专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

ES2311012T3 LIGANDOS DEL RECEPTOR D3 DE LA DOPAMINA PARA EL TRATAMIENTO DE LA ADICCION. 未知
公开(公告)号：ES2311012T3
公开(公告)日：2009-02-01
申请号：ES01923699
申请日：2001-03-26
申请人： ABBOTT GMBH & CO KG
发明人： STARCK DOROTHEA , TREIBER HANS JORG , UNGER LILIANE , TESCHENDORF HANS-JURGEN , GROSS GERHARD
IPC分类号： A61K31/505 , A61K31/495 , A61K31/496 , A61K31/506 , A61P25/28 , A61P25/30 , A61P25/32 , A61P25/34 , A61P25/36 , A61P43/00
摘要： Empleo de los compuestos, que se eligen entre el 2-[(3-{4-[2-terc.-butil-6-(triflúormetil)-4-pirimidinil]-1-piperazinil}propil)-sulfanil]-4-pirimidinol, la 5-({3-[4-(3,5-diclorofenil)-1-piperazinil]propil}sulfanil)-1,3,4-tiadiazol-2-amina, la 5-[(2-metil-3-(4-[3-(triflúormetil)fenil]-1-piperazinil)propil)sulfanil]-1,3,4-tiadiazol-2-amina, el 2-[{3-(4-[3-(triflúormetil)fenil]-1-piperazinil}propil)sulfanil]-4-pirimidinol, la 5-(6-{4-[3-(triflúormetil)fenil]-1-piperazinil)hexil)-1,3,4-tiadiazol-2-amina, el dicloruro de 1-{(2E)-4-[(4-hidroxi-2-pirimidinil)sulfanil]-2-butenil}-4-[3-(triflúormetil)fenil]piperazindiio, la 4-metil-5-[(3-(4-[3-(triflúormetil)fenil]-1-piperazinil)propil)sulfanil]-4H-1,2,4-triazol-3-amina, el 2-([3-(4-[3-(triflúormetil)fenil]-3,6-dihidro-1(2H)-piridinil)propil]sulfanil)-4-pirimidinol, el 2-({3-[4-(3-isopropilfenil)-1-piperazinil]propil}sulfanil)-4-pirimidinol, la 5-[(3-{4-[6-(triflúormetil)-2-piridinil]-1-piperazinil}propil)sulfanil}-1,3,4-tiadiazol-2-amina, la 5-[((2E)-4-(4-[6-(triflúormetil)2-piridinil]-1-piperazinil)-2-butenil)sulfanil]-1,3,4-tiadiazol-2-amina, la 5-({3-[4-(3,5-diterc.-butilfenil)1-piperazinil]propil}sulfanil)-4-metil-4H-1,2,4-triazol-3-amina, la 5-({7-[4-(3-isopropilfenil)-1-piperazinil]heptil}sulfanil)-1,3,4-tiadiazol-2-amina, la 4-etil-5-[(3-(4-[3-(triflúormetil)fenil]-1-piperazinil)propil)sulfanil]-4H-1,2,4-triazol-3-amina, el 3-(4-{8-[(5-amino-1,3,4-tiadiazol-2-il)sulfanil]octil)-1-piperazinil)-benzonitrilo, la 5-[(3-(4-[6-metil-2-(1H-pirrol-1-il)-4-pirimidinil]-1-piperazinil}propil)-sulfanil]-1,3,4-tiadiazol-2-amina, la 4-metil-5-[(3-{4-[6-metil-2-(1H-pirrol-1-il)-4-pirimidinil]-1-piperazinil}-propil)sulfanil]-4H-1,2,4-triazol-3- amina, la 5-[{(2E)-4-(4-[2-terc.-butil-6-(triflúormetil)-4-pirimidinil]-1-piperazinil)-2-metil-2-butenil}sulfanil]-4-metil-4H-1,2,4-triazol-3-amina, el dicloruro de 1-[3-(diflúormetil)fenil)-4-(3-([4-metil-5-(metilamonio)-4H-1,2,4-triazol-3-il]sulfanil)propil)piperazin- 4-io y la 5-({3-[4-(2,6-diterc.-butil-4-pirimidinil)-1-piperazinil]propil}sulfanil)-1,3,4-tiadiazol-2-amina, o de sus sales con ácidos fisiológicamente compatibles, para la obtención de un medicamento para el tratamiento de la adicción.

2. 发明专利

ES2202348T3 未知
公开(公告)号：ES2202348T3
公开(公告)日：2004-04-01
申请号：ES95901436
申请日：1994-11-26
申请人： ABBOTT GMBH & CO KG
发明人： STEINER GERD , MUNSCHAUER RAINER , UNGER LILIANE , TESCHENDORF HANS-JURGEN , HIGER THOMAS
IPC分类号： C07D401/04 , A61K31/40 , A61K31/403 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/505 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/18 , A61P25/28 , A61P43/00 , C07D209/02 , C07D209/46 , C07D209/52 , C07D209/90 , C07D209/96 , C07D403/04 , C07D403/06 , C07D405/06 , C07D409/04 , C07D409/06 , C07D413/06
摘要： PCT No. PCT/EP94/03910 Sec. 371 Date Apr. 19, 1996 Sec. 102(e) Date Apr. 19, 1996 PCT Filed Nov. 26, 1994 PCT Pub. No. WO95/15312 PCT Pub. Date Jun. 8, 1995Compounds of the formula I I where the substituents have the meanings given in the description, and their preparation are described. The novel compounds are suitable for the control of diseases.

