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    • 4. 发明专利
    • Integrated microneedle array delivery system
    • AU2015227524A1
    • 2015-10-08
    • AU2015227524
    • 2015-09-18
    • 3M INNOVATIVE PROPERTIES CO
    • COLBURN DAVID JJOHNSON ERIK JBRANDWEIN DAVID HGYSBERS JEROME EYOUNG PATRICK JCANTOR ADAM S
    • A61M5/00
    • The present disclosure provides low-profile systems and methods for delivering a microneedle 5 array. A delivery system includes a housing that may be secured to and temporarily worn on a patient's skin. A carrier assembly coupled to a microneedle array is received in the housing proximate a stored energy device. The stored energy device can be designed to store a predetermined amount of potential energy that is greater or substantially greater than the energy necessary to release said energy. As the stored energy device is potentially capable of 10 releasing substantially more energy than is required to cause the release, the amount of normal force applied to the skin can be minimized while sufficient application velocity is still generated. Certain implementations of the delivery system can be activated without creating a significant skin dome and without substantially stretching the skin or otherwise disturbing the surface. While a small activation force in a direction orthogonal to the skin may be necessary 15 to activate a stored energy device, the forces generated normal to the skin surface can be essentially reacted against one another within the housing. Accordingly, the force actually applied to the skin in a direction normal to the plane of the skin can be zero or near zero.