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1. 发明申请

WO2008079359A8 HUMAN ANTIBODIES THAT BIND HUMAN IL-12 AND METHODS FOR PRODUCING 审中-公开
标题翻译：人类IL-12的人体抗体和生产方法
公开(公告)号：WO2008079359A8
公开(公告)日：2009-07-30
申请号：PCT/US2007026212
申请日：2007-12-21
申请人： ABBOTT GMBH & CO KG , SALFELD JOCHEN G , ROGUSKA MICHAEL , PASKIND MICHAEL , BANERJEE SUBHASHIS , TRACEY DANIEL EDWARD , WHITE MICHAEL , KAYMAKCALAN ZEHRA , LABKOVSKY BORIS , SAKORAFAS PAUL , VELDMAN GEERTRUIDA M , VENTURINI AMY , WIDOM ANGELA , FRIEDRICH STUART , WARNE NICHOLAS W , MYLES ANGELA , ELVIN JOHN GAWAIN , DUNCAN ALEXANDER ROBERT , DERBYSHIRE ELAINE J , CARMEN SARA , HOLTET THOR LAS , DU FOU SARAH LEILA , SMITH STEPHEN
发明人： SALFELD JOCHEN G , ROGUSKA MICHAEL , PASKIND MICHAEL , BANERJEE SUBHASHIS , TRACEY DANIEL EDWARD , WHITE MICHAEL , KAYMAKCALAN ZEHRA , LABKOVSKY BORIS , SAKORAFAS PAUL , VELDMAN GEERTRUIDA M , VENTURINI AMY , WIDOM ANGELA , FRIEDRICH STUART , WARNE NICHOLAS W , MYLES ANGELA , ELVIN JOHN GAWAIN , DUNCAN ALEXANDER ROBERT , DERBYSHIRE ELAINE J , CARMEN SARA , HOLTET THOR LAS , DU FOU SARAH LEILA , SMITH STEPHEN
IPC分类号： A61K8/18 , A61Q13/00 , C07K16/24 , C12P21/06
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/30 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.
摘要翻译：公开了特异性结合人白细胞介素-12（hIL-12）的人抗体，优选重组人抗体。优选的抗体对hIL-12具有高亲和力，并在体外和体内中和hIL-12活性。本发明的抗体可以是全长抗体或其抗原结合部分。本发明的抗体或抗体部分可用于检测hIL-12和抑制hIL-12活性，例如在患有hIL-12活性有害的病症的人类受试者中。用于表达本发明的重组人抗体的核酸，载体和宿主细胞以及合成重组人抗体的方法也包括在本发明中。

2. 发明申请

WO2008079359A3 HUMAN ANTIBODIES THAT BIND HUMAN IL-12 AND METHODS FOR PRODUCING 审中-公开
标题翻译：结合人IL-12的人抗体和生产方法
公开(公告)号：WO2008079359A3
公开(公告)日：2008-09-12
申请号：PCT/US2007026212
申请日：2007-12-21
申请人： ABBOTT GMBH & CO KG , ROGUSKA MICHAEL , BANERJEE SUBHASHIS , PASKIND MICHAEL , TRACEY DANIEL EDWARD , SALFELD JOCHEN G , WHITE MICHAEL , LABKOVSKY BORIS , SAKORAFAS PAUL , KAYMAKCALAN ZEHRA , VELDMAN GEERTRUIDA M , WIDOM ANGELA , VENTURINI AMY , FRIEDRICH STUART , ELVIN JOHN GAWAIN , MYLES ANGELA , WARNE NICHOLAS W , DUNCAN ALEXANDER ROBERT , HOLTET THOR LAS , DERBYSHIRE ELAINE J
发明人： ROGUSKA MICHAEL , BANERJEE SUBHASHIS , PASKIND MICHAEL , TRACEY DANIEL EDWARD , SALFELD JOCHEN G , WHITE MICHAEL , LABKOVSKY BORIS , SAKORAFAS PAUL , KAYMAKCALAN ZEHRA , VELDMAN GEERTRUIDA M , WIDOM ANGELA , VENTURINI AMY , FRIEDRICH STUART , ELVIN JOHN GAWAIN , MYLES ANGELA , WARNE NICHOLAS W , DUNCAN ALEXANDER ROBERT , HOLTET THOR LAS , DERBYSHIRE ELAINE J
IPC分类号： A61K8/18 , A61Q13/00 , C07K16/24 , C12P21/06
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/30 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.
摘要翻译：公开了特异性结合人白细胞介素-12（hIL-12）的人抗体，优选重组人抗体。优选的抗体对hIL-12具有高亲和力并在体外和体内中和hIL-12活性。本发明的抗体可以是全长抗体或其抗原结合部分。例如，本发明的抗体或抗体部分可用于检测hIL-12并抑制hIL-12活性，例如在患有hIL-12活性有害的病症的人类受试者中。用于表达本发明的重组人抗体的核酸，载体和宿主细胞以及合成重组人抗体的方法也包括在本发明中。

