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1. 发明申请

WO2008089452A3 METHODS OF MODIFYING MYOCARDIAL INFARCTION EXPANSION 审中-公开
标题翻译：改善心肌梗塞扩张的方法
公开(公告)号：WO2008089452A3
公开(公告)日：2009-08-06
申请号：PCT/US2008051505
申请日：2008-01-18
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , MICHAL EUGENE T , BASU SHUBHAYU , SHEEHY ALEXANDER J , SPINALE FRANCIS G , MUKHERJEE RUPAK
发明人： MICHAL EUGENE T , BASU SHUBHAYU , SHEEHY ALEXANDER J , SPINALE FRANCIS G , MUKHERJEE RUPAK
IPC分类号： A61L26/00
CPC分类号： A61L27/26 , A61L27/20 , A61L27/22 , A61L27/3834 , A61L27/50 , A61L27/52 , A61L2300/418 , A61L2300/64 , A61L2400/06 , A61L2430/20 , C08L5/04 , C08L89/00
摘要： A bioscaffolding can be formed within a post-myocardial infarct region sufficient to cause attenuation of a rate of myocardial infarct expansion. A bioscaffolding may further be formed in the post-myocardial infarct region to cause an increase in posterior left ventricular wall thickness. The gel or bioscaffolding can be formed from a mixture of gel components of different gelation systems. For example, a bioscaffolding can be formed by mixing at least two different components of at least two different two-component gelation systems to form a first mixture and by mixing at least two different components (other than the components that make up the first mixture) of the at least two different two-component gelation systems to form a second mixture.
摘要翻译：可以在足以引起心肌梗死扩张速率衰减的后心肌梗死区域中形成生物支架。在心肌梗死后区域可进一步形成生物支架以引起左后壁厚度的增加。凝胶或生物支架可以由不同凝胶化系统的凝胶组分的混合物形成。例如，生物支架可以通过混合至少两种不同的双组分凝胶化体系的至少两种不同组分形成第一混合物并通过混合至少两种不同组分（构成第一混合物的组分）的至少两种不同的双组分凝胶化体系以形成第二混合物。

2. 发明申请

WO2008008139A2 METHODS AND DEVICES FOR FORMING TREATMENT AGENT CARRIERS 审中-公开
标题翻译：用于形成处理剂载体的方法和设备
公开(公告)号：WO2008008139A2
公开(公告)日：2008-01-17
申请号：PCT/US2007013315
申请日：2007-06-05
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , BASU SHUBHAYU , MICHAL EUGENE T
发明人： BASU SHUBHAYU , MICHAL EUGENE T
IPC分类号： A61K9/14
CPC分类号： A61K9/4833 , A61K9/145 , A61K9/5031 , A61K38/30
摘要： A method is described including passing a solution having a biodegradable polymer, a solvent and a treatment agent through an electrocharged nozzle to form particles encapsulating the treatment agent. The particles emitted from the electrocharged nozzle may be exposed to a charge opposite that of the nozzle. The particles may be deposited in a collection assembly comprising a liquid phase. A further method including combining a biodegradable polymer, a solvent and a treatment agent to form a solution, electrodepositing the solution in a particle form wherein the particles encapsulate the treatment agent in a collection assembly comprising a liquid phase and mixing the particles with a bioerodable material capable of forming a gel is described. An apparatus having an electrocharged nozzle, a grounded electrode having an opposite charge to that of the nozzle and a collection assembly comprising a liquid phase is further disclosed.
摘要翻译：描述了一种方法，包括使具有生物可降解聚合物，溶剂和处理剂的溶液通过电动喷嘴以形成包封处理剂的颗粒。从电动喷嘴喷出的颗粒可能暴露在与喷嘴相反的电荷下。颗粒可以沉积在包含液相的收集组件中。另一种方法包括将生物可降解聚合物，溶剂和处理剂混合以形成溶液，将溶液电沉积成颗粒形式，其中颗粒将处理剂包封在包含液相的收集组件中，并将颗粒与生物可蚀性材料描述了能够形成凝胶的能力。还公开了具有电动喷嘴，具有与喷嘴的电荷相反的电荷的接地电极和包含液相的收集组件的设备。

