or pharmaceutical acceptable salts, wherein A, R1,R2, R3 and m, are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as Glycogen Synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janus Kinases (JAK), Ala, PAK4, PLK, CK2, KDR, MK2, JNK I, aurora, pim I and nek 2.No suitable figure

4. 发明专利

NZ586301A BENZOTHIAZOLE AND BENZOXAZOLE DERIVATIVES AND METHODS OF USE 未知
公开(公告)号：NZ586301A
公开(公告)日：2012-10-26
申请号：NZ58630108
申请日：2008-12-18
申请人： ABBOTT LAB
发明人： BLACK LAWRENCE A , COWART MARLON D , GFESSER GREGORY A , WAKEFIELD BRIAN D , ALTENBACH ROBERT J , LIU HUAQING , ZHAO CHEN , HSIEH GIN C
IPC分类号： C07D413/14 , A61K31/423 , A61K31/426 , A61K31/428 , A61P3/10 , A61P25/00 , C07D277/82 , C07D417/14
摘要： Disclosed are 2-(pyrrolidin-1-yl)benzo[d]thiazole derivatives as represented by the general formula (I), wherein Z is sulfur; n is an integer from 0 to 2; p is an integer from 0 to 1; and wherein the remaining substituents are as defined herein; and radiolabelled analogues thereof. Representative compounds include 6-(1-methyl-1H-pyrazol-4-yl)-2-(3-(piperidin-1-yl)azetidin-1-yl)benzo[d]thiazole, (R)-4-(2-(1,3'-bipyrrolidin-1'-yl)benzo[d]thiazol-6-yl)benzonitrile, (R)-6-(1-(11C)methyl-1H-pyrazol-4-yl)-2-(3-(piperidin-1-yl)pyrrolidin-1-yl)benzo[d]thiazole, (R)-6-(1-methyl-1H-pyrazol-4-yl)-2-(3-(4-(18F)fluoro-piperidin-1-yl)pyrrolidin-1-yl)benzo[d]thiazole, (R)-2-(2-(3-(4-(18F)fluoro-piperidin-1-yl)pyrrolidin-1-yl)benzo[d]thiazol-6-yl)pyridazin-3(2R)-one; (R)-3-(2-(3-(4-(18F)fluoro-piperidin-1-yl)pyrrolidin-1-yl)benzo[d]thiazol-6-yl)oxazolidin-2-one, (S)-3-hydroxy-1-(2-((R)-3-(4-(18F)fluoro-piperidin-1-yl)pyrrolidin-1-yl)benzo[d]thiazol-6-yl)pyrrolidin-2-one and (R)-N-(2-(18F)fluoroethyl)-2-(3-(piperidin-1-yl)pyrrolidin-1-yl)benzo[d]thiazole-6-carboxamide. Further disclosed is a pharmaceutical composition comprising a therapeutically effective amount of a compound as defined above in combination with a pharmaceutically acceptable carrier for treating a condition or disorder modulated by the histamine-3 receptors selected from acute myocardial infarction, Alzheimer's disease, asthma, attention-deficit hyperactivity disorder, bipolar disorder, cognitive dysfunction, cognitive deficits in psychiatric disorders, deficits of memory, deficits of learning, dementia, cutaneous carcinoma, drug abuse, diabetes, type II diabetes, depression, epilepsy, gastrointestinal disorders, inflammation, insulin resistance syndrome, jet lag, medullary thyroid carcinoma, melanoma, Meniere's disease, metabolic syndrome, mild cognitive impairment, migraine, mood and attention alteration, motion sickness, narcolepsy, neurogenic inflammation, obesity, obsessive compulsive disorder, pain, neuropathic pain, osteoarthritis pain, Parkinson's disease, polycystic ovary syndrome, schizophrenia, cognitive deficits of schizophrenia, seizures, septic shock, Syndrome X, Tourette's syndrome, vertigo, and sleep disorders.

