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1. 发明公开

KR1020040026175A 연자육의 진통효과 검증방법 및 연자육 진통 제제 有权
标题翻译： NELUMBO NUCIFERA GAERTNER和含有LONICERA JAPONICA THUNBERG的制剂的分析效果分析
公开(公告)号：KR1020040026175A
公开(公告)日：2004-03-30
申请号：KR1020020057535
申请日：2002-09-23
申请人： 학교법인 경희학원 , 심인섭
发明人： 심인섭 , 황혜정 , 함대현 , 임사비나 , 이혜정 , 이배환 , 김창주 , 한승무 , 박히준 , 이지숙 , 김경아
IPC分类号： A61K36/62 , A61P29/00
摘要： PURPOSE: Provided are an analysis method of analgesics effect of Nelumbo nucifera gaertner and an analgesics preparation containing, as an active ingredient, Nelumbo nucifera gaertner which has excellent pain relieving effects. CONSTITUTION: An analysis method of analgesics effect of Nelumbo nucifera gaertner is characterized by using formalin test with a neuropathic pain model. An analgesics preparation containing, as an active ingredient, Nelumbo nucifera gaertner has excellent pain relieving effects on tonic pain, such as inflammation pain. The main components of Nelumbo nucifera gaertner include anonaine, asimilobine, dehydronuciferine, dehydroroemerine, dehydroanonaine, demethylcoclaurine1-(p-hydroxybenzyl)-6,7-dihydroxy-1,2-3,4-tetrahydroisoquinoline, isoliensinine, liensinine, lirinidine and liriodenine.
摘要翻译：目的：提供Nelumbo nucifera gaertner的镇痛作用分析方法和含有作为活性成分的Nelumbo nucifera gaertner具有优异的止痛效果的止痛剂制剂。构成：Nelumbo nucifera gaertner的镇痛作用分析方法的特点是使用福尔马林试验与神经性疼痛模型。含有Nelumbo nucifera gaertner作为活性成分的止痛剂具有对强直性疼痛（如炎症疼痛）的极好的止痛作用。 Nelumbo nucifera gaertner的主要成分包括anonaine，asimilobine，脱氢叶绿素，脱氢阿维菌素，脱氢脯氨酸，去甲基青蒿琥酯1-（对羟基苄基）-6,7-二羟基-1,2,3,4-四氢异喹啉，间苯二酚，留生素，lirinidine和liriodenine。

2. 发明公开

KR1020040026170A 금은화의 진통효과 검증방법 및 금은화 진통 제제 有权
标题翻译： LONICERA JAPONICA THUNBERG和含有LONICERA JAPONICA THUNBERG的制剂的分析效果分析
公开(公告)号：KR1020040026170A
公开(公告)日：2004-03-30
申请号：KR1020020057527
申请日：2002-09-23
申请人： 학교법인 경희학원 , 심인섭
发明人： 심인섭 , 함대현 , 이혜정 , 황혜정 , 이배환 , 임사비나
IPC分类号： A61K36/35 , A61P29/00
摘要： PURPOSE: Provided is an analysis method of analgesics effect of Lonicera japonica Thunberg by formalin test with a neuropathic pain model and an analgesics preparation containing as an active ingredient Lonicera japonica Thunberg which has excellent pain relieving effects. CONSTITUTION: An analysis method of analgesics effect of Lonicera japonica Thunberg is characterized by using formalin test with a neuropathic pain model. Analgesics preparation containing as an active ingredient Lonicera japonica Thunberg has excellent pain relieving effects on tonic pain, such as inflammation pain. The main components of Lonicera japonica Thunberg include vanillic acid, eugenol, chlorogenic acid, 2-phenylethanol, benzyl alcohol, caffeic acid methyl ester, choline, beta-carotene, and cryptoxanthin, zeaxanthin.
摘要翻译：目的：本文提供了一种通过福尔马林试验与忍冬止痛模型和含有作为活性成分的忍冬药物Thunberg具有优异的止痛效果的止痛剂制剂的忍冬药物镇痛效果的分析方法。构成：忍冬药汤镇痛效果分析方法的特点是使用福尔马林试验与神经性疼痛模型。含有作为活性成分的镇痛剂制剂忍冬金属Thunberg对强直性疼痛如炎症疼痛具有优异的止痛效果。金银花的主要成分包括香草酸，丁子香酚，绿原酸，2-苯基乙醇，苯甲醇，咖啡酸甲酯，胆碱，β-胡萝卜素和隐黄质，玉米黄质。

