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1. 发明申请

WO2011026618A3 HYDROXYLAPATITMATERIAL SOWIE VERFAHREN ZU DESSEN HERSTELLUNG 审中-公开
公开(公告)号：WO2011026618A3
公开(公告)日：2011-03-10
申请号：PCT/EP2010/005383
申请日：2010-09-02
申请人： AAP BIOMATERIALS GMBH , DINGELDEIN, Elvira , HEIMANN, Lydia , GASQUERES, Georgiana , WOLFSTÄDTER, Marco
发明人： DINGELDEIN, Elvira , HEIMANN, Lydia , GASQUERES, Georgiana , WOLFSTÄDTER, Marco
IPC分类号： A61L24/02 , A61L27/12
摘要： Die Erfindung betrifft ein Hydroxylapatitmaterial, zu dessen Herstellung eine nanoskalige Hydroxylapatitpaste getempert wird.

2. 发明申请

WO2010139451A2 OSTEOSYNTHESIS WITH NANO-SILVER 审中-公开
标题翻译：具有纳米银的氧化还原作用
公开(公告)号：WO2010139451A2
公开(公告)日：2010-12-09
申请号：PCT/EP2010/003308
申请日：2010-06-01
申请人： AAP BIOMATERIALS GMBH , DINGELDEIN, Elvira , GASQUERES, Cyrille , WITTE, Frank , ELIZIER, Amir
发明人： DINGELDEIN, Elvira , GASQUERES, Cyrille , WITTE, Frank , ELIZIER, Amir
CPC分类号： C25D11/024 , A61L27/306 , A61L27/54 , A61L31/088 , A61L31/16 , A61L2300/102 , A61L2300/104 , A61L2300/606 , A61L2300/802 , A61L2400/12 , A61L2400/18 , A61L2420/06 , C25D11/005 , C25D11/022
摘要： The present invention relates generally to an antibacterial coating which is composed of silver, to medical tools and to implants comprising such a coating and to a method as well to an apparatus for the production of such a coating. The medical tools or the dental or orthopaedic implant comprises a metal or metal alloy having a treated surface wherein the treated surface is at least partially converted to an oxide film by plasma electrolytic oxidation using a colloid-dispersed system and wherein the converted surface is partially covered by islands formed by colloid-dispersed silver-particles of the colloid-dispersed system. An Ag-TiO 2 coating according to the invention shows excellent properties in terms of antibacterial efficacy (even against multi-resistant strains), adhesion and biocompatibility. The life-time of an implant in a human body is increased. The antibacterial coating can be used in the field of traumatology, orthopaedic, osteosynthesis and/or endoprothesis, especially where high infection risk exists. A high number of currently existing medical tools and implants can benefit from such a coating.
摘要翻译：本发明一般涉及一种由银组成的抗菌涂层，医用工具以及包含这种涂层的植入物以及制备这种涂层的方法。医疗工具或牙科或矫形植入物包括具有处理表面的金属或金属合金，其中经处理的表面至少部分地通过使用胶体分散系统的等离子体电解氧化转化为氧化膜，并且其中转换的表面被部分覆盖由胶体分散体系的胶体分散的银颗粒形成的岛。根据本发明的Ag-TiO 2涂层在抗菌功效（甚至针对多抗性菌株），粘附和生物相容性方面表现出优异的性质。植入物在人体内的寿命增加。抗菌涂层可用于创伤学，骨科，骨接合术和/或内切除术领域，特别是在存在高感染风险的地方。目前存在的大量医疗工具和植入物可以受益于这种涂层。

