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1. 发明申请

WO2005016275A2 FORMULATIONS CONTAINING AN IMMUNE RESPONSE MODIFIER 审中-公开
标题翻译：含有免疫反应调节剂的配方
公开(公告)号：WO2005016275A2
公开(公告)日：2005-02-24
申请号：PCT/US2004/025277
申请日：2004-08-05
申请人： 3M INNOVATIVE PROPERTIES COMPANY , HAMMERBECK, David, M. , GUY, Cynthia, A. , LEUNG, Suzanne, S.
发明人： HAMMERBECK, David, M. , GUY, Cynthia, A. , LEUNG, Suzanne, S.
IPC分类号： A61K
CPC分类号： A61K31/437
摘要： Pharmaceutical formulations in an aqueous (preferably, sprayable) formulaiton including an immune response modifier (IRM), such as those chosen from imidazoquinoline amines, tetrahydroimidazoquinoline amines, imidazopyridine amines, 6,7-fused cycloalkylimidazopyridine amines, 1,2-bridged imidazoquinoline amines, imidazonaphthyridine amines, imidazotetrahydronaphthyridine amines, oxazoloquinoline amines, thiazoloquinoline amines, oxazolopyridine amines, thiazolopyridine amines, oxazolonaphthyridine amines, thiazolonaphthyridine amines, and 1 H -imidazo dimers fused to pyridine amines, quinoline amines, tetrahydroquinoline amines, naphthyridine amines, or tetrahydronaphthyridine amines, are provided. In one embodiment, the aqueous formulations are advantageous for treatment and/or prevention of allergic rhinitis, viral infections, sinusitis, and asthma.
摘要翻译：包含免疫应答调节剂（IRM）的水性（优选可喷雾的）配方中的药物制剂，例如选自咪唑并喹啉胺，四氢咪唑并喹啉胺，咪唑并吡啶胺，6,7-稠合的环烷基咪唑并吡啶胺，1,2-桥连的咪唑并喹啉胺，咪唑并噻吩胺，咪唑并四氢萘啶胺，恶唑并喹啉胺，噻唑并喹啉胺，恶唑并吡啶胺，噻唑并吡啶胺，恶唑烷萘啶胺，噻唑并萘啶胺和与吡啶胺，喹啉胺，四氢喹啉胺，萘啶胺或四氢萘啶胺稠合的1H-咪唑并二聚体。在一个实施方案中，水性制剂对于治疗和/或预防过敏性鼻炎，病毒感染，鼻窦炎和哮喘是有利的。

2. 发明申请

WO2006130399A2 THERAPEUTIC COMBINATIONS AND METHODS INCLUDING IRM COMPOUNDS 审中-公开
标题翻译：治疗组合和包括IRM化合物的方法
公开(公告)号：WO2006130399A2
公开(公告)日：2006-12-07
申请号：PCT/US2006/020009
申请日：2006-05-24
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： TOMAI, Mark, A. , GULLIKSON, Gary, W. , HAMMERBECK, David, M. , EGGING, Elaine, A. , REITER, Michael, J. , GRAM, Christopher, D. , VASILAKOS, John, P. , ALKAN, Sefik, S.
IPC分类号： A61K31/4745 , A61K31/573 , A61K39/395
CPC分类号： A61K45/06
摘要： The present invention provides therapeutic combinations that include an immune response modifier (IRM) compound and an anti-inflammatory component. The inventions further provide methods of treating a condition by administering to one having the condition a therapeutic combination that includes an IRM compound and an anti-inflammatory component.
摘要翻译：本发明提供包括免疫应答调节剂（IRM）化合物和抗炎组分的治疗组合。本发明还提供了通过给予具有包含IRM化合物和抗炎组分的治疗组合的病症治疗病症的方法。

3. 发明申请

WO2005065678A1 IMMUNOMODULATORY COMBINATIONS 审中-公开
标题翻译：免疫组织结合
公开(公告)号：WO2005065678A1
公开(公告)日：2005-07-21
申请号：PCT/US2004/043892
申请日：2004-12-30
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： HAMMERBECK, David, M. , KEDL, Ross, M. , MILLER, Richard, L. , TOMAI, Mark, A. , VASILAKOS, John, P.
IPC分类号： A61K31/34
CPC分类号： A61K45/06 , A61K31/34 , A61K31/38 , A61K31/47 , A61K2300/00
摘要： The present invention provides immunomodulatory combinations that includes an IRM component and a therapeutic agent, each in an amount that, when in combination with the other, is effective for inducing an immune response in a subject.
摘要翻译：本发明提供免疫调节组合，其包括IRM组分和治疗剂，每种组合物的量与当时与另一种组合有效诱导受试者的免疫应答有效。

