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    • 7. 发明公开
    • 피부 자극감 완화 효과 평가방법
    • 评估皮肤感觉刺激减轻效果的方法
    • KR1020100046668A
    • 2010-05-07
    • KR1020080105619
    • 2008-10-28
    • (주)아모레퍼시픽
    • 이은영안수선김서영조선아이태룡
    • A61B5/05A61B10/00
    • PURPOSE: An evaluation method is provided to objectively measure the relief effect of sensory skin irritation by quantifying the relief effect of sensory skin irritation about various anti-irritants through the change of concrete threshold. CONSTITUTION: A sensory skin irritation relief effect evaluation method comprises a step of measuring the change of a threshold before and after spreading an anti-irritant to a stimulus applied to the skin sensory nerve. The evaluation method quantitatively measures the change of the threshold by using a device. The evaluation method measures the change of the threshold value about a stimulus applied to at least one skin sensory nerve which is selected in a group which includes Aα, Aβ, Aδ, and C-fiber type. The evaluation method measures the change of the threshold value about a stimulus which is applied to the skin sensory nerve of Aδ or C-fiber type.
    • 目的:通过改变混凝土阈值,量化消除各种抗刺激剂对皮肤刺激的缓解作用,提供评估方法,客观地测量感觉皮肤刺激的缓解作用。 构成:感官皮肤刺激缓解效果评估方法包括测量在将抗刺激剂涂抹于皮肤感觉神经的刺激之前和之后的阈值变化的步骤。 评价方法通过使用装置定量地测量阈值的变化。 评估方法测量关于施加到包括Aα,Aβ,Aδ和C纤维类型的组中选择的至少一种皮肤感觉神经的刺激的阈值变化。 评估方法测量施加于Aδ或C纤维类型的皮肤感觉神经的刺激的阈值变化。
    • 8. 发明公开
    • 글루코실스핑고신 또는 그 유도체의 용도
    • 葡萄球菌素或其衍生物的使用
    • KR1020080050786A
    • 2008-06-10
    • KR1020060121508
    • 2006-12-04
    • (주)아모레퍼시픽
    • 김형준김대권성기사김혁조선아김광미노민수이창훈김정주
    • A61K31/133
    • A method for inducing itch and a method for screening an itch inhibiting material using glucosylsphingosine are provided to be useful for studying and understanding the itch, thereby being very usefully used for developing a therapeutic agent for the itch and evaluating the effect of a medicine. A method for inducing itch comprises a step of administering at least one compound selected from the group consisting of glucosylsphingosine and a derivative thereof into an animal except human. A method for screening an itch inhibiting material comprises the steps of: (a) administering an itch inhibition candidate material to an animal where the itch is induced by administering at least one compound selected from the group consisting of the glucosylsphingosine and the derivative thereof; and (b) counting a number when the animal scratches. A method for evaluating the itch inhibition effect comprises the steps of: (a) administering an itch inhibition material to an animal where the itch is induced by administering at least one compound selected from the group consisting of the glucosylsphingosine and the derivative thereof; and (b) counting a number when the animal scratches. A composition for inducing itch comprises at least one compound selected from the group consisting of the glucosylsphingosine and the derivative thereof as an effective ingredient.
    • 提供诱导瘙痒的方法和使用葡糖基鞘氨醇来筛选瘙痒抑制物质的方法,可用于研究和理解瘙痒,从而非常有用地用于开发瘙痒治疗剂并评估药物的效果。 诱导瘙痒的方法包括向除人之外的动物中施用至少一种选自葡糖基鞘氨醇及其衍生物的化合物的步骤。 筛选瘙痒抑制物质的方法包括以下步骤:(a)通过施用至少一种选自葡糖基鞘氨醇及其衍生物的化合物,向瘙痒诱导的动物施用瘙痒抑制候选物质; 和(b)当动物划伤时计数。 评估瘙痒抑制效果的方法包括以下步骤:(a)向通过施用至少一种选自葡糖基鞘氨醇及其衍生物的化合物诱导瘙痒的动物施用瘙痒抑制物质; 和(b)当动物划伤时计数。 用于诱导瘙痒的组合物包含至少一种选自葡糖基鞘氨醇及其衍生物的化合物作为有效成分。
    • 9. 发明公开
    • CCL27/CTACK의 발현을 억제시키는 방법
    • 抑制CCL27 / CTACK表达的方法
    • KR1020080034575A
    • 2008-04-22
    • KR1020060100703
    • 2006-10-17
    • (주)아모레퍼시픽
    • 성기사김형준김혁김대권조선아김광미이창훈김정주
    • A61K31/047A61K31/13
    • A61K31/047
    • A method for inhibiting the expression of CCL27/CTACK(Cutaneous T-cell-attracting chemokine) is provided to regulate SPC(sphingosylphosphorylcholine) inducing expression of CCL27/CTACK, so that the method is useful for prevention and treatment of diseases associated with overexpression of CCL27/CTACK including atopic dermatitis, psoriasis and inflammatory skin disease. The expression of CCL27/CTACK is inhibited by administering an effective amount of sphingosylphosphorylcholine regulator capable of inhibiting activity of SPC or competing with the mechanism of SPC inducing overexpression of CCL27/CTACK to a mammal requiring the expression reduction of CCL27/CTACK. A method for screening the SPC regulator comprises the steps of: (1) treating a testing cell such as keratinocyte with 2-10 muM of SPC or its derivatives to induce overexpression of CCL27/CTACK; and (2) treating the overexpression of CCL27/CTACK-induced cell with a candidate material and measuring the expression inhibition of CCL27/CTACK. Further, the mammal has an atopic dermatitis or psoriasis.