3. 发明申请

WO2012084072A1 VERFAHREN ZUR HERSTELLUNG EINER SILBERNANOPARTIKELHALTIGEN DISPERSION SOWIE VERWENDUNG EINER SILBERNANOPARTIKELHALTIGEN MISCHUNG ALS BESCHICHTUNGSMITTEL 审中-公开
标题翻译：一种用于生产纳米银粒子分散含与银纳米粒混合物作为涂层剂中的应用
公开(公告)号：WO2012084072A1
公开(公告)日：2012-06-28
申请号：PCT/EP2011/004211
申请日：2011-08-22
申请人： AAP BIOMATERIALS GMBH , NUSKO, Robert , MAIER, Georg , DINGELDEIN, Elvira , WOLFSTÄDTER, Marco
发明人： NUSKO, Robert , MAIER, Georg , DINGELDEIN, Elvira , WOLFSTÄDTER, Marco
IPC分类号： A01N59/16 , A61L24/00 , A61L24/06 , A61L27/34 , A61L27/54
CPC分类号： A61L24/0015 , A01N59/16 , A61L24/0089 , A61L27/34 , A61L27/54 , A61L2300/104 , A61L2300/606 , A01N25/04
摘要： Die Erfindung betrifft ein Verfahren zur Herstellung einer silbernanopartikelhaltigen Dispersion, insbesondere zur Herstellung von Knochenzement oder eines Beschichtungsmittels für Implantate aus einem Silbersalz.
摘要翻译：本发明涉及一种用于制备银含纳米粒子的分散体，特别是用于生产骨水泥或银盐的植入物的涂布剂的方法。

4. 发明申请

WO2012007181A1 APATITE COATINGS ON MG SREWS 审中-公开
标题翻译：粉末涂料在MG SREWS上
公开(公告)号：WO2012007181A1
公开(公告)日：2012-01-19
申请号：PCT/EP2011/003582
申请日：2011-07-18
申请人： AAP BIOMATERIALS GMBH , DINGELDEIN, Elvira , GASQUERES, Cyrille , ELIEZER, Amir , WOLFSTÄDTER, Marco , HEIMANN, Lydia
发明人： DINGELDEIN, Elvira , GASQUERES, Cyrille , ELIEZER, Amir , WOLFSTÄDTER, Marco , HEIMANN, Lydia
IPC分类号： A61L31/08 , C25D11/30 , A61L31/02 , A61L31/14
CPC分类号： A61L31/086 , A61L31/022 , A61L31/148 , A61L2400/18 , C25D11/026 , C25D11/30
摘要： The present invention relates generally to a bio-degradable implant based on magnesium having a reduced corrosion rate and to a method for the production of such an implant. It is a a method for treating a surface of a bio-degradable metallic implant comprising the following steps: providing a dispersed system comprising a colloid-dispersed apatite and adding an apatite powder to the dispersed system, subjecting an implant to the dispersed system such that a surface of the implant which is to be treated is immersed in the dispersed system wherein the implant comprises a magnesium based alloy, applying an AC voltage difference between the implant as a first electrode and a second electrode positioned in the dispersed system for generating a plasma electrolytic oxidation on the immersed surface of the implant so that the immersed surface is converted to an oxide film which is at least partially covered by apatites formed by the colloid-dispersed apatite and the apatite powder. The evolution of corrosion induced hydrogen gas evolution is decreased and osseointegration is improved.
摘要翻译：本发明一般涉及具有降低的腐蚀速率的基于镁的生物可降解植入物和用于生产这种植入物的方法。它是用于处理生物可降解金属植入物的表面的方法，包括以下步骤：提供包含胶体分散的磷灰石并将磷灰石粉末加入到分散体系中的分散体系，使植入物经受分散体系，使得将待处理的植入物的表面浸入分散体系中，其中植入物包括镁基合金，在作为第一电极的植入物和位于分散系统中的第二电极之间施加AC电压差以产生等离子体电解质在植入物的浸渍表面上氧化，使得浸入的表面转化为至少部分被由胶体分散的磷灰石和磷灰石粉末形成的磷灰石覆盖的氧化膜。腐蚀诱导氢气演化的演化减少，骨整体提高。

