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1. 发明专利

CA2037202A1 Mini-Size Universal Hydraulic Excavator 未知
公开(公告)号：CA2037202A1
公开(公告)日：1991-10-05
申请号：CA2037202
申请日：1991-02-27
申请人： ZHONG PEI QIAN , YANG JUN ZHI , LIANG JIAN HE , XU XI TIAN , ZHENG WEN KANG , ZHOU DONG SHEN
发明人： ZHONG PEI-QIAN , YANG JUN-ZHI , LIANG JIAN-HE , XU XI-TIAN , ZHENG WEN-KANG , ZHOU DONG-SHEN
IPC分类号： E02F3/96 , E02F5/00 , E02F3/28 , E02F3/36
摘要： A mini-size universal hydraulic excavator capable of performing independently many operating processes, such as digging, pushing, grabbing, drilling and chipping, having essentially three main sections, namely, a chassis carrying traveling device pivotally connected with an earth-moving means, a complete swivel upper carriage provided with a power generator and a driver's seat, and an excavating arm having a boom, a bucket arm, and a bucket. A hydraulic chipper can be connected to the main machine without the necessity of removal of the bucket and the earth-moving means, so that chipping and site clearing can be carried on simultaneously solely by one single machine. A backhoe bucket carrying a scraper employs a multi-bar linkage mechanism having a bucket body, a scraper, and a bucket arm so that the bucket can have sufficient bucket capacity in a relatively greater excavating revolving angle range. Specially-set accessory operating equipment oil lines are used to drive all the hydraulic operation equipments except the bucket.

2. 发明申请

WO2011022085A1 ACOUSTIC LENS FOR SHOCKWAVE LITHOTRIPSY AND RELATED METHODS 审中-公开
标题翻译：用于震荡岩石的声学透镜及相关方法
公开(公告)号：WO2011022085A1
公开(公告)日：2011-02-24
申请号：PCT/US2010/026654
申请日：2010-03-09
申请人： DUKE UNIVERSITY , ZHONG, Pei , PREMINGER, Glenn, M. , SANKIN, Georgy, N. , COCKS, Franklin, Hadley , SIMMONS, Walter, Neal
发明人： ZHONG, Pei , PREMINGER, Glenn, M. , SANKIN, Georgy, N. , COCKS, Franklin, Hadley , SIMMONS, Walter, Neal
IPC分类号： A61B17/22
CPC分类号： A61B17/225 , A61B17/22004
摘要： Systems and methods for providing therapeutic shock waves are provided. A modified acoustic lens can include a first lens portion for directing a first part of an acoustic shock wave pulse toward a target and a second lens portion for directing a second part of the acoustic shock wave pulse toward the target. The second lens portion can be offset relative to the first portion such that transmission of the second part of the acoustic shock wave pulse through the second lens portion is delayed by a predetermined amount relative to transmission of the first part through the first lens portion. In situ superposition of the first and second pulses near and at the target can lead to the formation of a pressure waveform with idealized pulse profile and broadened focal width, which can provide for improved comminution of a concretion located within a living body with reduced tissue injury.
摘要翻译：提供了提供治疗性冲击波的系统和方法。改进的声透镜可以包括用于将声波冲击波脉冲的第一部分引向目标的第一透镜部分和用于将声波冲击波脉冲的第二部分引向目标的第二透镜部分。第二透镜部分可以相对于第一部分偏移，使得通过第二透镜部分的声波冲击波脉冲的第二部分的传输相对于穿过第一透镜部分的第一部分的透射被延迟预定量。第一和第二脉冲在靶附近和在靶处的原位叠加可以导致形成具有理想脉冲轮廓和扩大的焦距宽度的压力波形，其可以提供位于活体内的凝结物的减少的组织损伤的改善粉碎。

3. 发明申请

WO2003042365A3 METHOD AND APPARATUS TO REDUCE TISSUE INJURY IN SHOCK WAVE LITHOTRIPSY 审中-公开
公开(公告)号：WO2003042365A3
公开(公告)日：2003-05-22
申请号：PCT/US2002/035922
申请日：2002-11-08
申请人： DUKE UNIVERSITY , ZHONG, Pei , ZHOU, Yufeng , COCKS, Franklin, H. , PREMINGER, Glenn, M.
发明人： ZHONG, Pei , ZHOU, Yufeng , COCKS, Franklin, H. , PREMINGER, Glenn, M.
IPC分类号： A61B17/22
摘要： A method to reduce vascular injury produced by lithotripter shock waves comprising the use of particular multi-pulsed shock waves which comminute human concretions with reduced vascular damage.

