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1. 发明申请

WO2008149169A1 SYSTEM FOR HANDLING SLIDES 审中-公开
标题翻译：处理滑块系统
公开(公告)号：WO2008149169A1
公开(公告)日：2008-12-11
申请号：PCT/HU2008/000065
申请日：2008-06-06
申请人： 3DHISTECH KFT. , VIRÁG, Tibor , MOLNÁR, Béla , SZIPÖCS, Ferenc , NÉMETH, Ottó , BILETZKY, Attila , VARGA, Viktor Sebestyén , LÁSZLÓ, Attila
发明人： VIRÁG, Tibor , MOLNÁR, Béla , SZIPÖCS, Ferenc , NÉMETH, Ottó , BILETZKY, Attila , VARGA, Viktor Sebestyén , LÁSZLÓ, Attila
IPC分类号： G01N35/00 , G01N35/04 , G02B21/34
CPC分类号： G02B21/34 , G01N2035/00138 , G01N2035/00376
摘要： The invention relates to a system for handling slides comprising a tray moving on a carriage provided with seats for the slides and with a tray moving mechanism; a slide loading arm; and a slide holding frame provided with a slide loading arm driving motor, wherein the slide holder (30) is provided with slide holding elements; there are outstretched Maltese crosses (13) on the lower side of the tray (6) of the slide feeder (1 ) and a crank (14) is arranged in the carriage (4), opposite to and parallel with the crosses (13), said crank being coupled to said crosses; said slide loading arm (9) is arranged movably and tillable above (30) and a supporting plate (11 ) is arranged movably and tiltable below the slide holder, said supporting plate cooperating with said slide loading arm. The slide holding frame (7) is provided with lifting means for tilting the slide loading arm (9) and the supporting plate (11 ), said lifting means being actuated by controlling means arranged on the disk (15) of the crank (14).
摘要翻译：本发明涉及一种用于处理滑块的系统，其包括在滑架上移动的托架，该托架设置有用于滑块的座和托盘移动机构; 滑动装载臂; 以及设置有滑动装载臂驱动电动机的滑动保持框架，其中，所述滑动架（30）设置有滑动保持元件; 在滑动进料器（1）的托盘（6）的下侧有伸出的马耳他十字架（13），并且在滑架（4）中布置有与十字架（13）相对并平行的曲柄（14）所述曲柄与所述十字架相连; 所述滑动装载臂（9）在上方（30）的上方可移动地放置，并且支撑板（11）可滑动地设置在滑动架的下方，所述支撑板与所述滑动装载臂配合。滑动保持框架（7）设置有用于使滑动装载臂（9）和支撑板（11）倾斜的提升装置，所述提升装置由设置在曲柄（14）的盘（15）上的控制装置致动，。

2. 发明申请

WO2011064609A3 SYSTEM AND METHOD FOR DIGITIZING A MOVING SLIDE 审中-公开
公开(公告)号：WO2011064609A3
公开(公告)日：2011-06-03
申请号：PCT/HU2010/000130
申请日：2010-11-29
申请人： 3DHISTECH KFT. , MOLNÁR, Béla , VIRÁG, Tibor , VARGA, Viktor Sebestyén
发明人： MOLNÁR, Béla , VIRÁG, Tibor , VARGA, Viktor Sebestyén
IPC分类号： G06K9/00
摘要： The present invention relates to a system and a method of digitizing a moving slide (4). According to the invention, the slide (4) is displaced via stepper motors (6X, 6Y, 6Z) and the exposition of said slide (4) for imaging purposes is performed in synchronous with pre-set numbers of steppings (nx, nγ, nz) accomplished by said stepper motors (6X, 6Y, 6Z) by activating a light source (2) that is capable of emitting a luminous flux high enough. Said light source (2) is preferably controlled directly by the stepper motors (6X, 6Y, 6Z).

