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1. 发明专利

CA2398668C DELIVERY SYSTEMS USING PREFORMED BIODEGRADABLE POLYMER COMPOSITIONS AND METHODS 未知
公开(公告)号：CA2398668C
公开(公告)日：2010-06-15
申请号：CA2398668
申请日：2001-02-16
申请人： 3M INNOVATIVE PROPERTIES CO
发明人： TRUONG MYHANH T , POURNOOR KAVEH , CHOI HYE-OK , VELASQUEZ DAVID J , FERBER RICHARD H , BERNATCHEZ STEPHANIE F
IPC分类号： A61K9/16 , A61K47/42 , A61K9/14 , A61K9/20 , A61K9/70 , A61K47/48 , C08G65/329
摘要： A preformed object for delivering an active agent to a subject, the preformed object including crosslinked protein, and methods of making and using.

2. 发明专利

BR0108471A 未知
公开(公告)号：BR0108471A
公开(公告)日：2002-10-29
申请号：BR0108471
申请日：2001-02-16
申请人： 3M INNOVATIVE PROPERTIES CO
发明人： TRUONG MYHANH T , POURNOOR KAVEH , CHOI HYE-OK , VELASQUEZ DAVID J , FERBER RICHARD H , BERNATCHEZ STEPHANIE F
IPC分类号： A61K47/42 , A61K9/14 , A61K9/16 , A61K9/20 , A61K9/70 , A61K47/48 , C08G65/329 , A61K9/00
摘要： A preformed object for delivering an active agent for a subject, the preformed object including crosslinked protein, and methods of making and using.

3. 发明专利

DE60225859D1 未知
公开(公告)号：DE60225859D1
公开(公告)日：2008-05-08
申请号：DE60225859
申请日：2002-07-15
申请人： 3M INNOVATIVE PROPERTIES CO
发明人： DELMORE MICHAEL D , FLEMING PATRICK R , HUNTLEY DOUGLAS A , KEISTER JAMIESON C , THOMAS CRISTINA U , FERBER RICHARD H
IPC分类号： A61M37/00
摘要： Microneedle arrays, methods of manufacturing microneedles and methods of using microneedle anays. The microneedles (20) in the microneedle arrays may be in the form of tapered structures that include at least one channel (22) formed in the outside surface of each microneedle. The microneedles may have bases (26) that are elongated in one direction. The channels in microneedles with elongated bases may extend from on of the ends of the elongated bases towards the tips of the microneedles. The channels formed along the sides of the microneedles may optionally be terminated short of the tips of the microneedles The microneedle arrays may also include conduit structures formed on the surface of the substrate on which the microneedle array is located. The channels in the microneedles may be in fluid communication with the conduit structures. One manner of using microneedle arrays of the present invention is in methods involving the penetration of skin to deliver medicaments or other substances and/or extract blood or tissue.

4. 发明专利

AT390167T 未知
公开(公告)号：AT390167T
公开(公告)日：2008-04-15
申请号：AT06101150
申请日：2002-07-15
申请人： 3M INNOVATIVE PROPERTIES CO
发明人： DELMORE MICHAEL D , FLEMING PATRICK R , HUNTLEY DOUGLAS A , KEISTER JAMIESON C , THOMAS CRISTINA U , FERBER RICHARD H
IPC分类号： A61M37/00
摘要： Microneedle arrays, methods of manufacturing microneedles and methods of using microneedle anays. The microneedles (20) in the microneedle arrays may be in the form of tapered structures that include at least one channel (22) formed in the outside surface of each microneedle. The microneedles may have bases (26) that are elongated in one direction. The channels in microneedles with elongated bases may extend from on of the ends of the elongated bases towards the tips of the microneedles. The channels formed along the sides of the microneedles may optionally be terminated short of the tips of the microneedles The microneedle arrays may also include conduit structures formed on the surface of the substrate on which the microneedle array is located. The channels in the microneedles may be in fluid communication with the conduit structures. One manner of using microneedle arrays of the present invention is in methods involving the penetration of skin to deliver medicaments or other substances and/or extract blood or tissue.

5. 发明专利

NZ537546A Microneedle devices and microneedle delivery apparatus 未知
公开(公告)号：NZ537546A
公开(公告)日：2007-04-27
申请号：NZ53754603
申请日：2003-07-10
申请人： 3M INNOVATIVE PROPERTIES CO
发明人： CLARKE GRAHAM M , FERBER RICHARD H , DELMORE MICHAEL D , DOMROESE MICHAEL K , JACOBS JAY D , KEISTER JAMIESON C , FREDERICKSON FRANK
IPC分类号： A61K9/00 , A61K9/70 , A61M5/00 , A61M37/00
摘要： Microneedle devices and methods for delivering non-therapeutic substances are disclosed. The device includes at least one microneedle (30) projecting from a substrate (22), where the microneedle is tapered from the base (34) to a flat tip (32) having an area between 20 and 250 square micrometers. The device is forced against skin to provide perforations and a non-therapeutic substance is applied to the perforated area.

6. 发明专利

CA2534042A1 COMPOSITIONS FOR ENCAPSULATION AND CONTROLLED RELEASE 未知
公开(公告)号：CA2534042A1
公开(公告)日：2005-02-10
申请号：CA2534042
申请日：2004-07-29
申请人： 3M INNOVATIVE PROPERTIES CO
发明人： STEIN STEPHEN W , ZOU WEI , SAHOUANI HASSAN , BERNATCHEZ STEPHANIE F , GABRIO BRIAN J , FERBER RICHARD H , VOGEL DENNIS E , VOGEL KIM M , SCHERRER ROBERT A
IPC分类号： A01N25/14 , A61K9/00 , A61K9/16 , A61K47/22 , A61K47/34 , B01J13/16
摘要： The invention comprises compositions and methods useful for encapsulation an d controlled release of guest molecules, such as drugs. Compositions of the present invention comprise a matrix comprising molecules that are non- covalently crosslinked by multi-valent cations, wherein the molecules that a re non-covalently crosslinked are non-polymeric, have more than one carboxy functional group, and have at least partial aromatic or heteroaromatic character. The compositions are characterized in that a guest molecule may b e encapsulated within the matrix and subsequently released.