4. 发明申请

WO2011038235A1 METHODS AND APPARATUSES FOR GENERATING A STEERABLE PRESSURE FIELD IN A SHOCK WAVE LITHOTRIPTER 审中-公开
标题翻译：用于在震荡波形中产生可控压力场的方法和装置
公开(公告)号：WO2011038235A1
公开(公告)日：2011-03-31
申请号：PCT/US2010/050209
申请日：2010-09-24
申请人： DUKE UNIVERSITY , ZHONG, Pei , SIMMONS, Walter, Neal , SANKIN, Georgy, N. , SMITH, Nathan , COCKS, Franklin, Hadley , PREMINGER, Glenn, M.
发明人： ZHONG, Pei , SIMMONS, Walter, Neal , SANKIN, Georgy, N. , SMITH, Nathan , COCKS, Franklin, Hadley , PREMINGER, Glenn, M.
IPC分类号： A61B17/225
CPC分类号： A61B17/225
摘要： Lithotripter apparatuses and methods are provided for selectively modifying an acoustic pressure field and can include a shock wave source operable to generate a shock wave having a substantially axisymmetric acoustic pressure field, an acoustic focusing member positioned between the shock wave source and a target, and an acoustic barrier positioned between the shock wave source and the acoustic focusing member. The acoustic barrier can be operable to selectively block a portion of the shock wave generated by the shock wave source such that the substantially axisymmetric pressure field is transformed into a modified acoustic pressure field.
摘要翻译：提供了光折射器装置和方法，用于选择性地修改声压场，并且可以包括可操作以产生具有基本上轴对称声压场的冲击波的冲击波源，定位在冲击波源和目标之间的声聚焦构件，位于冲击波源和声聚焦构件之间的声屏障。声屏障可以可操作地选择性地阻挡由冲击波源产生的冲击波的一部分，使得基本上轴对称的压力场被转换成修改的声压场。

5. 发明申请

WO2005018469A1 APPARATUS FOR IMPROVED SHOCK-WAVE LITHOTRIPSY (SWL) USING A PIEZOELECTRIC ANNULAR ARRAY (PEAA) SHOCK-WAVE GENERATOR IN COMBINATION WITH A PRIMARY SHOCK WAVE 审中-公开
标题翻译：使用压电环形阵列（PEAA）冲击波发生器与主震波组合的改进的震荡波形（SWL）的装置
公开(公告)号：WO2005018469A1
公开(公告)日：2005-03-03
申请号：PCT/US2003/025305
申请日：2003-08-14
申请人： DUKE UNIVERSITY , ZHONG, Pei , XI, Xufeng , COCKS, Franklin, H. , PREMINGER, Glenn, M.
发明人： ZHONG, Pei , XI, Xufeng , COCKS, Franklin, H. , PREMINGER, Glenn, M.
IPC分类号： A61B17/22
CPC分类号： A61B17/225 , A61B2017/22008 , A61B2017/22027 , A61B2017/22028 , G10K15/043
摘要： Six focused sets of piezoelectric elements (212) are positioned around the reflector R and the axis of the primary shock wave source (210) to form a combined shock wave generator (200).
摘要翻译：六个聚焦组的压电元件（212）围绕反射器R和主冲击波源（210）的轴线定位，以形成组合的冲击波发生器（200）。