3. 发明申请

WO2007099382A1 AUTOMATED DIGITAL IMAGE RECORDING SYSTEM FOR AND METHOD OF DIGITIZING SLIDES 审中-公开
标题翻译：自动数字图像记录系统和数字滑块的方法
公开(公告)号：WO2007099382A1
公开(公告)日：2007-09-07
申请号：PCT/HU2007/000018
申请日：2007-03-05
申请人： 3DHISTECH KFT. , MOLNÁR, Béla , TAGSCHERER, Attila , VARGA, Viktor Sebestyén , VIRÁG, Tibor
发明人： MOLNÁR, Béla , TAGSCHERER, Attila , VARGA, Viktor Sebestyén , VIRÁG, Tibor
IPC分类号： G01N21/84 , G01N15/14 , G06K9/00 , B01L3/00
CPC分类号： G01N21/84 , G02B21/365
摘要： The present invention relates to an automated digital image recording system (1) for digitizing slides (6). The image recording system (1) comprises a slide holding means (7, 17), a mechanism for actuating it, a first digital image recording means, a second digital image recording means of high magnification and a control unit (4) for a software-based control of the automated image recording. The image recording system (1) is adapted for digitizing a slide (6) having one or more regions with sample and at least one separate region that comprises a field of information. The first digital image recording means is adapted for reading out the at least one region comprising the field of information and comprises a digital preview camera (2) capturing a low resolution preview image of each of the one or more regions with sample separately. The control unit is provided with a routine for searching points of the low resolution preview images that belong to the sample.
摘要翻译：本发明涉及一种用于数字化幻灯片（6）的自动数字图像记录系统（1）。图像记录系统（1）包括滑动保持装置（7,17），用于致动它的机构，第一数字图像记录装置，高倍率的第二数字图像记录装置和用于软件的控制单元（4）的自动图像记录控制。图像记录系统（1）适于将具有一个或多个区域的幻灯片（6）数字化，其中包括样本和至少一个包括信息领域的分离区域。第一数字图像记录装置适于读出包括信息领域的至少一个区域，并且包括数字预览相机（2），分别用样本捕获一个或多个区域中的每一个的低分辨率预览图像。控制单元设置有用于搜索属于样本的低分辨率预览图像的点的例程。

4. 发明申请

WO2006030326A1 METHOD AND COMPUTER PROGRAM PRODUCT FOR THE STORAGE ENSURING FAST RETRIEVAL AND EFFICIENT TRANSFER OF INTERRELATED HIGH-VOLUME 3D INFORMATION 审中-公开
标题翻译：方法和计算机程序产品，用于存储快速检索和有效传输中断的大容量3D信息
公开(公告)号：WO2006030326A1
公开(公告)日：2006-03-23
申请号：PCT/IB2005/050344
申请日：2005-01-27
申请人： 3DHISTECH KFT. , VIRÁG, Tibor , LÁSZLÓ, Attila , MOLNÁR, Béla , TAGSCHERER, Attila , VARGA, Viktor Sebestyén
发明人： VIRÁG, Tibor , LÁSZLÓ, Attila , MOLNÁR, Béla , TAGSCHERER, Attila , VARGA, Viktor Sebestyén
IPC分类号： G06F19/00
CPC分类号： G06F17/3028 , G06F19/321 , H04N19/60 , H04N19/63 , H04N19/70
摘要： A method for the storage ensuring fast retrieval and efficient transfer of interrelated, highvolume, mainly 3D, information, whereby the input information is assigned to two files, so that image data information required for histological reconstruction is stored in one file and information regarding predetermined parameters of the image data is stored in the other file, whereas in the course of the storing of the received information, associated information regarding the hierarchical relationship of individual image data is also stored in a further file. A computer program product for the storage ensuring fast retrieval and efficient transfer of interrelated, high-volume, mainly 3D, information, contains a computer-readable storage medium including a computer-readable programme code, further a software tool to store associated information regarding the hierarchical relationship of individual image data, while storing input information.
摘要翻译：一种用于存储的方法，其确保快速检索和有效传输相关的高体积，主要是3D信息，由此将输入信息分配给两个文件，使得组织学重建所需的图像数据信息被存储在一个文件中以及关于预定参数的信息的图像数据的存储在另一文件中，而在存储接收到的信息的过程中，关于各个图像数据的分层关系的关联信息也被存储在另外的文件中。用于存储的计算机程序产品确保快速检索和有效传输相关的，大容量的主要3D信息，包含计算机可读存储介质，其包括计算机可读程序代码，还有一个软件工具，用于存储关于同时存储输入信息的单独图像数据的分层关系。

