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1. 发明申请

WO2006038923A3 ARYL SUBSTITUTED IMIDAZONAPHTHYRIDINES 审中-公开
标题翻译：芳基取代的咪唑并吡啶
公开(公告)号：WO2006038923A3
公开(公告)日：2006-06-01
申请号：PCT/US2005021436
申请日：2005-06-17
申请人： 3M INNOVATIVE PROPERTIES CO , NIWAS SHRI , MERRILL BRYON A , HEPPNER PHILIP D , KSHIRSAGAR TUSHAR A , LUNDQUIST GREGORY D JR , AMOS DAVID T , LINDSTROM KYLE J
发明人： NIWAS SHRI , MERRILL BRYON A , HEPPNER PHILIP D , KSHIRSAGAR TUSHAR A , LUNDQUIST GREGORY D JR , AMOS DAVID T , LINDSTROM KYLE J
IPC分类号： A61K31/44 , C07D471/04 , C07D471/06
CPC分类号： C07D471/14
摘要： Imidazonaphthyridine ring systems substituted with an aryl substituent, pharmaceutical compositions containing the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
摘要翻译：公开了用芳基取代基取代的咪唑并萘啶环系统，含有该化合物的药物组合物，以及将这些化合物用作免疫调节剂的方法，用于在动物中诱导细胞因子生物合成以及治疗疾病，包括病毒和肿瘤疾病。

2. 发明申请

WO2006107771A3 PYRAZOLO[3,4-c]QUINOLINES, PYRAZOLO[3,4-c]NAPHTHYRIDINES, ANALOGS THEREOF, AND METHODS 审中-公开
标题翻译：吡唑并[3,4-c]喹啉，吡唑并[3,4-c]萘啶，其类似物及方法
公开(公告)号：WO2006107771A3
公开(公告)日：2007-10-04
申请号：PCT/US2006012031
申请日：2006-03-31
申请人： COLEY PHARM GROUP INC , MERRILL BRYON A , DANIELSON MICHAEL E , HAYS DAVID S , AMOS DAVID T , HEPPNER PHILIP D , KSHIRSAGAR TUSHAR A , LUNDQUIST GREGORY D JR , MOSER WILLIAM H
发明人： MERRILL BRYON A , DANIELSON MICHAEL E , HAYS DAVID S , AMOS DAVID T , HEPPNER PHILIP D , KSHIRSAGAR TUSHAR A , LUNDQUIST GREGORY D JR , MOSER WILLIAM H
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： Pyrazolo[3,4-c]quinolines, pyrazolo[4,5-c]naphthyridines, and analogs thereof, eg., 6,7,8,9-tetrahydro pyrazolo[3,4-c]quinolines, and, pharmaceutical compositions containing the compounds, intermediates, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inhibiting cytokine biosynthesis in animals and in the therapeutic or prophylactic treatment of diseases by inhibiting cytokine biosynthesis are disclosed.
摘要翻译：吡唑并[3,4-c]喹啉，吡唑并[4,5-c]萘啶及其类似物，例如6,7,8,9-四氢吡唑并[3,4-c]喹啉，以及药物组合物公开了含有化合物，中间体，制备这些化合物的方法，以及这些化合物作为免疫调节剂的用途，用于抑制动物中的细胞因子生物合成以及通过抑制细胞因子生物合成来治疗或预防性治疗疾病。

3. 发明申请

WO2005123079A3 UREA SUBSTITUTED IMIDAZOPYRIDINES, IMIDAZOQUINOLINES, AND IMIDAZONAPHTHYRIDINES 审中-公开
标题翻译：尿嘧啶取代的咪唑啉，咪唑啉和咪唑嗪
公开(公告)号：WO2005123079A3
公开(公告)日：2006-06-22
申请号：PCT/US2005020895
申请日：2005-06-14
申请人： 3M INNOVATIVE PROPERTIES CO , KSHIRSAGAR TUSHAR A , LUNDQUIST GREGORY D JR , CELEBI ABDULAZIZ A , GRIESGRABER GEORGE W , JOHANNESSEN SARAH C , HEPPNER PHILIP D , AMOS DAVID T , ZIMMERMANN BERNHARD M , LANGER SCOTT E
发明人： KSHIRSAGAR TUSHAR A , LUNDQUIST GREGORY D JR , CELEBI ABDULAZIZ A , GRIESGRABER GEORGE W , JOHANNESSEN SARAH C , HEPPNER PHILIP D , AMOS DAVID T , ZIMMERMANN BERNHARD M , LANGER SCOTT E
IPC分类号： C07D471/14 , A61K31/437 , A61K31/4745
CPC分类号： C07D471/04 , C07D471/14
摘要： Imidazopyridine, imidazoquinoline, and imidazonaphthyridine compounds having a urea substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
摘要翻译：咪唑并吡啶，咪唑并喹啉和咪唑并吡啶化合物在2-位上具有尿素取代基，含有化合物的药物组合物，中间体及其制备方法以及这些化合物作为免疫调节剂的用途，用于调节动物中的细胞因子生物合成和治疗公开了包括病毒和肿瘤疾病在内的疾病。

