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1. 发明申请

WO2006074003A3 CHIRAL FUSED [1,2]IMIDAZO[4,5-c] RING COMPOUNDS 审中-公开
标题翻译： CHIRAL FUSED [1,2]咪唑并[4,5-c]环化合物
公开(公告)号：WO2006074003A3
公开(公告)日：2007-11-22
申请号：PCT/US2005047258
申请日：2005-12-29
申请人： 3M INNOVATIVE PROPERTIES CO , GRIESGRABER GEORGE W , KSHIRSAGAR TUSHAR A , CELEBI AZIM A , SLANIA SARAH J , DANIELSON MICHAEL E , RICE MICHAEL J , WURST JOSHUA R
发明人： GRIESGRABER GEORGE W , KSHIRSAGAR TUSHAR A , CELEBI AZIM A , SLANIA SARAH J , DANIELSON MICHAEL E , RICE MICHAEL J , WURST JOSHUA R
IPC分类号： A61K31/4745 , C07D487/22
CPC分类号： C07D498/14 , C07D471/14 , C07D498/22
摘要： Fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a -CH(-X 1 -R 1 )-group in the fused ring at the 1-position of the imidazo ring, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
摘要翻译：熔融[1,2]咪唑并[4,5-c]环化合物（例如咪唑并[4,5-c]喹啉，6,7,8,9-四氢咪唑并[4,5-c]喹啉，咪唑并[4 ，5-c]萘啶和6,7,8,9-四氢咪唑并[4,5-c]萘啶）与-CH（-X 1 R 1 -R 1） >） - 咪唑环1位的稠合环中的基团，含有化合物的药物组合物，中间体，制备化合物的方法，以及这些化合物作为免疫调节剂的方法，用于在动物中诱导细胞因子生物合成公开了包括病毒和肿瘤疾病在内的疾病的治疗。

2. 发明专利

AU2005326708C1 Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds 未知
公开(公告)号：AU2005326708C1
公开(公告)日：2012-08-30
申请号：AU2005326708
申请日：2005-12-29
申请人： 3M INNOVATIVE PROPERTIES CO
发明人： SLANIA SARAH J , KSHIRSAGAR TUSHAR A , GRIESGRABER GEORGE W , DANIELSON MICHAEL E
IPC分类号： C07D471/02 , A61K31/4745
摘要： Substituted fused [1,2]imidazo[4,5-] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a -CH(-R)- group in the fused ring at the 1-position of the imidazo ring, wherein R includes a functional group, for example, an amide, sulfonamide, urea, carbamate, ester, ketone, ether, a thio analog of the forgoing, sulfone, oxime, or hydroxylamine, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

3. 发明专利

CA2592904C CHIRAL FUSED [1,2]IMIDAZO[4,5-C] RING COMPOUNDS 未知
公开(公告)号：CA2592904C
公开(公告)日：2015-04-07
申请号：CA2592904
申请日：2005-12-29
申请人： 3M INNOVATIVE PROPERTIES CO
发明人： GRIESGRABER GEORGE W , KSHIRSAGAR TUSHAR A , CELEBI AZIM A , SLANIA SARAH J , DANIELSON MICHAEL E , RICE MICHAEL J , WURST JOSHUA R
IPC分类号： C07D491/02
摘要： Fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a -CH(-X1-R1)-group in the fused ring at the 1-position of the imidazo ring, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

