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1. 发明专利

JP3474941B2 Drug resistance overcoming agent 失效
标题翻译：空值
公开(公告)号：JP3474941B2
公开(公告)日：2003-12-08
申请号：JP25006794
申请日：1994-09-19
申请人：ポーラ化成工業株式会社
发明人：隆男伊藤 , 正彦土屋 , 孝雄服部
IPC分类号： C07D295/08 , A61K31/495 , A61K31/496 , A61K45/00 , A61P31/04 , A61P33/02 , A61P35/00 , A61P43/00 , C07D215/20 , C07D215/22
CPC分类号： Y02A50/411
摘要： PURPOSE: To obtain a new compound useful as a medicinal resistance overcoming agent low in calcium antagonistic activity, provided with the resistance to chemotherapeutic agents, overcoming the medicinal resistance to cancers or pathogenic microbes and improving the therapeutic effect by chemotherapeutic agents. CONSTITUTION: This compound (a physiologically permissible salt thereof) is expressed by formula I [X and Y are each H or a halogen; R1 is a halogen, alkyl, alkyloxy, or monocyclic or bicyclic aromatic ring which may contain one nitrogen atom in the ring], e.g. 1-(3,3-diphenylpropyl)-4-[2- hydroxy-3-(quinolin-5-yloxy)propyl]piperazine. The compound of formula I is obtained by the following process: a compound of formula III is prepared by reaction of a halogen compound of formula II with piperazine; separately, an epoxy compound of formula V is formed by reaction between a compound of formula IV and an epihalohydrin in the presence of sodium hydride; and the compound of formula III and the epoxy compound of formula V are subjected to ring opening condensation reaction. The microbial infectious diseases associated with this compound are involved in Staphylococcus aureus, Plasmodium, Trypanosoma, etc.
摘要翻译：目的：获得一种新的化合物，可用作抗钙化拮抗作用的药物抵抗剂，具有抗化学治疗药物，克服对癌症或致病微生物的药用抗性，并改善化学治疗剂的治疗效果。构成：该化合物（其生理上允许的盐）由式I表示[X和Y各自为H或卤素; R1是可以在环中含有一个氮原子的卤素，烷基，烷氧基或单环或双环芳环]，例如。 1-（3,3-二苯基丙基）-4- [2-羟基-3-（喹啉-5-基氧基）丙基]哌嗪。式I化合物通过以下方法获得：式III化合物通过式II的卤素化合物与哌嗪的反应来制备; 另外，通过式IV化合物与表卤代醇在氢化钠存在下反应形成式V的环氧化合物; 并使式III化合物和式V的环氧化合物进行开环缩合反应。与该化合物相关的微生物感染性疾病涉及金黄色葡萄球菌，疟原虫，锥虫病等。

2. 发明专利

JP3808907B2 The anti-tumor agent liposomal formulation 失效
公开(公告)号：JP3808907B2
公开(公告)日：2006-08-16
申请号：JP7685594
申请日：1994-04-15
申请人：ポーラ化成工業株式会社
发明人：豊彦三木 , 孝雄服部 , 正行遠藤
IPC分类号： A61K9/127 , A61K31/085 , A61K31/675 , A61K31/70 , A61K38/00 , A61K45/00 , A61K47/26 , A61P35/00

4. 发明专利

JP4568527B2 Benzofuran derivatives and skin external preparation containing the same 有权
公开(公告)号：JP4568527B2
公开(公告)日：2010-10-27
申请号：JP2004127055
申请日：2004-04-22
申请人：ポーラ化成工業株式会社
发明人：孝雄服部
IPC分类号： A61K8/49 , C07D307/86 , A61K8/00 , A61K31/343 , A61K31/36 , A61P17/00 , A61Q19/00 , A61Q19/02 , C07D407/04

5. 发明专利

JP3638536B2 Piperazine derivatives and drug sensitivity recovery agent 有权
公开(公告)号：JP3638536B2
公开(公告)日：2005-04-13
申请号：JP2001197705
申请日：2001-06-29
申请人：ポーラ化成工業株式会社
发明人：豊彦三木 , 隆男伊藤 , 一徳原田 , 正彦土屋 , 正一坂口 , 善之宮田 , 正規小林 , 孝雄服部 , 誠木村 , 勤竹内 , 勝美蓮田
IPC分类号： C07D215/22 , A61K31/496 , A61P43/00 , C07D215/36
CPC分类号： Y02A50/411
摘要： PROBLEM TO BE SOLVED: To obtain a piperazine derivative having excellent sensitivity restorative effect on cancer and pathogenic microbes each having drug resistance. SOLUTION: This piperazine derivative is represented by formula (1) (wherein, X is O or S; R1 is H; and R2 is a 7-chloro-4-quinolyl group). Salts thereof and a drug sensitivity restorative agent comprising the above derivative are also provided, respectively.

