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1. 发明申请

WO2009025926A2 NANOPARTICLE-COATED MEDICAL DEVICES AND FORMULATIONS FOR TREATING VASCULAR DISEASE 审中-公开
标题翻译：用于治疗血管疾病的纳米涂层医疗装置和制剂
公开(公告)号：WO2009025926A2
公开(公告)日：2009-02-26
申请号：PCT/US2008/067015
申请日：2008-06-13
申请人： ABBOTT CARDIOVASCULAR SYSTEMS INC. , LUDWIG, Florian, N. , HOSSAINY, Syed, F., A. , MURASE, Katsuyuki , ZHAO, Li , ASTAFIEVA, Irina
发明人： LUDWIG, Florian, N. , HOSSAINY, Syed, F., A. , MURASE, Katsuyuki , ZHAO, Li , ASTAFIEVA, Irina
IPC分类号： A61L27/34 , A61L27/54
CPC分类号： A61L31/10 , A61K9/1075 , A61K9/127 , A61K9/51 , A61L31/16 , A61L2300/624 , A61L2300/626 , A61L2400/12
摘要： Nanoparticle-coated medical devices, nanoparticle-containing formulations and methods of using for treating a vascular disease are disclosed.
摘要翻译：公开了纳米颗粒涂覆的医疗装置，含纳米颗粒的制剂和用于治疗血管疾病的方法。

2. 发明申请

WO2008076847A3 REGIONAL DELIVERY OF THERAPEUTIC AGENTS FOR THE TREATMENT OF VASCULAR DISEASES 审中-公开
公开(公告)号：WO2008076847A3
公开(公告)日：2008-06-26
申请号：PCT/US2007/087487
申请日：2007-12-13
申请人： ABBOTT CARDIOVASCULAR SYSTEMS INC. , PACETTI, Stephen, D. , CONSIGNY, Paul , HEIL, Ronald, W. , LUDWIG, Florian, N. , DAVALIAN, Dariush , ZHAO, Li , ASTAFIEVA, Irina , WAN, Jinping , EL-NOUNOU, Fozan , MURASE, Katsuyuki , HOSSAINY, Syed, Faiyaz Ahmed , BRIGHT, Rachel , ELLIS, Jeffrey
发明人： PACETTI, Stephen, D. , CONSIGNY, Paul , HEIL, Ronald, W. , LUDWIG, Florian, N. , DAVALIAN, Dariush , ZHAO, Li , ASTAFIEVA, Irina , WAN, Jinping , EL-NOUNOU, Fozan , MURASE, Katsuyuki , HOSSAINY, Syed, Faiyaz Ahmed , BRIGHT, Rachel , ELLIS, Jeffrey
IPC分类号： A61M29/02 , A61F2/84 , A61F2/82
摘要： The present invention relates to the regional delivery of therapeutic agents for the treatment of vascular diseases wherein regional delivery refers to delivery of a therapeutically effective amount of the therapeutic agent to an area of the vessel that includes not only afflicted tissue but non-afflicted tissue at the periphery of the afflicted tissue as well.

3. 发明申请

WO2009070209A2 SUSTAINED RELEASE OF APO A-I MIMETIC PEPTIDES AND METHODS OF TREATMENT 审中-公开
标题翻译：可持续发布的APO A-I型胶原蛋白和治疗方法
公开(公告)号：WO2009070209A2
公开(公告)日：2009-06-04
申请号：PCT/US2008/012767
申请日：2008-11-14
申请人： ABBOTT CARDIOVASCULAR SYSTEMS INC. , MURASE, Katsuyuki , HOSSAINY, Syed, F.A. , ASTAFIEVA, Irina , ZHAO, Li , MA, Hong
发明人： MURASE, Katsuyuki , HOSSAINY, Syed, F.A. , ASTAFIEVA, Irina , ZHAO, Li , MA, Hong
IPC分类号： A61K9/14 , A61K9/16 , A61K38/17
CPC分类号： C07K7/08 , A61F2/95 , A61K9/1075 , A61K9/127 , A61K38/00 , A61L29/16 , A61L2300/25 , A61L2300/802 , A61M25/1011 , A61M2025/0086 , A61M2025/105 , A61M2025/1075 , C07K7/06 , C07K14/775
摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.
摘要翻译：一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白AI（apo AI）合成模拟肽的组合物引入所述特定区域或血管周围部位的血管壁中，其中所述肽具有使所述肽有效反转的性质胆固醇运输。包含载体载脂蛋白AI（apo AI）合成肽或apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸序列以与各种apo AI模拟肽或内源性载脂蛋白AI类似物的顺序相反的顺序，或内源性apo AI的螺旋1和螺旋9的嵌合体。

