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1. 发明申请

WO2004098576A1 ABUSE-RESISTANT TRANSDERMAL DOSAGE FORM 审中-公开
标题翻译：耐药性变态剂量形式
公开(公告)号：WO2004098576A1
公开(公告)日：2004-11-18
申请号：PCT/US2004/008857
申请日：2004-03-23
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： HART, John R., , STEBBINGS, Deanna L.,
IPC分类号： A61K9/70
CPC分类号： B09B3/0075 , A61K9/7061 , A61K9/7092 , A61K31/4468 , A61K31/485 , B09B2220/14
摘要： The invention comprises a transdermal dosage form comprising a active agent component comprising a polymeric matrix and an abusable drug substance, an overlay backing, a porous material, and an antagonist reservoir comprising an antagonist to the abusable drug substance. The porous material adjoins the antagonist reservoir and is in fluid communication with the skin-contacting surface defined by the active agent component. In one embodiment, the device comprises a barrier layer interposed between the active agent component and the antagonist reservoir.
摘要翻译：本发明包括透皮剂型，其包含包含聚合物基质和可滥用药物的活性剂组分，覆盖背衬，多孔材料和包含对可滥用药物的拮抗剂的拮抗剂储库。多孔材料邻接拮抗剂储存器并且与由活性剂组分限定的皮肤接触表面流体连通。在一个实施方案中，该装置包括介于活性剂组分和拮抗剂储库之间的阻隔层。

2. 发明申请

WO2006062848A1 MEDICAL DEVICE 审中-公开
标题翻译：医疗装置
公开(公告)号：WO2006062848A1
公开(公告)日：2006-06-15
申请号：PCT/US2005/043769
申请日：2005-12-05
申请人： 3M INNOVATIVE PROPERTIES COMPANY , CARTER, Chad J., , FREDERICKSON, Franklyn L. , HANSEN, Richard G., , HART, John R., , LANDIN, Donald T., , TOKIE, Jeffrey H., , WIRTANEN, David J.,
发明人： CARTER, Chad J., , FREDERICKSON, Franklyn L. , HANSEN, Richard G., , HART, John R., , LANDIN, Donald T., , TOKIE, Jeffrey H., , WIRTANEN, David J.,
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61M2037/0023
摘要： A medical device (20) is provided that is suitable for use in the delivery of active component into or through the skin. The medical device comprises: an extension member (22) having a first major surface (24) and a second major surface (26), the first major surface comprising a first portion and a second portion; an array retaining member (28) extending from the first portion of the first major surface of the extension member, the array retaining member comprising an array surface (30) having at least one microneedle (32) extending from the array surface; and pressure sensitive adhesive (34) disposed on the second portion of the first major surface of the extension member to facilitate the adhesive attachment of the device to mammalian skin when the at least one microneedle is inserted through the stratum corneum.
摘要翻译：提供了适用于将活性成分输送入皮肤或通过皮肤的医疗装置（20）。医疗装置包括：具有第一主表面（24）和第二主表面（26）的延伸构件（22），所述第一主表面包括第一部分和第二部分; 阵列保持构件（28），其从所述延伸构件的所述第一主表面的第一部分延伸，所述阵列保持构件包括具有从所述阵列表面延伸的至少一个微针（32）的阵列表面（30）以及设置在延伸构件的第一主表面的第二部分上的压敏粘合剂（34），以便当至少一个微针穿过角质层时，便于将装置粘附到哺乳动物皮肤上。

3. 发明授权

EP1819393B1 MEDICAL DEVICE 有权转让
公开(公告)号：EP1819393B1
公开(公告)日：2010-10-06
申请号：EP05852855.5
申请日：2005-12-05
申请人： 3M Innovative Properties Company
发明人： CARTER, Chad J. , FREDERICKSON, Franklyn L. , HANSEN, Richard G., , HART, John R., , LANDIN, Donald T., , TOKIE, Jeffrey H., , WIRTANEN, David J.,
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61M2037/0023