3. 发明申请

WO2004009776A3 TREATMENT OF TNFalpha RELATED DISORDERS 审中-公开
标题翻译：治疗TNFalpha相关疾病
公开(公告)号：WO2004009776A3
公开(公告)日：2004-10-21
申请号：PCT/US0322566
申请日：2003-07-18
申请人： ABBOTT BIOTECH LTD , BANERJEE SUBHASHIS , TAYLOR LORI K , SPIEGLER CLIVE E , TRACEY DANIEL EDWARD , CHARTASH ELLIOT KEITH , HOFFMAN REBECCA S , BARCHUK WILLIAM T , YAN PHILIP , MURTAZA ANWAR , SALFELD JOCHEN G , FISCHKOFF STEVEN
发明人： BANERJEE SUBHASHIS , TAYLOR LORI K , SPIEGLER CLIVE E , TRACEY DANIEL EDWARD , CHARTASH ELLIOT KEITH , HOFFMAN REBECCA S , BARCHUK WILLIAM T , YAN PHILIP , MURTAZA ANWAR , SALFELD JOCHEN G , FISCHKOFF STEVEN
IPC分类号： A61K20060101 , A61K39/395 , C07K20060101 , C07K16/24 , C07K16/00
CPC分类号： C07K16/241 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2299/00 , C07K2317/21 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Methods of treating TNFalpha-related disorders comprising administering TNFalpha inhibitors, including TNFalpha antibodies are described.
摘要翻译：描述了治疗TNFalpha相关病症的方法，包括给予TNFα抑制剂，包括TNFα抗体。

4. 发明申请

WO9841232A3 COMPOSITIONS FOR MODULATING RESPONSIVENESS TO CORTICOSTEROIDS 审中-公开
标题翻译：用于调节对角质素的响应的组合物
公开(公告)号：WO9841232A3
公开(公告)日：2000-10-05
申请号：PCT/US9804916
申请日：1998-03-12
申请人： BASF AG , SEKUT LES , CARTER ADAM , GHAYUR TARIQ , BANERJEE SUBHASHIS , TRACEY DANIEL E
发明人： SEKUT LES , CARTER ADAM , GHAYUR TARIQ , BANERJEE SUBHASHIS , TRACEY DANIEL E
IPC分类号： A61K45/06 , A61K31/40 , A61K31/505 , A61K38/20 , A61K38/46 , A61K39/395 , A61P3/10 , A61P9/02 , A61P11/06 , A61P29/00 , A61P37/06 , A61P43/00 , C07K16/24 , A61K31/57
CPC分类号： C07K16/244 , A61K31/56 , A61K38/1793 , A61K45/06 , A61K2300/00
摘要： Method for modulating responsiveness to corticosteroids in a subjet are provided. In the method of the invention, an agent which antagonizes a target that regulates production of IFN- gamma in the subject is administered to the subject in combination with a corticosteroid such that responsiveness of the subject to the corticosteroid is modulated as compared to when a corticosteroid alone is administered to the subject. In one embodiment, the agent is an IL-18 antagonist. In another embodiment, the agent is an interleukin-12 (IL-12) antagonist. In yet another embodiment, the agent is an NK cell antagonist. In a preferred embodiment, the agent is an inhibitor of a caspase family protease, preferably an ICE inhibitor. In another preferred embodiment, the agent is an anti-IL-12 monoclonal antibody. In yet another preferred embodiment, the agent is an anti-asialo-GM1 antibody or an NK1.1 antibody. Other preferred agents include phosphodiesterase IV inhibitors and beta-2 agonists. The methods of the invention can be used in the treatment of a variety of inflammatory and immunological diseases and disorders. Pharmaceutical compositions comprising an agent which antagonizes a target that regulates production of IFN- gamma in a subject, a corticosteroid and a pharmaceutically acceptable carrier are also provided. A preferred composition comprises an ICE inhibitor, a corticosteroid and a pharmaceutically acceptable carrier.
摘要翻译：提供了一种用于调节子流体中对皮质类固醇的反应性的方法。在本发明的方法中，将拮抗受试者中IFN-γ产生的靶标拮抗剂的试剂与皮质类固醇组合给予受试者，使得受试者对皮质类固醇的反应性与皮质类固醇相比被调节单独对受试者施用。在一个实施方案中，该药剂是IL-18拮抗剂。在另一个实施方案中，该药剂是白细胞介素-12（IL-12）拮抗剂。在另一个实施方案中，该药剂是NK细胞拮抗剂。在优选的实施方案中，所述试剂是半胱天冬酶家族蛋白酶，优选ICE抑制剂的抑制剂。在另一个优选的实施方案中，所述试剂是抗IL-12单克隆抗体。在另一个优选的实施方案中，该试剂是抗脱唾液酸-GM1抗体或NK1.1抗体。其它优选的试剂包括磷酸二酯酶IV抑制剂和β-2激动剂。本发明的方法可用于治疗各种炎症和免疫疾病和病症。还提供了包含拮抗受试者中的IFN-γ生成的靶的药剂，皮质类固醇和药学上可接受的载体的药物组合物。优选的组合物包含ICE抑制剂，皮质类固醇和药学上可接受的载体。

