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1. 发明申请

WO2004026822A3 PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) 审中-公开
标题翻译：作为DIPPTIDYL PEPTIDASE-IV（DPP-IV）抑制剂的药物组合物
公开(公告)号：WO2004026822A3
公开(公告)日：2004-05-06
申请号：PCT/US0329018
申请日：2003-09-15
申请人： ABBOTT LAB
发明人： MADAR DAVID , PEI ZHONGHUA , PIREH DAISY , DJURIC STEVAN W , WIEDEMAN PAUL E , YONG HONG , FEENSTRA MELISSA J , KOPECKA HANA , LI XIAOFENG , LONGENECKER KENTON , SHAM HING L , STEWART KENT D , SZCZEPANKIEWICZ BRUCE G
IPC分类号： A61P37/02 , C07D207/16 , C07D207/26 , C07D207/27 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12 , A61K31/401 , A61K31/4439 , A61K31/506
CPC分类号： C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要： The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R ,R and R have the definitions given in the description.
摘要翻译：本发明涉及抑制二肽基肽酶IV（DPP-IV）的式I化合物，其可用于预防或治疗糖尿病，特别是II型糖尿病，以及高血糖症，X综合征，高胰岛素血症，肥胖症，动脉粥样硬化和各种免疫调节疾病。或其药学上可接受的盐或前药，其中X，R，R 1，R 2和R 3具有说明书中给出的定义。

2. 发明公开

EP0595924A4 PLATELET ACTIVATING FACTOR ANTAGONISTS 失效
标题翻译： PLATELET激活因子拮抗剂
公开(公告)号：EP0595924A4
公开(公告)日：1994-08-24
申请号：EP92915895
申请日：1992-07-14
申请人： ABBOTT LAB
发明人： SUMMERS JAMES B , DAVIDSEN STEVEN K , HOLMS JAMES H , PIREH DAISY , HEYMAN H ROBIN , MARTIN MICHAEL B , STEINMAN DOUGLAS H , SHEPPARD GEORGE S , CARRERA GEORGE M JR
IPC分类号： A61K31/44 , A61K31/4406 , A61K49/00 , A61K49/06 , A61P1/04 , A61P7/02 , A61P7/06 , A61P9/02 , A61P11/06 , A61P17/06 , A61P29/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07B47/00 , C07D213/69 , C07D487/04 , C07D498/04 , C07D513/04 , C07F5/00 , C07F13/00
CPC分类号： C07D487/04 , A61K49/06 , C07D213/69 , C07D513/04

3. 发明公开

EP0574494A4 INDOLES USEFUL AS PLATELET ACTIVATING FACTOR ANTAGONISTS 失效
标题翻译：有限的平板电脑激活因子拮抗剂
公开(公告)号：EP0574494A4
公开(公告)日：1994-07-06
申请号：EP92906944
申请日：1992-02-14
申请人： ABBOTT LAB
发明人： SUMMERS JAMES B , SHEPPARD GEORGE S , PHILLIPS JAMES G , PIREH DAISY , STEINMAN DOUGLAS H , MAY PAUL D , GUINN DENISE E , HEYMAN H ROBIN , CARRERA GEORGE M JR , DAVIDSEN STEVEN K
IPC分类号： A61K31/44 , A61K31/4427 , A61K31/4433 , A61P7/02 , A61P11/00 , A61P29/00 , C07D401/14 , C07D403/14 , C07D409/14 , C07D417/14
CPC分类号： C07D409/14 , C07D417/14

4. 发明专利

CY1110361T1 ΦΑΡΜΑΚΕΥΤΙΚΕΣ ΣΥΝΘΕΣΕΙΣ ΩΣ ΑΝΑΣΤΟΛΕΙΣ ΔΙΠΕΠΤΙΔΥΛΙΚΗΣ ΠΕΠΤΙΔΑΣΗΣ IV (DPP-IV) 未知
公开(公告)号：CY1110361T1
公开(公告)日：2015-04-29
申请号：CY071101364
申请日：2007-10-23
申请人： ABBOTT LAB
发明人： MADAR DAVID , PEI ZHONGHUA , PIREH DAISY , DJURIC STEVAN W , WIEDEMAN PAUL E , YONG HONG , MICHMERHUIZEN MELISSA J , KOPECKA HANA , LI XIAOFENG , LONGENECKER KENTON , SHAM HING L , STEWART KENT D , SZCZEPANKIEWICZ BRUCE G
IPC分类号： C07D207/00 , A61P37/02 , C07D207/16 , C07D207/26 , C07D207/27 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要： ΗπαρούσαεφεύρεσησχετίζεταιμεενώσειςτουτύπουΙ οιοποίεςαναστέλλουντηνδιπεπτιδυλικήπεπτιδάση IV (DPP-IV) καιείναιχρήσιμεςγιατηνπρόληψηή τηναγωγήτουδιαβήτη, ειδικάτουδιαβήτητύπουΙΙ, όπωςεπίσηςτηςυπεργλυκαιμίας, τουΣυνδρόμουΧ, τηςυπερινσουλιναιμίας, τηςπαχυσαρκίας, τηςαθηροσκλήρωσης, καιδιαφόρωνανοσορρυθμιστικώννόσων. Ήφαρμακευτικώςαποδεκτάάλαταή προφάρμακααυτών, όπουτα X, R, R1, R2 και R3 έχουντουςορισμούςπουδίνονταιστηνπεριγραφή.

