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    • 6. 发明公开
    • 독활 추출물을 포함하는 염증 및 알러지 질환의 예방 또는개선용 건강보조식품
    • 包含ARALIA CORDATA THUNB提取物的健康食品用于预防或改善炎症和过敏疾病
    • KR1020070076564A
    • 2007-07-24
    • KR1020070054611
    • 2007-06-04
    • 영남대학교 산학협력단
    • 장현욱강삼식배기환김현표손건호성용경
    • A23L1/29A23L1/30
    • A23L33/10A23V2002/00A23V2200/304A23V2250/21A23V2300/14
    • A health supplementary food containing Aralia cordata Thunb extract having effects of inhibiting the formation of leukotriene C4(LTC4) involved in allergic and inflammation reaction is provided to be useful for prevention and improvement of bronchial asthma, allergic rhinitis, allergic asthma or allergic dermatitis. The health supplementary food contains 0.1 to 50% by weight of Aralia cordata extract and food acceptable additives. The Aralia cordata extract is obtained by finely cutting the whole plant, root or above-ground part(leaves and stems) of Aralia cordata, adding 1 to 20 times the weight of water, C1-4 lower alcohol or a mixed solvent thereof and extracting it at 10 to 80deg.C for 1 to 24hr. The health supplementary food can contain a carrier, excipient and diluent. The Aralia cordata extract has an effective dose of 0.0001 to 100mg/kg, preferably 0.001 to 10mg/kg per day. The health supplementary drink contains 0.02 to 5g Aralia cordata extract, based on 100ml.
    • 提供含有抑制过敏和炎症反应的白细胞三烯C4(LTC4)形成的作用的含有Aralia cordata Thunb提取物的健康补充食品可用于预防和改善支气管哮喘,过敏性鼻炎,过敏性哮喘或过敏性皮炎。 健康补充食品含有0.1〜50重量%的Aralia cordata提取物和食品可接受的添加剂。 通过将Aralia cordata的整个植物,根部或地上部分(叶和茎)细切割,加入水的重量的1至20倍,C 1-4低级醇或其混合溶剂,并提取 在10〜80℃下1〜24小时。 健康补充食品可以含有载体,赋形剂和稀释剂。 芦荟提取物的有效剂量为0.0001〜100mg / kg,优选为0.001〜10mg / kg /天。 健康补充饮料含有0.02至5g Aralia cordata提取物,基于100ml。
    • 8. 发明公开
    • 단삼 추출물을 유효성분으로 함유하는 천식 및 알러지성질환의 예방 및 치료용 조성물.
    • 包含SALVIA ​​MILTIORRHIZA BUNGE提取物用于预防和治疗哮喘和过敏性疾病的组合物
    • KR1020080023570A
    • 2008-03-14
    • KR1020060087608
    • 2006-09-11
    • 영남대학교 산학협력단
    • 장현욱손종근이승호손건호남경수김철호
    • A61K36/537A61P37/08
    • A61K36/537A23V2200/304A23V2200/314A61K2236/331A61K2236/333A61K2236/35Y10S514/826
    • A composition comprising the extract of Salvia miltiorrhiza BUNGE is provided to inhibit production of leukotriene C4(LTC4) depending on 5-LOX(5-lipoxygenase), production of prostaglandin D2(PGD2) depending on COX-2(cyclooxygenase-2), and degranulation in mast cells, so that the composition is useful for prevention and treatment of asthma and allergic disease. A composition for prevention and treatment of asthma and allergic disease including bronchial asthma, allergic rhinitis, allergic asthma and allergic dermatitis comprises the crude extract of Salvia miltiorrhiza BUNGE which is prepared with water, C1-C4 lower alcohol or a mixed solvent thereof, the polar solvent extract of Salvia miltiorrhiza BUNGE which is prepared with water, methanol, ethanol, butanol or a mixed solvent thereof, or the non-polar solvent extract of Salvia miltiorrhiza BUNGE which is prepared with hexane, chloroform or ethylacetate, and is a pharmaceutical or health food composition having a formulation of powder, granule, tablet, capsule or drink.
