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1. 发明公开

KR1020100009364A 비스에틸헥실프탈레이트의 항암제로서의 용도 失效
标题翻译：使用双 - （2-乙基己基）邻苯二甲酸酯的抗癌剂
公开(公告)号：KR1020100009364A
公开(公告)日：2010-01-27
申请号：KR1020080070216
申请日：2008-07-18
申请人： 건국대학교 산학협력단
发明人： 안중훈 , 임융호 , 정유훈 , 홍성원 , 이영한 , 신순영 , 용연중 , 강경래 , 구본성 , 윤상홍 , 여윤수 , 김수진 , 이창묵 , 이미혜
IPC分类号： A61K31/194 , A61P35/00
摘要： PURPOSE: A pharmaceutical composition containing bis-(2-ethylhexyl) phthalate for anti-cancer is provided to suppress activation of Akt protein in cancer cells and suppress cancer cell proliferation. CONSTITUTION: An anti-cancer composition contains bis-(2-ethylhexyl) phthalate of chemical formula 1. The composition suppresses cancer cell proliferation and induces apoptosis. The bis-(2-ethylhexyl) phthalate is isolated from Aeromonas hydrophila. A method for isolating bis-(2-ethylhexyl) phthalate comprises: a step of extracting Aeromonas hydrophila culture medium using solvent; a step of filtering and concentrating; and a step of isolating through chromatography. The solvent is alcohol including methanol, ethanol, isopropanol, and ethyleneglycol, and halogen-substituted hydrocarbon including methylene chloride, chloroform, and carbon tetrachloride.
摘要翻译：目的：提供含有邻苯二甲酸二（2-乙基己基）酯抗癌药物组合物，以抑制癌细胞中Akt蛋白的活化，抑制癌细胞增殖。构成：抗癌组合物含有化学式1的邻苯二甲酸二（2-乙基己基）酯。该组合物抑制癌细胞增殖并诱导细胞凋亡。邻苯二甲酸双（2-乙基己基）酯由嗜水气单胞菌分离。一种分离邻苯二甲酸双（2-乙基己基）酯的方法，包括：使用溶剂萃取嗜水气单胞菌培养液的步骤; 过滤和集中的一个步骤; 和通过色谱分离的步骤。溶剂是包括甲醇，乙醇，异丙醇和乙二醇的醇，以及包括二氯甲烷，氯仿和四氯化碳的卤素取代的烃。

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