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1. 发明申请

WO2004012725A1 TOPICAL FORMULATIONS CONTAINING KETOPROFEN STABILISED WITH SULISOBENZONE 审中-公开
标题翻译：包含稳定于SULISOBENZONE的KETOPROFEN的局部制剂
公开(公告)号：WO2004012725A1
公开(公告)日：2004-02-12
申请号：PCT/EP2003/008351
申请日：2003-07-29
申请人： A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. , BACCANI CARIDI, Claudio , TOSETTI, Alessandro
发明人： BACCANI CARIDI, Claudio , TOSETTI, Alessandro
IPC分类号： A61K31/19
CPC分类号： A61K31/19 , A61K2300/00
摘要： Topical pharmaceutical formulations are described, in particular gels and spray gel, containing ketoprofen or its S(+) isomer dexketoprofen or mixtures of the two isomers, together with a special UV filter and a special antioxidant in defined quantities. The formulations allow the photostability of the active ingredient, they have no, or very low, irritant effect on the skin, are well tolerated and show an adequate penetration across the skin and an optimum analgesic efficiency.
摘要翻译：描述了局部药物制剂，特别是含有酮洛芬或其S（+）异构体右克洛芬或两种异构体的混合物的凝胶和喷雾凝胶，以及特定的UV过滤器和特定的抗氧化剂。制剂允许活性成分的光稳定性，它们对皮肤没有或非常低的刺激性作用，良好的耐受性，并且在皮肤上显示出足够的穿透和最佳的止痛效率。

2. 发明申请

WO2005082780A1 BIOMIMETIC COMPOUNDS CONTAINING HYDROXYAPATITES SUBSTITUTED WITH MAGNESIUM AND CARBONATE, AND THE PROCESSES USED TO OBTAIN THEM 审中-公开
标题翻译：含有镁和碳酸钙的羟基磷灰石的生物化学物质以及用于获取它们的方法
公开(公告)号：WO2005082780A1
公开(公告)日：2005-09-09
申请号：PCT/EP2005/050815
申请日：2005-02-25
申请人： A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.r.l. , ROVERI, Norberto , BIAGINI, Graziella , TAMPIERI, Anna , TOSETTI, Alessandro , ALTAMURA, Maria , GOSO, Cristina
发明人： ROVERI, Norberto , BIAGINI, Graziella , TAMPIERI, Anna , TOSETTI, Alessandro , ALTAMURA, Maria , GOSO, Cristina
IPC分类号： C01B25/34
CPC分类号： C01B25/34 , A61F2310/00293 , A61L27/46 , A61L31/127 , C01B25/16
摘要： Carbonate hydroxyapatites containing magnesium, composite materials consisting of said hydroxyapatites and natural polymers are described; processes for the preparation of said materials and their use in orthopaedics and dentistry fields are also described.
摘要翻译：描述含有镁的碳酸盐羟基磷灰石，由所述羟基磷灰石和天然聚合物组成的复合材料; 还描述了用于制备所述材料的方法及其在骨科和牙科领域中的应用。

3. 发明授权

EP1526849B1 TOPICAL FORMULATIONS CONTAINING KETOPROFEN STABILISED WITH SULISOBENZONE 有权
标题翻译：局部组合物含有稳定化舒利苯酮酮基布洛芬
公开(公告)号：EP1526849B1
公开(公告)日：2006-04-05
申请号：EP03766339.0
申请日：2003-07-29
申请人： A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L.
发明人： BACCANI CARIDI, Claudio , TOSETTI, Alessandro
IPC分类号： A61K31/19 , A61P29/00
CPC分类号： A61K31/19 , A61K2300/00
摘要： Topical pharmaceutical formulations are described, in particular gels and spray gel, containing ketoprofen or its S(+) isomer dexketoprofen or mixtures of the two isomers, together with a special UV filter and a special antioxidant in defined quantities. The formulations allow the photostability of the active ingredient, they have no, or very low, irritant effect on the skin, are well tolerated and show an adequate penetration across the skin and an optimum analgesic efficiency.