6. 发明申请

WO03042365A2 METHOD AND APPARATUS TO REDUCE TISSUE INJURY IN SHOCK WAVE LITHOTRIPSY 审中-公开
标题翻译：减少震荡波中组织损伤的方法和装置
公开(公告)号：WO03042365A2
公开(公告)日：2003-05-22
申请号：PCT/US0235922
申请日：2002-11-08
申请人： UNIV DUKE , ZHONG PEI , ZHOU YUFENG , COCKS FRANKLIN H , PREMINGER GLENN M
发明人： ZHONG PEI , ZHOU YUFENG , COCKS FRANKLIN H , PREMINGER GLENN M
IPC分类号： A61B17/00 , A61B17/22 , A61B17/225 , C12N
CPC分类号： A61B17/22004 , A61B17/22029 , A61B17/2251 , A61B2017/0073 , A61B2017/22008 , A61B2017/22009
摘要： A method to reduce vascular injury produced by lithotripter shock waves comprising the use of particular multi-pulsed shock waves which comminute human concretions with reduced vascular damage.
摘要翻译：一种减少碎石冲击波产生的血管损伤的方法，包括使用特定的多脉冲冲击波，其消除具有减少的血管损伤的人体结构。

7. 发明申请

US20150105460A1 LABDANE DITERPENOID COMPOUNDS, SEMEN BIOTAE EXTRACT, AND PREPARATION METHOD AND USE THEREOF 审中-公开
标题翻译： LABDANE DITERPENOID化合物，SEMEN BIOTAE EXTRACT及其制备方法及其用途
公开(公告)号：US20150105460A1
公开(公告)日：2015-04-16
申请号：US14404644
申请日：2012-06-04
申请人： Weiwei Su , Yonggang Wang , Fengyin Liang , Ning Wang , Zhong Pei , Haibin Liu
发明人： Weiwei Su , Yonggang Wang , Fengyin Liang , Ning Wang , Zhong Pei , Haibin Liu
IPC分类号： A61K36/14 , C07C62/36 , C07C62/32 , C07C61/35 , C07D307/58 , C07C62/30 , C07C49/755 , C07D307/60 , C07C62/38
CPC分类号： A61K36/14 , A61K31/194 , A61K31/341 , A61K31/365 , C07C49/755 , C07C61/35 , C07C62/30 , C07C62/32 , C07C62/36 , C07C62/38 , C07D307/20 , C07D307/28 , C07D307/58 , C07D307/60
摘要： Provided in the present invention are various labdane diterpenoid compounds and derivatives thereof for use in preparation of a pharmaceutical composition for preventing or treating neurodegenerative diseases. Also provided in the present invention is a semen biotae extract comprising one or more labdane diterpenoid compounds and derivatives thereof for use in preparation of a pharmaceutical composition for preventing or treating neurodegenerative diseases.
摘要翻译：在本发明中提供了用于制备用于预防或治疗神经变性疾病的药物组合物的各种实体烷二酮化合物及其衍生物。本发明还提供了含有一种或多种实体烷二酮化合物及其衍生物的精液生物提取物，其用于制备用于预防或治疗神经变性疾病的药物组合物。

8. 发明申请

US20160082059A1 METHOD FOR PREVENTING OR TREATING NEURODEGENERATIVE DISEASES 审中-公开
标题翻译：预防或治疗神经营养因子疾病的方法
公开(公告)号：US20160082059A1
公开(公告)日：2016-03-24
申请号：US14961823
申请日：2015-12-07
申请人： Weiwei Su , Yonggang Wang , Fengyin Liang , Ning Wang , Zhong Pei , Haibin Liu
发明人： Weiwei Su , Yonggang Wang , Fengyin Liang , Ning Wang , Zhong Pei , Haibin Liu
IPC分类号： A61K36/14 , A61K31/19 , A61K31/047 , A61K31/194 , A61K31/122 , A61K31/341 , A61K31/365 , A61K31/215
CPC分类号： A61K36/14 , A61K31/00 , A61K31/047 , A61K31/122 , A61K31/19 , A61K31/194 , A61K31/215 , A61K31/341 , A61K31/365 , A61K2236/00
摘要： Provided herein is a method for preventing or treating neurodegenerative disease in a subject, comprising administrating to the subject an effective amount of a composition which comprises a semen biotae extract. The neurodegenerative disease is associated with α-synuclein, such as Alzheimer's disease, Parkinson's disease, Huntington disease, or Amyotrophic lateral sclerosis.
摘要翻译：本文提供了一种用于预防或治疗受试者的神经退行性疾病的方法，其包括向受试者施用有效量的包含精液生物提取物的组合物。神经变性疾病与α-突触核蛋白如阿尔茨海默病，帕金森病，亨廷顿病或肌萎缩性侧索硬化有关。