5. 发明申请

WO2011038905A2 KNOCHENZEMENT UND VERFAHREN ZU DESSEN HERSTELLUNG 审中-公开
标题翻译：骨水泥及其生产方法
公开(公告)号：WO2011038905A2
公开(公告)日：2011-04-07
申请号：PCT/EP2010/005951
申请日：2010-09-30
申请人： AAP BIOMATERIALS GMBH , SATTIG, Christoph , DINGELDEIN, Elvira
发明人： SATTIG, Christoph , DINGELDEIN, Elvira
IPC分类号： A61L24/00
CPC分类号： A61K6/087 , A61L24/0036 , A61L24/0042 , A61L24/0084 , A61L27/46 , A61L27/56 , A61L27/58 , A61L2300/406 , A61L2430/02
摘要： Die Erfindung betrifft einen Knochenzement bestehend aus einer hydrophilen und einer hydrophoben Komponente, wobei über die hydrophile Komponente biodegradierbares Material in Poren des Knochenzements eingelagert wird.
摘要翻译：
本发明涉及一种骨水泥组成的亲水性和疏水性组分，所述导航用途。结合在亲水性成分的可生物降解材料在骨水泥的孔中

6. 发明授权

EP2482861B1 KNOCHENZEMENT UND VERFAHREN ZU DESSEN HERSTELLUNG 有权
标题翻译：骨水泥和方法及其
公开(公告)号：EP2482861B1
公开(公告)日：2016-09-07
申请号：EP10763320.8
申请日：2010-09-30
申请人： AAP Biomaterials GmbH
发明人： SATTIG, Christoph , DINGELDEIN, Elvira
IPC分类号： A61L24/00 , A61L24/02 , A61L24/06
CPC分类号： A61K6/087 , A61L24/0036 , A61L24/0042 , A61L24/0084 , A61L27/46 , A61L27/56 , A61L27/58 , A61L2300/406 , A61L2430/02

7. 发明公开

EP2654429A1 VERFAHREN ZUR HERSTELLUNG EINER SILBERNANOPARTIKELHALTIGEN DISPERSION SOWIE VERWENDUNG EINER SILBERNANOPARTIKELHALTIGEN MISCHUNG ALS BESCHICHTUNGSMITTEL 有权
标题翻译：一种用于生产纳米银粒子分散含与银纳米粒混合物作为涂层剂中的应用
公开(公告)号：EP2654429A1
公开(公告)日：2013-10-30
申请号：EP11758380.7
申请日：2011-08-22
申请人： aap Biomaterials GmbH
发明人： NUSKO, Robert , MAIER, Georg , DINGELDEIN, Elvira , WOLFSTÄDTER, Marco
IPC分类号： A01N59/16 , A61L24/00 , A61L24/06 , A61L27/34 , A61L27/54
CPC分类号： A61L24/0015 , A01N59/16 , A61L24/0089 , A61L27/34 , A61L27/54 , A61L2300/104 , A61L2300/606 , A01N25/04
摘要： The invention relates to a method for producing a dispersion containing silver nanoparticles, in particular for producing bone cement or a coating agent for implants from a silver salt.
摘要翻译：本发明涉及一种用于生产分散体的含银纳米颗粒，特别是用于制造骨水泥或用于从银盐植入物的涂布剂的方法。

