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2. 发明公开

KR1020100085879A 변형된 인간 트롬보포이에틴 폴리펩타이드 절편 및 그의 제조방법 失效
标题翻译：改性人类血小板聚糖片段及其制备方法
公开(公告)号：KR1020100085879A
公开(公告)日：2010-07-29
申请号：KR1020100005348
申请日：2010-01-20
申请人： 한올바이오파마주식회사
发明人： 김성욱 , 전성수 , 박승국 , 정재갑 , 이성률 , 송연정 , 심원조
IPC分类号： C07K14/505 , C12N15/12 , C12N15/63 , A61K38/17
CPC分类号： C07K14/515 , A61K38/196 , Y02A50/473
摘要： PURPOSE: A mutated human thrombopoietin polypeptide fragment is provided to ensure platelet proliferation ability in vivo and in vitro and improved resistance to protease in vivo. CONSTITUTION: A human thrombopoietin polypeptide fragment contains mutated or substituted amino acid at 3rd, 6th, 8-12th, 14-18th, 20-23th, 25th, 26th, 31-34th, 39-41th, 43-46th, 48-52th, 55-57th, 56th, 60th, 62th, 64-67th, 69-79th, 81th, 86th, 89-91th, 93th, 95th, 97-104th, 107-109th, 112th, 116th, 117th, 120-123th, 126th, 128th, 129th, 131th, 133-147th, 150th, or 152th amino acid. A pharmaceutical formulation contains mutated TPO fragment having the mutated amino acid. A pharmaceutical composition for preventing or treating thrombocytopenia or diseases caused by thrombocytopenia contains the mutated TPO fragment.
摘要翻译：目的：提供突变的人血小板生成素多肽片段，以确保体内和体外的血小板增殖能力，并提高体内对蛋白酶的抗性。构成：人血小板生成素多肽片段在第3,6,6,8,12,14,18,20-23,25,26,31-34,49-41,43-46,48-52，含有突变或取代的氨基酸，第55-57号，第56号，第六十六次，第六十六次，第六十六次，第六十六次，第六次，第六次，第六次，第六次，第六十六次，第六十七次，第六十六次，第128位，第129位，第131位，第133-147位，第150位或第152位氨基酸。药物制剂含有具有突变的氨基酸的突变的TPO片段。用于预防或治疗由血小板减少症引起的血小板减少症或疾病的药物组合物含有突变的TPO片段。

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