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1. 发明申请

WO2012023660A1 크레이스토카릭스 오페르쿠라투스로부터 얻은 조류, 돼지 인플루엔자 및 신종플루에 대한 항바이러스제 审中-公开
标题翻译：来自CLEISTOCALYX操作的AVIAN和SWINE INFLUENZA和NOVEL FLU的抗病毒药物
公开(公告)号：WO2012023660A1
公开(公告)日：2012-02-23
申请号：PCT/KR2010/007442
申请日：2010-10-28
申请人： 주식회사 중앙백신연구소 , 윤인중 , 김은희 , 최환원 , 오원근 , 다오트롱투완 , 텅풍티엔
发明人： 윤인중 , 김은희 , 최환원 , 오원근 , 다오트롱투완 , 텅풍티엔
IPC分类号： A61K31/352 , A61K31/35 , A61P31/12 , A61P31/00
CPC分类号： A61K31/35 , A61K31/352
摘要： 본 발명은 크레이스토카릭스 오페르쿠라투스 유래의 뉴라미니데이즈 효소(neuraminidase)를 저해하는 화합물 및 이를 유효성분으로 포함하는 조류 및 돼지 인플루엔자와 신종플루의 예방과 치료에 사용하는 조성물에 관한 것이다.
摘要翻译：本发明涉及一种抑制神经氨酸酶的Cleistocalyx operculatus来源的化合物，以及用于预防和治疗禽流感和猪流感的新型流感的组合物，其含有活性成分。

2. 发明授权

KR101334143B1 폴리갈라 카렌시움 추출물 및 이로부터 분리된 잔톤계 화합물을 함유하는 감기, 조류 인플루엔자, 돼지 인플루엔자 또는 신종플루의 예방 또는 치료용 조성물 有权
标题翻译：包含用于治疗或预防感冒，AVIAN INFLUENZA，SWINE INFLUENZA或NOVEL INFLUENZA分离的聚甘氨酸或其他化合物的组合物的组合物
公开(公告)号：KR101334143B1
公开(公告)日：2013-11-28
申请号：KR1020120062490
申请日：2012-06-12
申请人： 조선대학교산학협력단 , 주식회사 중앙백신연구소
发明人： 오원근 , 다오트롱투완 , 누엔버치트 , 최환원 , 원호근 , 윤인중
IPC分类号： A61K31/352 , A61K31/35 , A61P31/16 , A61P31/12
摘要： The present invention relates to a composition containing a Polygala karensium extract and xanthone-based compounds isolated from the same for preventing or treating flu, avian influenza, swine influenza, or novel swine-origin influenza. The Polygala karensium extract and xanthone-based compounds isolated from the same effectively and non-selectively suppress neuraminidase of flu virus, avian influenza virus, swine influenza virus, novel swine-origin influenza, and Tamiflu resistant novel swine-origin influenza virus, thereby being used as a therapeutic agent for treating flu, avian influenza, swine influenza, and swine-origin influenza and being applied in cosmetic products, health foods, animal feeds, and an animal medicinal industry. [Reference numerals] (AA) Swine influenza virus (H1N1);(BB,HH,NN,TT) Compound 1;(CC,II,OO,UU) Compound 2;(DD,JJ,PP,VV) Compound 3;(EE,KK,QQ,WW) Compound 4;(FF,LL,RR,XX) Compound 5;(GG) Avian influenza virus (H9N2);(MM) Novel swine-origin influenza virus (novel H1N1);(SS) Novel swine-origin influenza virus resistant to Tamiflu (H1N1[H274Y])
摘要翻译：本发明涉及含有从其分离的Polygala karensium提取物和基于呫吨酮的化合物预防或治疗流感，禽流感，猪流感或新型猪源性流感的组合物。从同样有效和非选择性地抑制流感病毒，禽流感病毒，猪流感病毒，新型猪源性流感病毒和Tamiflu抗性新型猪源性流感病毒的神经氨酸酶分离的Polygala karensium提取物和基于呫吨酮的化合物，从而被用作治疗流感，禽流感，猪流感和猪源性流感的治疗剂，并用于化妆品，保健食品，动物饲料和动物医药行业。化合物1;（CC，II，OO，UU）化合物2;（DD，JJ，PP，VV）化合物3;（AA）猪流感病毒（H1N1）;（BB，HH，NN，TT）（EE，KK，QQ，WW）化合物4;（FF，LL，RR，XX）化合物5;（GG）禽流感病毒（H9N2）;（MM）新型猪源性流感病毒（新型H1N1））抗Tamiflu（H1N1 [H274Y]）新型猪源性流感病毒