3. 发明申请

WO2010028087A2 NANOPARTICLE-STEM CELL CONJUGATES FOR POST-INFARCTION TREATMENT 审中-公开
标题翻译：纳米颗粒干细胞共轭物用于干燥后处理
公开(公告)号：WO2010028087A2
公开(公告)日：2010-03-11
申请号：PCT/US2009055784
申请日：2009-09-02
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , HENG BOON CHIN ALEXIS , BASU SHUBHAYU , COWAN CATHERINE M , DAVALIAN DARIUSH , STANKUS JOHN , DUONG DUC H
发明人： HENG BOON CHIN ALEXIS , BASU SHUBHAYU , COWAN CATHERINE M , DAVALIAN DARIUSH , STANKUS JOHN , DUONG DUC H
IPC分类号： A61L27/38 , A61F2/02 , A61F2/82 , A61L27/28 , A61L27/34 , A61L27/54
CPC分类号： A61M25/0054 , A61M25/0052 , A61M2025/0089
摘要： The present invention relates to constructs comprising living cells, preferably stem cells, which have been coated with one or more layers of polyelectrolytes of alternating charge and to the outermost layer of which is electrostatically conjugated nanoparticles that carry one or more therapeutic agents. The invention further relates to the use of the constructs to treat myocardial infarction.
摘要翻译：本发明涉及包含活细胞（优选干细胞）的构建体，所述活细胞已经用一层或多层交替电荷的聚电解质涂覆，并且其最外层是携带一种或多种治疗剂的静电缀合的纳米颗粒。本发明进一步涉及构建体用于治疗心肌梗塞的用途。

4. 发明申请

WO2008063418A3 MODIFIED TWO-COMPONENT GELATION SYSTEMS, METHODS OF USE AND METHODS MANUFACTURE 审中-公开
标题翻译：改进的双组分凝胶系统，使用方法和方法制造
公开(公告)号：WO2008063418A3
公开(公告)日：2009-03-26
申请号：PCT/US2007023419
申请日：2007-11-06
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , MICHAL GENE , BASU SHUBHAYU
发明人： MICHAL GENE , BASU SHUBHAYU
IPC分类号： A61L26/00 , A61L27/26 , A61L27/38 , A61L27/52
CPC分类号： A61K35/28 , A61K33/14 , A61K33/20 , A61K38/1858 , A61K38/363 , A61K38/4833 , A61L27/26 , A61L27/3873 , A61L27/52 , C12Y304/21005 , A61K2300/00 , A61K38/00
摘要： A bioscaffolding can be formed from a mixture of gel components of different gelation systems. For example, a bioscaffolding can be formed by mixing at least two different components of at least two different two-component gelation systems to form a first mixture and by mixing at least two different components (other than the components that make up the first mixture) of the at least two different two-component gelation systems to form a second mixture. A treatment agent, such as a cell type or a growth factor, can be added to either the first mixture or the second mixture. In some embodiments, the treatment agent is not added to either mixture. The first mixture can be co-injected with the second mixture to form a bioscaffolding in an infarct region for treatment thereof.
摘要翻译：生物支架可以由不同凝胶化系统的凝胶组分的混合物形成。例如，生物支架可以通过混合至少两种不同的双组分凝胶化体系的至少两种不同组分形成第一混合物并通过混合至少两种不同组分（构成第一混合物的组分）的至少两种不同的双组分凝胶化体系以形成第二混合物。可以将第一混合物或第二混合物中的处理剂如细胞类型或生长因子加入。在一些实施方案中，处理剂不加入任何混合物中。可以将第一混合物与第二混合物共注射以在梗塞区域中形成生物支架，用于治疗它们。