5. 发明申请

WO0119373A3 METHODS AND COMPOSITIONS FOR MODULATING RESPONSIVENESS TO CORTICOSTEROIDS 审中-公开
标题翻译：调节对角质疏螺旋体的响应的方法和组合物
公开(公告)号：WO0119373A3
公开(公告)日：2001-10-04
申请号：PCT/US0024725
申请日：2000-09-08
申请人： BASF AG , SEKUT LES , CARTER ADAM , GHAYUR TARIQ , BANERJEE SUBHASHIS , TRACEY DANIEL E
发明人： SEKUT LES , CARTER ADAM , GHAYUR TARIQ , BANERJEE SUBHASHIS , TRACEY DANIEL E
IPC分类号： A61K31/57 , A61K39/395 , A61K45/06 , C07K16/28
CPC分类号： C07K16/28 , A61K31/57 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2300/00
摘要： Method for modulating responsiveness to corticosteroids in a subject are provided. In the method of the invention, an agent which antagonizes a target that regulates production of IFN- gamma in the subject is administered to the subject in combination with a corticosteroid such that responsiveness of the subject to the corticosteroid is modulated as compared to when a corticosteroid alone is administered to the subject. In one embodiment, the agent is an IL-18 antagonist. In another embodiment, the agent is an interleukin-12 (IL-12) antagonist. In yet another embodiment, the agent is an NK cell antagonist. In a preferred embodiment, the agent is an inhibitor of a caspase family protease, preferably an ICE inhibitor. In another preferred embodiment, the agent is an anti-IL-12 monoclonal antibody. In yet another preferred embodiment, the agent is an anti-asialo-GM1 antibody or an NK1.1 antibody. Other preferred agents include phosphodiesterase IV inhibitors and beta-2 agonists. The methods of the invention can be used in the treatment of a variety of inflammatory and immunological diseases and disorders. Pharmaceutical compositions comprising an agent which antagonizes a target that regulates production of IFN- gamma in a subject, a corticosteroid and a pharmaceutically acceptable carrier are also provided. A preferred composition comprises an ICE inhibitor, a corticosteroid and a pharmaceuticaly acceptable carrier.
摘要翻译：提供了调节受试者对皮质类固醇的反应性的方法。在本发明的方法中，将拮抗受试者中IFN-γ产生的靶标拮抗剂的试剂与皮质类固醇组合给予受试者，使得受试者对皮质类固醇的反应性与皮质类固醇相比被调节单独对受试者施用。在一个实施方案中，该药剂是IL-18拮抗剂。在另一个实施方案中，该药剂是白细胞介素-12（IL-12）拮抗剂。在另一个实施方案中，该药剂是NK细胞拮抗剂。在优选的实施方案中，所述试剂是半胱天冬酶家族蛋白酶，优选ICE抑制剂的抑制剂。在另一个优选的实施方案中，所述试剂是抗IL-12单克隆抗体。在另一个优选的实施方案中，该试剂是抗脱唾液酸-GM1抗体或NK1.1抗体。其它优选的试剂包括磷酸二酯酶IV抑制剂和β-2激动剂。本发明的方法可用于治疗各种炎症和免疫疾病和病症。还提供了包含拮抗受试者中的IFN-γ生成的靶的药剂，皮质类固醇和药学上可接受的载体的药物组合物。优选的组合物包含ICE抑制剂，皮质类固醇和药物可接受的载体。