6. 发明专利

JP4671721B2 Differentiation method of action on the skin 有权
公开(公告)号：JP4671721B2
公开(公告)日：2011-04-20
申请号：JP2005069046
申请日：2005-03-11
申请人：ポーラ化成工業株式会社
发明人：博之佐々木 , 真澄倉沢 , 哲夫前田 , 卓也山本 , 孝雄服部
IPC分类号： G01N33/50

7. 发明专利

JP4422329B2 Useful benzo [b] pyran derivative as a skin external preparation 有权
公开(公告)号：JP4422329B2
公开(公告)日：2010-02-24
申请号：JP2000529326
申请日：1999-01-28
申请人：ポーラ化成工業株式会社
发明人：秀之伊東 , 好男北田 , 隆志吉田 , 孝雄服部 , 崇行片桐
IPC分类号： A61K8/49 , C07H17/06 , A61K8/00 , A61K8/02 , A61K8/60 , A61K31/352 , A61K31/353 , A61K31/7042 , A61K31/7048 , A61P17/16 , A61Q17/04 , A61Q19/02 , C07D311/60 , C07H17/04
CPC分类号： A61Q19/02 , A61K8/0212 , A61K8/498 , A61K8/602 , C07D311/60 , C07H17/04

8. 发明专利

JP3474940B2 Drug resistance overcoming agent 失效
标题翻译：空值
公开(公告)号：JP3474940B2
公开(公告)日：2003-12-08
申请号：JP25003494
申请日：1994-09-19
申请人：ポーラ化成工業株式会社
发明人：隆男伊藤 , 正彦土屋 , 孝雄服部
IPC分类号： C07D295/18 , A61K31/495 , A61K31/496 , A61K45/00 , A61P31/04 , A61P33/02 , A61P35/00 , A61P43/00 , C07D215/20 , C07D215/22
CPC分类号： Y02A50/411
摘要： PURPOSE: To obtain a new compound useful as medicinal resistance overcoming agent low in calcium antagonistic activity, provided with the resistance to chemotherapeutic agents, overcoming the medicinal resistance to cancers or pathogenic microbes and improving the therapeutic effect by chemotherapeutic agents. CONSTITUTION: This compound (a physiologically permissible salt thereof) is expressed by formula I [X and Y are each H or a halogen; (n) is 1-4; R1 is a halogen, 1-4C alkyl, 1-4C alkyloxy, or (nitro-substituted or N-contg.) monocyclic or bicyclic aromatic ring], e.g. 1-(2,2-diphenylethylcarbonyl)-4-[3-(7- chloroquinolin-4-yloxy)-2-hydroxypropyl]piperazine of formula II. The compound of formula I is obtained by the following process: a compound of formula IV is prepared by reaction of a halogen compound of formula III with piperazine; separately, an epoxy compound of formula V is formed by reaction between a compound of formula R OH and an epihalohydrin in the presence of sodium hydride; and the compound of formula IV and the epoxy compound of formula V are subjected to ring opening condensation reaction.
摘要翻译：目的：获得一种新的化合物，作为抗钙化拮抗作用的药物抵抗药物，具有抵抗化学治疗剂的作用，克服了对癌症或致病微生物的药用抗性，并提高了化疗药物的治疗效果。构成：该化合物（其生理上允许的盐）由式I表示[X和Y各自为H或卤素; （n）为1-4; R1是卤素，1-4C烷基，1-4C烷氧基或（硝基取代或N-对 - ）单环或双环芳族环]，例如 4- [3-（4-氯喹啉-4-基氧基）-2-羟基丙基]哌嗪的1-（2,2-二苯基乙基羰基）-4- [ 式I的化合物通过以下方法获得：式IV的化合物通过式III的卤素化合物与哌嗪的反应来制备; 分别地，在氢化钠存在下，通过式R 1 OH的化合物与表卤代醇反应形成式Ⅴ的环氧化合物; 并且式Ⅳ化合物和式Ⅴ的环氧化合物进行开环缩合反应。

9. 发明专利

JP4761852B2 Skin external preparation 有权
标题翻译：空值
公开(公告)号：JP4761852B2
公开(公告)日：2011-08-31
申请号：JP2005187939
申请日：2005-06-28
申请人：ポーラ化成工業株式会社 , 敏男宮瀬
发明人：敏男宮瀬 , 孝雄服部 , 麻那本郷 , 崇行片桐
IPC分类号： A61K8/49 , A61K8/97 , A61K31/353 , A61K36/48 , A61P17/16 , A61P29/00 , A61Q19/00 , A61Q19/02
摘要： PROBLEM TO BE SOLVED: To provide a new excellently safe external preparation for skin for inhibiting melanin formation. SOLUTION: The external preparation for the skin comprising lespedezaflavanone E represented by the chemical formula and/or a salt thereof or an extract of a plant body containing the same is provided. Thereby, the external preparation for the skin not only exhibiting excellent effects on prophylaxis and amelioration of skin pigmentation based on inhibitory actions on the melanin formation but also safely usable without adverse effects on the skin can be provided. COPYRIGHT: (C)2007,JPO&INPIT

10. 发明专利

JP4524221B2 Skin external preparation 有权
标题翻译：空值
公开(公告)号：JP4524221B2
公开(公告)日：2010-08-11
申请号：JP2005187935
申请日：2005-06-28
申请人：ポーラ化成工業株式会社 , 敏男宮瀬
发明人：敏男宮瀬 , 孝雄服部 , 麻那本郷 , 崇行片桐
IPC分类号： A61K8/49 , A61K8/97 , A61K31/353 , A61K36/48 , A61P17/16 , A61P29/00 , A61Q19/00 , A61Q19/02
摘要： PROBLEM TO BE SOLVED: To provide a new excellently safe external preparation for skin for inhibiting melanin formation. SOLUTION: The external preparation for the skin for inhibiting the melanin formation comprising euchrenone a6 represented by the chemical formula and/or a salt thereof or an extract of a plant body containing the same as an active ingredient is provided. Thereby, the external preparation for the skin not only exhibiting excellent effects on prophylaxis and amelioration of skin pigmentation based on inhibitory actions on the melanin formation but also safely usable without adverse effects on the skin can be provided. COPYRIGHT: (C)2007,JPO&INPIT

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