4. 发明申请

WO2008123937A1 SEQUENTIALLLY INFLATABLE BALLOONS FOR DELIVERY OF TREATMENT AGENTS 审中-公开
标题翻译：用于递送治疗药剂的顺铂可充气气球
公开(公告)号：WO2008123937A1
公开(公告)日：2008-10-16
申请号：PCT/US2008/003976
申请日：2008-03-26
申请人： ABBOTT CARDIOVASCULAR SYSTEMS INC. , FOREMAN, Philip, C. , MURASE, Katsuyuki
发明人： FOREMAN, Philip, C. , MURASE, Katsuyuki
IPC分类号： A61M25/10
CPC分类号： A61M25/1011 , A61M25/1002 , A61M2025/105 , A61M2025/1052 , A61M2025/1059 , A61M2025/1068 , A61M2025/1072
摘要： An apparatus including a cannula (215) having a dimension suitable for insertion into a blood vessel and an expandable body (218) coupled thereto, the expandable body comprising a first expandable member (216a) and a second expandable member (216f) to isolate a length of the vessel upon expansion within the blood vessel. The expandable body having an intermediate expandable member (216b, 216c, 216d, 216e) along a working length between the first expandable member and the second expandable. A method including introducing a cannula and an expandable body coupled thereto into a blood vessel at a point coextensive with a treatmentsite and expanding a first expandable member (216a) and a second expandable member (216f) the expandable body to isolate a length of the vessel adjacent the treatment site. The method further including delivering a treatment agent to a vessel" region between the first expandable member (216a) and the second expandable member (216f) while inflating and deflating an intermediate expandable member.
摘要翻译：一种包括具有适于插入血管的尺寸的套管（215）和与其联接的可膨胀体（218）的装置，所述可膨胀体包括第一可膨胀构件（216a）和第二可膨胀构件（216f），以隔离在血管内扩张时的血管长度。所述可膨胀体具有沿着所述第一可膨胀构件和所述第二可膨胀构件之间的工作长度的中间可膨胀构件（216b，216c，216d，216e）。一种方法，包括将与其连接的套管和可扩张体引入到与治疗组共同延伸的点处并扩张第一可膨胀构件（216a）和扩张体的第二可膨胀构件（216f）以分离血管的长度毗邻治疗现场。所述方法还包括在对中间可膨胀构件进行充气和放气的同时将处理剂递送到第一可膨胀构件（216a）和第二可膨胀构件（216f）之间的容器“区域。

5. 发明申请

WO2009070210A2 SUSTAINED RELEASE OF APO A-I MIMETIC PEPTIDES AND METHODS OF TREATMENT 审中-公开
标题翻译： APO A-I模拟肽的持续释放和治疗方法
公开(公告)号：WO2009070210A2
公开(公告)日：2009-06-04
申请号：PCT/US2008/012793
申请日：2008-11-14
申请人： ABBOTT CARDIOVASCULAR SYSTEMS INC. , MURASE, Katsuyuki , WAN, Jinping , STANKUS, John , DAVALIAN, Dariush , LUDWIG, Florian
发明人： MURASE, Katsuyuki , WAN, Jinping , STANKUS, John , DAVALIAN, Dariush , LUDWIG, Florian
IPC分类号： A61K9/14 , A61K9/16 , A61K38/17 , A61K9/50
CPC分类号： A61K31/661 , A61K9/0019 , A61K9/0024 , A61K9/127 , A61K9/1647 , A61K9/5153 , A61K38/17
摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.
摘要翻译：一种方法，包括使递送装置通过血管腔推进到血管中的特定区域; 并且将包含缓释载体和载脂蛋白AI（apo AI）合成模拟肽的组合物引入血管的特定区域或血管周围部位的壁中，其中所述肽具有使肽有效反转的性质胆固醇运输。以适合递送到血管中的形式包含载脂蛋白AI（apo AI）合成肽或者apo AI合成模拟肽和酰基CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合物，所述肽包括氨基酸序列的顺序与各种apo AI模拟肽或内源性apo AI类似物或内源性apo AI的螺旋1和螺旋9的嵌合体的顺序相反。

