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1. 发明申请

WO2009135799A2 METHOD FOR EVALUATING THE SOLUBILITY OF A CRYSTALLINE SUBSTANCE IN A POLYMER 审中-公开
标题翻译：评估聚合物中晶体物质的溶解性的方法
公开(公告)号：WO2009135799A2
公开(公告)日：2009-11-12
申请号：PCT/EP2009/055233
申请日：2009-04-29
申请人： ABBOTT GMBH & CO. KG , ZHANG, Geoff, G., Z. , YU, Lian , TAO, Jing , SUN, Ye , MAEGERLEIN, Markus
发明人： ZHANG, Geoff, G., Z. , YU, Lian , TAO, Jing , SUN, Ye , MAEGERLEIN, Markus
IPC分类号： G01N33/15
CPC分类号： G01N33/15 , G01N25/4866
摘要： A viable strategy to enhance the bioavailability of poorly soluble drugs is to use amorphous solids in place of the more commonly used crystalline solids in pharmaceutical formulations. However, amorphous solids are physically meta-stable and tend to revert back to their crystalline counterpart. An effective approach to stabilizing an amorphous drug against crystallization is to disperse it in a polymer matrix. The drug's solubility in the chosen polymer defines the upper limit of drug loading without any risk of crystallization. Measuring the solubility of a drug in a polymer has been a scientific and technological challenge because the high viscosity of polymers makes achieving solubility equilibrium difficult and because pharmaceutically important drug/polymer dispersions are glasses, which undergo structural relaxation over time. The invention provides a method based on Differential Scanning Calorimetry (DSC) for measuring the solubility of crystalline drugs in polymeric matrices. The method relies on the detection of the dissolution endpoint of a drug/polymer mixture prepared by cryomilling.
摘要翻译：提高难溶性药物的生物利用度的可行策略是使用无定形固体代替药物制剂中更常用的结晶固体。然而，无定形固体物理上是元稳定的，并且倾向于回复到它们的结晶对应物。稳定无定形药物抗结晶的有效方法是将其分散在聚合物基质中。药物在所选聚合物中的溶解度限定了药物负载的上限，而没有结晶的风险。测量药物在聚合物中的溶解度已经是科学和技术挑战，因为聚合物的高粘度使得难以实现溶解度平衡，并且因为药物重要的药物/聚合物分散体是随时间经历结构松弛的玻璃。本发明提供了一种基于差示扫描量热法（DSC）测量结晶药物在聚合物基质中的溶解度的方法。该方法依赖于通过冷冻法制备的药物/聚合物混合物的溶解终点的检测。

