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1. 发明授权

KR101315056B1 페길화된 피부주름개선 기능성 펜타펩타이드 유도체 有权
标题翻译：聚乙二醇化抗皱皮肤恢复五肽衍生物
公开(公告)号：KR101315056B1
公开(公告)日：2013-10-08
申请号：KR1020110074417
申请日：2011-07-27
申请人： 경성대학교 산학협력단 , (주)해림파메틱
发明人： 나동희 , 김명선 , 박은지 , 김형석
IPC分类号： A61K8/65 , A61K38/08 , C07K7/06 , A61Q19/08
摘要： 본 발명은 폴리에틸렌글리콜이 결합된 피부기능성 펜타펩타이드 유도체로써, 더욱 상세하게는 피부주름개선 기능을 가진 펜타펩타이드(KTTKS)의 비활성부위에 단분산성 폴리에틸렌글리콜 (polyethylene glycol, PEG)을 결합시킴으로써 얻어진 폴리에틸렌글리콜이 결합된 피부기능성 콜라겐 펩타이드 유도체이고, 이러한 콜라겐 펩타이드 유도체는 화학적으로 안정하고 독성이 낮으며 생리활성이 우수하다.

2. 发明公开

KR1020120091982A 페길화된 피부주름개선 기능성 펜타펩타이드 유도체 有权
标题翻译：聚乙二醇抗皱皮肤复原皮质激素衍生物及其制备方法
公开(公告)号：KR1020120091982A
公开(公告)日：2012-08-20
申请号：KR1020110074417
申请日：2011-07-27
申请人： 경성대학교 산학협력단 , (주)해림파메틱
发明人： 나동희 , 김명선 , 박은지 , 김형석
IPC分类号： A61K8/65 , A61K38/08 , C07K7/06 , A61Q19/08
摘要： PURPOSE: A polyethylene glycol-conjugated skin functional pentapeptide derivative and a method for preparing the same are provided to ensure chemical stability and excellent physical activity. CONSTITUTION: A pegylated pentapeptide derivative is denoted by chemical formula(CH_3O-(CH_2CH_2O)_m-(CH_2)_n-CH_2-NH-Lys-Thr-Thr-Lys-Ser). In chemical formula, m is 2-48 integer; n is 1-3 integer; and NH is N-terminal amine group. A mono-PEG pentapeptide derivative is prepared by reacting collagen peptides and polyethylene glycol(PEG) in a molar ratio of 1:1-1:5 in a buffer solution containing 5-50 mM of sodium cyanoborohydride.
摘要翻译：目的：提供聚乙二醇缀合的皮肤功能性五肽衍生物及其制备方法，以确保化学稳定性和优异的身体活性。构成：化学式（CH_3O-（CH_2CH_2O）_m-（CH_2）_n-CH_2-NH-Lys-Thr-Thr-Lys-Ser）表示聚乙二醇化五肽衍生物。在化学式中，m为2-48整数; n为1-3个整数; NH为N-末端胺基。通过在含有5-50mM氰基硼氢化钠的缓冲溶液中使胶原肽和摩尔比为1：1-1：5的聚乙二醇（PEG）反应制备单PEG五肽衍生物。

3. 发明公开

KR1020120112278A Ｎ-Ａｃｅｔｙｌｔｈｉａｚｏｌｉｄｉｎｅｃａｒｂｏｘｙｌｉｃａｃｉｄ를 유효성분으로 함유하는 식물영양제용 복합비료 无效
标题翻译：用于植物营养的复合肥料的组合物，包括作为有效成分的ATCA
公开(公告)号：KR1020120112278A
公开(公告)日：2012-10-11
申请号：KR1020120040904
申请日：2012-04-19
申请人： (주)해림파메틱
发明人： 김형석 , 김재훈
IPC分类号： C05G1/00 , C05D11/00 , A01N37/00
CPC分类号： C05G1/00 , A01N37/00
摘要： PURPOSE: A compound fertilizer for plant nutrients with excellent absorption rate into plant is provided to improve biological property and plant growth. CONSTITUTION: A compound fertilizer for plant nutrients with excellent absorption rate into plant uses N-Acetyl thiazolidine carboxylic acid(ATCA). 1-10 wt% of the ATCA is added to composite fertilizer or complex fertilizer. A vield increase culturing method of one of fruit vegetables including tomato, cucumis sativus, eggplant, pumpkin and Capsicum annuum comprises the following step: after 40 days from transplanting fruit vegetables, spraying the ATCA 3-5 times at 20-200 ppm concentration in every 10 days.
摘要翻译：目的：提高植物营养成分对植物吸收率的复合肥，以改善生物性状和植物生长。构成：对植物吸收率高的植物营养素复合肥使用N-乙酰基噻唑烷羧酸（ATCA）。将1-10％的ATCA加入到复合肥料或复合肥料中。水果蔬菜包括番茄，黄瓜，茄子，南瓜，辣椒等水果蔬菜的培养方法包括以下步骤：移栽水果蔬菜40天后，每次以20-200ppm浓度喷洒ATCA 3-5次 10天。