    • 提供抑制CCL27 / CTACK(皮肤T细胞吸引趋化因子)表达的方法,以调节诱导CCL27 / CTACK表达的SPC(鞘氨醇磷酰胆碱),从而该方法可用于预防和治疗与过表达相关的疾病 CCL27 / CTACK包括特应性皮炎,牛皮癣和炎性皮肤病。 通过施用有效量的能够抑制SPC活性或与诱导CCL27 / CTACK过表达的SPC的机制竞争需要CCL27 / CTACK表达降低的哺乳动物,CCL27 / CTACK的表达被抑制。 用于筛选SPC调节剂的方法包括以下步骤:(1)用2-10μM的SPC或其衍生物处理测试细胞如角质细胞,以诱导CCL27 / CTACK的过度表达; 和(2)用候选物质治疗CCL27 / CTACK诱导的细胞的过度表达,并测量CCL27 / CTACK的表达抑制。 此外,哺乳动物具有特应性皮炎或牛皮癣。
    • 10. 发明公开
    • 생약 추출물을 함유하는 가려움증 억제 및 완화용 조성물
    • 组合物包含原发性药物提取物显示抗病毒作用
    • KR1020070107961A
    • 2007-11-08
    • KR1020060040588
    • 2006-05-04
    • (주)아모레퍼시픽
    • 김대권성대석김광미김형준한지숙김혁성기사박종희조선아이창훈김정주
    • A61K36/9068A61K36/754
    • A61K36/00A61K8/97A61K9/00A61K36/754A61K36/9062A61K36/9068A61K2236/33A61Q19/00A61Q19/005Y10S514/857
    • A composition comprising extracts of crude drugs is provided to suppress and relieve itching caused by inflammatory and atopic dermatitis without side effects such as toxicity and skin irritation. A composition for suppressing and relieving itching comprises 0.1-10 wt.% of the extracts of Zingiber officinale Rosc., Evodia officinalis and Alpinia katsumadai Hayata which are prepared by extracting them with water, C1-C4 lower alcohol or a mixed solvent thereof. The daily dosage of crude drug extracts is 0.001-100 mg/kg, preferably 0.1-30 mg/kg and the composition is a pharmaceutical composition having a formulation selected from ointment, plaster, lotion and liniment, or a cosmetic composition having a formulation selected from skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nutrition lotion, massage cream, nutrition cream, moisture cream, hand cream, foundation, essence, nutrition essence, pack, soap, cleansing foam, cleansing lotion, cleansing cream, body lotion and body cleanser.
    • 提供包含生药提取物的组合物以抑制和缓解由炎性和特应性皮炎引起的瘙痒,而没有副作用,例如毒性和皮肤刺激。 用于抑制和缓解瘙痒的组合物包括通过用水,C1-C4低级醇或其混合溶剂提取它们制备的姜黄提取物的0.1-10重量%的提取物。 生药提取物的日剂量为0.001-100mg / kg,优选0.1-30mg / kg,并且组合物是具有选自软膏,石膏,洗剂和搽剂的制剂的药物组合物或具有选择的制剂的化妆品组合物 从皮肤洗剂,皮肤柔肤剂,皮肤调色剂,收敛剂,乳液,乳液,滋润乳液,营养乳液,按摩霜,营养霜,保湿霜,护手霜,粉底,精华,营养精华,包装,肥皂,清洁泡沫,清洁 洗剂,清洁霜,身体乳液和身体清洁剂。