6. 发明专利

JP2012010702A Human antibody that bind human il-12 and method for producing them 审中-公开
标题翻译：人类IL-12的人体抗体及其生产方法
公开(公告)号：JP2012010702A
公开(公告)日：2012-01-19
申请号：JP2011161258
申请日：2011-07-22
申请人： Abbott Gmbh & Co Kg , アボットゲーエムベーハーウントカンパニーカーゲー
发明人： SALFELD JOCHEN G , ROGUSKA MICHAEL , PASKIND MICHAEL , BANERJEE SUBHASHIS , TRACEY DANIEL E , WHITE MICHAEL , KAYMAKCALAN ZEHRA , LABKOVSKY BORIS , SAKORAFAS PAUL , FRIEDRICH STUART , MYLES ANGELA , VELDMAN GEERTRUIDA M , VENTURINI AMY , WARNE NICHOLAS W , WIDOM ANGELA , ELVIN JOHN G , DUNCAN ALEXANDER R , DERBYSHIRE ELAINE J , CARMEN SARA , SMITH STEPHEN , HOLTET THOR LAS , DU FOU SARAH L
IPC分类号： C12N15/09 , G01N33/53 , A61K39/395 , A61K45/00 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P5/16 , A61P7/00 , A61P7/02 , A61P7/04 , A61P7/06 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/14 , A61P11/00 , A61P11/06 , A61P11/08 , A61P11/16 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/08 , A61P21/02 , A61P21/04 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/18 , A61P33/00 , A61P35/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/02 , C12N15/13 , C12P21/02 , C12P21/08
CPC分类号： C07K16/00 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： PROBLEM TO BE SOLVED: To provide human antibodies that bind to human IL-12 and methods for treating and preventing acute or chronic diseases involving IL-12 using the human anti-IL-12 antibodies.SOLUTION: The invention relates to: human antibodies that specifically bind to human interleukin-12 (hIL-12) and have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo or the antigen binding portion thereof. There is also provided: nucleic acids, vectors and host cells for expressing the human antibodies; and methods of synthesizing the recombinant human antibodies; and uses for detecting hIL-12 or for inhibiting hIL-12 activity in a human subject suffering from a disorder in which hIL-12 activity is identified.
摘要翻译：待解决的问题：提供结合人IL-12的人抗体以及使用人抗IL-12抗体治疗和预防涉及IL-12的急性或慢性疾病的方法。解决方案：本发明涉及：特异性结合人白细胞介素-12（hIL-12）并对hIL-12具有高亲和力并在体外和体内中和hIL-12活性或其抗原结合部分的人抗体。还提供了用于表达人抗体的核酸，载体和宿主细胞; 和合成重组人抗体的方法; 以及用于检测hIL-12或用于在患有其中鉴定hIL-12活性的病症的人类受试者中抑制hIL-12活性的用途。版权所有（C）2012，JPO＆INPIT

7. 发明专利

JP2014138594A Human antibodies that bind to human il-12 and methods for producing the same 审中-公开
标题翻译：与人IL-12结合的人抗体及其生产方法
公开(公告)号：JP2014138594A
公开(公告)日：2014-07-31
申请号：JP2014026148
申请日：2014-02-14
申请人： Abbott Gmbh & Co Kg , アボットゲーエムベーハーウントカンパニーカーゲー
发明人： SALFELD JOCHEN G , ROGUSKA MICHAEL , PASKIND MICHAEL , BANERJEE SUBHASHIS , TRACEY DANIEL E , WHITE MICHAEL , KAYMAKCALAN ZEHRA , LABKOVSKY BORIS , SAKORAFAS PAUL , FRIEDRICH STUART , MYLES ANGELA , VELDMAN GEERTRUIDA M , VENTURINI AMY , WARNE NICHOLAS W , WIDOM ANGELA , ELVIN JOHN G , DUNCAN ALEXANDER R , DERBYSHIRE ELAINE J , CARMEN SARA , SMITH STEPHEN , HOLTET THOR LAS , DU FOU SARAH L
IPC分类号： C12N15/09 , G01N33/53 , A61K31/4164 , A61K31/519 , A61K31/52 , A61K31/573 , A61K31/575 , A61K31/606 , A61K38/00 , A61K39/395 , A61K45/00 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P5/16 , A61P7/00 , A61P7/02 , A61P7/04 , A61P7/06 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/14 , A61P11/00 , A61P11/06 , A61P11/16 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/08 , A61P21/04 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/18 , A61P33/00 , A61P35/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07K14/54 , C07K16/24 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/02 , C12N15/13 , C12P21/08 , G01N33/543
CPC分类号： C07K16/00 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： PROBLEM TO BE SOLVED: To provide human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12).SOLUTION: A preferred antibody has a high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibody or an antibody portion thereof is useful, e.g., for detecting hIL-12 and for inhibiting hIL-12 activity in a human subject suffering from a disorder in which hIL-12 activity is identified. There are provided a nucleic acid for a recombinant human antibody expression, a vector, a host cell, and a synthetic process of a recombinant human antibody.
摘要翻译：要解决的问题：提供特异性结合人白细胞介素-12（hIL-12）的人抗体，优选重组人抗体。解决方案：优选的抗体对hIL-12具有高亲和力并且在体外中和hIL-12活性和体内。本发明的抗体可以是全长抗体或其抗原结合部分。抗体或其抗体部分可用于例如在患有hIL-12活性被识别的病症的人类受试者中检测hIL-12和抑制hIL-12活性。提供重组人抗体表达的核酸，载体，宿主细胞和重组人抗体的合成方法。