5. 发明申请

WO2008016490A3 MODIFIED TWO-COMPONENT GELATION SYSTEMS FOR THE TREATMENT OF POST-MYOCARDIAL INFARCTION 审中-公开
标题翻译：用于治疗心肌梗塞后改良的双组分凝血系统
公开(公告)号：WO2008016490A3
公开(公告)日：2008-10-30
申请号：PCT/US2007016433
申请日：2007-07-19
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , MICHAL EUGENE , TROLLSAS OLOF MIKAEL , BASU SHUBHAYU
发明人： MICHAL EUGENE , TROLLSAS OLOF MIKAEL , BASU SHUBHAYU
IPC分类号： A61K9/06 , A61K38/18 , A61K48/00 , A61L31/06 , A61L31/16
CPC分类号： A61K47/34 , A61K9/0024 , A61K9/06 , A61K35/12 , A61K38/00 , A61L27/26 , A61L27/38 , A61L27/50 , A61K2300/00
摘要： In one embodiment, a first component can include a first functionalized polymer and a substance having at least one cell adhesion site combined in a first buffer at a pH of approximately 6.5. A second component can include a second buffer in a pH of between about 7.5 and 9.0. A second functionalized polymer can be included in the first or second component. In some embodiments the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition (s) of the present invention can be delivered by a dual bore injection device to a treatment area, such as a post-myocardial infarct region.
摘要翻译：在一个实施方案中，第一组分可以包括第一官能化聚合物和具有在约6.5的pH下在第一缓冲液中组合的至少一个细胞粘附位点的物质。第二组分可以包括pH在约7.5和9.0之间的第二缓冲液。第二官能化聚合物可以包括在第一或第二组分中。在一些实施方案中，组合物可以包括至少一种细胞类型和/或至少一种生长因子。在一些实施方案中，本发明的组合物可以通过双孔注射装置递送至治疗区域，例如心肌梗死后区域。

6. 发明申请

WO2007145909A3 METHODS AND COMPOSITIONS FOR TREATING POST-MYOCARDIAL INFARCTION DAMAGE 审中-公开
标题翻译：治疗心肌梗死后损伤的方法和组合
公开(公告)号：WO2007145909A3
公开(公告)日：2008-04-03
申请号：PCT/US2007013181
申请日：2007-06-04
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , MICHAL EUGENE , BASU SHUBHAYU , KUO HAI-CHIEN
发明人： MICHAL EUGENE , BASU SHUBHAYU , KUO HAI-CHIEN
IPC分类号： A61K9/06 , A61K9/127 , A61K9/70 , A61P9/10
CPC分类号： A61K9/0024 , A61K31/4439 , A61K31/557 , A61K31/56 , A61K38/195 , A61K38/27 , A61K38/30 , A61K47/36 , A61L27/26 , A61L27/52 , C08L5/08 , C08L89/06
摘要： Methods and compositions for treating post-myocardial infarction damage are herein disclosed. In some embodiments, a carrier with a treatment agent may be fabricated. The carrier can be formulated from a bioerodable, sustained-release substance. The resultant loaded carrier may then be suspended in at least one component of a two- component matrix system for simultaneous delivery to a post-myocardial infarction treatment area.
摘要翻译：本文公开了治疗心肌梗死后损伤的方法和组合物。在一些实施方案中，可以制造具有处理剂的载体。载体可以由生物可蚀刻的缓释物质配制。然后将所得负载的载体悬浮在双组分基质系统的至少一个组分中，以同时递送至心肌梗死后治疗区域。

7. 发明公开

EP2331154A4 NANOPARTICLE-STEM CELL CONJUGATES FOR POST-INFARCTION TREATMENT 审中-公开
标题翻译：纳米颗粒干细胞共轭治疗鼻炎后治疗
公开(公告)号：EP2331154A4
公开(公告)日：2014-10-22
申请号：EP09812185
申请日：2009-09-02
申请人： ABBOTT CARDIOVASCULAR SYSTEMS
发明人： HENG BOON CHIN ALEXIS , BASU SHUBHAYU , COWAN CATHERINE M , DAVALIAN DARIUSH , STANKUS JOHN , DUONG DUC H
IPC分类号： A61M25/00
CPC分类号： A61M25/0054 , A61M25/0052 , A61M2025/0089

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