5. 发明专利

MX2009013213A INDAZOLES 5-SUSTITUIDOS 5-HETEROARILO COMO INHIBIDORES DE CINASA. 未知
公开(公告)号：MX2009013213A
公开(公告)日：2010-03-30
申请号：MX2009013213
申请日：2008-06-04
申请人： ABBOTT LAB
发明人： KALVIN DOUGLAS M , WANG LU , GASIECKI ALAN F , GRACIAS VIJAYA J , AKRITOPOULOU-ZANZE IRINI , LI BIQIN , PATEL JYOTI R , SHUAI QI , TURNER SEAN C , DJURIC STEVAN W , BAKKER MARGARETHA , VASUDEVAN ANIL , MICHMERHUIZEN MELISSA J , SARRIS KATHY , HOBSON ADRIAN , TEUSCH NICOLE , MACK HELMUT , WAKEFIELD BRIAN D , JOHNSON ERIC T , KOVAR PETER J , LONG ANDREW J , MOORE NIGEL ST JOHN , GEORGE DAWN , FRANK KRISTINE
IPC分类号： C07D403/04 , C07D413/04 , C07D417/04
摘要： La presente invención se refiere a compuestos de la fórmula (I) o sales farmacéuticamente aceptables, en donde A, R1, R2, R3 y m, son como se definieron en la descripción. La presente invención se refiere también a métodos para elaborar los compuestos, y composiciones que contienen los compuestos los cuales son útiles para inhibir las cinasas tales como Glicógeno Cintaza cinasa 3 (GSK-3), Rho cinasa (ROCK), Janus Cinasas (JAK), AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 y nek 2.

6. 发明专利

CA2709961A1 BENZOTHIAZOLE AND BENZOXAZOLE DERIVATIVES AND METHODS OF USE 未知
公开(公告)号：CA2709961A1
公开(公告)日：2009-07-09
申请号：CA2709961
申请日：2008-12-18
申请人： ABBOTT LAB
发明人： BLACK LAWRENCE A , COWART MARLON D , GFESSER GREGORY A , WAKEFIELD BRIAN D , ALTENBACH ROBERT J , LIU HUAQING , ZHAO CHEN , HSIEH GIN C
IPC分类号： A61K31/423 , A61K31/428 , A61P3/10 , A61P25/00 , C07D413/14 , C07D417/14
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions of compounds of formula (I), methods for using such compounds and compositions, and a process for preparing the compounds.

8. 发明专利

AU2008343115A1 Benzothiazole and benzoxazole derivatives and methods of use 未知
公开(公告)号：AU2008343115A1
公开(公告)日：2009-07-09
申请号：AU2008343115
申请日：2008-12-18
申请人： ABBOTT LAB
发明人： HSIEH GIN C , ZHAO CHEN , BLACK LAWRENCE A , LIU HUAQING , COWART MARLON D , WAKEFIELD BRIAN D , GFESSER GREGORY A , ALTENBACH ROBERT J
IPC分类号： C07D413/14 , A61K31/423 , A61K31/428 , A61P3/10 , A61P25/00 , C07D417/14
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions of compounds of formula (I), methods for using such compounds and compositions, and a process for preparing the compounds.

9. 发明专利

CA2689117A1 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS 未知
公开(公告)号：CA2689117A1
公开(公告)日：2008-12-18
申请号：CA2689117
申请日：2008-06-04
申请人： ABBOTT GMBH & CO KG , ABBOTT LAB
发明人： WAKEFIELD BRIAN D , AKRITOPOULOU-ZANZE IRINI , MACK HELMUT , FRANK KRISTINE , LI BIQIN , VASUDEVAN ANIL , HOBSON ADRIAN , LONG ANDREW J , DJURIC STEVAN W , KOVAR PETER J , JOHNSON ERIC T , TURNER SEAN C , GEORGE DAWN , GASIECKI ALAN F , WANG LU , ST JOHN MOORE NIGEL , MICHMERHUIZEN MELISSA J , GRACIAS VIJAYA J , SARRIS KATHY , KALVIN DOUGLAS M , SHUAI QI , PATEL JYOTI R , BAKKER MARGARETHA , TEUSCH NICOLE
IPC分类号： C07D403/04 , C07D413/04 , C07D417/04
摘要： The present invention relates to compounds of formula (I) or pharmaceutic al acceptable salts, wherein A, R1, R2, R3 and m, are defined in the descrip tion. The present invention relates also to methods of making said compounds , and compositions containing said compounds which are useful for inhibiting kinases such as Glycogen Synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janu s Kinases (JAK), AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 and nek 2.

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