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    • 2. 发明专利
    • Composition for treating articular cartilage damage
    • 用于治疗大便性损伤的组合物
    • JP2012107026A
    • 2012-06-07
    • JP2012008349
    • 2012-01-18
    • Chul-Won HaMedipost Co Ltdハー チョル ウォンメディポスト・カンパニー・リミテッドMedipost Co., Ltd.
    • HA CHUL-WONYANG YOON-SUNYANG SUNG-EUN
    • A61K35/14A61K47/24A61K35/44A61K47/30A61K47/32A61K47/34A61K47/36A61K47/42A61P19/02C12N5/071C12N5/0775
    • A61K35/28A61K35/51
    • PROBLEM TO BE SOLVED: To provide a novel composition for treating articular cartilage damage constituted of a readily available cell and a biocompatible polymer, considering that treating methods of articular cartilage damage developed heretofore require a process for extracting bone marrow and have many problems from the viewpoints of operation processes and effects.SOLUTION: The composition for treating articular cartilage damage is constituted of a cell ingredient, which is isolated, proliferated or differentiated from umbilical cord blood, and a nutrient medium therefor. The cell ingredient is preferably at least one cell ingredient selected from among mesenchymal stem cell isolated from umbilical cord blood, a precursor cell which is derived from the mesenchymal stem cell and can be differentiated into a chondrocyte or an osteocyte, and a chondrocyte or an osteocyte differentiated from the mesenchymal stem cell. The biocompatible polymer is preferably at least one selected from among fibrin, gelatin, collagen, hyaluronic acid, polyphosphazine, polyacrylate, polyglactic acid, polyglycolic acid, pluronic acid, and alginic acid and a salt thereof.
    • 要解决的问题:为了提供用于治疗由容易获得的细胞和生物相容性聚合物构成的关节软骨损伤的新型组合物,考虑到迄今为止开发的关节软骨损伤的治疗方法需要提取骨髓的方法并且具有许多问题 从操作过程和效果的角度。 解决方案:用于治疗关节软骨损伤的组合物由与脐带血分离,增殖或分化的细胞成分及其营养培养基构成。 细胞成分优选为选自从脐带血分离的间充质干细胞中的至少一种细胞成分,源自间充质干细胞的前体细胞,可分化为软骨细胞或骨细胞,以及软骨细胞或骨细胞 与间充质干细胞分化。 生物相容性聚合物优选为选自纤维蛋白,明胶,胶原,透明质酸,聚磷腈,聚丙烯酸酯,聚乳酸,聚乙醇酸,普朗尼克酸,藻酸及其盐中的至少一种。 版权所有(C)2012,JPO&INPIT