6. 发明申请

WO2009070211A1 SUSTAINED RELEASE OF APO A-I MIMETIC PEPTIDES AND METHODS OF PRODUCING THEM 审中-公开
标题翻译： APO A-I模拟肽的持续释放及其生产方法
公开(公告)号：WO2009070211A1
公开(公告)日：2009-06-04
申请号：PCT/US2008/012794
申请日：2008-11-14
申请人： ABBOTT CARDIOVASCULAR SYSTEMS INC. , HOSSAINY, Syed, F.A. , WAN, Jinping , DAVALIAN, Dariush , LUDWIG, Florian , MURASE, Katsuyuki
发明人： HOSSAINY, Syed, F.A. , WAN, Jinping , DAVALIAN, Dariush , LUDWIG, Florian , MURASE, Katsuyuki
IPC分类号： A61K9/14 , A61K9/16 , A61K38/17 , A61K9/50
CPC分类号： A61K31/661 , A61K9/1647 , A61K9/5084 , A61K38/00
摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.
摘要翻译：一种方法，包括使递送装置通过血管腔推进到血管中的特定区域; 并且将包含缓释载体和载脂蛋白AI（apo AI）合成模拟肽的组合物引入血管的特定区域或血管周围部位的壁中，其中所述肽具有使肽有效反转的性质胆固醇运输。以适合递送到血管中的形式包含载脂蛋白AI（apo AI）合成肽或者apo AI合成模拟肽和酰基CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合物，所述肽包括氨基酸序列的顺序与各种apo AI模拟肽或内源性apo AI类似物或内源性apo AI的螺旋1和螺旋9的嵌合体的顺序相反。

7. 发明授权

EP2217294B1 NANOPARTICLE-COATED MEDICAL DEVICES AND FORMULATIONS FOR TREATING VASCULAR DISEASE 有权
标题翻译：纳米粒子涂覆的医疗器具和制剂血管疾病的治疗
公开(公告)号：EP2217294B1
公开(公告)日：2016-09-14
申请号：EP08780819.2
申请日：2008-06-13
申请人： Abbott Cardiovascular Systems Inc.
发明人： LUDWIG, Florian, N. , HOSSAINY, Syed, F., A. , MURASE, Katsuyuki , ZHAO, Li , ASTAFIEVA, Irina
IPC分类号： A61L27/34 , A61L27/54 , A61L31/08 , A61L31/16 , A61L31/18
CPC分类号： A61L31/10 , A61K9/1075 , A61K9/127 , A61K9/51 , A61L31/16 , A61L2300/624 , A61L2300/626 , A61L2400/12

8. 发明公开

EP2217294A2 NANOPARTICLE-COATED MEDICAL DEVICES AND FORMULATIONS FOR TREATING VASCULAR DISEASE 有权
标题翻译：纳米粒子涂覆的医疗器具和制剂血管疾病的治疗
公开(公告)号：EP2217294A2
公开(公告)日：2010-08-18
申请号：EP08780819.2
申请日：2008-06-13
申请人： Abbott Cardiovascular Systems Inc.
发明人： LUDWIG, Florian, N. , HOSSAINY, Syed, F., A. , MURASE, Katsuyuki , ZHAO, Li , ASTAFIEVA, Irina
IPC分类号： A61L27/34 , A61L27/54 , A61L31/08 , A61L31/16 , A61L31/18
CPC分类号： A61L31/10 , A61K9/1075 , A61K9/127 , A61K9/51 , A61L31/16 , A61L2300/624 , A61L2300/626 , A61L2400/12
摘要： Nanoparticle-coated medical devices, nanoparticle-containing formulations and methods of using for treating a vascular disease are disclosed.

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