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    • 8. 发明公开
    • 코디세핀을 유효성분으로 하는 혈관재협착 방지용 조성물
    • 用于预防和治疗包含CORDYCEPIN作为主动成分的抑制剂的药物组合物
    • KR1020040066376A
    • 2004-07-27
    • KR1020030003417
    • 2003-01-17
    • 정광회장양수황기철
    • 장양수황기철
    • C01G19/02B82B3/00
    • A61K31/7076A61L31/08A61L31/14
    • PURPOSE: A pharmaceutical composition for prevention and treatment of restenosis comprising cordycepin as an active ingredient is provided, which cordycepin(3-deoxyadenosine) is derived from Cordyceps pruinosa, and inhibits growth of human umbilical vein endothelial cells(HUVECS), growth and migration of smooth muscle cell, and secretion of monocyte chemoattractant protein-1, so that it can be useful for prevention and treatment of restenosis after stent insertion. CONSTITUTION: The pharmaceutical composition for prevention and treatment of restenosis comprises cordycepin derived from Cordyceps pruinosa as an active ingredient and pharmaceutically acceptable carriers, wherein the pharmaceutical composition is non-orally and locally administered by using a nano-sized carrier for drug delivery using balloon; and the pharmaceutical composition is non-orally and locally administered as a form of stent coating.
    • 目的:提供一种用于预防和治疗包含虫草素作为活性成分的再狭窄的药物组合物,其中冬虫夏草素(3-脱氧腺苷)源自冬虫夏草,并抑制人脐静脉内皮细胞(HUVECS)的生长,生长和迁移 平滑肌细胞和单核细胞趋化蛋白-1的分泌,使其可用于预防和治疗支架插入后的再狭窄。 构成:用于预防和治疗再狭窄的药物组合物包括源自冬虫夏草的冬虫夏草作为活性成分和药学上可接受的载体,其中所述药物组合物通过使用纳米尺寸载体进行药物递送使用气囊而非口服和局部施用; 并且药物组合物作为支架涂层的形式是非口服和局部施用的。