专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1993003059A1 CYCLIC HEXAPEPTIDES AS TACHYQUININ ANTAGONISTS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF 审中-公开
标题翻译：作为TACHYQUININ拮抗剂的周期性外切剂，其制备和药物组合物
公开(公告)号：WO1993003059A1
公开(公告)日：1993-02-18
申请号：PCT/EP1992001760
申请日：1992-08-03
申请人： A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE ... , QUARTARA, Laura , MAGGI, Carlo, Alberto , PATACCHINI, Riccardo , PESTELLINI, Vittorio , GIACHETTI, Antonio , ARCAMONE, Federico, Maria
发明人： A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE ...
IPC分类号： C07K07/64
CPC分类号： C07K7/56 , C07K7/22 , C07K7/64
摘要： A description is given of hexapeptide analogues of tachyquinines and their pharmaceutically acceptable salts as per general formula (I) effective in the treatment of diseases, where tachyquinines play a pathogenetic role, in particular in the treatment of arthritis, asthma, inflammations, tumoral growth, gastrointestinal hypermotility, Huntington's disease, neuritis, neuralgia, migraine, hypertension, incontinence of urine, urticaria, carcinoid syndrome symptoms, influenza, and cold.
摘要翻译：根据对治疗疾病有效的通式（I），描述了速效喹哪啶及其药学上可接受的盐，其中速效喹诺酮起着致病作用，特别是治疗关节炎，哮喘，炎症，肿瘤生长，胃肠过度运动，亨廷顿病，神经炎，神经痛，偏头痛，高血压，尿失禁，荨麻疹，类癌综合征症状，流行性感冒和感冒。

2. 发明申请

WO1992002546A1 SYNTHETIC PEPTIDES THAT ANTAGONIZE NEUROKININ A, THEIR SALTS AND THEIR MANUFACTURING PROCESSES 审中-公开
标题翻译：合成神经调节素A，其销售及其制造工艺的合成肽
公开(公告)号：WO1992002546A1
公开(公告)日：1992-02-20
申请号：PCT/IT1991000067
申请日：1991-07-26
申请人： A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE ... , GIULIANI, Sandro , MAGGI, Carlo, Alberto , PATACCHINI, Riccardo , PESTELLINI, Vittorio , QUARTARA, Laura , ROVERO, Paolo
发明人： A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE ...
IPC分类号： C07K07/06
CPC分类号： C07K7/22 , A61K38/00
摘要： Linear and cyclic synthetic peptides with the formula: X-Asp-Tyr-DTrp-Val-DTrp-DTrp-Y (I) where Y=A-R; A is one of the following amino acids: Lys, Orn, Glu, Gln, Asp, Asn, His, Ala, beta Ala, Val, Leu, Nle, Ile, Gly, Pro, Trp, Ser, Thr; R=NH2 (C-terminal carboxamide); X=H (free N-terminal amino group) or A is one of the following amino acids: Arg, Lys, Orn, Glu, Gln, Asp, Asn, His, Ala, beta Ala, Val, Leu, Nle, Ile, Gly, Pro, Phe, Trp, DTrp, Tyr, Met, Ser, Thr; when R and X together constitute an amide bond that joins together the two ends of the peptide chain to give a cyclic peptide; and their pharmaceutically acceptable salts with organic and inorganic acids or bases. These compounds are competitive antagonists of neurokinin A and are highly selective for the NK-2 receptor.
摘要翻译：具有下式的X-Asp-Tyr-DTrp-Val-DTrp-DTrp-Y（I）的线性和环状合成肽，其中Y = A-R; A是以下氨基酸之一：Lys，Orn，Glu，Gln，Asp，Asn，His，Ala，βAla，Val，Leu，Nle，Ile，Gly，Pro，Trp，Ser，Thr; R = NH 2（C-末端羧酰胺）; X = H（游离N-末端氨基）或A是以下氨基酸之一：Arg，Lys，Orn，Glu，Gln，Asp，Asn，His，Ala，βAla，Val，Leu，Nle，Ile， Gly，Pro，Phe，Trp，DTrp，Tyr，Met，Ser，Thr; 当R和X一起构成将肽链的两端连接在一起以产生环肽的酰胺键时; 及其与有机和无机酸或碱的药学上可接受的盐。这些化合物是神经激肽A的竞争性拮抗剂，对NK-2受体具有高选择性。

