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1. 发明专利

AU2003287316A1 ASSAYS RELATING TO TOLL-LIKE RECEPTOR ACTIVITY 未知
公开(公告)号：AU2003287316A1
公开(公告)日：2004-06-30
申请号：AU2003287316
申请日：2003-10-31
申请人： 3M INNOVATIVE PROPERTIES CO
发明人： GUPTA SHALLEY K , GHOSH TARUN K , FINK JASON R
IPC分类号： C12N15/85 , C12Q1/68 , G01N33/53 , G01N33/567
摘要： The present invention provides assays useful for detecting agonists of Toll-like receptors. The assays include, generally, providing a cell culture transfected with a nucleic acid sequence that encodes a reporter operably linked to a TLR-inducible expression control sequence; contacting the cell culture with a test compound; and identifying the compound as a TLR agonist if TLR-inducible expression of the reporter can be detected.

2. 发明专利

AU2003287324A8 Gene expression systems and recombinant cell lines 未知
公开(公告)号：AU2003287324A8
公开(公告)日：2004-06-30
申请号：AU2003287324
申请日：2003-10-31
申请人： 3M INNOVATIVE PROPERTIES CO
发明人： GUPTA SHALLEY K , GHOSH TARUN K , FINK JASON R
IPC分类号： A61K38/00 , C07K14/705 , C12N5/02 , G01N33/50 , C12P21/06 , C12N15/72
摘要： The present invention provides gene expression systems useful for detecting agonists of Toll-like receptors. The gene expression systems include a nucleic acid sequence encoding a Toll-like receptor and a second nucleic acid sequence that encodes a reporter operably linked to an expression control sequence. The recombinant cell lines include a gene expression system according to the present invention.

3. 发明专利

AU2003287324A1 GENE EXPRESSION SYSTEMS AND RECOMBINANT CELL LINES 未知
公开(公告)号：AU2003287324A1
公开(公告)日：2004-06-30
申请号：AU2003287324
申请日：2003-10-31
申请人： 3M INNOVATIVE PROPERTIES CO
发明人： GHOSH TARUN K , FINK JASON R , GUPTA SHALLEY K
IPC分类号： A61K38/00 , C07K14/705 , C12N5/02 , G01N33/50
摘要： The present invention provides gene expression systems useful for detecting agonists of Toll-like receptors. The gene expression systems include a nucleic acid sequence encoding a Toll-like receptor and a second nucleic acid sequence that encodes a reporter operably linked to an expression control sequence. The recombinant cell lines include a gene expression system according to the present invention.

4. 发明申请

WO2004053452A3 ASSAYS RELATING TO TOLL-LIKE RECEPTOR ACTIVITY 审中-公开
标题翻译：相对于类似感受器活动的测定
公开(公告)号：WO2004053452A3
公开(公告)日：2007-08-16
申请号：PCT/US0334554
申请日：2003-10-31
申请人： 3M INNOVATIVE PROPERTIES CO
发明人： GUPTA SHALLEY K , GHOSH TARUN K , FINK JASON R
IPC分类号： G01N33/53 , C07H21/02 , C12N5/00 , C12N15/00 , C12N15/85 , C12Q1/68 , G01N33/567
CPC分类号： C12Q1/6897
摘要： The present invention provides assays useful for detecting agonists of Toll-like receptors. The assays include providing a cell culture transfected with a nucleic acid sequence that encodes a reporter operably linked to a TLR-inducible expression control sequence.
摘要翻译：本发明提供了用于检测Toll样受体的激动剂的测定法。所述测定包括提供用编码可操作地连接到TLR诱导型表达控制序列的报告基因的核酸序列转染的细胞培养物。

5. 发明申请

WO2004075865A3 SELECTIVE MODULATION OF TLR-MEDIATED BIOLOGICAL ACTIVITY 审中-公开
标题翻译： TLR介导的生物学活性的选择性调节
公开(公告)号：WO2004075865A3
公开(公告)日：2004-11-18
申请号：PCT/US2004006115
申请日：2004-02-27
申请人： 3M INNOVATIVE PROPERTIES CO
发明人： FINK JASON R , GORDEN KEITH B , GORSKI KEVIN S , GUPTA SHALLEY K , QIU XIAOHONG , VASILAKOS JOHN P
IPC分类号： A61K31/00 , A61K31/44 , G01N33/566 , G01N33/50 , A61K49/00
CPC分类号： G01N33/566 , A61K31/00 , A61K31/44 , G01N2500/10
摘要： Methods of identifying a compound that selectively modulates at least one TLR-mediated cellular activity are disclosed. Generally, the methods include identifying a compound as a compound that selectively modulates at least one TLR-mediated cellular activity if the compound modulates one TLR-mediated cellular activity to a different extent than it modulates a second TLR-mediated cellular activity. Compounds so identified and pharmaceutical compositions including such compounds are also disclosed. Methods of selectively modulating immune cells and methods of treating certain conditions are also provided. Such methods include administering to cells or a subject a compound that selectively modulates a TLR-mediated cellular activity.
摘要翻译：公开了鉴定选择性调节至少一种TLR介导的细胞活性的化合物的方法。一般而言，所述方法包括将化合物鉴定为选择性调节至少一种TLR介导的细胞活性的化合物，如果所述化合物调节一种TLR介导的细胞活性的程度与调节第二种TLR介导的细胞活性的程度不同。还公开了如此鉴定的化合物和包含这些化合物的药物组合物。还提供了选择性调节免疫细胞的方法和治疗某些病症的方法。此类方法包括向细胞或受试者施用选择性调节TLR介导的细胞活性的化合物。

