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    • 9. 发明授权
    • 생체적합성 실리콘 나노입자의 제조 방법
    • 생체적합성실리콘나노입자의제조방법
    • KR100644968B1
    • 2006-11-14
    • KR1020050102333
    • 2005-10-28
    • 한국과학기술연구원
    • 조운조이수진한일기최원준이정일박재관
    • A61L24/02A61L31/02B82Y40/00B82Y5/00
    • Provided is a preparation method of biocompatible silicon nano particles excellent in dispersion stability for use in fluorescent probe in biological studies that include cancer diagnosis and cell imaging. The preparation method of biocompatible silicon nano particles comprises the steps of: obtaining silicon nano particle colloid by treating Si-containing zintl salt with diethylene glycol diethyl ether(DGDE) under ultrasonic radiation; and mixing the silicon nano particle colloid with a hydrogen halide solution. In detail, Si-containing zintl salt and DGDE are used in a ratio of 1:10 to 1:100,000 by weight and are subjected to ultrasonic radiation for 1 minute to 10 hours under an inert gas atmosphere such as Ar, He, N and so on. Preferably, the hydrogen halide solution has a concentration of 1 to 35 wt%, and is mixed in an amount of 0.01 to 1 wt% with respect to the weight of silicon nano particle collide.
    • 本发明提供一种在生物学研究中用于荧光探针的分散稳定性优异的生物相容性硅纳米粒子的制备方法,其包括癌症诊断和细胞成像。 一种生物相容性硅纳米颗粒的制备方法,包括以下步骤:用超声辐射处理含二乙二醇二乙醚(DGDE)的含硅锌盐,得到硅纳米颗粒胶体; 并将硅纳米颗粒胶体与卤化氢溶液混合。 具体而言,含Si的锌盐和DGDE以1:10至1:100,000的重量比使用,并且在诸如Ar,He,N和N的惰性气体气氛下经受超声辐射1分钟至10小时 等等。 优选卤化氢溶液的浓度为1〜35重量%,相对于硅纳米粒子的重量碰撞而混合0.01〜1重量%。