3. 发明申请

WO1994006803A1 PENEM DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：派宁衍生物，其制剂和含有它们的药物组合物
公开(公告)号：WO1994006803A1
公开(公告)日：1994-03-31
申请号：PCT/EP1993002493
申请日：1993-09-15
申请人： A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE ... , ISTITUTO LUSOFARMACO D'ITALIA S.P.A. , ALTAMURA, Maria , ARCAMONE, Federico, Maria , PERROTTA, Enzo , PESTELLINI, Vittorio , SBRACI, Piero , CASCIO, Giuseppe
发明人： A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE ... , ISTITUTO LUSOFARMACO D'ITALIA S.P.A.
IPC分类号： C07D499/88
CPC分类号： C07D499/88
摘要： Described are penems derivatives of general formula (I) wherein R1 is chosen in the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy, C3-C7 cycloalkyl, optionally protected C1-C6 hydroxyalkyle; R2 is chosen in the group consisting of carboxyl group free or esterified with a group easily activated "in vivo", carboxylate anion; R3 is chosen in the group consisting of H, C1-C4 alkyl optionally substituted; R4 is chosen in the group consisting of: H, C1-C6 alkyl optionally substituted, C1-C6 hydroxyalkyl optionally substituted, C1-C6 mercaptoalkyl optionally substituted, C1-C6 aminoalkyl optionally substituted, C1-C6 alkyl substituted by a quaternary ammonium group, C1-C6 carboxyalkyl optionally substituted, cycloalkyl, aryl, arylalkyl, heterocyclyl-alkyl optionally substituted, saturated or unsaturated heterocycle wherein the heteroatoms in the heterocyclic ring can be N, O, S, or R3 and R4 linked together form a heterocyclic ring having 3-7 atoms, optionally substituted, saturated or unsaturated which can contain other heteroatoms as O, N, S. R5 and R6 independently from one another are chosen in the group consisting of: H, C1-C6 alkyl, C1-C6 hydroxyalkyl, C1-C6 mercaptoalkyl, C1-C6 aminoalkyl, alkenyl, cycloalkyl, aryl, arylalkyl, alkylaryl, heterocyclyl-alkyl, C1-C6 alkyl carboxyamide wherein the alkyl group can be linear or branched (all these groups optionally substituted), or R5 and R6 taken together form an heterocyclic ring having 3-7 atoms optionally substituted, n is chosen in the group consisting of: 1, 2, 3; and their pharmaceutically acceptable salts.
摘要翻译：描述的是通式（I）的青蒿衍生物，其中R 1选自H，C 1 -C 6烷基，C 1 -C 6烷氧基，C 3 -C 7环烷基，任选保护的C 1 -C 6羟基烯烃; R2选自无羧基或酯基化，易于活化的“体内”，羧酸根阴离子; R3选自H，任选取代的C 1 -C 4烷基; R4选自：任选取代的H，任选取代的C 1 -C 6烷基，任选取代的C 1 -C 6羟基烷基，任选取代的C 1 -C 6巯基烷基，任选取代的C 1 -C 6氨基烷基，被季铵基团取代的C 1 -C 6烷基， C 1 -C 6羧基烷基任选取代的，环烷基，芳基，芳基烷基，杂环基 - 烷基任选取代的饱和或不饱和杂环，其中杂环中的杂原子可以是N，O，S或R 3和R 4连接在一起形成具有3 -7个原子，任选取代的，饱和或不饱和的，其可以含有其它杂原子作为O，N，S。R5和R6彼此独立地选自：H，C1-C6烷基，C1-C6羟基烷基，C1 -C 6巯基烷基，C 1 -C 6氨基烷基，烯基，环烷基，芳基，芳基烷基，烷基芳基，杂环基 - 烷基，C 1 -C 6烷基羧酰胺，其中烷基可以是直链或支链（所有这些基团任选取代） d R6一起形成任选取代的具有3-7个原子的杂环，n选自：1,2,3; 及其药学上可接受的盐。