4. 发明公开

EP1740499A1 BIOMIMETIC COMPOUNDS CONTAINING HYDROXYAPATITES SUBSTITUTED WITH MAGNESIUM AND CARBONATE, AND THE PROCESSES USED TO OBTAIN THEM 审中-公开
标题翻译：镁碳酸盐和羟基磷灰石仿生含氮化合物及其制造方法
公开(公告)号：EP1740499A1
公开(公告)日：2007-01-10
申请号：EP05729753.3
申请日：2005-02-25
申请人： A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L.
发明人： ROVERI, Norberto , BIAGINI, Graziella , TAMPIERI, Anna , TOSETTI, Alessandro , ALTAMURA, Maria , GOSO, Cristina
IPC分类号： C01B25/34 , A61L27/00 , A61L31/12 , A61F2/28
CPC分类号： C01B25/34 , A61F2310/00293 , A61L27/46 , A61L31/127 , C01B25/16
摘要： Carbonate hydroxyapatites containing magnesium, composite materials consisting of said hydroxyapatites and natural polymers are described; processes for the preparation of said materials and their use in orthopaedics and dentistry fields are also described.

5. 发明公开

EP1526849A1 TOPICAL FORMULATIONS CONTAINING KETOPROFEN STABILISED WITH SULISOBENZONE 有权
标题翻译：局部组合物含有稳定化舒利苯酮酮基布洛芬
公开(公告)号：EP1526849A1
公开(公告)日：2005-05-04
申请号：EP03766339.0
申请日：2003-07-29
申请人： A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L.
发明人： BACCANI CARIDI, Claudio , TOSETTI, Alessandro
IPC分类号： A61K31/19
CPC分类号： A61K31/19 , A61K2300/00
摘要： Topical pharmaceutical formulations are described, in particular gels and spray gel, containing ketoprofen or its S(+) isomer dexketoprofen or mixtures of the two isomers, together with a special UV filter and a special antioxidant in defined quantities. The formulations allow the photostability of the active ingredient, they have no, or very low, irritant effect on the skin, are well tolerated and show an adequate penetration across the skin and an optimum analgesic efficiency.

6. 发明申请

WO2009122252A2 DENTAL COMPOSITION FOR TREATING PERI-IMLANTITIS 审中-公开
标题翻译：用于治疗腹膜炎的牙齿组合物
公开(公告)号：WO2009122252A2
公开(公告)日：2009-10-08
申请号：PCT/IB2009/005094
申请日：2009-03-27
申请人： ITALMED S.R.L. , TOSETTI, Alessandro
发明人： TOSETTI, Alessandro
CPC分类号： A61K9/0063 , A61K31/00 , A61K31/431 , A61K31/496 , A61K45/06 , A61K47/10 , A61K47/32 , A61K2300/00
摘要： A new composition for treating peri-implantitis, i.e. of bacterial inflammatory processes that occur in a bone tissue close to a dental implant, comprising at least one biocompatible acrylic resin, said or each acrylic resin permeable to water, but insoluble to water; an antibiotic mixture; an organic solvent that in use is adapted to gradually evaporate, such that said at least one resin forms a protective film that gradually releases said antibiotic mixture. The antibiotic mixture comprises piperacillin sodium and tazobactam sodium in a predetermined weight ratio. In particular, said or each acrylic resin is permeable to water, but insoluble to water, and ensures the permanence of the film in the mouth even if saliva is present and at the same time releases piperacillin sodium and tazobactam sodium. The composition achieves a gradual release of the therapeutic agent directly close to the pathogenic process and allows eliminating the bacterial deposits from the raw surface of the dental implant.
摘要翻译：一种用于治疗种植体周围炎的新组合物，即在靠近牙齿植入物的骨组织中发生的细菌性炎症过程，包括至少一种生物相容的丙烯酸树脂，所述或每种可渗透水的丙烯酸树脂，但不溶于水; 抗生素混合物; 使用中的有机溶剂适于逐渐蒸发，使得所述至少一种树脂形成逐渐释放所述抗生素混合物的保护膜。抗生素混合物以预定的重量比包含哌拉西林钠和他唑巴坦钠。特别地，所述丙烯酸树脂或每种丙烯酸树脂可透水，但不溶于水，并且即使存在唾液并且同时释放哌拉西林钠和他唑巴坦钠，也能确保膜在口中的持久性。该组合物使治疗剂逐渐释放直接接近致病过程，并且可以消除来自牙种植体的原始表面的细菌沉积物。