2. 发明申请

WO2011089202A1 METHOD FOR EVALUATING THE SOLUBILITY OF A CRYSTALLINE SUBSTANCE IN A POLYMER 审中-公开
标题翻译：评估聚合物中晶体物质的溶解性的方法
公开(公告)号：WO2011089202A1
公开(公告)日：2011-07-28
申请号：PCT/EP2011/050792
申请日：2011-01-21
申请人： ABBOTT GMBH & CO. KG , ZHANG, Geoff G. Z. , YU, Lian , TAO, Jing , SUN, Ye , MAEGERLEIN, Markus
发明人： ZHANG, Geoff G. Z. , YU, Lian , TAO, Jing , SUN, Ye , MAEGERLEIN, Markus
IPC分类号： G01N25/48 , G01N33/15
CPC分类号： G01N33/15 , G01N25/4866 , G01N2013/006
摘要： A method for evaluating the solubility of a crystalline substance in a polymer comprises a) providing at least one sample of an intimate crystalline substance/polymer mixture at a predetermined crystalline substance concentration; b) annealing the sample at a constant temperature T a for a period of time; c) heating the annealed sample while recording the heat flux over time by DSC; d) identifying a DSC dissolution endotherm in the recorded heat flux, if any; e) considering the crystalline substance concentration as a concentration above the crystalline substance solubility in the polymer at temperature T a when there is a DSC dissolution endotherm identified, and considering the crystalline substance concentration as a concentration less than or equal to the crystalline substance solubility in the polymer at temperature T a when there is no DSC dissolution endotherm identified. Thus, the method yields the upper and lower bounds for the equilibrium solubility at a given temperature or the upper and lower bounds for the equilibrium solubility temperature at a given crystalline substance concentration. The method improves accuracy of measurement near the glass transition temperature.
摘要翻译：用于评价结晶物质在聚合物中的溶解度的方法包括a）以预定的结晶物质浓度提供至少一种紧密结晶物质/聚合物混合物的至少一个样品; b）在恒温Ta下将样品退火一段时间; c）加热退火样品，同时通过DSC随时间记录热通量; d）识别记录的热通量中的DSC溶解吸热（如果有的话）; e）当确定DSC溶解吸热时，考虑结晶物质浓度高于结晶物质在聚合物中的溶解度的浓度，考虑到结晶物质浓度小于或等于结晶物质溶解度的浓度聚合物在温度Ta时没有DSC溶解吸热确定。因此，该方法产生在给定温度下的平衡溶解度的上限和下限，或者给定在给定结晶物质浓度下的平衡溶解度温度的上限和下限。该方法提高玻璃化转变温度附近的测量精度。

3. 发明申请

WO2005052934A3 PARAMETER OPTIMIZATION FOR OPTICAL DISC RECORDING 审中-公开
公开(公告)号：WO2005052934A3
公开(公告)日：2005-06-09
申请号：PCT/IB2004/052495
申请日：2004-11-22
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , TAO, Jing , TANG, Fulong , CHEN, Dianyong , LANGEREIS, Gerardus Rudolph
发明人： TAO, Jing , TANG, Fulong , CHEN, Dianyong , LANGEREIS, Gerardus Rudolph
IPC分类号： G11B7/125 , G11B7/0045 , G11B20/10 , G11B20/14
摘要： A method for optimizing writing parameters (1) comprising the following steps: acquiring the variation of a mark runlength (s20, s30); determining a modulation amount of the writing parameters based on a relationship between the variable of the mark runlength and the modulation amount of the writing parameters (s51, s52); and modulating the writing parameters (s60). The method is applicable to multifarious optical disc systems, it can adopt multifarious strategies for the writing process, it can optimize the power, the starting time, and the stopping time of a plurality of laser pulses, thereby optimizing the mark runlength.

4. 发明申请

WO2008001314A1 A METHOD AND APPARATUS OF OPTIMIZING WRITE PARAMETERS FOR A REWRITABLE OPTICAL DISC 审中-公开
标题翻译：用于优化光盘的优化写参数的方法和装置
公开(公告)号：WO2008001314A1
公开(公告)日：2008-01-03
申请号：PCT/IB2007/052482
申请日：2007-06-27
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , ZHONG, Jianyi , TAO, Jing , WEI, Gongming
发明人： ZHONG, Jianyi , TAO, Jing , WEI, Gongming
IPC分类号： G11B20/10 , G11B7/0045 , G11B7/006 , G11B7/125
CPC分类号： G11B20/10009 , G11B7/0062 , G11B7/1267 , G11B20/10481
摘要： A method of optimizing write parameters for a rewritable optical disc comprises the steps of: reading out (310) predefined write parameters from the rewritable optical disc, which predefined write parameters comprise a power indicator Pwind and an initial Epsilon value ε, selecting (320) a Tmp from a range [8T/40, 14T/40] and a dTtop from a range [11T/40, 17T/40], where Tmp is a multiple pulse time, dTtop is a first pulse lead-time, and T is a clock period, adjusting (330) ε to adapt to a jitter value according to the value of Pwind, and generating (340) an optimized write power Pw based on the jitter value and the adjusted ε.
摘要翻译：一种优化可重写光盘的写入参数的方法包括以下步骤：从可重写光盘中读出（310）预定义的写入参数，该预定义的写参数包括功率指示器Pwind和初始Epsilon值e，选择（320）来自范围[8T / 40,14T / 40]的Tmp和来自范围[11T / 40,17T / 40]的dTtop，其中Tmp是多脉冲时间，dTtop是第一脉冲提前时间，T是时钟周期，根据Pwind的值调整（330）e以适应抖动值，并且基于抖动值和调整的e生成（340）优化的写入功率Pw。