9. 发明授权

US5184933A Mini-size universal hydraulic excavator 失效
标题翻译：小型通用液压挖掘机
公开(公告)号：US5184933A
公开(公告)日：1993-02-09
申请号：US661985
申请日：1991-02-27
申请人： Zhong Pei-qian , Zheng Wen-kang , Xu Xi-tian , Liang Jian-he , Zhou Dong-shen , Yang Jun-zhi
发明人： Zhong Pei-qian , Zheng Wen-kang , Xu Xi-tian , Liang Jian-he , Zhou Dong-shen , Yang Jun-zhi
IPC分类号： E02F3/96 , E02F5/00
CPC分类号： E02F5/00 , E02F3/963
摘要： A mini-size universal hydraulic excavator capable of performing independently many operating processes, such as digging, pushing, grabbing, drilling and chipping, having essentially three main sections, namely, a chassis carrying traveling device pivotally connected with an earth-moving means, a complete swivel upper carriage provided with a power generator and a driver's seat, and an excavating arm having a boom, a bucket arm, and a bucket. A hydraulic chipper can be connected to the main machine without the necessity of removal of the bucket and the earth-moving means, so that chipping and site clearing can be carried on simultaneously solely by one single machine. A backhoe bucket carrying a scraper employs a multi-bar linkage mechanism having a bucket body, a scraper, and a bucket arm so that the bucket can have sufficient bucket capacity in a relatively greater excavating revolving angle range. Specially-set accessory operating equipment oil lines are used to drive all the hydraulic operation equipments except the bucket.
摘要翻译：一种小型通用液压挖掘机，其能够独立地执行诸如挖掘，推动，抓取，钻孔和切屑的许多操作过程，其具有基本上三个主要部分，即与地球移动装置枢转连接的底盘承载行进装置，具有动力发电机和驾驶员座椅的完整的转动上部托架，以及具有起重臂，铲斗和铲斗的挖掘臂。液压切片机可以连接到主机，而不需要移除铲斗和移土装置，从而可以通过一台机器同时进行切屑和现场清理。携带刮板的反铲斗采用具有铲斗本体，铲斗和铲斗臂的多杆连杆机构，使得铲斗能够在相对较大的挖掘旋转角度范围内具有足够的铲斗容量。专用配套操作设备油路用于驱动除铲斗外的所有液压操作设备。

10. 发明授权

US09682111B2 Method for preventing or treating neurodegenerative diseases 有权
公开(公告)号：US09682111B2
公开(公告)日：2017-06-20
申请号：US14961823
申请日：2015-12-07
申请人： Weiwei Su , Yonggang Wang , Fengyin Liang , Ning Wang , Zhong Pei , Haibin Liu
发明人： Weiwei Su , Yonggang Wang , Fengyin Liang , Ning Wang , Zhong Pei , Haibin Liu
IPC分类号： A61K31/34 , A61K36/14 , A61K31/365 , A61K31/19 , A61K31/215 , A61K31/194 , A61K31/122 , A61K31/341 , A61K31/047 , A61K31/00
CPC分类号： A61K36/14 , A61K31/00 , A61K31/047 , A61K31/122 , A61K31/19 , A61K31/194 , A61K31/215 , A61K31/341 , A61K31/365 , A61K2236/00
摘要： Provided herein is a method for preventing or treating neurodegenerative disease in a subject, comprising administrating to the subject an effective amount of a composition which comprises a semen biotae extract. The neurodegenerative disease is associated with α-synuclein, such as Alzheimer's disease, Parkinson's disease, Huntington disease, or Amyotrophic lateral sclerosis.

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