5. 发明申请

WO2004113989A1 SLIDE FEEDING UNIT FOR AN AUTOMATIC SCANNING MICROSCOPE 审中-公开
标题翻译：用于自动扫描显微镜的滑动进给单元
公开(公告)号：WO2004113989A1
公开(公告)日：2004-12-29
申请号：PCT/HU2004/000019
申请日：2004-02-27
申请人： 3DHISTECH KFT. , VIRÁG, Tibor , LÁSZLÓ, Attila , VARGA, Viktor Sebestyén , MOLNÁR, Béla
发明人： VIRÁG, Tibor , LÁSZLÓ, Attila , VARGA, Viktor Sebestyén , MOLNÁR, Béla
IPC分类号： G02B21/34
CPC分类号： G02B21/34 , G01N35/0099 , G01N2035/00039 , G01N2035/00089 , G01N2035/00138
摘要： A slide feeding unit for a microscope includes a slide magazine having a base plate; a toothed rack secured to a magazine side wall; and slide guiding elements perpendicular to an open magazine side. The unit further includes a magazine moving mechanism having a magazine-receiving trough including opposite side plates. Two rotary shafts supported by the trough extend along the trough side plates. Magazine-advancing feeding gears are supported by the side plates and may mesh with the toothed magazine rack. Lifting gears, held in the side plates, have pins on which the magazine is supported when raised or lowered. Driving worm gears are rotated by the shafts and mesh with the feeding gears and the lifting gears. The unit also includes a slide feeding device having a robot arm displaceable perpendicularly to the direction of advance of the magazine for removing a slide from the magazine.
摘要翻译：用于显微镜的滑动进给单元包括具有底板的滑动架; 齿条固定在料斗侧壁上; 并且引导元件垂直于打开的刀库侧滑动。该单元还包括具有包括相对侧板的料盒接收槽的料盒移动机构。由槽支撑的两个旋转轴沿着槽侧板延伸。杂志推进进给齿轮由侧板支撑，并可与带齿的刀架架啮合。保持在侧板上的提升齿轮具有在升高或降低时支撑仓的销。驱动蜗轮由轴旋转并与进给齿轮和提升齿轮啮合。该单元还包括滑动进给装置，其具有可垂直于料仓前进方向移动的机器人臂，用于从料盒移除滑动件。

6. 发明申请

WO2006024967A1 FOCUSING METHOD FOR THE HIGH-SPEED DIGITALISATION OF MICROSCOPE SLIDES AND SLIDE DISPLACING DEVICE, FOCUSING OPTICS, AND OPTICAL RANGEFINDER 审中-公开
标题翻译：用于高速数字化显微镜滑块和滑动位移装置，聚焦光学和光学范围的聚焦方法
公开(公告)号：WO2006024967A1
公开(公告)日：2006-03-09
申请号：PCT/IB2005/050351
申请日：2005-01-27
申请人： 3D HISTECH KFT. , VIRÁG, Tibor , LÁSZLÓ, Attila , MOLNÁR, Béla , TAGSCHERER, Attila , VARGA, Viktor, Sebestyén
发明人： VIRÁG, Tibor , LÁSZLÓ, Attila , MOLNÁR, Béla , TAGSCHERER, Attila , VARGA, Viktor, Sebestyén
IPC分类号： G02B21/24
CPC分类号： G02B21/245 , G02B21/242 , G02B21/26 , G02B21/34
摘要： A focusing method is provided for the high speed digitalisation of microscope slides using an imaging device, wherein the slide is divided into fields of view according to the imaging device and focusing is performed by applying a rough focusing or a fine focusing. During the rough focusing, several images are captured within the focus range using large focus steps. On the basis of this set of images the position of the best contrast is determined. Fine focusing is performed by adjusting the focus according to the focus distance already determined for another field of view and by focusing with fine steps. A slide displacing device is provided, which enables the displacement of a slide parallel to the optical axis. The slide displacing device comprises slide holding means affixed to one side of a supporting means having two parallel sides, which are connected by stiffening elements defining at least two parallel planes. The stiffening elements are adjoined to said sides via resilient elements (29).
摘要翻译：提供了一种用于使用成像装置对显微镜载片进行高速数字化的聚焦方法，其中根据成像装置将幻灯片分成视场，并且通过应用粗略聚焦或精细聚焦进行聚焦。在粗调聚焦期间，使用大的对焦步骤在对焦范围内捕获多个图像。在这组图像的基础上，确定最佳对比度的位置。通过根据已经为另一视场确定的对焦距离调整焦点，并通过精细对焦进行精细对焦。提供了一种滑动位移装置，其使平行于光轴的滑块位移。滑动位移装置包括固定在具有两个平行侧面的支撑装置的一侧上的滑动保持装置，它们由限定至少两个平行平面的加强元件连接。加强元件通过弹性元件（29）邻接于所述侧面。