4. 发明公开

EP1819393A1 MEDICAL DEVICE 有权转让
标题翻译：医疗装置
公开(公告)号：EP1819393A1
公开(公告)日：2007-08-22
申请号：EP05852855.5
申请日：2005-12-05
申请人： 3M Innovative Properties Company
发明人： CARTER, Chad J. , FREDERICKSON, Franklyn L. , HANSEN, Richard G., , HART, John R., , LANDIN, Donald T., , TOKIE, Jeffrey H., , WIRTANEN, David J.,
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61M2037/0023
摘要： A medical device (20) is provided that is suitable for use in the delivery of active component into or through the skin. The medical device comprises: an extension member (22) having a first major surface (24) and a second major surface (26), the first major surface comprising a first portion and a second portion; an array retaining member (28) extending from the first portion of the first major surface of the extension member, the array retaining member comprising an array surface (30) having at least one microneedle (32) extending from the array surface; and pressure sensitive adhesive (34) disposed on the second portion of the first major surface of the extension member to facilitate the adhesive attachment of the device to mammalian skin when the at least one microneedle is inserted through the stratum corneum.
摘要翻译：提供了适用于将活性成分输送到皮肤中或穿过皮肤的医疗装置（20）。医疗装置包括：具有第一主表面（24）和第二主表面（26）的延伸构件（22），第一主表面包括第一部分和第二部分; 从延伸构件的第一主表面的第一部分延伸的阵列保持构件，阵列保持构件包括具有从阵列表面延伸的至少一个微针的阵列表面; 和设置在延伸构件的第一主表面的第二部分上的压敏粘合剂（34），以便在至少一根微针穿过角质层插入时促进装置与哺乳动物皮肤的粘合附着。

5. 发明授权

EP1620080B1 ABUSE-RESISTANT TRANSDERMAL DOSAGE FORM 有权
公开(公告)号：EP1620080B1
公开(公告)日：2018-06-20
申请号：EP04760496.2
申请日：2004-03-23
申请人： 3M Innovative Properties Company
发明人： HART, John R., , STEBBINGS, Deanna L.,
IPC分类号： A61K9/70
CPC分类号： B09B3/0075 , A61K9/7061 , A61K9/7092 , A61K31/4468 , A61K31/485 , B09B2220/14
摘要： The invention comprises a transdermal dosage form comprising a active agent component comprising a polymeric matrix and an abusable drug substance, an overlay backing, a porous material, and an antagonist reservoir comprising an antagonist to the abusable drug substance. The porous material adjoins the antagonist reservoir and is in fluid communication with the skin-contacting surface defined by the active agent component. In one embodiment, the device comprises a barrier layer interposed between the active agent component and the antagonist reservoir.

6. 发明公开

EP1620080A1 ABUSE-RESISTANT TRANSDERMAL DOSAGE FORM 有权
标题翻译：滥用药物滥用剂量表格
公开(公告)号：EP1620080A1
公开(公告)日：2006-02-01
申请号：EP04760496.2
申请日：2004-03-23
申请人： 3M Innovative Properties Company
发明人： HART, John R., , STEBBINGS, Deanna L.,
IPC分类号： A61K9/70
CPC分类号： B09B3/0075 , A61K9/7061 , A61K9/7092 , A61K31/4468 , A61K31/485 , B09B2220/14
摘要： The invention comprises a transdermal dosage form comprising a active agent component comprising a polymeric matrix and an abusable drug substance, an overlay backing, a porous material, and an antagonist reservoir comprising an antagonist to the abusable drug substance. The porous material adjoins the antagonist reservoir and is in fluid communication with the skin-contacting surface defined by the active agent component. In one embodiment, the device comprises a barrier layer interposed between the active agent component and the antagonist reservoir.
摘要翻译：本发明包括经皮剂型，其包含含有聚合物基质和可滥用药物的活性剂组分，覆盖背衬，多孔材料和含有可滥用药物拮抗剂的拮抗剂储库。多孔材料邻接拮抗剂储库并且与由活性剂组分限定的皮肤接触表面流体连通。在一个实施方案中，该装置包含介于活性剂组分和拮抗剂储库之间的阻挡层。

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