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2. 发明公开

KR1020050017946A 적정 농도의 에스-아데노실-엘-메치오닌(ＳＡＭ)에 의해스트렙토마이세스 속 균주로부터 항생제 생성을촉진시키는 방법 및 ＳＡＭ의 아날로그에 의한 항생제생성 촉진 방법 有权
标题翻译：通过将S-亚苯基-L-甲硫氨酸（SAM）和SAM类似物的特异性浓度加入到中等量的大量生产抗生素的方法
公开(公告)号：KR1020050017946A
公开(公告)日：2005-02-23
申请号：KR1020030055538
申请日：2003-08-11
申请人： 서주원 , 학교법인 명지학원
发明人： 서주원 , 양영열 , 김동진 , 허정현 , 조심청 , 이명
IPC分类号： C12P21/00
摘要： PURPOSE: Methods for mass production of antibiotics using specific concentration of S-adenosyl-L-methionine(SAM) and SAM analogues are provided, which S-adenosyl-L-methionine(SAM) is a methyl donor being important for the primary and secondary metabolism in a biomass, so that SAM can stimulate the antibiotic production of a microorganism. CONSTITUTION: The method for mass production of antibiotics pristinamycin comprises adding 50 micromole of S-adenosyl-L-methionine(SAM) into a medium for Streptomyces pristinaespiralis(ATCC 25486). The method for mass production of antibiotics granaticin comprises adding 10 micromole of S-adenosyl-L-methionine(SAM) into a medium for Streptomyces violaceoruver Tu22. The method for mass production of antibiotics oleandomycin comprises adding 1 micromole of S-adenosyl-L-methionine(SAM) into a medium for Streptomyces antibioticus(ATCC 11981). The method for mass production of antibiotics avermectin comprises adding 1 micromole of S-adenosyl-L-methionine(SAM) into a medium for Streptomyces avermitilis. The method for mass production of antibiotics actinodin comprises adding 2M of S-adenosyl-L-methionine(SAM), ATP, ADP or AMP into a medium for Streptomyces coelicolorA3(2)M130.
摘要翻译：目的：提供使用特异浓度的S-腺苷-L-甲硫氨酸（SAM）和SAM类似物大规模生产抗生素的方法，其中S-腺苷-L-甲硫氨酸（SAM）是甲基供体，对于初级和次级生物质中的代谢，使得SAM可以刺激微生物的抗生素生产。构成：大规模生产抗生素原始霉素的方法包括将50微摩尔的S-腺苷-L-甲硫氨酸（SAM）加入到原生链霉菌（Streptomyces pristinaespiralis）（ATCC 25486）的培养基中。大规模生产抗生素颗粒状蛋白的方法包括将10微摩尔S-腺苷-L-甲硫氨酸（SAM）加入到用于Streptomyces violaceoruver Tu22的培养基中。批量生产油菜霉素的方法包括将1微摩尔S-腺苷-L-甲硫氨酸（SAM）加入到抗链霉菌抗生素（ATCC 11981）的培养基中。大量生产抗生素阿维菌素的方法包括将1微摩尔的S-腺苷-L-甲硫氨酸（SAM）加入阿维链霉菌的培养基中。大量生产抗生素放线菌素的方法包括将2M-腺苷-L-甲硫氨酸（SAM），ATP，ADP或AMP加入到Streptomyces coelicolorA3（2）M130的培养基中。

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