7. 发明申请

WO2007138369A1 METHOD AND SYSTEM FOR DIGITIZING A SPECIMEN WITH FLUORESCENT TARGET POINTS 审中-公开
标题翻译：用荧光目标点数字化的方法和系统
公开(公告)号：WO2007138369A1
公开(公告)日：2007-12-06
申请号：PCT/HU2007/000047
申请日：2007-05-25
申请人： 3DHISTECH KFT. , VARGA, Viktor, Sebestyén , MOLNÁR, Béla , KAMARÁS, Viktor, Imre
发明人： VARGA, Viktor, Sebestyén , MOLNÁR, Béla , KAMARÁS, Viktor, Imre
IPC分类号： G02B21/36
CPC分类号： G02B21/367 , G02B21/16
摘要： The present invention relates to a method and an automated fluorescent imaging system for digitizing a specimen with fluorescent target points on a microscope slide. The method uses the fluorescence microscope system for detecting and scanning said fluorescent target points. The method comprises the steps of marking the position of said specimen on said slide by visible marking means to define a specimen area containing said specimen and said fluorescent target points; capturing a bright field image of at least a portion of the slide at a first optical magnification, said portion(s) containing the specimen area and determining, from the visible marking means, a position of target fields falling within said specimen area; and scanning the target fields of the specimen area at a second optical magnification higher than said first optical magnification, said scanning including focusing on at least a part of said target fields.
摘要翻译：本发明涉及一种用于在显微镜载玻片上用荧光目标点数字化标本的方法和自动荧光成像系统。该方法使用荧光显微镜系统来检测和扫描所述荧光目标点。该方法包括以下步骤：通过可见标记装置将所述样品的位置标记在所述载玻片上，以限定包含所述样本和所述荧光目标点的样本区域; 以第一光学倍率捕获至少一部分幻灯片的亮场图像，所述部分包含样本区域，并且从可视标记装置确定落在所述标本区域内的目标场的位置; 并且以高于所述第一光学倍率的第二光学倍率扫描样本区域的目标场，所述扫描包括聚焦于所述目标场的至少一部分。

8. 发明申请

WO2010100516A1 METHOD AND SETUP FOR DARK AND/OR BRIGHT FIELD DIGITIZATION OF A SAMPLE IN TRANSMITTED LIGHT 审中-公开
标题翻译：用于透射光的样品的深色和/或亮度场的数字化方法和设置
公开(公告)号：WO2010100516A1
公开(公告)日：2010-09-10
申请号：PCT/HU2010/000027
申请日：2010-03-08
申请人： 3DHISTECH KFT. , MOLNÁR, Béla , HEGEDÜS, Márton , VIRÁG, Tibor
发明人： MOLNÁR, Béla , HEGEDÜS, Márton , VIRÁG, Tibor
IPC分类号： G02B21/12 , G02B21/36
CPC分类号： G02B21/125 , G02B21/365
摘要： The present invention relates to a setup for dark field and/or bright field digitization of a sample (9) with or without dyestuff visible in transmitted light. The present invention also relates to a method using the setup. According to the inventive solutions, when digitizing the sample (9) arranged on a slide (4), illumination of said sample (9) selected as desired from dark field illumination and bright field illumination is provided by a light source that is movable along an appropriate path and forms part of a setup capable of providing both illuminations, upon choice one at a time.
摘要翻译：本发明涉及具有或不具有在透射光中可见的染料的样品（9）的暗场和/或亮场数字化的设置。本发明还涉及使用该设置的方法。根据本发明的解决方案，当将布置在载玻片（4）上的样品（9）进行数字化时，由暗场照明和明场照明选择的所述样品（9）的照明由可沿着适当的路径，并形成能够提供两个照明的设置的一部分，一次选择一个。