5. 发明专利

HK1082733A1 Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-iv (dpp-iv) 未知
公开(公告)号：HK1082733A1
公开(公告)日：2006-06-16
申请号：HK06101745
申请日：2006-02-09
申请人： ABBOTT LAB
发明人： MADAR DAVID , PEI ZHONGHUA , PIREH DAISY , DJURIC STEVAN W , PAUL WIEDEMAN E , HONG YONG , FEENSTRA MELISSA J , KOPECKA HANA , LI XIAOFENG , LONGENECKER KENTON , SHAM HING L , STEWART KENT D , SZCZEPANKIEWICZ BRUCE G
IPC分类号： C07D20060101 , A61P37/02 , C07D207/16 , C07D207/26 , C07D207/27 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要： The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R ,R and R have the definitions given in the description.

6. 发明专利

AR041289A1 COMPUESTOS DE PIRROLIDINA COMO INHIBIDORES DE LA DIPEPTIDIL PEPTIDASA - IV ( DPP-IV ) 未知
公开(公告)号：AR041289A1
公开(公告)日：2005-05-11
申请号：ARP030103370
申请日：2003-09-17
申请人： ABBOTT LAB
发明人： FEENSTRA MELISSA , KOPECKA HANA , LI LI , LONGENECKER K , SHAM HING L , STEWART KENT D , MADAR DAVID , PEI ZHONGHUA , PIREH DAISY , DJURIC STEVAN W , WIEDEMAN PAUL E , YONG HONG , SZCZEPANKIEWICZ BRUCE G
IPC分类号： C07D207/16 , A61K31/4025 , A61K31/428 , A61K31/4439 , A61K31/4523 , A61K31/4709 , A61P3/04 , A61P3/10 , A61P5/50 , A61P37/02 , C07D207/26 , C07D207/277 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12 , C07F5/00
摘要： Compuestos que inhiben la dipeptidil peptidasa IV (DPP-IV) y son de utilidad en la prevención o tratamiento de la diabetes, especialmente la diabetes de tipo II, y también de la hiperglucemia, el Síndrome X, la hiperinsulinemia, la obesidad, laarterosclerosis, y diversas enfermedades inmunomoduladoras. Reivindicación 1: Un compuesto caracterizado porque responde a la fórmula (1), o una sal o prodroga aceptable para uso farmacéutico del mismo, donde X es un miembro seleccionado entre elgrupo que comprende CH2, CHF y CF2; R se selecciona entre el grupo que comprende alquilcarbonilo, arilcarbonilo, ciano, heterociclilcarbonilo, R4R5NC(O)-, B(OR6)2, (1,2,3)-dioxoborolano y 4,4,5,5-tetrametil-(1,2,3)-dioxoborolano; R1 se seleccionaentre el grupo que comprende alcoxialquilo, alquilo, alquilcarbonilo, alquenilo, alquinilo, alenilo, arilaquilo, cicloalquilo, cicloalquilalquilo, ciano, haloalquilo, haloalquenilo, heterociclilalquilo, e hidroxialquilo; R2 y R3 se seleccionan enforma independiente entre el grupo que comprende hidrógeno, alcoxialquilo, alquilo, alquenilo, alquinilo, cicloalquilo, cicloalquilalquilo, arilo, arilalquilo, heterociclo, heterociclilalquilo, hidroxialquilo; o R2 y R3 junto con los átomos a loscuales están unidos forman un heterociclo mono o bicíclico seleccionado entre el grupo que comprende 2-indolinilo, 2-indolilo, 3-isoquinolina, 2-piperazina, 2-piperidina, 2-pirrolidina, 2-pirrol, 2-piridina, 2-quinolinilo, 2-tetrahidroquinolinilo, y3-tetrahidroisoquinolinilo, donde dicho heterociclo puede estar sustituido con 0, 1, 2 o 3 sustituyentes seleccionados en forma independiente entre alquenilo, alcoxi, alcoxialquilo, alcoxicarbonilo, alcoxicarbonilalquilo, alquilo, alquilcarbonilo,alquilcarbonilalquilo, alquilcarboniloxi, alquilsulfonilo, alquiltio, alquinilo, arilo, arilalcoxi, arilalquilo, arilcarbonilo, ariloxi, carboxi, carboxialquilo, ciano, cianoalquilo, formilo, halógeno, haloalquilo, hidroxi, hidroxialquilo, mercapto,nitro, fenilo, RaRbN-, RcRdNC(O)-, y RcRdNS(O)2-; R4, R5 y R6 se seleccionan cada uno en forma independiente entre el grupo que comprende hidrógeno, alquilo, y arilalquilo; Ra y Rb se selecciona cada uno en forma independiente entre el grupo quecomprende alquilo, alquilcarbonilo, alcoxicarbonilo, alquilsulfonilo; o Ra y Rb junto con el nitrógeno al cual están unidos forman un anillo seleccionado entre el grupo que comprende piperidina, piperazina y morfolina; y Rc y Rd se seleccionan cadauno en forma independiente entre el grupo que comprende hidrógeno y alquilo.