3. 发明授权

KR100554082B1 연자육의 진통효과 검증방법 및 연자육 진통 제제 有权
标题翻译： NELUMBO NUCIFERA GAERTN
公开(公告)号：KR100554082B1
公开(公告)日：2006-02-22
申请号：KR1020020057535
申请日：2002-09-23
申请人： 학교법인 경희학원 , 심인섭
发明人： 심인섭 , 황혜정 , 함대현 , 임사비나 , 이혜정 , 이배환 , 김창주 , 한승무 , 박히준 , 이지숙 , 김경아
IPC分类号： A61K36/62 , A61P29/00
摘要： 본 발명은, 행동학적 지표인 신경병리성 통증(neuropathic pain) 모델과 포르말린 테스트(formalin test))를 이용한 동물모델을 이용한 통증에 대한 연자육의 진통효과 검증방법 및 이 진통효과 검증방법을 이용하여 진통효과가 검증된 연자육를 유효성분으로 하는 연자육 진통 제제에 대한 것으로, 신경손상으로 통증을 느끼는 동통환자뿐만 아니라, 일반 동통질환에도 상기 약재의 이용을 통하여 통증 완화효과를 기대할 수 있다.

4. 发明授权

KR100554079B1 금은화의 진통효과 검증방법 및 금은화 진통 제제 有权
标题翻译： LONICERA JAPONICA THUNB
公开(公告)号：KR100554079B1
公开(公告)日：2006-02-22
申请号：KR1020020057527
申请日：2002-09-23
申请人： 학교법인 경희학원 , 심인섭
发明人： 심인섭 , 함대현 , 이혜정 , 황혜정 , 이배환 , 임사비나
IPC分类号： A61K36/35 , A61P29/00
摘要： 본 발명은, 행동학적 지표인 신경병리성 통증(neuropathic pain) 모델과 포르말린 테스트(formalin test))를 이용한 동물모델을 이용한 통증에 대한 금은화의 진통효과 검증방법 및 이 진통효과 검증방법을 이용하여 진통효과가 검증된 금은화를 유효성분으로 하는 금은화 진통 제제에 대한 것으로, 신경손상으로 통증을 느끼는 동통환자뿐만 아니라, 일반 동통질환에도 상기 약재의 이용을 통하여 통증 완화효과를 기대할 수 있다.

5. 发明公开

KR1020040062832A 비만 치료 또는 예방용 및, 비만과 관련된 유전자,단백질, 세포 발현 조절용 한약 추출물을 포함하는약제학적 조성물 无效
标题翻译：含有草药提取物的药物组合物可预防和治疗与肥胖有关的疾病
公开(公告)号：KR1020040062832A
公开(公告)日：2004-07-09
申请号：KR1020030000364
申请日：2003-01-03
申请人： 학교법인 경희학원
发明人： 김성옥 , 황은주 , 윤수진 , 정보미 , 임창용 , 이혜정 , 심인섭 , 함대현
IPC分类号： A61K36/804 , A61K36/8994 , A61K36/17 , A61P3/04
CPC分类号： A61K36/804 , A23L2/38 , A23L33/105 , A61K36/17 , A61K36/8994 , A61K2236/331 , A61K2300/00 , A61L9/013 , Y10S514/909
摘要： PURPOSE: Provided is a pharmaceutical composition containing herbal extracts which controls the genes and proteins related to an obesity at the cell level, thereby preventing or treating the obesity while minimizing harmful side effects. CONSTITUTION: The pharmaceutical composition comprises one or more extracts of Rehmanniae Radix, Coicis Semen, Ephedrae Herba, and Atractylodes japonica Rhizome to increase the expression of lipoprotein protease of mast cells, or inhibit the expression of leptin or resistin genes.
摘要翻译：目的：提供含有草药提取物的药物组合物，其控制与细胞水平的肥胖相关的基因和蛋白质，从而预防或治疗肥胖症，同时最小化有害的副作用。构成：药物组合物包含地黄，茯苓，麻黄和白术的一种或多种提取物，以增加肥大细胞脂蛋白的表达，或抑制瘦素或抵抗素基因的表达。