3. 发明授权

KR100950445B1 감초로부터 얻은 조류, 돼지 인플루엔자 및 신종플루에 대한 항바이러스제 有权
标题翻译：有关AVIAN和SWINE流感病毒或新型流感病毒的残留活性的抗病毒药物，由化合物分离自GLYCYRRZZZ URALENSIS
公开(公告)号：KR100950445B1
公开(公告)日：2010-04-02
申请号：KR1020090101628
申请日：2009-10-26
申请人： 주식회사 중앙백신연구소 , 조선대학교산학협력단
发明人： 윤인중 , 이홍식 , 김동원 , 오원근 , 박준수 , 부이탄텅 , 다오트롱투완
IPC分类号： A61K36/484 , A61P31/16 , A23L1/30 , A61K31/12
CPC分类号： A61K31/12 , A23K20/111 , A23L2/52 , A23L29/035 , A61K36/484 , A61K2236/333 , Y10S514/888
摘要： PURPOSE: A Glycyrrhiza uralensis extract and calcone based compounds suppressing neuraminidase are provided to treat novel swine-origin influenza. CONSTITUTION: A Glycyrrhiza uralensis extract for preventing or treating avian and swine ingluenza contains is extracted using ethanol or methanol and contains chalcone based compound. The chalcone based compound is Licochacone F, Echicnatin, Licochalcon D, Licochalcone A, Isoliquiritigenin, Licoagrochalcone A, 5-Prenylbutein and Kanzonol C. A functional health food for preventing or treating diseases relating to avian and swine influenza contains Glycyrrhiza uralensis extract. A pharmaceutical composition for preventing or treating diseases relating to avian and swine influenza contains Glycyrrhiza uralensis extract or chalcone compouns as active ingredient. The pharmaceutical composition also contains pharmaceutically acceptable carrier or excipient.
摘要翻译：目的：提供甘草提取物和基于煅烧物的抑制神经氨酸酶的化合物，用于治疗新型猪源性流感。构成：用乙醇或甲醇提取用于预防或治疗禽流感和猪流感病毒的甘草提取物，并含有查耳酮基化合物。基于查耳酮的化合物是Licochacone F，Echicnatin，Licochalcon D，Licochalcone A，Isoliquiritigenin，Licoagrochalcone A，5-丙氨酸丁醇和Kanzonol C.用于预防或治疗与禽流感和猪流感有关的疾病的功能保健食品含有甘草提取物。用于预防或治疗与禽流感和猪流感有关的疾病的药物组合物含有甘草提取物或查耳酮组合物作为活性成分。药物组合物还含有药学上可接受的载体或赋形剂。

4. 发明授权

KR101021830B1 크레이스토카릭스 오페르쿠라투스로부터 얻은 조류, 돼지 인플루엔자 및 신종플루에 대한 항바이러스제 有权
标题翻译：具有抗病毒活性的AVIAN和SWINE流感病毒或新型流感病毒的抗病毒药物可从CLEISTOCALYX手术中分离出来
公开(公告)号：KR101021830B1
公开(公告)日：2011-03-17
申请号：KR1020100079391
申请日：2010-08-17
申请人： 주식회사 중앙백신연구소
发明人： 윤인중 , 김은희 , 최환원 , 오원근 , 다오트롱투완 , 텅풍티엔
IPC分类号： A61K31/352 , A61K31/35 , A61P31/12 , A61P31/00
CPC分类号： A61K31/35 , A61K31/352
摘要： PURPOSE: A compound which suppresses Cleistocalyx operculatus-derived neuraminidase is provided. CONSTITUTION: A pharmaceutical composition for preventing or treating avian and swine influenza contains Cleistocalyx operculatus extract. The extract is isolated using 50-100% ethanol solution. A health food for preventing avian or swine influenza contains the Cleistocalyx operculatus extract. The health food is daily products and nutrition products. The pharmaceutical composition further contains pharmaceutically acceptable carrier or excipient. A feed additive for preventing avian and swine influenza contains the Cleistocalyx operculatus extract as an active ingredient and pharmaceutically acceptable carrier or excipient.
摘要翻译：目的：提供抑制Cleistocalyx operculatus的神经氨酸酶的化合物。构成：用于预防或治疗禽流感和猪流感的药物组合物含有Cleistocalyx operculatus提取物。使用50-100％乙醇溶液分离提取物。用于预防禽流感或猪流感的保健食品含有Cleistocalyx operculatus提取物。保健食品是日用品和营养品。药物组合物还含有药学上可接受的载体或赋形剂。用于预防禽流感和猪流感的饲料添加剂含有Cleistocalyx operculatus提取物作为活性成分和药学上可接受的载体或赋形剂。

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