5. 发明申请

WO2007069158A2 METHOD AND APPARATUS FOR OPTIMIZING OPTICAL DISC WRITING STRATEGY 审中-公开
标题翻译：用于优化光盘写入策略的方法和设备
公开(公告)号：WO2007069158A2
公开(公告)日：2007-06-21
申请号：PCT/IB2006/054674
申请日：2006-12-08
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , ZHONG, Jianyi , TAO, Jing , WEI, Gongming
发明人： ZHONG, Jianyi , TAO, Jing , WEI, Gongming
IPC分类号： G11B7/125
CPC分类号： G11B7/006 , G11B7/00736 , G11B7/1267
摘要： The present invention provides a method and apparatus for optimizing optical disc writing strategy. The method for optimizing optical disc writing strategy comprises the steps of obtaining the information concerning whether said area to be written has experienced any writing before; searching for an area that has the corresponding information in the writing optimization area on said optical disc; and performing writing test on said area that has the corresponding information to optimize and determine an optical disc writing strategy for writing said optical disc. The method and apparatus could not only reduce the difference between the optical disc writing strategy and the real optical disc writing condition as much as possible, but also lower the requirement on the optical disc writing equipment and the cost, and could be easily realized.
摘要翻译：本发明提供了一种用于优化光盘写入策略的方法和装置。用于优化光盘写入策略的方法包括以下步骤：获得关于所述待写入区域是否经历过任何写入的信息; 在所述光盘上的写入优化区域中搜索具有相应信息的区域; 以及对具有相应信息的所述区域执行写入测试以优化和确定用于写入所述光盘的光盘写入策略。该方法和装置不仅能够尽可能地减少光盘写入策略和实际光盘写入条件之间的差异，而且也降低了对光盘写入设备的要求和成本，并且可以容易地实现。 / p>

6. 发明申请

WO2007052221A2 METHOD OF ADJUSTING WRITING PARAMETERS, OPTICAL DISC WRITER AND METHOD OF RECORDING DATA USING THE SAME 审中-公开
标题翻译：写入参数的方法，光盘写入和记录数据的方法
公开(公告)号：WO2007052221A2
公开(公告)日：2007-05-10
申请号：PCT/IB2006/054036
申请日：2006-11-01
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , TAO, Jing , ZHONG, Jianyi
发明人： TAO, Jing , ZHONG, Jianyi
IPC分类号： G11B7/125
CPC分类号： G11B7/0062 , G11B7/1267
摘要： The present invention discloses a method of adjusting writing parameters, comprising the steps of testing a region to be written in a re-writeable optical disc without changing writing power level; calculating writing parameters in the region to be written based on the tested result; and adjusting writing parameters based on the calculated result. According to embodiments of the present invention, the direct over writing compatibility problem can be resolved. Moreover, power level adjusting is kept unchanged so as to avoid possible damage to direct over writing cycleability.
摘要翻译：本发明公开了一种调整写入参数的方法，包括以下步骤：在不改变写入功率电平的情况下测试要写入可重写光盘的区域; 根据测试结果计算要写入区域的写入参数; 并根据计算结果调整写入参数。根据本发明的实施例，可以解决直接写入兼容性问题。此外，功率电平调整保持不变，以避免可能损害直接写入循环性。

