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2. 发明专利

JP4383427B2 Skin moisturizer and dermatitis treatment agent 有权
标题翻译：空值
公开(公告)号：JP4383427B2
公开(公告)日：2009-12-16
申请号：JP2006137006
申请日：2006-05-16
申请人：株式会社スリービー
发明人：和則加藤 , 篤四郎吉成
IPC分类号： A61K36/07 , A61K8/97 , A61K31/715 , A61P17/00 , A61P17/04 , A61P17/06 , A61P17/08 , A61P17/16 , A61P37/08 , A61Q19/00
CPC分类号： A61K8/68 , A61K31/715 , A61K36/07 , A61Q19/00
摘要： A therapeutic agent for dermatitis or skin moisturizer containing Pleurotus cornucopiae-derived ceramide as an active ingredient is disclosed. The Pleurotus cornucopiae-derived ceramide has an effect of inhibiting the production of two kinds of chemokines which play an important role in the onset of dermatitis, that is, an effect of inhibiting the production of chemokine CCL1 in a Langerhans cell and an effect of inhibiting the production of dermatitis-inducing chemokine CCL27 in epidermal keratinocytes. Further, the Pleurotus cornucopiae-derived ceramide shows a moisturizing effect and an effect of inhibiting the onset of dermatitis in a dermatitis model mouse. The therapeutic agent for dermatitis or skin moisturizer of the invention has few side effects and can be used for a long period of time.
摘要翻译：公开了一种含有侧耳状聚宝拉金来源的神经酰胺作为活性成分的皮炎或皮肤保湿剂的治疗剂。侧耳聚宝层衍生的神经酰胺具有抑制在皮炎发作中起重要作用的两种趋化因子的产生的作用，即抑制朗格汉斯细胞中趋化因子CCL1产生的作用和抑制作用在表皮角质形成细胞中产生诱导皮炎的趋化因子CCL27。此外，侧耳聚宝层衍生的神经酰胺显示出保湿效果和抑制皮炎模型小鼠中皮炎发作的效果。本发明的皮炎或皮肤保湿剂用治疗剂的副作用少，长时间使用。

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