7. 发明申请

WO2009098531A1 DENTAL COMPOSITION FOR DESENSITIZATION AND DISINFECTION OF EXPOSED DENTIN 审中-公开
标题翻译：牙齿组合物用于脱毒和消毒暴露的丹参
公开(公告)号：WO2009098531A1
公开(公告)日：2009-08-13
申请号：PCT/IB2008/000271
申请日：2008-02-07
申请人： ITALMED S.R.L. , TOSETTI, Alessandro
发明人： TOSETTI, Alessandro
IPC分类号： A61K6/00 , A61K9/00 , A61K33/14 , A61K33/16 , A61K33/30 , A61Q11/00
CPC分类号： A61K8/19 , A61K8/27 , A61K8/416 , A61K8/43 , A61K8/4926 , A61K9/0063 , A61K31/315 , A61K33/00 , A61K33/24 , A61K33/30 , A61Q11/00 , A61K2300/00
摘要： Dental composition for desensitization and disinfection of exposed dentin comprising a determined amount of a disinfectant, at least one soluble salt selected from the group comprised of : a soluble zinc salt, a soluble potassium salt, a soluble strontium salt, a combination thereof. In particular, the disinfectant is a cationic disinfectant selected from the group comprised of: benzalkonium chloride, benzethonium chloride, chlorhexidine gluconate, cetrimide, cetylpyridinium chloride, a combination thereof. The composition can be used replacing underlayers, or for desensitising and disinfecting treatment and replacing underlayers or for treatment of pillars at a prosthesis application for treatment of gingival withdrawal in consequence of uncovering amelo-cement junctions, after scaling and root planning treatments, and after whitening treatments. In particular, the dental composition is can be fixed topically with a small brush or microsponge on a zone of interest, or as a mouthwash, or in the form of gel, or toothpaste, by a toothbrush.
摘要翻译：用于对暴露牙质进行脱敏和消毒的牙科组合物，其包含确定量的消毒剂，至少一种选自以下的可溶性盐：可溶性锌盐，可溶性钾盐，可溶性锶盐及其组合。特别地，消毒剂是选自以下的阳离子消毒剂：苯扎氯铵，苄索氯铵，葡萄糖酸氯己定，西曲肽，氯化十六烷基吡啶，它们的组合。组合物可用于替代底层，或用于脱敏和消毒处理和替换底层或用于在假体应用处处理柱，用于治疗牙龈抽出，由于揭开痤疮 - 水泥接合处，结垢和根部规划处理之后，以及美白后治疗。特别地，牙科用组合物可用牙刷上的小型刷子或微型海绵局部固定在感兴趣的区域上，或作为漱口剂，或以凝胶形式或牙膏形式固定。

