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1. 发明公开

KR1020010003195A 지방산이 결합된 합성 펩타이드를 인지질 막에 재조합하여 제조한 조합물 및 그 제조방법 有权
标题翻译：合成肽与脂肪酸和磷脂膜的重组体及其制备方法
公开(公告)号：KR1020010003195A
公开(公告)日：2001-01-15
申请号：KR1019990023397
申请日：1999-06-22
申请人： 한국과학기술연구원 , 주식회사 펩트론
发明人： 김길룡 , 강주현 , 맹철영 , 조미숙 , 박정현
IPC分类号： C07K14/00
CPC分类号： C07K14/001 , A61K39/29 , C07K2319/00
摘要： PURPOSE: Provided are a recombinant of a synthetic peptide bound to a fatty acid and a phospholipid membrane and a preparation method thereof. The recombinant has an increased stability, and is used as a stable immunogenic vaccine material (for antigen peptide) and is used to effectively deliver a drug (for low molecular weight of the peptide exhibiting a pharmacological activity). CONSTITUTION: The preparation method comprises the steps of : (1) binding the fatty acid to the hydrophilic peptide at C-terminal, N-terminal or an intermediate chain thereof to prepare a lipopeptide; and (2) recombining the lipopeptide of the step (1) and lipid or phospholipid mixture. The peptide may be p26 peptide (preS2 (120-145)) having a sequence represented by SEQ ID NO : 1, a peptide which plays a role of an epitope or low molecular weight of the peptide exhibiting a pharmacological activity, and the fatty acid is selected from the group consisting of palmitic acid, myristic acid, stearic acid, oleic acid and arachidonic acid.
摘要翻译：目的：提供与脂肪酸和磷脂膜结合的合成肽的重组体及其制备方法。重组体具有增加的稳定性，并且用作稳定的免疫原性疫苗材料（用于抗原肽），并用于有效递送药物（对于显示药理活性的肽的低分子量）。构成：制备方法包括以下步骤：（1）将脂肪酸与C端，N-末端或其中间链的亲水性肽结合以制备脂肽; 和（2）重组步骤（1）的脂肽和脂质或磷脂混合物。肽可以是具有由SEQ ID NO：1表示的序列的p26肽（preS2（120-145）），表现出药理活性的肽的表位或低分子量的作用的肽，脂肪酸选自棕榈酸，肉豆蔻酸，硬脂酸，油酸和花生四烯酸。

2. 发明授权

KR100326938B1 지방산이 결합된 합성 펩타이드를 인지질 막에 재조합하여 제조한 조합물 및 그 제조방법 有权
标题翻译：通过混合与脂肪酸和磷脂结合的合成肽制备的化合物及其制备方法
公开(公告)号：KR100326938B1
公开(公告)日：2002-03-13
申请号：KR1019990023397
申请日：1999-06-22
申请人： 한국과학기술연구원 , 주식회사 펩트론
发明人： 김길룡 , 강주현 , 맹철영 , 조미숙 , 박정현
IPC分类号： C07K14/00
摘要： 본발명은지방산이결합된합성펩타이드를인지질막에재조합하여제조한조합물및 그제조방법에관한것으로, 보다상세하게는친수성(hydrophilic) 펩타이드의 N 말단, C 말단, 또는그 중간사슬에지방산을결합하여리포펩타이드 (lipopeptide)를제조하고, 이를지질또는인지질혼합물과재조합하여제조한조합물및 그제조방법에관한것으로, 본발명의조합물은펩타이드를직접지질또는인지질과혼합하여제조한조합물에비해안정성이증가될뿐만아니라, 항원펩타이드를사용할경우에는안정적이고면역원성이높은백신재료로이용될수 있으며, 약리활성을가진저분자량의펩타이드를사용할경우에는효과적인약물전달시스템에이용되는등 사용하는펩타이드의종류에따라다양하게응용될수 있다.

3. 发明授权

KR100289231B1 아스퍼질러스 니가에서 분리한 새로운 항진균성 단백질 失效
标题翻译：从黑曲霉分离的新型抗真菌蛋白
公开(公告)号：KR100289231B1
公开(公告)日：2001-05-02
申请号：KR1019990009957
申请日：1999-03-24
申请人： 한국과학기술연구원
发明人： 이동건 , 함경수 , 김길룡 , 맹철영 , 신송엽 , 서무열
IPC分类号： C07K14/195 , C07K14/38
摘要： 본발명은아스퍼질러스니가 (Aspergillus niger)의배양액으로부터최초로분리된항진균성단백질에관한것으로, 인체에무해하고대량배양이가능한아스퍼질러스니가로부터분리되어서열 1의아미노산서열을가지는본 발명의항진균성단백질은다양한병원성진균에대하여항진균활성을나타냄으로써진균성질환의예방및 치료제로유용하게사용될수 있다.

4. 发明公开

KR1020000061133A 아스퍼질러스 니가에서 분리한 새로운 항진균성 단백질 失效
标题翻译：从ASPERGILLUS NIGER分离的新型抗体蛋白
公开(公告)号：KR1020000061133A
公开(公告)日：2000-10-16
申请号：KR1019990009957
申请日：1999-03-24
申请人： 한국과학기술연구원
发明人： 이동건 , 함경수 , 김길룡 , 맹철영 , 신송엽 , 서무열
IPC分类号： C07K14/195 , C07K14/38
CPC分类号： C07K14/38 , A61K38/164
摘要： PURPOSE: Provided is a novel antimycotic protein isolated from the medium of Aspergillus niger which is harmless to a human body and mass cultured. The protein is excellent in antimycotic activity against variable pathogenic fungi therefore, it can be used for prevention and treatment of mycotic diseases. CONSTITUTION: A novel antimycotic protein consists of 58 amino acids represented by sequence No. 1 and its molecular weight is 6.2-7.0 kDa. The antimycotic protein shows antimycotic activity against pathogenic fungi such as Aspergillus fumigatus, Apergillus flavus, Candida albicans, Trichosporon beigelii and Saccaromyces cerevisiae and vegetable pathogenic fungi such as Fusarium oxysporum, Fusarium solani, and Aspergillus niger. The novel antimycotic protein is prepared by following steps: (a)inoculating a spore of Aspergillus niger to YPD medium containing 2% of dextrose, 1% of peptone, 0.5% of yeast extract; (b)performing shaking culture at 20 to 40°C for three to five days; (c)performing Amicon ultrafiltration of supernatant of culture after removing cell line; (d)separating supernatant of culture by ion-exchange filter using CM-sepharose ion exchange column; and (e)purifying the protein.
摘要翻译：目的：提供从黑曲霉培养基中分离的新型抗真菌蛋白，对人体无害，大量培养。因此，蛋白质对可变致病真菌的抗真菌活性优异，可用于预防和治疗真菌病。构成：新型抗真菌蛋白由序列号1所示的58个氨基酸组成，分子量为6.2-7.0kDa。抗真菌蛋白质显示出对致病性真菌的抗真菌活性，例如烟曲霉，黄曲霉，白色念珠菌，白头翁和酿酒酵母，以及植物致病真菌如尖孢镰刀菌，茄病黑曲霉和黑曲霉。通过以下步骤制备新型抗真菌蛋白质：（a）将黑曲霉孢子接种到含有2％葡萄糖，1％蛋白胨，0.5％酵母提取物的YPD培养基中; （b）在20〜40℃下进行振荡培养3〜5天; （c）除去细胞系后进行培养上清的Amicon超滤; （d）使用CM-sepharose离子交换柱通过离子交换过滤器分离培养上清; 和（e）纯化蛋白质。

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