7. 发明申请

WO2005104101A1 METHOD AND APPARATUS FOR DETERMINING AN ERASING POWER OF A REWRITABLE OPTICAL DISC 审中-公开
标题翻译：用于确定可折射光盘的擦除功率的方法和装置
公开(公告)号：WO2005104101A1
公开(公告)日：2005-11-03
申请号：PCT/IB2005/051149
申请日：2005-04-08
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , TANG, Fulong , TIEKE, Benno , HELLMIG, Jochen , TAO, Jing , LANGEREIS, Geert
发明人： TANG, Fulong , TIEKE, Benno , HELLMIG, Jochen , TAO, Jing , LANGEREIS, Geert
IPC分类号： G11B7/0055
CPC分类号： G11B7/1267 , G11B7/00557
摘要： The present invention provides a method for determining the erasing power of rewritable optical disk and the apparatus thereof. The method comprises the steps: setting up a plurality of erasing test powers firstly; then testing optical disk writing using a designated writing power of optical disk together with the plurality of erasing test powers of optical disk respectively to obtain the parameters corresponding to every erasing test power of optical disk, the parameters representing the effects of erasing optical disk, such as the data-to-clock jitter; and then determining an erasing power used for said rewritable optical disk by establishing the corresponding variation relation between the parameters and the erasing test powers of optical disk according to the plurality of erasing test powers of optical disk and said corresponding parameters.
摘要翻译：本发明提供了一种用于确定可重写光盘的擦除功率的方法及其装置。该方法包括以下步骤：首先建立多个擦除测试功率; 然后分别使用光盘的指定写入功率与光盘的多个擦除测试功率一起测试光盘写入，以获得与光盘的每个擦除测试功率相对应的参数，表示擦除光盘的效果的参数作为数据到时钟抖动; 然后通过根据光盘的多个擦除测试功率和所述相应参数建立光盘的参数和擦除测试功率之间的相应变化关系来确定用于所述可重写光盘的擦除功率。

8. 发明申请

WO2006018770A2 METHOD AND APPARATUS FOR DETERMINING OPTICAL DISC RECORDING PARAMETERS 审中-公开
标题翻译：确定光盘记录参数的方法和设备
公开(公告)号：WO2006018770A2
公开(公告)日：2006-02-23
申请号：PCT/IB2005/052601
申请日：2005-08-04
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , TAO, Jing , TANG, Fulong , ZHONG, Jianyi
发明人： TAO, Jing , TANG, Fulong , ZHONG, Jianyi
IPC分类号： G11B7/00
CPC分类号： G11B7/1267 , G11B7/00456 , G11B7/00736
摘要： A method and apparatus for determining the parameters for disc recording is provided. For those discs that haven't pre-stored recording information or have pre-stored recording information not meeting the quality requirement, according to the method of the present invention, set the initial values of record strategy parameters firstly, then perform disc recording test with a group of parameters that have close relevancy among each other according to the method designed in the experiment, and finally determine the relationship between each optimal parameters and the optical disc recording quality, so that optimal parameters value corresponding to each parameter can be obtained for disc recording. According to the present invention, the optimal disc recording parameters can be determined within the limited time and limited space of disc recording test.
摘要翻译：提供了用于确定用于盘记录的参数的方法和设备。对于没有预先存储记录信息或者预存的记录信息不符合质量要求的光盘，按照本发明的方法，首先设置记录策略参数的初始值，然后进行光盘记录测试根据实验中设计的方法确定一组相互紧密相关的参数，最终确定各个最优参数与光盘记录质量的关系，从而得到各个参数对应的最优参数值记录。根据本发明，可以在盘记录测试的有限时间和有限空间内确定最佳盘记录参数。