7. 发明专利

AU2003251831A1 MICRONEEDLE DEVICES AND MICRONEEDLE DELIVERY APPARATUS 未知
公开(公告)号：AU2003251831A1
公开(公告)日：2004-02-09
申请号：AU2003251831
申请日：2003-07-10
申请人： 3M INNOVATIVE PROPERTIES CO
发明人： CLARKE GRAHAM M , DELMORE MICHAEL D , DOMROESE MICHAEL K , FERBER RICHARD H , JACOBS JAY D , KEISTER JAMIESON C , FREDERICKSON FRANK
IPC分类号： A61K9/00 , A61K9/70 , A61M5/00 , A61M37/00
摘要： Microneedle devices with microneedles having a truncated tapered shape are disclosed. The microneedles of microneedle devices may also have a controlled aspect ratio. Microneedle delivery apparatus are disclosed that include drivers designed to deliver microneedles at velocities that may enhance perforation of the stratum corneum while limiting the sensation of pain experienced at the delivery site.

8. 发明专利

DE60225859T2 未知
公开(公告)号：DE60225859T2
公开(公告)日：2009-04-09
申请号：DE60225859
申请日：2002-07-15
申请人： 3M INNOVATIVE PROPERTIES CO
发明人： DELMORE MICHAEL D , FLEMING PATRICK R , HUNTLEY DOUGLAS A , KEISTER JAMIESON C , THOMAS CRISTINA U , FERBER RICHARD H
IPC分类号： A61M37/00
摘要： Microneedle arrays, methods of manufacturing microneedles and methods of using microneedle anays. The microneedles (20) in the microneedle arrays may be in the form of tapered structures that include at least one channel (22) formed in the outside surface of each microneedle. The microneedles may have bases (26) that are elongated in one direction. The channels in microneedles with elongated bases may extend from on of the ends of the elongated bases towards the tips of the microneedles. The channels formed along the sides of the microneedles may optionally be terminated short of the tips of the microneedles The microneedle arrays may also include conduit structures formed on the surface of the substrate on which the microneedle array is located. The channels in the microneedles may be in fluid communication with the conduit structures. One manner of using microneedle arrays of the present invention is in methods involving the penetration of skin to deliver medicaments or other substances and/or extract blood or tissue.

9. 发明专利

ES2304758T3 MATRICES DE MICROAGUJAS. 未知
公开(公告)号：ES2304758T3
公开(公告)日：2008-10-16
申请号：ES06101150
申请日：2002-07-15
申请人： 3M INNOVATIVE PROPERTIES CO
发明人： DELMORE MICHAEL D , FLEMING PATRICK R , HUNTLEY DOUGLAS A , KEISTER JAMIESON C , THOMAS CRISTINA U , FERBER RICHARD H
IPC分类号： A61M37/00
摘要： Un dispositivo consistente en una matriz de microagujas que comprende - una pluralidad de microagujas (20,120,220,320,420,520,620) que se proyectan desde la superficie de un sustrato (12,412), en el que cada una de las microagujas (20,120,220,320,420,520,620) comprende una forma que se estrecha gradualmente que comprende una superficie externa, una base (26,126,226,326) próxima a la superficie del sustrato (12,412) y una punta (24,124,224,324,424,524,624) distal de la base (26,126,226,326), - en el que cada microaguja (20,120,220,320,420,520,620) de la pluralidad de microagujas (20,120,220,320,420, 520,620) está provista de un canal (22,122,212,322,622) que se extiende desde la base (26,126,226,326) de la microaguja (20,120,220,320,420,520,620) hacia su punta (24,124,224,324,424,524,624), caracterizado porque - cada canal (22,122,212,322,622) está formado en la superficie externa de la microaguja (20,120,220,320,420,520, 620), extendiéndose a lo largo de la superficie externa desde la base (26,126,226,326) hacia la punta (24,124,224,324, 424,524,624) de la microaguja (20,120,220,320, 420,520,620) y terminando en las proximidades de la punta (24,124, 224,324,424,524,624) de la microaguja (20,120,220,320,420,520,620).

10. 发明专利

AT384549T 未知
公开(公告)号：AT384549T
公开(公告)日：2008-02-15
申请号：AT02794032
申请日：2002-11-26
申请人： 3M INNOVATIVE PROPERTIES CO
发明人： FLEMING PATRICK R , DELMORE MICHAEL D , ERICKSON LUTHER E , FERBER RICHARD H
IPC分类号： A61M37/00 , A61B5/00 , A61B5/145 , A61B5/1459 , A61B5/1473 , A61B5/15 , A61B5/157
摘要： Microneedle devices and methods of manufacturing the microneedle devices. The microneedle devices include microneedles protruding from a substrate, with the microneedles piercing a cover placed over the substrate surface from which the microneedles protrude. The cover and the microneedle substrate together define a capillary volume in fluid communication with the base of each microneedle. One manner of using microneedle arrays of the present invention is in methods involving the penetration of skin to deliver medicaments or other substances and/or extract blood or tissue. Manufacturing methods may include simultaneous application of pressure and ultrasonic energy when piercing the cover with the microneedles.

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