9. 发明申请

WO2009115852A2 SAMPLING UNIT 审中-公开
标题翻译：采样单元
公开(公告)号：WO2009115852A2
公开(公告)日：2009-09-24
申请号：PCT/HU2009/000027
申请日：2009-03-17
申请人： 3DHISTECH KFT. , VIRÁG, Tibor , LÁSZLÓ, Attila , MOLNÁR, Béla , ANGELI, Vivien , KRENÁCS, Tibor
发明人： VIRÁG, Tibor , LÁSZLÓ, Attila , MOLNÁR, Béla , ANGELI, Vivien , KRENÁCS, Tibor
IPC分类号： C12M1/26 , G01N1/28
CPC分类号： G01N1/286 , G01N1/08 , G01N2001/2873 , G01N2001/288 , G01N2001/368
摘要： The invention relates to a sampling unit for collecting and expelling tissue samples, to be used in devices for preparing tissue micro array (TMA) blocks, and contains a carriage traveling on a horizontal rail, a slide moved in vertical direction on said carriage and means for boring tissue blocks, punching tissue samples and expelling tissue samples, wherein the carriage (9) is provided with three drives; wherein the first drive (24) moves the slide (10) in vertical direction; the second drive is an electric motor (11) which is detachably coupled to a chuck (13) designated to clamp a drill (22), sampling punch (16) or ejector (15); and the third drive (25) moves the ejector (15) in vertical direction within the chuck (13). The unit preferably is connected to a computer.
摘要翻译：本发明涉及一种用于收集和排出组织样本的取样单元，其用于制备组织微阵列（TMA）块的装置中，并且包含在水平轨道上行进的滑架，滑动移动的滑架在所述托架上以垂直方向移动，以及用于钻取组织块，冲压组织样本和排出组织样本的装置，其中托架（9）设置有三个驱动器; 其中所述第一驱动器（24）使所述滑块（10）沿竖直方向移动; 第二驱动装置是电动马达（11），其可拆卸地联接到卡盘（13）上，卡盘（13）用于夹紧钻头（22），采样冲头（16）或喷射器（15）。并且第三驱动器（25）在卡盘（13）内沿垂直方向移动喷射器（15）。该设备最好连接到电脑。

10. 发明申请

WO2017037486A2 CONFOCAL SLIDE-DIGITIZING APPARATUS 审中-公开
标题翻译：协同幻灯片放映设备
公开(公告)号：WO2017037486A2
公开(公告)日：2017-03-09
申请号：PCT/HU2016/050039
申请日：2016-08-31
申请人： 3DHISTECH KFT.
发明人： VARGA, Viktor Sebestyén , MOLNÁR, Béla , KOVÁCH, Gergely , LUCZI, Dániel
CPC分类号： G02B21/24 , G02B21/0028 , G02B21/0036 , G02B21/26 , G02B21/361 , G02B21/362 , G02B21/367
摘要： The object of the present invention is a confocal slide-digitizing apparatus (100), comprising a slide handling unit (20) and an imaging unit (10), wherein said slide handling unit (20) has a slide supplier unit (90) configured to handle slides (92), especially to store, supply and move slides (92) one after the other to and/or position in an imaging position, said slides (92) carrying a sample to be digitized; and said imaging unit (10) has a light source (40) to illuminate the sample to be digitized at the imaging position through an objective (18) arranged in a light path that enables confocal imaging of at least a region of the sample, and an image recording unit to receive light with information on at least an illuminated region of the sample through the objective (18) and generate a digital image of a section of a given thickness of said illuminated region. Moreover, said slide handling unit (20) and said imaging unit (10) are joined mechanically together in a tiltable manner relative to one another, thereby correcting the light path of said confocal imaging.
摘要翻译：本发明的目的是一种包括滑动处理单元（20）和成像单元（10）的共焦滑动数字化设备（100），其中所述滑动处理单元（20）具有配置在所述滑动装置以便处理幻灯片（92），特别是将幻灯片（92）一个接一个地存储，供应和移动到成像位置和/或位于成像位置，所述幻灯片（92）携带要被数字化的样本; 并且所述成像单元（10）具有光源（40），以通过布置在光路中的物镜（18）照亮在成像位置被数字化的样品，所述物镜能够使至少一部分样品的区域共焦成像，以及图像记录单元，用于通过物镜（18）至少接收样品的照明区域的信息来接收光，并产生所述照明区域的给定厚度的部分的数字图像。此外，所述滑动处理单元（20）和所述成像单元（10）以可相对于彼此的倾斜方式机械地结合在一起，从而校正所述共焦成像的光路。

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