4. 发明专利

ES2392648T3 Compuestos quirales sustituidos que contienen un núcleo 1,2-imidazo-4,5-c condensado 未知
公开(公告)号：ES2392648T3
公开(公告)日：2012-12-12
申请号：ES05857242
申请日：2005-12-29
申请人： 3M INNOVATIVE PROPERTIES CO
发明人： DANIELSON MICHAEL E , SLANIA SARAH J , KSHIRSAGAR TUSHAR A , GRIESGRABER GEORGE W
IPC分类号： C07D471/14 , A61K31/437 , A61P31/00 , C07D471/22
摘要： Un compuesto de la Formula II o IV en las que: X es un enlace X' es un alquileno C1. Z se selecciona entre el grupo que consiste en-O- y -N (-Y-R2) -; R1 se selecciona entre el grupo que consiste en: - X1-Y-R4, -X1-Y-X''-Y1-R4 y -X1-R5; X1 se selecciona entre el grupo que consiste en alquileno y alquenileno, en el que el alquileno y el alquenileno están opcionalmente interrumpidos por uno o más grupos -O- y opcionalmente sustituidos con un grupo hidroxi o metoxi; X" se selecciona entre el grupo que consiste en alquileno, alquenileno, alquinileno, arileno, heteroarileno y heterociclileno, en el que los grupos alquileno, alquenileno y alquinileno pueden estar opcionalmente interrumpidos o terminados por arileno, heteroarileno o heterociclileno y opcionalmente interrumpidos por uno o más grupos -O-; Y se selecciona entre el grupo que consiste en: un enlace, -S (O) 2-, -S (O) 2-N (R8) -, -C (R6) -, -C (R6) -N (R8) -, -C (R6) -N (R8) -C (R6) -, -C (R6) -N (R8) -S (O) 2- y -C (R6) -O-; Y' se selecciona entre el grupo que consiste en: - O-, -S (O) 0-2-, -S (O) 2-N (R8) -, -C (R6) -, -C (R6) -O-, -O-C (R6) -, -O-C (O) -O-, -N (R8) -Q-, -C (R6) -N (R8) -, -O-C (R6) -N (R8) -, -C (R6) -N (OR9) -, -O-N (R8) -Q-, -O-N>=C (R4) -, -C (>=N-O-R8) -, -CH (-N (-O-R8) -Q-R4) -, o sustituidos con uno o más sustituyentes seleccionados independientemente entre el grupo que consiste en alquilo; alcoxi; alquiltio; alcanoílo; alcanoiloxi; alcoxicarbonilo; hidroxialquilo; haloalquilo; haloalcoxi; halógeno; nitro; hidroxi; mercapto; ciano; arilo; ariloxi; ariltio; arilalquilenoxi; heteroarilo; heteroariloxi; heteroarilalquilenoxi; heterociclilo; amino; alquilamino; dialquilamino; (dialquilamino) alquilenoxi; en el caso de alquilo, alquenilo, alquinilo, y heterociclilo, oxo; y, en el caso de arilo, metilendioxi; R4 se selecciona entre el grupo que consiste en hidrógeno, alquilo, alquenilo, alquinilo, arilo, arilalquilenilo, ariloxialquilenilo, alquilarilenilo, heteroarilo, heteroarilalquiloenilo, heteroariloxialquilenilo, alquilheteroarilenilo y heterociclilo, en el que los grupos alquilo, alquenilo, alquinilo, arilo, arilalquilenilo, ariloxialquilenilo, alquilarilenilo, heteroarilo, heteroarilalquiloenilo, heteroariloxialquilenilo, alquilheteroarilenilo y heterociclilo pueden estar sin sustituir o sustituidos con uno o más sustituyentes seleccionados independientemente entre el grupo que consiste en alquilo; alcoxi; hidroxialquilo; haloalquilo; haloalcoxi; halógeno; nitro; hidroxi; mercapto; ciano; arilo; ariloxi; arilalquilenoxi; heteroarilo; heteroariloxi; heteroarilalquilenoxi; heterociclilo; amino; alquilamino; dialquilamino; (dialquilamino) alquilenoxi; y, en el caso de alquilo, alquenilo, alquinilo y heterociclilo, oxo; R5 se selecciona entre el grupo que consiste en: 25 R6 se selecciona entre el grupo que consiste en >=O y >=S; 30 R7 es alquileno C2-7; R8 se selecciona entre el grupo que consiste en hidrógeno, alquilo C1-10, alquenilo C2-10, hidroxi-alquilenilo C1-10, alcoxi C1-10-alquilenilo C1-10, aril-alquilenilo C1-10 y heteroaril-alquilenilo C1-10; R9 se selecciona entre el grupo que consiste en hidrógeno y alquilo; R10 es alquileno C3-8; A se selecciona entre el grupo que consiste en-CH2-, -O-, -C (O) -, -S (O) 0-2- y -N (-Q-R4) -; A' se selecciona entre el grupo que consiste en-O-, -S (O) 0-2-, -N (-Q-R4) -y -CH2-; Q se selecciona entre el grupo que consiste en un enlace, -C (R6) -, -C (R6) -C (R6) -, -S (O) 2-, -C (R6) -N (R8) -W-, -S (O) 2-N (R8) -, -C (R6) -O-, -C (R6) -S- y -C (R6) -N (OR9) -; V se selecciona entre el grupo que consiste en-C (R6) -, -O-C (R6) -, -N (R8) -C (R6) - y -S (O) 2-; W se selecciona entre el grupo que consiste en un enlace, -C (O) - y -S (O) 2-; y a y b son independientemente números enteros de 1 a 6 con la condición de que a + b sea =N-O-R8) -, -CH (-N (-O-R8) -Q-R4) -, en las que V es -C (R6) -, o R5 está enlazado a X) y R5 es en la que V es -C (R6) - o o una sal farmacéuticamente aceptable de los mismos, en los que los términos "alquilo", "alquenilo", "alquinilo" y el prefijo "alq. ", a menos que se indique otra cosa, incluyen grupos de cadena lineal y ramificada, y grupos cíclicos, y estos grupos contienen de 1 a 20 átomos de carbono, conteniendo los grupos alquenilo alquinilo de 2 a 20 átomos de carbono.