3. 发明专利

CZ292909B6 Thiadiazole derivatives, their use and pharmaceutical compositions in which the derivatives are comprised 未知
公开(公告)号：CZ292909B6
公开(公告)日：2004-01-14
申请号：CZ9497
申请日：1995-07-14
申请人： ABBOTT GMBH & CO KG
发明人： HELLENDAHL BEATE , LANSKY ANNEGRET , REDENBACH-MULLER BEATRICE , BACH ALFRED , UNGER LILIANE , TESCHENDORF HANS-JURGEN , WICKE KARSTEN
IPC分类号： C07D277/22 , A61K31/425 , A61K31/426 , A61K31/433 , A61K31/435 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/454 , A61K31/496 , A61K31/54 , C07D277/20 , C07D277/32 , C07D277/36 , C07D277/42 , C07D285/12 , C07D285/125 , C07D285/135 , C07D417/12 , C07D417/14
摘要： The present invention relates to thiadiazole derivatives, their use and pharmaceutical compositions containing them. The invented thiadiazole compounds are of the general formula I, in which A represents a straight-chain or branched alkylene group containing 3 to 14 carbon atoms, B denotes cyclic groups, Re1 represents a hydrogen atom, ORe3, NRe2Re3 or alkyl having 1 to i8 carbon atoms, Re2 and Re3 represent independently on each other a hydrogen atom or alkyl containing 1 to 8 carbon atoms, Ar denotes pyridyl, pyrimidinyl or triazinyl, where the group Ar contains one or four substituents or Ar represents naphthyl, and their salts with physiologically acceptable acids.

4. 发明专利

ES2194918T3 未知
公开(公告)号：ES2194918T3
公开(公告)日：2003-12-01
申请号：ES95926897
申请日：1995-07-14
申请人： ABBOTT GMBH & CO KG
发明人： HELLENDAHL BEATE , LANSKY ANNEGRET , RENDENBACH-MULLER BEATRICE , BACH ALFRED , UNGER LILIANE , TESCHENDORF HANS-JURGEN
IPC分类号： C07D277/22 , A61K31/425 , A61K31/426 , A61K31/433 , A61K31/435 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/454 , A61K31/496 , A61K31/54 , C07D277/20 , C07D277/32 , C07D277/36 , C07D277/42 , C07D285/12 , C07D285/125 , C07D285/135 , C07D417/12
摘要： PCT No. PCT/EP95/02783 Sec. 371 Date Jan. 14, 1997 Sec. 102(e) Date Jan. 14, 1997 PCT Filed Jul. 14, 1995 PCT Pub. No. WO96/02249 PCT Pub. Date Feb. 1, 1996The present invention relates to the use of thiazole and thiadiazole compounds of the following formula: where R1, A, B and Ar have the meanings stated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders of the central nervous system.

5. 发明专利

AU3111595A Use of thiazole and thiadiazole compounds as d3 dopamine receptor ligands 未知
公开(公告)号：AU3111595A
公开(公告)日：1996-02-16
申请号：AU3111595
申请日：1995-07-14
申请人： ABBOTT GMBH & CO KG
发明人： HELLENDAHL BEATE , LANSKY ANNEGRET , RENDENBACH-MULLER BEATRICE , BACH ALFRED , UNGER LILIANE , TESCHENDORF HANS-JURGEN , WICKE KARSTEN
IPC分类号： C07D277/22 , A61K31/425 , A61K31/426 , A61K31/433 , A61K31/435 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/454 , A61K31/496 , A61K31/54 , C07D277/20 , C07D277/32 , C07D277/36 , C07D277/42 , C07D285/12 , C07D285/125 , C07D285/135 , C07D417/12
摘要： PCT No. PCT/EP95/02783 Sec. 371 Date Jan. 14, 1997 Sec. 102(e) Date Jan. 14, 1997 PCT Filed Jul. 14, 1995 PCT Pub. No. WO96/02249 PCT Pub. Date Feb. 1, 1996The present invention relates to the use of thiazole and thiadiazole compounds of the following formula: where R1, A, B and Ar have the meanings stated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders of the central nervous system.

6. 发明专利

SK284987B6 Substituted aza- and diazacycloheptane and -cyclooctane compounds, pharmaceutical composition containing thereof and their use 未知
公开(公告)号：SK284987B6
公开(公告)日：2006-04-06
申请号：SK94198
申请日：1997-01-10
申请人： ABBOTT GMBH & CO KG
发明人： TREIBER HANS-JORG , BLANK STEFAN , STARCK DOROTHEA , UNGER LILIANE , TESCHENDORF HANS-JURGEN , WICKE KARSTEN
IPC分类号： C07D243/08 , A61K31/00 , C07D403/00 , A61K31/40 , A61K31/4025 , A61K31/41 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/4439 , A61K31/505 , A61K31/506 , A61K31/55 , A61K31/551 , A61K31/5513 , A61P25/18 , A61P43/00 , C07D213/00 , C07D213/73 , C07D223/04 , C07D243/00 , C07D245/02 , C07D401/00 , C07D401/04 , C07D401/14 , C07D403/02 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/00 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要： Aza- and diazacyclohexane and -cyclooctane compounds of the following formula (I) where Ar1, A, B and Ar2 have the meanings stated in the description have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.