8. 发明公开

EP2593152A1 APATITE COATINGS ON MG SREWS 有权转让
标题翻译： APATITBESCHICHTUNGEN AUF MG-SCHRAUBEN
公开(公告)号：EP2593152A1
公开(公告)日：2013-05-22
申请号：EP11748888.2
申请日：2011-07-18
申请人： AAP Biomaterials GmbH
发明人： DINGELDEIN, Elvira , GASQUERES, Cyrille , ELIEZER, Amir , WOLFSTÄDTER, Marco , HEIMANN, Lydia
IPC分类号： A61L31/08 , C25D11/30 , A61L31/02 , A61L31/14
CPC分类号： A61L31/086 , A61L31/022 , A61L31/148 , A61L2400/18 , C25D11/026 , C25D11/30
摘要： The present invention relates generally to a bio-degradable implant based on magnesium having a reduced corrosion rate and to a method for the production of such an implant. It is a a method for treating a surface of a bio-degradable metallic implant comprising the following steps: providing a dispersed system comprising a colloid-dispersed apatite and adding an apatite powder to the dispersed system, subjecting an implant to the dispersed system such that a surface of the implant which is to be treated is immersed in the dispersed system wherein the implant comprises a magnesium based alloy, applying an AC voltage difference between the implant as a first electrode and a second electrode positioned in the dispersed system for generating a plasma electrolytic oxidation on the immersed surface of the implant so that the immersed surface is converted to an oxide film which is at least partially covered by apatites formed by the colloid-dispersed apatite and the apatite powder. The evolution of corrosion induced hydrogen gas evolution is decreased and osseointegration is improved.
摘要翻译：本发明一般涉及具有降低的腐蚀速率的基于镁的生物可降解植入物和用于生产这种植入物的方法。它是用于处理生物可降解金属植入物的表面的方法，包括以下步骤：提供包含胶体分散的磷灰石并将磷灰石粉末加入到分散体系中的分散体系，使植入物经受分散体系，使得将要处理的植入物的表面浸入分散体系中，其中植入物包括镁基合金，在作为第一电极的植入物和位于分散系统中的第二电极之间施加AC电压差以产生等离子体电解质在植入物的浸渍表面上氧化，使浸入的表面转化为至少部分被由胶体分散的磷灰石和磷灰石粉末形成的磷灰石覆盖的氧化膜。腐蚀诱导的氢气演化的演化减少，骨整体提高。

9. 发明公开

EP1732618A1 VERFAHREN ZUR HERSTELLUNG EINES KNOCHEN-IMPLANTATMATERIALS 有权
标题翻译：用于生产骨植入材料
公开(公告)号：EP1732618A1
公开(公告)日：2006-12-20
申请号：EP05731553.3
申请日：2005-03-23
申请人： Aap Biomaterials GmbH & Co. KG
发明人： KAPS, Hans-Peter , SATTIG, Christoph , WÜST, Edgar , DINGELDEIN, Elvira , WAHLIG, Helmut
IPC分类号： A61L24/00
CPC分类号： A61L24/0036 , A61F2/28 , A61L24/0042 , A61L24/0063
摘要： The invention relates to a method for producing a bone implant material having improved mechanical stability on the basis of molded bodies in the form of porous implant material, preferably porous hydroxylapatite ceramic material. The pores of the molded bodies produced from the ceramic material are filled with a filling compound that is mixed with water to give a flowable consistency and the filling compound is allowed to solidify in the pores. The filling compound is a powdery component that substantially consists of a mixture of hydroxylapatite and calcium sulfate. The hydroxylapatite powder consists of synthetically produced, precipitated high-purity crystalline nano particles having a crystal size of 10 to 20 nm width and 50 to 60 nm length.

10. 发明公开

EP2473204A2 HYDROXYLAPATITMATERIAL SOWIE VERFAHREN ZU DESSEN HERSTELLUNG 有权转让
标题翻译：羟丙基纤维素维生素ZU DESSEN HERSTELLUNG
公开(公告)号：EP2473204A2
公开(公告)日：2012-07-11
申请号：EP10762590.7
申请日：2010-09-02
申请人： AAP Biomaterials GmbH
发明人： DINGELDEIN, Elvira , HEIMANN, Lydia , GASQUERES, Georgiana , WOLFSTÄDTER, Marco
IPC分类号： A61L24/02
CPC分类号： A61L27/12 , A61L2400/12 , C01B25/327 , Y10T428/2982
摘要： The invention relates to a hydroxylapatite material, for the production of which a nanoscale hydroxylapatite paste is subjected to a thermal treatment.
摘要翻译：本发明涉及一种羟基磷灰石材料，用于生产纳米级羟基磷灰石膏体经受热处理。

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