5. 发明专利

CA2594674C SUBSTITUTED CHIRAL FUSED [1,2]IMIDAZO[4,5-C] RING COMPOUNDS 未知
公开(公告)号：CA2594674C
公开(公告)日：2016-05-17
申请号：CA2594674
申请日：2005-12-29
申请人： 3M INNOVATIVE PROPERTIES CO
发明人： GRIESGRABER GEORGE W , KSHIRSAGAR TUSHAR A , SLANIA SARAH J , DANIELSON MICHAEL E
IPC分类号： C07D471/14 , A61K31/437 , C07D471/22
摘要： Substituted fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a -CH(-R1)- group in the fused ring at the 1-position of the imidazo ring, wherein Rl includes a functional group, for example, an amide, sulfonamide, urea, carbamate, ester, ketone, ether, a thio analog of the forgoing, sulfone, oxime, or hydroxylamine, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

6. 发明专利

AU2005326708B2 Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds 未知
公开(公告)号：AU2005326708B2
公开(公告)日：2012-03-15
申请号：AU2005326708
申请日：2005-12-29
申请人： 3M INNOVATIVE PROPERTIES CO
发明人： DANIELSON MICHAEL E , KSHIRSAGAR TUSHAR A , GRIESGRABER GEORGE W , SLANIA SARAH J
IPC分类号： C07D471/02 , A61K31/4745
摘要： Substituted fused [1,2]imidazo[4,5-] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a -CH(-R)- group in the fused ring at the 1-position of the imidazo ring, wherein R includes a functional group, for example, an amide, sulfonamide, urea, carbamate, ester, ketone, ether, a thio analog of the forgoing, sulfone, oxime, or hydroxylamine, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

7. 发明专利

AU2005322898B2 Chiral fused (1,2)imidazo(4,5-c) ring compounds 未知
公开(公告)号：AU2005322898B2
公开(公告)日：2011-11-24
申请号：AU2005322898
申请日：2005-12-29
申请人： 3M INNOVATIVE PROPERTIES CO
发明人： GRIESGRABER GEORGE W , DANIELSON MICHAEL E , WURST JOSHUA R , SLANIA SARAH J , RICE MICHAEL J , CELEBI AZIM A , KSHIRSAGAR TUSHAR A
IPC分类号： C07D487/22 , A61K31/4745
摘要： Fused [1,2]imidazo[4,5-] ring compounds (, imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a -CH(-X-R)-group in the fused ring at the 1-position of the imidazo ring, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

8. 发明专利

CA2594674A1 SUBSTITUTED CHIRAL FUSED [1,2]IMIDAZO[4,5-C] RING COMPOUNDS 未知
公开(公告)号：CA2594674A1
公开(公告)日：2006-08-10
申请号：CA2594674
申请日：2005-12-29
申请人： 3M INNOVATIVE PROPERTIES CO
发明人： GRIESGRABER GEORGE W , SLANIA SARAH J , KSHIRSAGAR TUSHAR A , DANIELSON MICHAEL E
IPC分类号： C07D471/14 , A61K31/437 , C07D471/22
摘要： Substituted fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5- c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5- c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a - CH(-R1)- group in the fused ring at the 1-position of the imidazo ring, wherein Rl includes a functional group, for example, an amide, sulfonamide, urea, carbamate, ester, ketone, ether, a thio analog of the forgoing, sulfon e, oxime, or hydroxylamine, pharmaceutical compositions containing the compound s, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, ar e disclosed.

9. 发明公开

EP1831221A4 SUBSTITUTED CHIRAL FUSED 1,2 IMIDAZO 4,5-C RING COMPOUNDS 有权
标题翻译：取代的手性的，合并1.2咪唑并-4,5--C-RING CONNECTIONS
公开(公告)号：EP1831221A4
公开(公告)日：2008-11-05
申请号：EP05857242
申请日：2005-12-29
申请人： 3M INNOVATIVE PROPERTIES CO
发明人： DANIELSON MICHAEL E , SLANIA SARAH J , KSHIRSAGAR TUSHAR A , GRIESGRABER GEORGE W
IPC分类号： C07D471/14 , A61K31/437 , A61P31/00 , C07D471/22
CPC分类号： C07D471/04 , C07D471/14

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