4. 发明申请

WO2005048933A3 OXIME SUBSTITUTED IMIDAZO RING COMPOUNDS 审中-公开
标题翻译： OXIME取代咪唑环化合物
公开(公告)号：WO2005048933A3
公开(公告)日：2005-12-01
申请号：PCT/US2004037854
申请日：2004-11-12
申请人： 3M INNOVATIVE PROPERTIES CO , KSHIRSAGAR TUSHAR A , LUNDQUIST GREGORY D JR , AMOS DAVID T , DELLARIA JOSEPH F JR , ZIMMERMANN BERNHARD M , HEPPNER PHILIP D
发明人： KSHIRSAGAR TUSHAR A , LUNDQUIST GREGORY D JR , AMOS DAVID T , DELLARIA JOSEPH F JR , ZIMMERMANN BERNHARD M , HEPPNER PHILIP D
IPC分类号： A61K20060101 , C07D471/02 , C07D471/06
CPC分类号： C07D471/04 , C07D471/14 , C07D519/00
摘要： Imidazo ring compounds (e.g., imidazoquinolines, 6,7,8,9-tetrahydroimidazoquinolines, imidazonaphthyridines, and imidazopyridines) with an oxime substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
摘要翻译：含有在2-位具有肟取代基的咪唑环化合物（例如咪唑并喹啉，6,7,8,9-四氢咪唑并喹啉，咪唑并萘啶和咪唑并吡啶），含有这些化合物作为免疫调节剂的化合物，中间体和方法的药物组合物，用于在动物中诱导细胞因子生物合成以及用于治疗包括病毒和肿瘤疾病的疾病。

5. 发明申请

WO2005048945A3 HYDROXYLAMINE SUBSTITUTED IMIDAZO RING COMPOUNDS 审中-公开
标题翻译：羟基胺取代的咪唑环化合物
公开(公告)号：WO2005048945A3
公开(公告)日：2006-03-23
申请号：PCT/US2004038033
申请日：2004-11-12
申请人： 3M INNOVATIVE PROPERTIES CO , KSHIRSAGAR TUSHAR A , LUNDQUIST GREGORY D JR , AMOS DAVID T , DELLARIA JOSEPH F JR , ZIMMERMANN BERNHARD M , HEPPNER PHILIP D
发明人： KSHIRSAGAR TUSHAR A , LUNDQUIST GREGORY D JR , AMOS DAVID T , DELLARIA JOSEPH F JR , ZIMMERMANN BERNHARD M , HEPPNER PHILIP D
IPC分类号： C07D471/00 , A61K20060101 , A61K31/44 , C07D471/04 , C07D471/14
CPC分类号： C07D471/04 , C07D471/14
摘要： Imidazo ring compounds (e.g., imidazoquinolines, 6, 7, 8, 9-tetrahydroimidazoquinolines, imidazonaphthyridines, and imidazopyridines) with a hydroxylamine substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
摘要翻译：在2-位具有羟胺取代基的咪唑环化合物（例如咪唑并喹啉，6,7,8,9-四氢咪唑并喹啉，咪唑并吡啶和咪唑并吡啶），含有化合物的药物组合物，中间体以及这些化合物作为免疫调节剂的使用方法，用于在动物中诱导细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