4. 发明申请

WO1993021227A1 TACHYKININ ANTAGONIST TRICYCLIC COMPOUNDS, PREPARATION OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS 审中-公开
标题翻译： TACHYKININ拮抗剂三聚体化合物，其制备方法和含有这些化合物的药物组合物
公开(公告)号：WO1993021227A1
公开(公告)日：1993-10-28
申请号：PCT/EP1993000893
申请日：1993-04-13
申请人： A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE ... , LABORATORI GUIDOTTI S.P.A. , MALESCI - ISTITUTO FARMACOBIOLOGICO S.P.A. , PAVONE, Vincenzo , LOMBARDI, Angelina , PEDONE, Carlo , MAGGI, Carlo, Alberto , QUARTARA, Laura
发明人： A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE ... , LABORATORI GUIDOTTI S.P.A. , MALESCI - ISTITUTO FARMACOBIOLOGICO S.P.A.
IPC分类号： C07K07/56
CPC分类号： C07K7/56 , A61K38/00 , C07K7/22
摘要： A description is given of tachykinin antagonist tricyclic compounds having general formula (I) where: X1, X2, X3, X4, X5, and X6, identical or different, are each selected out of the group consisting of -NR'-CO-, -CO-NR'-, where R' is H or C1-3alkyl; Y is selected out of the group consisting of -CONR-, NRCO-, -OCO-, -COO-, -CH2-NR-, -NR-CH2-, -SS-, -CH2-CH2-, cis or trans -CH=CH-, where R is H or C1-3alkyl; R1, R2, R3, and R4 are each a hydrophobic group; n and m, identical or different, are each a whole number from 1 to 4, the preparation of same and pharmaceutical compositions containing said compounds.
摘要翻译：给出了具有通式（I）的速激肽拮抗剂三环化合物的描述，其中：X1，X2，X3，X4，X5和X6相同或不同，分别选自-NR'-CO-， -CO-NR'-，其中R'是H或C 1-3烷基; Y选自-CONR-，NRCO-，-OCO-，-COO-， - CH 2 -NR - ， - NR-CH 2 - ， - S - ， - CH 2 -CH 2 - ，顺式或反式 - CH = CH-，其中R是H或C 1-3烷基; R1，R2，R3和R4各自为疏水基团; n和m相同或不同，各自为1至4的整数，其制备方法和含有所述化合物的药物组合物。

5. 发明申请

WO1991017995A1 NEW PENEM DITHIOCARBAMATES, THEIR USE AND PRODUCTION METHODS 审中-公开
标题翻译：新型二氢碳酸钠，其使用和生产方法
公开(公告)号：WO1991017995A1
公开(公告)日：1991-11-28
申请号：PCT/IT1991000041
申请日：1991-05-14
申请人： A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE ... , ALTAMURA, Maria , ARCAMONE, Federico , GIANNOTTI, Danilo , PESTELLINI, Vittorio , SBRACI, Piero
发明人： A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE ...
IPC分类号： C07D499/88
CPC分类号： C07D499/88
摘要： A compound of general formula (I), wherein R1 is a hydrogen atom, C1-C6 alkyl, C1-C6 alkoxy, cycloakyl or hydroxyalkyl, the alcoholic function of the hydroxyalkyl being free or protected; R2 is a free or esterified carboxy group or a carboxylate anion; R3 and R4 are each independently either hydrogen or C1-C6 alkyl, C1-C6 hydroxyalkyl or mercaptoalkyl, aminoalkyl or alkyl substituted with a quaternary ammonium group; cycloalkyl, arylalkyl or heterocyclyl-alkyl; a 5-6 membered, saturated or unsaturated heterocyclic ring, which can contain supplementary heteroatoms, such as oxygen, sulfur and nitrogen; an aryl group, or R3 and R4 form together a 3-7 membered, saturated or unsaturated heterocyclic ring, which can contain supplementary heteroatoms, such as oxygen, sulfur or nitrogen.
摘要翻译：通式（I）的化合物，其中R 1为氢原子，C 1 -C 6烷基，C 1 -C 6烷氧基，环烷基或羟基烷基，羟基烷基的醇官能团为游离或保护的; R2是游离的或酯化的羧基或羧酸根阴离子; R 3和R 4各自独立地为氢或C 1 -C 6烷基，C 1 -C 6羟烷基或巯基烷基，氨基烷基或被季铵基取代的烷基; 环烷基，芳基烷基或杂环基 - 烷基; 5-6元饱和或不饱和的杂环，其可以含有辅助杂原子，例如氧，硫和氮; 芳基或R 3和R 4一起形成3-7元饱和或不饱和的杂环，其可以含有辅助杂原子，例如氧，硫或氮。

