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1. 发明授权

US07468249B2 Detection of chromosomal disorders 失效
标题翻译：检测染色体异常
公开(公告)号：US07468249B2
公开(公告)日：2008-12-23
申请号：US10840208
申请日：2004-05-05
申请人： Zhiyi Xie , Soonkap Hahn , Tim Watanaskul
发明人： Zhiyi Xie , Soonkap Hahn , Tim Watanaskul
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q2537/143 , C12Q2531/113
摘要： Methods for detecting in a single assay any one of multiple chromosomal disorders that result from aneuploidy or certain mutations, particularly microdeletions, and kits for use therein. A polymerase chain reaction (PCR) is carried out to amplify eukaryotic genomic DNA using a plurality of primer oligonucleotide pairs wherein one primer of each pair has a detectable label attached 5′ thereto. A plurality of the primer pairs are targeted to DNA segments of different chromosomes of interest which are indicative of potential chromosomal disorders, and one pair is targeted for a control gene. The amplified PCR products are purified, and single-stranded DNA having the detectable labels is obtained therefrom and hybridized with spots on a microarray that each contain DNA oligonucleotide probes having nucleotide sequences complementary to a nucleotide sequence of one strand of each segment. The microarray is imaged for presence of labels on its respective spots, and the absence or presence of chromosomal disorders as indicated by one or more of the targeted DNA segments of interest is diagnosed by first comparing the imaging results to the imaging of spots specific to the control gene and then to results obtained from imaging normal DNA.
摘要翻译：在单次测定中检测由非整倍体或某些突变，特别是微缺失引起的多种染色体紊乱中的任何一种以及用于其中的试剂盒的方法。进行聚合酶链反应（PCR）以使用多个引物寡核苷酸对扩增真核基因组DNA，其中每对的一个引物具有附着5'的可检测标记。多个引物对靶向不同染色体的DNA片段，其指示潜在的染色体病症，一对靶向对照基因。纯化扩增的PCR产物，从其中获得具有可检测标记的单链DNA，并与微阵列上的斑点杂交，每个点均含有具有与每个片段的一条链的核苷酸序列互补的核苷酸序列的DNA寡核苷酸探针。成像微阵列以在其各自的斑点上存在标记，并且通过首先将成像结果与成像特异性的斑点的成像进行比较来诊断由一个或多个目标DNA片段指示的染色体病症的不存在或存在控制基因，然后从成像正常DNA获得的结果。

2. 发明授权

US07779309B2 Correlating complex errors with generalized end-user tasks 有权
标题翻译：将复杂错误与广义的最终用户任务相关联
公开(公告)号：US07779309B2
公开(公告)日：2010-08-17
申请号：US11936533
申请日：2007-11-07
申请人： Bernard Pham , Eric B. Watson , Zhiyi Xie
发明人： Bernard Pham , Eric B. Watson , Zhiyi Xie
IPC分类号： G06F11/00
CPC分类号： H04L41/22 , G06F11/0709 , G06F11/0715 , G06F11/0769 , G06F11/0784 , G06Q10/10 , H04L41/5074 , H04L43/0817
摘要： A system for reporting and/or displaying errors in a system that affect end-user tasks includes mechanisms for gathering, interpreting and displaying application status information in a convenient display. In one implementation, for example, distributed application programs in a system are configured to provide status reports (e.g., positive, negative, pending) to a centralized reporting service. The centralized service stores the status information in a database. An event interpreter module queries the database to identify the status of certain application components that affect or otherwise implicate performance of generalized end-user tasks, such as sending/receiving email, logging-in to the network, accessing the internet, remote computer management, or the like. A graphical user interface can then display this information to the administrator in a way that immediately indicates what end-user tasks might be affected by failure or correct execution of a given application component, as well as suggested corrective action as needed.
摘要翻译：用于报告和/或显示影响最终用户任务的系统中的错误的系统包括用于在方便的显示中收集，解释和显示应用状态信息的机制。在一个实现中，例如，系统中的分布式应用程序被配置为向集中式报告服务提供状态报告（例如，正，负，待定）。集中式服务将状态信息存储在数据库中。事件解释器模块查询数据库以识别某些应用程序组件的状态，这些应用程序组件影响或以其他方式影响广义的最终用户任务的性能，例如发送/接收电子邮件，登录到网络，访问互联网，远程计算机管理，或类似物。然后，图形用户界面可以以立即显示最终用户任务可能受到给定应用程序组件的失败或正确执行的影响以及根据需要建议的纠正措施的方式将该信息显示给管理员。