4. 发明申请

WO2005016273A2 INFECTION PROPHYLAXIS USING IMMUNE RESPONSE MODIFIER COMPOUNDS 审中-公开
标题翻译：使用免疫反应调节剂化合物的感染预防
公开(公告)号：WO2005016273A2
公开(公告)日：2005-02-24
申请号：PCT/US2004/025241
申请日：2004-08-05
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： HAMMERBECK, David, M. , GUY, Cynthia A.,
IPC分类号： A61K
CPC分类号： A61K31/437
摘要： The present invention provides methods of providing prophylaxis to a subject against an infectious agent. In general, the methods include topically administering to the respiratory tract of a subject an IRM compound in an amount effective to reduce infection by the agent.
摘要翻译：本发明提供了针对感染因子向受试者提供预防的方法。通常，所述方法包括以有效减少试剂感染的量向受试者的呼吸道局部施用IRM化合物。

5. 发明申请

WO2004078138A3 PROPHYLACTIC TREATMENT OF UV-INDUCED EPIDERMAL NEOPLASIA 审中-公开
公开(公告)号：WO2004078138A3
公开(公告)日：2004-09-16
申请号：PCT/US2004/006524
申请日：2004-03-04
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： EGGING, Elaine, A. , HAMMERBECK, David, M. , LEE, James, H.
IPC分类号： A61K31/66
摘要： The present invention provides a method of protecting a subject against UV-induced epidermal neoplasia. Generally, the method includes administering to a subject an IRM compound in an amount effective to provide protection against UV-induced epidermal neoplasia. The present invention also provides compositions that include an IRM compound in an amount effective for providing protection against UV-induced epidermal neoplasia.

6. 发明授权

EP1651190B1 FORMULATIONS CONTAINING AN IMMUNE RESPONSE MODIFIER 有权
标题翻译：有用于改性的免疫应答的制剂
公开(公告)号：EP1651190B1
公开(公告)日：2012-09-19
申请号：EP04780166.7
申请日：2004-08-05
申请人： 3M Innovative Properties Company
发明人： HAMMERBECK, David, M. , GUY, Cynthia, A. , LEUNG, Suzanne, S.
IPC分类号： A61K31/437
CPC分类号： A61K31/437

7. 发明公开

EP1651190A2 FORMULATIONS CONTAINING AN IMMUNE RESPONSE MODIFIER 有权
标题翻译：有用于改性的免疫应答的制剂
公开(公告)号：EP1651190A2
公开(公告)日：2006-05-03
申请号：EP04780166.7
申请日：2004-08-05
申请人： 3M Innovative Properties Company
发明人： HAMMERBECK, David, M. , GUY, Cynthia, A. , LEUNG, Suzanne, S.
IPC分类号： A61K9/14
CPC分类号： A61K31/437
摘要： Pharmaceutical formulations in an aqueous (preferably, sprayable) formulaiton including an immune response modifier (IRM), such as those chosen from imidazoquinoline amines, tetrahydroimidazoquinoline amines, imidazopyridine amines, 6,7-fused cycloalkylimidazopyridine amines, 1,2-bridged imidazoquinoline amines, imidazonaphthyridine amines, imidazotetrahydronaphthyridine amines, oxazoloquinoline amines, thiazoloquinoline amines, oxazolopyridine amines, thiazolopyridine amines, oxazolonaphthyridine amines, thiazolonaphthyridine amines, and 1H-imidazo dimers fused to pyridine amines, quinoline amines, tetrahydroquinoline amines, naphthyridine amines, or tetrahydronaphthyridine amines, are provided. In one embodiment, the aqueous formulations are advantageous for treatment and/or prevention of allergic rhinitis, viral infections, sinusitis, and asthma.

8. 发明公开

EP1601365A2 PROPHYLACTIC TREATMENT OF UV-INDUCED EPIDERMAL NEOPLASIA 审中-公开
标题翻译：紫外线引起的表皮肿瘤的预防性治疗
公开(公告)号：EP1601365A2
公开(公告)日：2005-12-07
申请号：EP04717371.1
申请日：2004-03-04
申请人： 3M Innovative Properties Company
发明人： EGGING, Elaine, A. , HAMMERBECK, David, M. , LEE, James, H.
IPC分类号： A61K31/66 , A61K31/55 , A61K31/535 , A61K31/44
CPC分类号： A61K31/00 , A61K8/4946 , A61K9/107 , A61K31/44 , A61K31/535 , A61K31/55 , A61K31/66 , A61K2800/522 , A61Q17/04 , C07D471/04
摘要： The present invention provides a method of protecting a subject against UV-induced epidermal neoplasia. Generally, the method includes administering to a subject an IRM compound in an amount effective to provide protection against UV-induced epidermal neoplasia. The present invention also provides compositions that include an IRM compound in an amount effective for providing protection against UV-induced epidermal neoplasia.

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