9. 发明公开

EP2274609A2 METHOD FOR EVALUATING THE SOLUBILITY OF A CRYSTALLINE SUBSTANCE IN A POLYMER 有权转让
标题翻译：评估方法结晶物质的溶解度的聚合物
公开(公告)号：EP2274609A2
公开(公告)日：2011-01-19
申请号：EP09742017.8
申请日：2009-04-29
申请人： Abbott GmbH & Co. KG
发明人： ZHANG, Geoff, G., Z. , YU, Lian , TAO, Jing , SUN, Ye , MAEGERLEIN, Markus
IPC分类号： G01N33/15 , G01N25/48
CPC分类号： G01N33/15 , G01N25/4866
摘要： A viable strategy to enhance the bioavailability of poorly soluble drugs is to use amorphous solids in place of the more commonly used crystalline solids in pharmaceutical formulations. However, amorphous solids are physically meta-stable and tend to revert back to their crystalline counterpart. An effective approach to stabilizing an amorphous drug against crystallization is to disperse it in a polymer matrix. The drug's solubility in the chosen polymer defines the upper limit of drug loading without any risk of crystallization. Measuring the solubility of a drug in a polymer has been a scientific and technological challenge because the high viscosity of polymers makes achieving solubility equilibrium difficult and because pharmaceutically important drug/polymer dispersions are glasses, which undergo structural relaxation over time. The invention provides a method based on Differential Scanning Calorimetry (DSC) for measuring the solubility of crystalline drugs in polymeric matrices. The method relies on the detection of the dissolution endpoint of a drug/polymer mixture prepared by cryomilling.

10. 发明公开

EP2526413A1 METHOD FOR EVALUATING THE SOLUBILITY OF A CRYSTALLINE SUBSTANCE IN A POLYMER 审中-公开
标题翻译：评价聚合物中结晶物质溶解度的方法
公开(公告)号：EP2526413A1
公开(公告)日：2012-11-28
申请号：EP11700563.7
申请日：2011-01-21
申请人： Abbott GmbH & Co. KG
发明人： ZHANG, Geoff G. Z. , YU, Lian , TAO, Jing , SUN, Ye , MAEGERLEIN, Markus
IPC分类号： G01N25/48 , G01N33/15
CPC分类号： G01N33/15 , G01N25/4866 , G01N2013/006
摘要： A method for evaluating the solubility of a crystalline substance in a polymer comprises a) providing at least one sample of an intimate crystalline substance/polymer mixture at a predetermined crystalline substance concentration; b) annealing the sample at a constant temperature T
a for a period of time; c) heating the annealed sample while recording the heat flux over time by DSC; d) identifying a DSC dissolution endotherm in the recorded heat flux, if any; e) considering the crystalline substance concentration as a concentration above the crystalline substance solubility in the polymer at temperature T
a when there is a DSC dissolution endotherm identified, and considering the crystalline substance concentration as a concentration less than or equal to the crystalline substance solubility in the polymer at temperature T
a when there is no DSC dissolution endotherm identified. Thus, the method yields the upper and lower bounds for the equilibrium solubility at a given temperature or the upper and lower bounds for the equilibrium solubility temperature at a given crystalline substance concentration. The method improves accuracy of measurement near the glass transition temperature.
摘要翻译：用于评估结晶物质在聚合物中的溶解度的方法包括：a）提供至少一种处于预定结晶物质浓度的紧密结晶物质/聚合物混合物的样品; b）在恒定温度T a下将样品退火一段时间; c）加热退火的样品，同时通过DSC随时间记录热通量; d）确定记录的热通量中的DSC溶解吸热（如果有的话）; e）当鉴定到DSC溶解吸热时，将结晶物质浓度视为高于聚合物中结晶物质溶解度的温度T a时的浓度，并且将结晶物质浓度视为低于或等于结晶物质在在没有DSC溶解吸热峰确定时在温度T a下的聚合物。因此，该方法得到给定温度下平衡溶解度的上限和下限或给定结晶物质浓度下平衡溶解度温度的上限和下限。该方法提高了玻璃化转变温度附近的测量精度。

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