7. 发明专利

CA2497725A1 PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) 未知
公开(公告)号：CA2497725A1
公开(公告)日：2004-04-01
申请号：CA2497725
申请日：2003-09-15
申请人： ABBOTT LAB
发明人： MADAR DAVID , KOPECKA HANA , LI XIAOFENG , FEENSTRA MELISSA J , SZCZEPANKIEWICZ BRUCE G , STEWART KENT D , PEI ZHONGHUA , YONG HONG , WIEDEMAN PAUL E , DJURIC STEVAN W , PIREH DAISY , LONGENECKER KENTON , SHAM HING L
IPC分类号： A61P37/02 , C07D207/16 , C07D207/26 , C07D207/27 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12 , A61K31/401 , A61K31/4439 , A61K31/506
摘要： The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia , Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R1,R2 and R3 have the definitions given in the description.

8. 发明专利

ES2191778T3 未知
公开(公告)号：ES2191778T3
公开(公告)日：2003-09-16
申请号：ES96940766
申请日：1996-11-06
申请人： ABBOTT LAB
发明人： OR YAT SUN , CHU DANIEL T , ELLIOTT RICHARD L , PIREH DAISY
IPC分类号： A61K31/00 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/00 , A61P31/04 , C07H17/08
摘要： A compound selected from groups (I), (II), and (III), wherein A, B, V, W, X and R are specifically defined; pharmaceutical compositions thereof; a method of treating or preventing bacterial infections by administering therapeutically effective pharmaceutical compositions thereof; and a process for the preparation thereof.

9. 发明专利

PT100698B 未知
公开(公告)号：PT100698B
公开(公告)日：1999-07-30
申请号：PT10069892
申请日：1992-07-16
申请人： ABBOTT LAB
发明人： SUMMERS JAMES B , STEINMAN DOUGLAS H , MARTIN MICHAEL B , CARRERA GEORGE M JR , HOLMS JAMES H , PIREH DAISY , HEYMAN ROBIN H , SHEPPARD GEORGE S , DAVIDSEN STEVE K
IPC分类号： A61K31/4406 , A61K49/00 , A61K49/06 , A61P1/04 , A61K31/44 , A61P7/02 , A61P7/06 , A61P9/02 , A61P11/06 , A61P17/06 , A61P29/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07B47/00 , C07D213/69 , C07D487/04 , C07D498/04 , C07D513/04 , C07F5/00 , C07F13/00
摘要： PCT No. PCT/US92/05890 Sec. 371 Date Dec. 2, 1993 Sec. 102(e) Date Dec. 2, 1993 PCT Filed Jul. 14, 1992 PCT Pub. No. WO93/01813 PCT Pub. Date Feb. 4, 1993.Indole compounds substituted at the 3-position by a 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]thiazole, 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]oxazole, or 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]pyrrole group are potent antagionists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointesinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.

10. 发明专利

CZ349698A3 3-DESCLADINOSO-2,3-ANHYDROERYTHROMYCIN DERIVATIVES 未知
公开(公告)号：CZ349698A3
公开(公告)日：1999-04-14
申请号：CZ349698
申请日：1997-04-25
申请人： ABBOTT LAB
发明人： ELLIOTT RICHARD L , OR YAT SUN , CHU DANIEL T , GRIESGRABER GEORGE W , PLATTNER JACOB J , PIREH DAISY
IPC分类号： A61K31/04 , A61K31/70 , A61K31/7048 , A61K31/7052 , C07H17/08
摘要： Novel 3-descladinose-2,3-anhydroerythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity selected from the group consisting of: (a) (I), (b) (II), (c) (III), and (d) (IV), pharmaceutical compositions comprising a therapeutically effective amount of a compound of formulas (I)-(IV) of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of formulas (I)-(IV) of the invention.

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