6. 发明申请

WO2006029115A2 2-AMINO 1H IMIDAZO RING SYSTEMS AND METHODS 审中-公开
标题翻译： 2-氨基-1H-咪唑环系统和方法
公开(公告)号：WO2006029115A2
公开(公告)日：2006-03-16
申请号：PCT/US2005031616
申请日：2005-09-01
申请人： 3M INNOVATIVE PROPERTIES CO , KSHIRSAGAR TUSHAR A , LANGER SCOTT E , NIWAS SHRI , HEPPNER PHILIP D , AMOS DAVID T
发明人： KSHIRSAGAR TUSHAR A , LANGER SCOTT E , NIWAS SHRI , HEPPNER PHILIP D , AMOS DAVID T
IPC分类号： A61K31/4172
CPC分类号： C07D471/04 , C07D471/14
摘要： 1H-Imidazo ring systems (e.g., imidazopyridines, imidazoquinolines, imidazonaphthyridines, 6,7,8,9-tetrahydro imidazoquinolines and imidazonaphthyridines) with an amino substituent at the 2-position, pharmaceutical compositions containing these compounds, methods of making the compounds, intermediates, and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
摘要翻译：在2-位具有氨基取代基的1H-咪唑环体系（例如咪唑并吡啶，咪唑并喹啉，咪唑并吡啶，6,7,8,9-四氢咪唑并喹啉和咪唑并吡啶），含这些化合物的药物组合物，制备化合物的方法，中间体，以及这些化合物作为免疫调节剂的用途，用于调节动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病的方法。

7. 发明申请

WO2005018556A2 HYDROXYLAMINE SUBSTITUTED IMIDAZO-CONTAINING COMPOUNDS 审中-公开
标题翻译：羟基取代的含有咪唑的化合物
公开(公告)号：WO2005018556A2
公开(公告)日：2005-03-03
申请号：PCT/US2004026158
申请日：2004-08-12
申请人： 3M INNOVATIVE PROPERTIES CO , KSHIRSAGAR TUSHAR A , AMOS DAVID T , DELLARIA JOSEPH F JR , HEPPNER PHILIP D , LANGER SCOTT E , ZIMMERMANN BERNHARD M
发明人： KSHIRSAGAR TUSHAR A , AMOS DAVID T , DELLARIA JOSEPH F JR , HEPPNER PHILIP D , LANGER SCOTT E , ZIMMERMANN BERNHARD M
IPC分类号： A61K20060101 , A61K31/437 , A61K31/4375 , A61K31/4745 , A61P31/12 , A61P37/02 , C07D471/04 , C07D471/14 , A61K
CPC分类号： C07D471/04 , C07D471/14
摘要： Imidazo-containing compounds (e.g., imidazoquinolines, imidazonaphthyridines, imidazopyridines) with a hydroxylamine substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
摘要翻译：在1位具有羟胺取代基的含咪唑化合物（例如咪唑并喹啉，咪唑并吡啶，咪唑并吡啶），含有这些化合物的化合物，中间体和使用这些化合物作为免疫调节剂的方法，用于在动物中诱导细胞因子生物合成公开了包括病毒和肿瘤疾病在内的疾病的治疗。

8. 发明申请

WO2005051324A3 HYDROXYLAMINE AND OXIME SUBSTITUTED IMIDAZOQUINOLINES, IMIDAZOPYRIDINES, AND IMIDAZONAPHTHYRIDINES 审中-公开
标题翻译：羟基胺和氧化物取代的咪唑啉酮，咪唑并吡啶和咪唑并噻吩
公开(公告)号：WO2005051324A3
公开(公告)日：2006-01-05
申请号：PCT/US2004039673
申请日：2004-11-24
申请人： 3M INNOVATIVE PROPERTIES CO , KREPSKI LARRY R , DELLARIA JOSEPH F JR , DUFFY DANIEL E , AMOS DAVID T , ZIMMERMANN BERNHARD M , SQUIRE DAVID J , MARSZALEK GREGORY J , HEPPNER PHILIP D , KSHIRSAGAR TUSHAR A
发明人： KREPSKI LARRY R , DELLARIA JOSEPH F JR , DUFFY DANIEL E , AMOS DAVID T , ZIMMERMANN BERNHARD M , SQUIRE DAVID J , MARSZALEK GREGORY J , HEPPNER PHILIP D , KSHIRSAGAR TUSHAR A
IPC分类号： A61K20060101 , A61K31/44 , A61K31/42 , C07D471/02 , C07D471/06
CPC分类号： C07D471/04 , C07D471/14
摘要： Imidazo-quinoline, -pyridine, and -naphthyridine ring systems substituted at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
摘要翻译：在1-位取代的咪唑并喹啉，吡啶和萘啶环体系，含有这些化合物的化合物，中间体和使用方法作为免疫调节剂的药物组合物，用于在动物中诱导细胞因子生物合成和治疗疾病，包括公开了病毒和肿瘤疾病。