    • 提供包含丹参提取物BUNGE的组合物以抑制依赖于5-LOX(5-脂氧合酶),依赖于COX-2(环氧合酶-2)的前列腺素D2(PGD2)的产生而产生白细胞三烯C4(LTC4) 在肥大细胞中脱颗粒,使得该组合物可用于预防和治疗哮喘和过敏性疾病。 用于预防和治疗哮喘和过敏性疾病(包括支气管哮喘,过敏性鼻炎,过敏性哮喘和过敏性皮炎)的组合物包括用水,C1-C4低级醇或其混合溶剂制备的丹参BUNGE的粗提物,极性 用水,甲醇,乙醇,丁醇或其混合溶剂制备的丹参溶剂提取物,或用己烷,氯仿或乙酸乙酯制备的丹参丹参的非极性溶剂提取物,是药物或健康 具有粉末,颗粒,片剂,胶囊或饮料制剂的食品组合物。
    • 9. 发明授权
    • 삼백초 추출물에서 분리된 사우세르네올 B 화합물을함유하는 염증, 알러지 및 천식 질환의 예방 및 치료용조성물
    • 삼백초삼백초물물물물분분분분된사사사올올올올올올염증염증알러알러알러알러알러알러및및및및및및물물물물물물물물물물물물물물
    • KR100739399B1
    • 2007-07-13
    • KR1020060031375
    • 2006-04-06
    • 영남대학교 산학협력단
    • 장현욱손종근강삼식배기환김현표손건호
    • A61K31/36A61P29/00A61P37/00A61P11/06
    • A composition for the prevention and treatment of inflammatory, allergy or asthma diseases comprising saucerneol B isolated from Saururus chinensis is provided to inhibit 5-lipoxygenase activity, production of cyclooxygenase-2 dependent prostaglandin D2, degranulation in a mast cell, production of nitric oxide radical, expression of iNOS(inducible nitric oxide synthase) and activity of MMP-9(matrix metalloproteinase-9), and to reduce side effects due to its low toxicity. The composition for the prevention and treatment of inflammatory, allergy or asthma diseases comprises 0.01-99.9%, preferably 0.1-90% of the saucerneol B isolated from Saururus chinensis and represented by the formula(1), wherein the saucerneol B is prepared by cutting dried roots, leaves or stems of Saururus chinensis, extracting the fragments of Saururus chinensis with a solvent selected from water, C1-C4 lower alcohol such as methanol at 20-30 deg.C for 1 hour to 10 days, filtering and concentrating the extract of Saururus chinensis under reduced pressure, fractionating the Saururus chinensis extract with n-hexane, ethylacetate, n-butanol and water, sequentially, and subjecting the fraction to chromatography. The daily dosage of the saucerneol B is 0.0001-100 mg/kg.
    • 提供了一种用于预防和治疗炎症,变态反应或哮喘疾病的组合物,其包含从Saururus chinensis分离的索诺酚B以抑制5-脂氧合酶活性,产生环加氧酶-2依赖性前列腺素D2,在肥大细胞中脱粒,产生一氧化氮自由基 ,iNOS(诱导型一氧化氮合酶)的表达和MMP-9(基质金属蛋白酶-9)的活性,并且由于其低毒性而减少副作用。 用于预防和治疗炎症,变态反应或哮喘疾病的组合物包含0.01-99.9%,优选0.1-90%的从Saururus chinensis分离的并且由式(1)表示的松香醇B,其中所述松香醇B通过切割 三白草的干燥根,叶或茎,用选自水,C 1 -C 4低级醇如甲醇的溶剂在20-30℃下提取三白草的片段1小时至10天,过滤并浓缩提取物 的三白草在减压下,依次用正己烷,乙酸乙酯,正丁醇和水分离三白草提取物,并将该部分进行色谱分离。 松香醇B的日剂量为0.0001-100mg / kg。