6. 发明公开

KR1020030080506A 초음파 에너지를 이용한 약물 주입 장치 失效
标题翻译：用超能量注射药物的装置
公开(公告)号：KR1020030080506A
公开(公告)日：2003-10-17
申请号：KR1020020019174
申请日：2002-04-09
申请人： 학교법인 경희학원
发明人： 한승무 , 임사비나 , 김창주 , 심인섭 , 박히준 , 이지숙 , 김경아
IPC分类号： A61M37/00
摘要： PURPOSE: An apparatus for injection of drug is provided to conduct non-invasive administration of drug in desired amount in order to maximize efficacy and effect of the drug and to relieve adverse-effect and pain at administration by using supersonic energy. CONSTITUTION: The apparatus comprises a supersonic energy generator(100) combined with low/high frequency horn(120) at 1 or 3MHz for administering drug in thick or thin skin layers of a human body; a key operational part(400) to transport control signals to a power supply(200) to provide a power (2.1W or 14W) corresponding to the low/high frequencies supersonic energy in order to control depth to be penetrated into human body; and a modification part(300) for changing modes of the supersonic frequency in order to alternate power supplying periods such as 1;2, 1:3, 1:5, 1:7, 1:9, 1:19 or 1:1, thereby adjusting the invasive depths.
摘要翻译：目的：提供用于注射药物的装置，以期望量的非侵入性药物给药，以使药物的功效和效果最大化，并通过使用超音速能量减轻给药时的不良反应和疼痛。构成：该装置包括与1 / 3MHz的低频/高频喇叭（120）组合的超音速能量发生器（100），用于在人体的厚或薄的皮肤层中施用药物; 用于将控制信号传送到电源（200）以提供对应于低/高频超音速能量的功率（2.1W或14W）的关键操作部分（400），以便控制深度穿透入人体; 以及用于改变超音速频率的模式的修改部分（300），以便交替供电周期，例如1; 2，1：3，1：5，1：7，1：9，1:19或1：1 ，从而调整侵入深度。

7. 发明公开

KR1020030055632A 황련을 이용한 약물 중독 예방 및 치료를 위한 약제학적조성물 无效
标题翻译：使用COPTIDIS RHIZOMA预防和治疗药物滥用的药物组合物
公开(公告)号：KR1020030055632A
公开(公告)日：2003-07-04
申请号：KR1020010085669
申请日：2001-12-27
申请人： 학교법인 경희학원
发明人： 심인섭 , 이봄비 , 함대현 , 이혜정
IPC分类号： A61K36/718 , A61P39/00
摘要： PURPOSE: A pharmaceutical composition using a Coptidis Rhizoma extract containing a substance capable of inhibiting the action of dopamine which is increased by repeated administration of a toxic drug such as cocaine is provided. Therefore, the composition is effective in prevention and treatment of drug addiction. CONSTITUTION: A pharmaceutical composition contains a Coptidis Rhizoma extract obtained by extracting Coptidis Rhizoma with 80% methanol in a water bath, followed by concentration under reduced pressure and freeze-drying. The Coptidis Rhizoma extract can specifically inhibit the increase of locomotor activity and the expression of c-fos as an indicator of nerve activity in nucleus accumbens and striatum as a portion related with drug addiction. The composition can be applied to all of the drug addiction which cause the increase of dopamine, but not limited to, cocaine addiction.
摘要翻译：目的：提供一种使用含有可抑制多巴胺作用的物质的黄连提取物的药物组合物，其通过重复施用毒性药物如可卡因而增加。因此，该组合物有效预防和治疗药物成瘾。构成：药物组合物含有通过在水浴中提取80％甲醇的黄连提取物，然后在减压下浓缩并冷冻干燥获得的黄连提取物。黄连提取物可以特异性抑制运动活性的增加和c-fos的表达，作为伏隔核和纹状体中作为与药物成瘾相关的部分的神经活动的指标。该组合物可以应用于导致多巴胺增加的所有药物成瘾，但不限于可卡因成瘾。

