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    • 4. 发明公开
    • GABA 수용체를 이용한 임신 중 알코올 노출에 의한 신경질환 치료제의 스크리닝 방법
    • 一种在使用GABA受体的孕激素治疗由酒精诱导的神经性疾病的药剂筛选方法
    • KR1020110127506A
    • 2011-11-25
    • KR1020100047035
    • 2010-05-19
    • 경상대학교산학협력단
    • 김명옥박문석양병철
    • G01N33/68G01N33/15
    • G01N33/9426G01N2500/04G01N2800/385
    • PURPOSE: A method for screening a therapeutic agent for treating nervous diseases due to alcohol exposure during pregnancy is provided to quickly select the therapeutic agent relating to treatment mechanism. CONSTITUTION: A method for screening a therapeutic agent for treating nervous diseases due to alcohol exposure during pregnancy comprises: a step of treating ethanol to a test sample; a step of suppressing the expression of GABAB1 receptor; and a step of treating a candidate material to the test sample and a control group to determine the increase of GABAB1 receptor, p-CREB, and PKA(protein kinase A) expression. The test sample is fetal brain at early pregnancy. The fetal brain is GD(gestational days) 12.5. The nervous diseases are hydrocephalus, microcephaly, cerebral dysplasia, agenesis of the corpus callosum, or fetal alcohol syndrome. A method for detecting GABAB1 receptor for diagnosing nervous diseases comprises a step of measuring reduction of the GABAB1 receptor expression.
    • 目的:提供一种筛选用于治疗怀孕期间酒精暴露引起的神经疾病的治疗剂的方法,以快速选择与治疗机制有关的治疗剂。 构成:筛选用于治疗怀孕期间酒精暴露的神经疾病的治疗剂的方法包括:将乙醇处理至测试样品的步骤; 抑制GABAB1受体表达的一个步骤; 以及将候选材料处理到测试样品和对照组以确定GABAB1受体,p-CREB和PKA(蛋白激酶A)表达的增加的步骤。 测试样品是早孕时的胎儿脑。 胎儿脑是GD(妊娠天)12.5。 神经病是脑积水,小头症,脑发育不良,胼the体发育迟缓或胎儿酒精综合征。 用于检测GABAB1受体以诊断神经疾病的方法包括测量GABAB1受体表达的降低的步骤。