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    • 3. 发明授权
    • 말론산 유도체의 백금착화합물 및 그 제조방법
    • 丙二酸衍生物的铂络合物及其制备方法
    • KR1019970010594B1
    • 1997-06-28
    • KR1019930021558
    • 1993-10-16
    • 한국과학기술연구원
    • 손연수정옥상이영아김관묵
    • C07F17/02
    • C07F15/0093
    • The invention concerns compounds of formula (1) wherein R stands for methyl or ethyl and stands for prophylene, butylene or pentylene in the case of ring shape formed by bonding two R's; A and A' stand for ammonia, methylamine, isoprophylamine, cycloprophylamine, cyclobutylamine, cyclopentylamine and cyclohexylamine and trans-1,2-diaminocyclohexane, 2,2-dimethyl-1,3-prophanediamine,1,1-cyclobutanediamine, ethylenediamine, 1,1-cyclopentandimethaneamine, 1,1-cyclohexanediamine and stands for terahydro-4H-piran-4,4-dimethaneamine in the case of a chelate form. A platinum chelate compound is produced by reacting a alkali metal and a platinum nitrate derivative or a platinum nitrate derivative of which mole ratio is 1 : 1 by using water as a solvent , followed by condensing and precipitating.
    • 本发明涉及式(1)的化合物,其中R代表甲基或乙基,代表通过键合两个R而形成环形的情况下的亚芳基或亚丁基; A和A'代表氨,甲胺,异丙胺,环丙胺,环丁胺,环戊胺和环己胺,反式-1,2-二氨基环己烷,2,2-二甲基-1,3-正己二胺,1,1-环丁烷二胺,乙二胺, 在一种螯合形式的情况下,1-环戊烷二甲烷,1,1-环己烷二胺代替三氢-4H-吡喃-4,4-二甲胺。 通过使用水作为溶剂使碱金属和硝酸铂衍生物或摩尔比为1:1的硝酸铂衍生物反应,然后冷凝和沉淀来制备铂螯合化合物。
    • 5. 发明授权
    • 유기주석 말로네이트 유도체 및 그 제조방법
    • 有机衍生物衍生物及其制备方法
    • KR1019950001702B1
    • 1995-02-28
    • KR1019920006404
    • 1992-04-16
    • 한국과학기술연구원
    • 손연수정옥상이영아
    • C07F7/22
    • The organo tin malonate derivs. of formula (I) is prepd. by reacting the organo tin halide of formula (II) with the metalic salt of malonate derivs. of formula (III) in the presence of the solvent of halomethane, alcohol or water where pref. the temp. of reaction is -250 - 60 deg.C. Pref. the solvent is dichloro methane, chloro form, ethyl alcohol, methyl alcohol or water, or the mixt. of them. In the formulas, R is phenyl, cyclohexyl, n-butyl, 3-methoxy-3-oxopropyl, methyl, t-butyl, or Cl; x is 2 or 3; R' is thiomethoxy or methyl when non-ring substd. gp. is substd., or ethylene dithio, methylene ditho or acetylene ditho when ring substd. gp. is substd.
    • 有机锡丙二酸酯衍生物。 式(I)的化合物是制备的。 通过使式(II)的有机锡卤化物与丙二酸酯衍生物的金属盐反应。 在式(III)的溶剂存在下,优选卤代甲烷,醇或水。 温度 的反应为-250-60℃。 县。 溶剂是二氯甲烷,氯代,乙醇,甲醇或水,或混合物。 的他们。 式中R是苯基,环己基,正丁基,3-甲氧基-3-氧代丙基,甲基,叔丁基或Cl; x为2或3; 当非环形化合物时,R'是硫代甲氧基或甲基。 GP。 是亚乙基二硫代,亚甲基双环或乙炔基,当环形成。 GP。 是不合格的
    • 7. 发明公开
    • 경구용 백금(IV) 착화합물 항암제 및 그 제조방법
    • (IV)用于口服给药的复合物及其生产方法
    • KR1020000064233A
    • 2000-11-06
    • KR1020007007188
    • 1998-12-23
    • 한국과학기술연구원
    • 손연수이숭실이영아김관묵이정옥
    • C07F13/00
    • C07C53/122C07C53/124C07C211/10C07C211/11C07C211/18C07C211/36C07D309/04C07F15/0093
    • PURPOSE: Anticancer (iv) complexes excellent in lipoid solubility when orally administered and absorbable in the stomach and the intestinal and process for preparation thereof by oxidizing diamine platinum complexes with hydrogen oxide and carrying out an electrophilic substitution reaction of four hydroxyl groups of the obtained diaminetetrahydroxyplatinum are provided which exhibit excellent anticancer effect. CONSTITUTION: Platinum complexes for oral administration represented by the structural formula (I) are prepared. In formula A-A is a symmetrical diamine that can chelate to platinum and is selected from the group consisting of ethylene diamine, t(+/-)-1,2-diaminocyclohexane, 2,2-dimethyl-1,3-propanediamine, cyclohexane-1,1-dimethaneamine and tetrahydro-4H-pyran-4,4-dimethaneamine; and R is propionyl, butyryl or valeryl. These complexes are useful in the treatment of cancer.
    • 目的:抗口服(iv)口服给药并在胃和肠中可吸收的脂质溶解性优异,通过用二氧化氢氧化二胺铂络合物并进行所得二氨基四羟基铂的四个羟基的亲电取代反应来制备 具有优异的抗癌作用。 构成:制备由结构式(I)表示的用于口服的铂络合物。 式中AA是可与铂螯合的对称二胺,选自乙二胺,t(+/-) - 1,2-二氨基环己烷,2,2-二甲基-1,3-丙二胺,环己烷 - 1,1-二甲胺和四氢-4H-吡喃-4,4-二甲胺; R是丙酰基,丁酰基或戊酰基。 这些复合物可用于治疗癌症。