8. 发明授权

KR100452107B1 초음파 에너지를 이용한 약물 주입 장치 失效
标题翻译： 초음파에너지를이용한약물주입장치
公开(公告)号：KR100452107B1
公开(公告)日：2004-10-08
申请号：KR1020020019174
申请日：2002-04-09
申请人： 학교법인 경희학원
发明人： 한승무 , 임사비나 , 김창주 , 심인섭 , 박히준 , 이지숙 , 김경아
IPC分类号： A61M37/00
摘要： PURPOSE: An apparatus for injection of drug is provided to conduct non-invasive administration of drug in desired amount in order to maximize efficacy and effect of the drug and to relieve adverse-effect and pain at administration by using supersonic energy. CONSTITUTION: The apparatus comprises a supersonic energy generator(100) combined with low/high frequency horn(120) at 1 or 3MHz for administering drug in thick or thin skin layers of a human body; a key operational part(400) to transport control signals to a power supply(200) to provide a power (2.1W or 14W) corresponding to the low/high frequencies supersonic energy in order to control depth to be penetrated into human body; and a modification part(300) for changing modes of the supersonic frequency in order to alternate power supplying periods such as 1;2, 1:3, 1:5, 1:7, 1:9, 1:19 or 1:1, thereby adjusting the invasive depths.
摘要翻译：目的：提供一种药物注射装置，以期望的量进行药物的非侵入性给药，从而使药物的功效和效果最大化，并通过使用超声能量来减轻给药时的不良反应和疼痛。本发明的装置包括一个与1MHz或3MHz的低/高频喇叭（120）组合的超声能发生器（100），用于在人体的厚或薄皮层中给药; （400），用于将控制信号传送到电源（200）以提供对应于低/高频率超声能量的功率（2.1W或14W），以便控制要穿入人体的深度; 和修改部分（300），用于改变超声波频率的模式以便交替供电时段，例如1：2,1：3,1：5,1：7,1：9,1：19或1：1 从而调整侵入深度。

9. 发明公开

KR1020030080507A 초음파 혼의 편심 이동에 의한 자동 마사지 물리치료 장치 无效
标题翻译：自动按摩器物理机器
公开(公告)号：KR1020030080507A
公开(公告)日：2003-10-17
申请号：KR1020020019175
申请日：2002-04-09
申请人： 학교법인 경희학원
发明人： 한승무 , 임사비나 , 김창주 , 심인섭 , 박히준 , 이지숙 , 김경아
IPC分类号： A61H23/02
摘要： PURPOSE: An automatic massage physical medicine apparatus by the eccentric movement of supersonic horn is provided to enable a user to take a massage and a finger-pressure therapy without a massager by using the eccentric movement of supersonic horn after fixing the apparatus to the affected part. CONSTITUTION: The automatic massage physical medicine apparatus by the eccentric movement of the supersonic horn includes a suction cup(100), a treating catheter(200), a treating catheter rotary device(300), a main control device(400) and a suction cable. The suction cup(100) has the shape of cupping glass with the top open and is fixed closely to the affected part by suction. The treating catheter(200) performs the eccentric rotary movement in the suction cup and performs the supersonic massage function by generating a supersonic vibration energy into the affected part. The main control device(400) measures the internal pressure to control the suction action, controls the drive of the treating catheter rotary device, and provides the electric power to the catheter to control the generation of the supersonic wave.
摘要翻译：目的：提供超音速偏心运动的自动按摩物理设备，使用户可以在将设备固定在受影响部位之后，通过使用超音速喇叭的偏心运动，无需按摩器进行按摩和手指压力治疗。构成：通过超音速角度偏心运动的自动按摩物理药物装置包括吸盘（100），处理导管（200），处理导管旋转装置（300），主控装置（400）和抽吸电缆。吸盘（100）具有顶部打开的杯形玻璃的形状，并通过抽吸紧密地固定在受影响的部分上。处理导管（200）在吸盘中执行偏心旋转运动，并通过在受影响的部分产生超音速振动能量来执行超音速按摩功能。主控制装置（400）测量内部压力以控制抽吸动作，控制处理导管旋转装置的驱动，并向导管提供电力以控制超声波的产生。

10. 发明授权

KR102046561B1 포탄체 제조용 지그 어셈블리 有权
公开(公告)号：KR102046561B1
公开(公告)日：2019-11-19
申请号：KR1020180070603
申请日：2018-06-20
申请人： 심인섭
发明人： 심인섭
IPC分类号： F42B33/00 , B23Q3/06

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