4. 发明公开

KR1020100086186A 엘-시스틴의 제조방법 有权
标题翻译：生产L- CYSTINE的方法
公开(公告)号：KR1020100086186A
公开(公告)日：2010-07-30
申请号：KR1020090005408
申请日：2009-01-22
申请人： (주)해림파메틱
发明人： 김형석 , 김재훈
IPC分类号： C07C319/28 , C07C323/58
摘要： PURPOSE: A method for preparing L-cystine is provided to collecting L-cystein of high purity through simple process and to reduce environmental pollution. CONSTITUTION: A method for preparing L-cystine comprises: a step of inputting 34% of H_2O_2 to filtrate of L-cystine and oxidizing for 3 hours or more; a step of inputting activated carbon to the oxidation reactant and decoloring and filtering at 45-55 °C; and a step of adding 25% of ammonia water to the filtered water to adjust pH 4.9; or a step of adding 35% of HCl; a step of hydrolyzing at 103 °C for 3 hours; and a step of oxidizing with 34% of H_2O_2 for 3 hours.
摘要翻译：目的：提供L-胱氨酸的制备方法，通过简单的方法收集高纯度的L-半胱氨酸，减少环境污染。构成：制备L-胱氨酸的方法包括：向L-胱氨酸滤液中输入34％H_2O_2至氧化3小时以上的步骤; 将活性炭输入氧化反应物并在45-55℃下脱色和过滤的步骤; 和向过滤水中加入25％氨水以调节pH 4.9的步骤; 或加入35％HCl的步骤; 在103℃下水解3小时的步骤; 和用34％H_2O_2氧化3小时的步骤。

5. 发明公开

KR1020140055241A N-acetyl-thioproline 및 인산 가용화 활성을 갖는 바실러스 서틸리스 (Bacillus subtilis) HR-1019균주 및 이를 포함하는 친환경 인산가용화균 미생물제제 无效
标题翻译：具有磷酸盐溶解活性的N-乙酰基 - 噻唑啉酮和百草枯HR-1019以及生物友好型磷酸盐溶解包含其的微生物剂
公开(公告)号：KR1020140055241A
公开(公告)日：2014-05-09
申请号：KR1020120121777
申请日：2012-10-31
申请人： (주)해림파메틱
发明人： 김형석 , 김재훈 , 최용락 , 이용석
IPC分类号： C12N1/20 , C05F11/08
摘要： The present invention relates to a microbial fodder including N-acetyl-thioproline and a Bacillus subtilis HR-1019 (KACC91711P) strain. The microbial fodder is perfused in soil and a plant is grown on the soil. As a result of inorganic analysis for the growth of the plant and the soil, the result in a standard amount treatment group which is 1,000 times more diluted than an official formulation is the most excellent. Accordingly, the microbial fodder of the present invention solubilizes poorly water-soluble phosphoric acid in soil and promotes the growth of a plant in an environmentally-friendly way.
摘要翻译：本发明涉及包含N-乙酰硫代脯氨酸和枯草芽孢杆菌HR-1019（KACC91711P）菌株的微生物饲料。微生物饲料在土壤中灌注，植物生长在土壤上。作为对植物和土壤生长的无机分析的结果，在标准量处理组中的结果是比官方制剂稀释1000倍是最优异的。因此，本发明的微生物饲料在土壤中溶解难溶于水的磷酸，并以环保的方式促进植物的生长。

6. 发明授权

KR100991525B1 Ｎ-아세틸티아졸리딘-4-카르복실산의 신규한 제조 방법 有权
标题翻译：制备N-乙酰基三唑啉-4-羧酸的新方法
公开(公告)号：KR100991525B1
公开(公告)日：2010-11-04
申请号：KR1020090114679
申请日：2009-11-25
申请人： (주)해림파메틱
发明人： 김형석 , 김재훈
IPC分类号： C07D277/06 , C07D277/04 , C07D277/02
摘要： PURPOSE: A novel method for preparing N-acetylthioazolidine 4-carboxylic acid is provided to used as a plant growth regulatore. CONSTITUTION: A method for preparing N-acetylthiazolidine-4-carboxylic acid of chemical formula 1 comprises: a step of reacting 0.95-1.1 mole of formaldehyde to 1 mole of L-cystein hydrochloride; and a step of reacting 0.95-1.1 mole of acetic anhydride to 1 mole of thioazolidine 4-carboxylic acid.
摘要翻译：目的：提供一种制备N-乙酰基噻唑烷-4-羧酸的新方法，用作植物生长调节剂。构成：制备化学式1的N-乙酰基噻唑烷-4-羧酸的方法包括：使0.95-1.1摩尔甲醛与1摩尔L-半胱氨酸盐酸盐反应的步骤; 和将0.95-1.1摩尔的乙酸酐与1摩尔的唑烷4羧酸反应的步骤。

7. 发明授权

KR101023538B1 엘-시스틴의 제조방법 有权
标题翻译：一种生产L-胱氨酸的方法
公开(公告)号：KR101023538B1
公开(公告)日：2011-03-21
申请号：KR1020090005408
申请日：2009-01-22
申请人： (주)해림파메틱
发明人： 김형석 , 김재훈
IPC分类号： C07C319/28 , C07C323/58
摘要： 본 발명은 아미노산중에서 황을 함유하는 엘-시스틴(L-Cystine)을 추출제조하는 방법을 개시한다. 엘-시스틴은 건강증진, 간기능개선용 식품첨가물과 원료의약품으로 사용되는 뛰어난 효과가 있다.
아미노산, 엘-시스틴, 아세틸시스테인, 건강증진, 간기능 개선

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