6. 发明申请

WO2004087049A3 SELECTIVE ACTIVATION OF CELLULAR ACTIVITIES MEDIATED THROUGH A COMMON TOLL-LIKE RECEPTOR 审中-公开
标题翻译：通过普通类似受体介导的细胞活性的选择性活化
公开(公告)号：WO2004087049A3
公开(公告)日：2004-12-29
申请号：PCT/US2004008979
申请日：2004-03-24
申请人： 3M INNOVATIVE PROPERTIES CO
发明人： FINK JASON R , GUPTA SHALLEY K
IPC分类号： G01N33/50 , A61K49/00
CPC分类号： G01N33/5047
摘要： Methods of identifying compounds that selectively modulate cellular activities mediated by a common TLR are provided. Generally, the methods include providing an assay to detect modulation of a first cellular activity mediated by a TLR; providing an assay to detect modulation of a second cellular activity mediated by the TLR; performing each assay using a test compound; and identifying the test compound as a compound that selectively modulates at least one cellular activity of a plurality of activities mediated by a common TLR if the test compound modulates the first cellular activity to a different extent than it modulates the second TLR-mediated cellular activity. Compounds identified by such methods, pharmaceutical compositions including such compounds, and methods of treating a condition by administering such pharmaceutical compositions to a subject are also provided.
摘要翻译：提供了鉴定选择性调节由常见TLR介导的细胞活性的化合物的方法。通常，所述方法包括提供检测由TLR介导的第一细胞活性的调节; 提供测定以检测由TLR介导的第二细胞活性的调节; 使用测试化合物进行每个测定; 以及如果测试化合物调节第一细胞活性与其调节第二TLR介导的细胞活性不同的程度，则将测试化合物鉴定为选择性调节由常见TLR介导的多种活性的至少一种细胞活性的化合物。还提供了通过这些方法鉴定的化合物，包括这些化合物的药物组合物，以及通过将这些药物组合物施用于受试者来治疗病症的方法。

7. 发明申请

WO2004053057A3 GENE EXPRESSION SYSTEMS AND RECOMBINANT CELL LINES 审中-公开
标题翻译：基因表达系统和重组细胞系
公开(公告)号：WO2004053057A3
公开(公告)日：2004-10-28
申请号：PCT/US0334563
申请日：2003-10-31
申请人： 3M INNOVATIVE PROPERTIES CO
发明人： GUPTA SHALLEY K , GHOSH TARUN K , FINK JASON R
IPC分类号： A61K38/00 , C07K14/705 , C12N5/02 , G01N33/50 , C12P21/06 , C12N15/72
CPC分类号： G01N33/5047 , A61K38/00 , C07K14/705
摘要： The present invention provides gene expression systems useful for detecting agonists of Toll-like receptors. The gene expression systems include a nucleic acid sequence encoding a Toll-like receptor and a second nucleic acid sequence that encodes a reporter operably linked to an expression control sequence. The recombinant cell lines include a gene expression system according to the present invention.
摘要翻译：本发明提供了用于检测Toll样受体激动剂的基因表达系统。基因表达系统包括编码Toll样受体的核酸序列和编码可操作地连接至表达控制序列的报道基因的第二核酸序列。重组细胞系包括根据本发明的基因表达系统。

8. 发明公开

EP1599726A4 SELECTIVE MODULATION OF TLR-MEDIATED BIOLOGICAL ACTIVITY 审中-公开
标题翻译： TLR介导的生物活性的选择性调制
公开(公告)号：EP1599726A4
公开(公告)日：2009-07-22
申请号：EP04715791
申请日：2004-02-27
申请人： 3M INNOVATIVE PROPERTIES CO
发明人： FINK JASON R , GORDEN KEITH B , GORSKI KEVIN S , GUPTA SHALLEY K , QIU XIAOHONG , VASILAKOS JOHN P
IPC分类号： A61K31/00 , A61K31/44 , G01N33/566 , G01N33/50 , A61K49/00
CPC分类号： G01N33/566 , A61K31/00 , A61K31/44 , G01N2500/10

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