8. 发明申请

WO2016185497A1 COMPOSITION FOR ODONTOIATRIC USE FOR SURGICAL TREATMENT OF PERI-IMPLANTITIS 审中-公开
标题翻译：用于皮肤植入术的外科治疗的组合物
公开(公告)号：WO2016185497A1
公开(公告)日：2016-11-24
申请号：PCT/IT2015/000139
申请日：2015-05-19
申请人： ITALMED SRL , TOSETTI, Alessandro
发明人： TOSETTI, Alessandro
IPC分类号： A61K47/02 , A61K9/00 , A61K9/06 , A61K9/08 , A61K47/36 , A61K6/00 , A61K9/14 , A61K31/00
CPC分类号： A61K9/08 , A61K6/0044 , A61K9/0063 , A61K9/06 , A61K9/14 , A61K31/14 , A61K31/155 , A61K31/431 , A61K31/496 , A61K45/06 , A61K47/02 , A61K47/36 , A61K2300/00
摘要： A new composition for dental use for the surgical treatment of peri-implantitis (and not for the local treatment in the peri-implant pocket) - that is, those inflammatory processes of bacterial origin which occur in the bone tissue surrounding a dental implant, which achieves a gradual release of the therapeutic agent in the immediate vicinity of the disease process - which allows to eliminate the bacterial deposits (BIOFILM) on the surface of the implant dentistry. This composition contains: - sodium hyaluronate with low and / or high molecular weight in the range respectively: 0.1-0.4 MDa, and between 2.31 to 6 MDa, pyrogen-free, sterile in an aqueous solution; - piperacillin sodium and tazobactam sodium in a given weight ratio, that is 1 to 8; - buffer system that includes: dibasic sodium phosphate and potassium phosphate monobasic; - chlorhexidine and / or cetrimide and orto-phosphoric acid: in particular, the salt selected from chlorhexidine digluconate is in the range of 0.5-4%; cetrimide is advantageously used, in the range 0.2-2%; orto phosphoric acid is used at 37%.
摘要翻译：用于牙周用于外植体炎（并非用于植入物口袋内的局部治疗）的牙科用新组合物 - 即在牙植入物周围的骨组织中发生的细菌起源的那些炎症过程，其中实现治疗剂在疾病进程附近逐渐释放 - 这允许消除植入物牙科表面上的细菌沉积物（BIOFILM）。该组合物包含： - 低分子量和/或高分子量的透明质酸钠分别为：0.1-0.4Mpa和2.31至6MDa，无热原，在水溶液中无菌; - 哌拉西林钠和他唑巴坦钠以给定的重量比，即1至8; - 缓冲系统，包括：磷酸氢二钠和磷酸二氢钾; - 氯己定和/或西曲肽和磷酸：特别是选自氯己啶二葡萄糖酸盐的盐在0.5-4％的范围内; 有利地使用西曲溴铵，范围为0.2-2％; 以磷酸为37％。

9. 发明申请

WO2005011639A2 EFFERVESCENT PHARMACEUTICAL COMPOSITIONS CONTAINING VITAMIN D, CALCIUM AND PHOSPATE AND THEIR THERAPEUTIC USE 审中-公开
标题翻译：温和的含维生素D，钙和磷酸盐的药物组合物及其治疗用途
公开(公告)号：WO2005011639A2
公开(公告)日：2005-02-10
申请号：PCT/EP2004/051473
申请日：2004-07-13
申请人： MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. , TOSETTI, Alessandro , VITI, Giovanni
发明人： TOSETTI, Alessandro , VITI, Giovanni
IPC分类号： A61K9/20
CPC分类号： A61K9/0007 , A61K31/592 , A61K31/593 , A61K33/42 , A61K2300/00
摘要： An effervescent pharmaceutical composition is described comprising vitamin D combined with a calcium salt, useful in the treatment of nutritional deficiencies of calcium and vitamin D in the elderly, for example in treatment of the pathological forms that involve loss of bone mass in the elderly, such as osteoporosis, and in the prevention of diseases linked to the metabolism of calcium in the elderly, such as fractures of the proximal femur and other non-vertebral fractures.
摘要翻译：描述了一种泡腾药物组合物，其包含与钙盐结合的维生素D，用于治疗老年人中钙和维生素D的营养缺乏，例如用于治疗涉及损失的病理形式老年人骨质量如骨质疏松症，以及预防与老年人钙代谢有关的疾病，如股骨近端骨折和其他非椎骨骨折。

10. 发明申请

WO2008056230A3 ELEMENT OF CONSTRUCTION AND/OR FINISHING WITH LUMINESCENT PORTIONS 审中-公开
公开(公告)号：WO2008056230A3
公开(公告)日：2008-05-15
申请号：PCT/IB2007/003370
申请日：2007-11-06
申请人： TOSETTI, Alessandro
发明人： TOSETTI, Alessandro
IPC分类号： B44C5/04
摘要： Element of construction and/or finishing and/or covering including a body (2) of substantially flattened shape on whose surface at sight (3) luminescent, particularly phosphorescent, portions (5) are visible.

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