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2. 发明公开

KR1020130115696A 신경보호제로서의 유레아 유도체 有权
标题翻译：尿素类似物作为神经保护剂
公开(公告)号：KR1020130115696A
公开(公告)日：2013-10-22
申请号：KR1020120038239
申请日：2012-04-13
申请人： 한국과학기술연구원
发明人： 추현아 , 배애님 , 김지윤 , 박병건 , 이지연 , 노은주 , 박정은 , 라현화
IPC分类号： C07D211/42 , C07D241/28 , A61K31/44 , A61P25/00
摘要： PURPOSE: A urea derivative is provided to selectively suppress the action of mPTP in the brain, thereby being used as a neuroprotective agent which improves the action of the mitochondria. CONSTITUTION: A urea derivative is denoted by chemical formula 1. A method for preparing the urea derivative comprises the steps of making a compound of chemical formula 2 react with isocyanate compounds or isothiocyanate compounds. The compound of chemical formula 2 is prepared by making a compound of chemical formula 3 react with benzyl halide compounds. A pharmaceutical composition for suppressing the action of mPTP contains the urea derivative or a pharmaceutically acceptable salt thereof as an active ingredient. A pharmaceutical composition for treating nervous diseases contains the urea derivative or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译：目的：提供尿素衍生物以选择性抑制脑中mPTP的作用，从而用作改善线粒体作用的神经保护剂。构成：以化学式1表示脲衍生物。制备尿素衍生物的方法包括使化学式2的化合物与异氰酸酯化合物或异硫氰酸酯化合物反应的步骤。通过使化学式3的化合物与苄基卤化合物反应来制备化学式2的化合物。用于抑制mPTP作用的药物组合物含有尿素衍生物或其药学上可接受的盐作为活性成分。用于治疗神经疾病的药物组合物含有尿素衍生物或其药学上可接受的盐作为活性成分。

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