9. 发明申请

WO2005018551A3 OXIME SUBSTITUTED IMIDAZO-CONTAINING COMPOUNDS 审中-公开
标题翻译： OXIME取代的含IMIDAZO的化合物
公开(公告)号：WO2005018551A3
公开(公告)日：2006-05-11
申请号：PCT/US2004026065
申请日：2004-08-12
申请人： 3M INNOVATIVE PROPERTIES CO , KSHIRSAGAR TUSHAR , AMOS DAVID T , DELLARIA JOSEPH F JR , HEPPNER PHILIP D , LANGER SCOTT E , ZIMMERMANN BERNHARD M
发明人： KSHIRSAGAR TUSHAR , AMOS DAVID T , DELLARIA JOSEPH F JR , HEPPNER PHILIP D , LANGER SCOTT E , ZIMMERMANN BERNHARD M
IPC分类号： A61K20060101 , A61K31/437 , A61K31/4375 , A61K31/4745 , A61P31/12 , A61P37/02 , C07D471/04 , C07D471/14 , C07D471/12
CPC分类号： C07D471/04 , C07D471/14
摘要： Imidazo-containing compounds (e.g., imidazoquinolines, imidazonaphthyridines, and imidazopyridines) with an oxime substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
摘要翻译：在1位具有肟取代基的含咪唑的化合物（例如咪唑并喹啉，咪唑并吡啶和咪唑并吡啶），含有这些化合物的化合物，中间体和使用这些化合物作为免疫调节剂的方法用于在动物中诱导细胞因子生物合成公开了包括病毒和肿瘤疾病在内的疾病的治疗。

10. 发明申请

WO2010039395A3 ORTHODONTIC COMPOSITION WITH HEAT MODIFIED MINERALS 审中-公开
标题翻译：具有热改性矿物的正交组合物
公开(公告)号：WO2010039395A3
公开(公告)日：2010-08-19
申请号：PCT/US2009056180
申请日：2009-09-08
申请人： 3M INNOVATIVE PROPERTIES CO , AMOS DAVID T , MORRIS GEOFFREY P
发明人： AMOS DAVID T , MORRIS GEOFFREY P
IPC分类号： A61K6/02 , A61K6/083
CPC分类号： A61K6/0023
摘要： The invention provides an orthodontic composition, related methods and packaged articles that include a hardenable component, a hardener, and a heat-modified inorganic mineral filler. The composition displays improved hardened remnant cleanup compared with compositions using traditional hard mineral fillers, while maintaining acceptable handling, bond strength and mechanical properties. Bond strength enhancement is achieved by heat-modifying a soft mineral filler, a process by which water of hydration is eliminated from the microstructure of the mineral to form a non-hydrated phase. By using heat-modified mineral fillers that are soft relative to human enamel, the hardened orthodontic composition can be conveniently removed using a low-speed abrasive disk or other mild abrasion process that is safer and more comfortable for the patient. The composition is especially beneficial for use in bonding orthodontic appliances to teeth.
摘要翻译：本发明提供包括可硬化组分，硬化剂和热改性无机矿物填料的正牙组合物，相关方法和包装物品。与使用传统硬质矿物填料的组合物相比，该组合物显示出改进的硬化残余物清洁，同时保持可接受的处理，粘合强度和机械性能。通过对软矿物填料进行热改性来实现粘结强度提高，该矿物填料是从矿物的微观结构中消除水合水以形成非水合相的过程。通过使用相对于人类牙釉质柔软的热改性矿物填料，可以使用低速研磨盘或其他适用于患者更安全和舒适的温和研磨方法来方便地去除硬化的正牙组合物。该组合物特别有利于将正畸矫正器与牙齿结合。

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