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1. 发明授权

KR100401008B1 항진균성 및 항암성이 있는 신규한 화합물 ＹＭ410,그의 제조방법 및 용도 失效
标题翻译： 항진균성및항암성있있합물합물합물YM410，그의제조방법및용도도
公开(公告)号：KR100401008B1
公开(公告)日：2003-10-10
申请号：KR1019990030089
申请日：1999-07-23
申请人： 정영륜
发明人： 문석식 , 황의형 , 김충환 , 정영륜
IPC分类号： C07D313/00
摘要： PURPOSE: Provided is a novel compound YM410 represented by the formula (i), which has an antifungal activity and an anticancer activity as well. Therefore, the novel compound can be used as an antifungal drug and an anticancer drug. A method for preparing the compound is also provided. CONSTITUTION: A novel compound YM410 represented by the general formula (I) is prepared by the following steps: (a) fermentation and cultivation of Kitasatospora cheerisanesis (KCTC 2395); (b) separation of the cell body and extraction and concentration thereof with methanol, to obtain liquid phase concentrated solution ; (c) elution of the resultant solution by silicagel medium pressure chromatography; (d) concentration of the elution fraction exhibiting strong antifungal activity, concentration of the elution fraction exhibiting an antifungal activity by chromatography, and then purification thereof, to obtain a solid phase sample; (e) dissolving the resultant sample in methanol and addition of ethylacetate thereto to remove the undissolved materials, to obtain a liquid phase sample ; and (f) analyzing the resultant sample by the high pressure chromatography.
摘要翻译：用途：提供了式（i）代表的新型化合物YM410，其也具有抗真菌活性和抗癌活性。因此，该新化合物可以用作抗真菌药物和抗癌药物。还提供了制备该化合物的方法。构成：通过以下步骤制备由通式（I）表示的新型化合物YM410：（a）Kitasatospora cheerisanesis（KCTC 2395）的发酵和培养; （b）分离细胞体并用甲醇萃取和浓缩，得到液相浓缩液; （c）用硅胶中压色谱法洗脱所得溶液; （d）表现出强抗菌活性的洗脱级分的浓度，通过色谱法表现出抗真菌活性的洗脱级分的浓度，然后纯化，以获得固相样品; （e）将所得样品溶解在甲醇中并向其中加入乙酸乙酯以除去未溶解的物质，从而获得液相样品; 和（f）通过高压色谱分析所得样品。

2. 发明公开

KR1020000075382A 항진균성 및 항암성이 있는 신규한 화합물 ＹＭ410,그의 제조방법 및 용도 失效
标题翻译：具有抗真菌活性的新型化合物YM410及其制备方法
公开(公告)号：KR1020000075382A
公开(公告)日：2000-12-15
申请号：KR1019990030089
申请日：1999-07-23
申请人： 정영륜
发明人： 문석식 , 황의형 , 김충환 , 정영륜
IPC分类号： C07D313/00
摘要： PURPOSE: Provided is a novel compound YM410 represented by the formula (i), which has an antifungal activity and an anticancer activity as well. Therefore, the novel compound can be used as an antifungal drug and an anticancer drug. A method for preparing the compound is also provided. CONSTITUTION: A novel compound YM410 represented by the general formula (I) is prepared by the following steps: (a) fermentation and cultivation of Kitasatospora cheerisanesis (KCTC 2395); (b) separation of the cell body and extraction and concentration thereof with methanol, to obtain liquid phase concentrated solution ; (c) elution of the resultant solution by silicagel medium pressure chromatography; (d) concentration of the elution fraction exhibiting strong antifungal activity, concentration of the elution fraction exhibiting an antifungal activity by chromatography, and then purification thereof, to obtain a solid phase sample; (e) dissolving the resultant sample in methanol and addition of ethylacetate thereto to remove the undissolved materials, to obtain a liquid phase sample ; and (f) analyzing the resultant sample by the high pressure chromatography.
摘要翻译：目的：提供由式（i）表示的新型化合物YM410，其具有抗真菌活性和抗癌活性。因此，该新化合物可用作抗真菌药物和抗癌药物。还提供了一种制备该化合物的方法。构成：由通式（I）表示的新型化合物YM410通过以下步骤制备：（a）发酵和培养Cheasisospora cheerisanesis（KCTC 2395）; （b）分离细胞体并用甲醇萃取和浓缩，得到液相浓缩溶液; （c）通过硅胶中压层析洗脱所得溶液; （d）显示强抗真菌活性的洗脱级分的浓度，通过色谱法显示抗真菌活性的洗脱级分的浓度，然后进行纯化，得到固相样品; （e）将所得样品溶解在甲醇中并加入乙酸乙酯以除去未溶解的物质，得到液相样品; 和（f）通过高压色谱分析所得样品。

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