9. 发明专利

CZ303725B6 Lidské protilátky, které se vází na lidský IL-12 a zpusoby jejich produkce 未知
公开(公告)号：CZ303725B6
公开(公告)日：2013-04-03
申请号：CZ20013434
申请日：2000-03-24
申请人： ABBOTT GMBH & CO KG
发明人： SALFELD JOCHEN G , ROGUSKA MICHAEL , PASKIND MICHAEL , BANERJEE SUBHASHIS , TRACEY DANIEL E , WHITE MICHAEL , KAYMAKCALAN ZEHRA , LABKOVSKY BORIS , SAKORAFAS PAUL , FRIEDRICH STUART , MYLES ANGELA , VELDMAN GEERTRUIDA M , VENTURINI AMY , WARNE NICHOLAS W , WIDOM ANGELA , ELVIN JOHN G , DUNCAN ALEXANDER R , DERBYSHIRE ELAINE J , CARMEN SARA , SMITH STEPHEN , HOLTET THOR LAS , DU FOU SARAH L
IPC分类号： C07K16/24 , G01N33/53 , A61K39/395 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/16 , A61P7/00 , A61P7/02 , A61P7/04 , A61P7/06 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/14 , A61P11/00 , A61P11/06 , A61P11/16 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/08 , A61P21/04 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/02 , A61P31/00 , A61P31/04 , A61P31/18 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07K16/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/02 , C12N15/13 , C12N15/63 , C12P21/08 , G01N33/577
摘要： Popisují se lidské protilátky, prednostne rekombinantní lidské protilátky, které se specificky vází na lidský interleukin-12 (hIL-12). Preferované protilátky mají vysokou afinitu pro IL-12 a neutralizují aktivitu hIL-12 in vitro a in vivo. Protilátkou muze být protilátka plné délky nebo její cást vázající se na antigen. Popsané protilátky nebo jejich cásti jsou pouzitelné pro detekci hIL-12 a pro inhibici aktivity hIL-12, napríklad u lidského subjektu trpícího poruchou, pri které je aktivita hIL-12 skodlivá. Také se popisují nukleové kyseliny, vektory a hostitelské bunky exprimující uvedené rekombinantní lidské protilátky a zpusoby syntézy rekombinantních lidských protilátek.

10. 发明专利

NZ577828A HUMAN ANTIBODIES THAT BIND HUMAN IL-12 AND METHODS FOR PRODUCING 未知
公开(公告)号：NZ577828A
公开(公告)日：2013-03-28
申请号：NZ57782807
申请日：2007-12-21
申请人： ABBOTT GMBH & CO KG
发明人： SALFELD JOCHEN G , ROGUSKA MICHAEL , PASKIND MICHAEL , BANERJEE SUBHASHIS , TRACEY DANIEL EDWARD , WHITE MICHAEL , KAYMAKCALAN ZEHRA , LABKOVSKY BORIS , SAKORAFAS PAUL , VELDMAN GEERTRUIDA M , VENTURINI AMY , WIDOM ANGELA , FRIEDRICH STUART , WARNE NICHOLAS W , MYLES ANGELA , ELVIN JOHN GAWAIN , DUNCAN ALEXANDER ROBERT , DERBYSHIRE ELAINE J , CARMEN SARA , HOLTET THOR LAS , SMITH STEPHEN , DU FOU SARA LEILA
IPC分类号： A61K8/18 , A61Q13/00 , C07K16/24 , C12P21/06
摘要： Disclosed are anti-p40 immunoglobulin (Ig) derived proteins, including isolated nucleic acids that encode two or more anti-p40 Ig derived protein, IL-12, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.

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