6. 发明申请

WO1994013694A1 TACHYQUININE ANTAGONISTS, THEIR PREPARATION AND USE IN PHARMACEUTICAL FORMULATIONS 审中-公开
标题翻译： TACHYQUININE ANTAGONISTS，他们的制备和使用药物制剂
公开(公告)号：WO1994013694A1
公开(公告)日：1994-06-23
申请号：PCT/EP1993003387
申请日：1993-12-02
申请人： A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE ... , MALESCI ISTITUTO FARMACOBIOLOGICO S.P.A. , ARCAMONE, Federico , LOMBARDI, Paolo , MANZINI, Stefano , POTIER, Edoardo , SISTO, Alessandro
发明人： A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE ... , MALESCI ISTITUTO FARMACOBIOLOGICO S.P.A.
IPC分类号： C07K05/02
CPC分类号： C07C233/84 , C07C237/24 , C07C2601/14 , C07D209/42
摘要： A description is given of tachyquinine antagonists having general formula (I), their preparation and use in pharmaceutical formulations.
摘要翻译：给出了具有通式（I）的速效喹啉拮抗剂及其在药物制剂中的应用。

7. 发明申请

WO1992009574A2 POLY-AMINOPYRROLECARBOXAMIDO DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：聚氨基吡啶氧化物衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：WO1992009574A2
公开(公告)日：1992-06-11
申请号：PCT/EP1991002220
申请日：1991-11-20
申请人： A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE ... , BRISTOL-MYERS SQUIBB S.P.A. , ANIMATI, Fabio , ARCAMONE, Federico , LOMBARDI, Paolo , ROSSI, Cristina
发明人： A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE ... , BRISTOL-MYERS SQUIBB S.P.A.
IPC分类号： C07D207/34
CPC分类号： C07D207/34
摘要： The present invention relates to polyaminopyrrolecarboxamido derivatives of general formula (I) and pharmaceutical acceptable salts thereof, wherein X1, X2 and X3, same or different, represent either -CONH- or NHCO- group, the case wherein X1 = X2 = X3 = -CONH- being excluded, to processes for their preparation and to pharmaceutical compositions having antiviral and antitumoral properties containing them.
摘要翻译：本发明涉及通式（I）的聚氨基吡咯酰胺衍生物及其药学上可接受的盐，其中X1，X2和X3相同或不同，表示-CONH-或NHCO-基团，其中X1 = X2 = X3 = - CONH-被排除，其制备方法和具有含有它们的抗病毒和抗肿瘤性质的药物组合物。

8. 发明申请

WO1993013739A2 RETROREVERSE PYRROLE-AMIDINO OLIGOPEPTIDE ANTICANCER AGENT ANALOGUES, PREPARATION OF SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH ANALOGUES 审中-公开
标题翻译：反义寡糖 - 氨基脲寡糖抗原剂代谢物类似物，其制备和含有这种类似物的药物组合物
公开(公告)号：WO1993013739A2
公开(公告)日：1993-07-22
申请号：PCT/EP1993000002
申请日：1993-01-04
申请人： A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE ... , BRISTOL-MYERS SQUIBB S.P.A. , ARCAMONE, Federico , LOMBARDI, Paolo , ANIMATI, Fabio
发明人： A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE ... , BRISTOL-MYERS SQUIBB S.P.A.
IPC分类号： A61K0
CPC分类号： C07D207/34
摘要： A description is given of compounds as per general formula (I), and of pharmaceutically acceptable salts thereof, active as anticancer and antivirus agents.
摘要翻译：给出根据通式（I）的化合物及其药学上可接受的盐作为抗癌剂和抗病毒剂活性的描述。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式