7. 发明专利

CZ295346B6 Pyrimidine compounds, process of their preparation, pharmaceutical composition and their use for treating disorders associated with dopamine D3 ligands 未知
公开(公告)号：CZ295346B6
公开(公告)日：2005-07-13
申请号：CZ12397
申请日：1995-07-14
申请人： ABBOTT GMBH & CO KG
发明人： HELLENDAHL BEATE , LANSKY ANNEGRET , MUNSCHAUER RAINER , BIALOJAN SIEGRIED , TESCHENDORF HANS-JURGEN , WICKE KARSTEN , DRESCHER KARLA , UNGER LILIANE
IPC分类号： C07D239/26 , A61K31/505 , A61K31/506 , A61P25/16 , A61P25/24 , A61P25/26 , C07D239/38 , C07D239/46 , C07D239/56 , C07D239/60 , C07D401/00 , C07D401/12 , A61P25/00
摘要： In the present invention, there is disclosed the use of pyrimidine compounds of the general formula I, in which A represents alkylene having 1 to 18 carbon atoms and optionally containing at least one group being selected from the group consisting of oxygen or sulfur atom, NRe4, CONRe4, NRe4CO, COO, OCO and double or triple bond, and their salts with physiologically acceptable acids for the preparation of a pharmaceutical composition intended for the treatment of disorders associated with Di3 dopamine antagonists or agonist receptors. The invention also relates to pyrimidine compounds and their salts with physiologically acceptable acids, as well as process for preparing these compounds. The invented pharmaceutical composition contains at least one compound having optionally a physiologically acceptable carrier and/or auxiliary substances. A therapeutically effective amount of the compounds can be used for preparing a medicament intended for the treatment of disorders associated with dopamine Di3 ligands.

8. 发明专利

ES2198947T3 未知
公开(公告)号：ES2198947T3
公开(公告)日：2004-02-01
申请号：ES99942792
申请日：1999-07-20
申请人： ABBOTT GMBH & CO KG
发明人： STEINER GERD , HOGER THOMAS , UNGER LILIANE , TESCHENDORF HANS-JURGEN , JUCHELKA FRIEDER
IPC分类号： A61K31/4184 , A61P25/20 , A61P25/24 , A61P25/30 , C07D403/06
摘要： The invention relates to compounds of formula (1), wherein R , R and R have the meaning cited in the description. The novel substances are suitable for use in disease control.

9. 发明专利

AU8731698A Triazole compounds and the use thereof as dopamine-d₃-ligands 未知
公开(公告)号：AU8731698A
公开(公告)日：1999-02-08
申请号：AU8731698
申请日：1998-07-03
申请人： ABBOTT GMBH & CO KG
发明人： STARCK DOROTHEA , BLANK STEFAN , TREIBER HANS-JORG , UNGER LILIANE , NEUMANN-SCHULTZ BARBARA , BRIS THEOPHILE-MARIE LE , TESCHENDORF HANS-JURGEN , WICKE KARSTEN
IPC分类号： A61K31/33 , A61K31/41 , A61K31/4196 , A61K31/454 , A61K31/506 , A61K31/53 , A61K31/551 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P43/00 , C07D249/08 , C07D249/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Triazole compounds of the following formula:where Ar1, A, B and Ar2 have the meanings given in the description, possess a high affinity for the dopamine D3 receptor and can therefore be used for treating diseases which respond to dopamine D3 ligands.

10. 发明专利

AU1240395A N-substituted azabicycloalkane derivatives as neuroleptika asf 未知
公开(公告)号：AU1240395A
公开(公告)日：1995-06-19
申请号：AU1240395
申请日：1994-11-26
申请人： ABBOTT GMBH & CO KG
发明人： STEINER GERD , MUNSCHAUER RAINER , UNGER LILIANE , TESCHENDORF HANS-JURGEN , HOGER THOMAS
IPC分类号： A61K31/40 , A61K31/403 , A61K31/404 , A61P21/02 , A61P25/08 , A61P25/20 , A61P25/24 , A61P25/26 , C07D209/14 , C07D209/18 , C07D209/44 , C07D209/52 , C07D487/04 , C07D491/048 , C07D497/04
摘要： PCT No. PCT/EP94/03913 Sec. 371 Date Jun. 6, 1996 Sec. 102(e) Date Jun. 6, 1996 PCT Filed Nov. 26, 1994 PCT Pub. No. WO95/15327 PCT Pub. Date Jun. 8, 1995Compounds of the formula I I where B, R1, R2, n and A have the meanings given in the description, and their preparation are described. The novel compounds are suitable for the control of diseases.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式