3. 发明申请

US20070016976A1 Plant genes involved in defense against pathogens 审中-公开
标题翻译：涉及防治病原体的植物基因
公开(公告)号：US20070016976A1
公开(公告)日：2007-01-18
申请号：US09887272
申请日：2001-06-22
申请人： Fumiaki Katagiri , Yu-Ming Hou , Sheng Quan , Hur-Song Chang , Tong Zhu , Steve Whitham , Steve Goff , Bret Cooper , Jane Glazebrook , Wenquiong Chen , Zhiyi Xie , Yi Tao , Guangzhou Zou
发明人： Fumiaki Katagiri , Yu-Ming Hou , Sheng Quan , Hur-Song Chang , Tong Zhu , Steve Whitham , Steve Goff , Bret Cooper , Jane Glazebrook , Wenquiong Chen , Zhiyi Xie , Yi Tao , Guangzhou Zou
IPC分类号： A01H5/00 , C07H21/04 , C12N5/04
CPC分类号： C07K14/415 , C12N15/8239 , C12N15/8279 , C12N15/8281 , C12N15/8282 , C12N15/8283
摘要： Methods to identify genes, the expression of which are altered in response to pathogen infection, are provided, as well as the genes identified thereby and their corresponding promoters.
摘要翻译：提供了识别基因，其表达被响应于病原体感染而改变的方法，以及由此鉴定的基因及其相应的启动子。

4. 发明授权

US08983945B1 Matching video content to video bibliographic data 有权
标题翻译：将视频内容与视频书目数据进行匹配
公开(公告)号：US08983945B1
公开(公告)日：2015-03-17
申请号：US13342617
申请日：2012-01-03
申请人： Zhiyi Xie , Varun Kacholia , Minya Dai , Patrick Hung , Kun Zhang , Jonathan Eng , Nicola Muscettola , Omer Bar-or , Aparna Chennapragada , Nitin Khandelwal
发明人： Zhiyi Xie , Varun Kacholia , Minya Dai , Patrick Hung , Kun Zhang , Jonathan Eng , Nicola Muscettola , Omer Bar-or , Aparna Chennapragada , Nitin Khandelwal
IPC分类号： G06F17/30
CPC分类号： G06F17/3082 , G06F17/30823
摘要： The present disclosure relates to the identification of video content. In one aspect, a method includes generating a query based on bibliographic data. The method also includes obtaining a collection of resources responsive to the query, wherein one or more of the resources include text and video content. The method further includes calculating occurrence scores for the resources. A particular occurrence score for a particular resource is based at least in part on the bibliographic data matching text included in the particular resource and the text being associated with video content. The method further includes selecting one or more resources as including video content identified by the bibliographic data using the occurrence scores. The method further includes storing data associating the selected resources with the bibliographic data.
摘要翻译：本公开涉及视频内容的识别。一方面，一种方法包括基于书目数据生成查询。该方法还包括响应于查询获得资源集合，其中一个或多个资源包括文本和视频内容。该方法还包括计算资源的发生得分。特定资源的特定出现分数至少部分地基于包括在特定资源中的书目数据匹配文本和与视频内容相关联的文本。该方法还包括使用发生得分将一个或多个资源选择为包括由书目数据标识的视频内容。该方法还包括存储将所选择的资源与书目数据相关联的数据。

5. 发明申请

US20090119545A1 CORRELATING COMPLEX ERRORS WITH GENERALIZED END-USER TASKS 有权
标题翻译：与通用的最终用户任务相关的复杂错误
公开(公告)号：US20090119545A1
公开(公告)日：2009-05-07
申请号：US11936533
申请日：2007-11-07
申请人： Bernard Pham , Eric B. Watson , Zhiyi Xie
发明人： Bernard Pham , Eric B. Watson , Zhiyi Xie
IPC分类号： G06F11/30 , G06F11/32 , G06F17/30
CPC分类号： H04L41/22 , G06F11/0709 , G06F11/0715 , G06F11/0769 , G06F11/0784 , G06Q10/10 , H04L41/5074 , H04L43/0817
摘要： A system for reporting and/or displaying errors in a system that affect end-user tasks includes mechanisms for gathering, interpreting and displaying application status information in a convenient display. In one implementation, for example, distributed application programs in a system are configured to provide status reports (e.g., positive, negative, pending) to a centralized reporting service. The centralized service stores the status information in a database. An event interpreter module queries the database to identify the status of certain application components that affect or otherwise implicate performance of generalized end-user tasks, such as sending/receiving email, logging-in to the network, accessing the internet, remote computer management, or the like. A graphical user interface can then display this information to the administrator in a way that immediately indicates what end-user tasks might be affected by failure or correct execution of a given application component, as well as suggested corrective action as needed.
摘要翻译：用于报告和/或显示影响最终用户任务的系统中的错误的系统包括用于在方便的显示中收集，解释和显示应用状态信息的机制。在一个实现中，例如，系统中的分布式应用程序被配置为向集中式报告服务提供状态报告（例如，正，负，待定）。集中式服务将状态信息存储在数据库中。事件解释器模块查询数据库以识别某些应用程序组件的状态，这些应用程序组件影响或以其他方式影响广义的最终用户任务的性能，例如发送/接收电子邮件，登录到网络，访问互联网，远程计算机管理，或类似物。然后，图形用户界面可以以立即显示最终用户任务可能受到给定应用程序组件的失败或正确执行的影响以及根据需要建议的纠正措施的方式将该信息显示给管理员。

6. 发明申请

US20050250111A1 Detection of chromosomal disorders 失效
标题翻译：检测染色体异常
公开(公告)号：US20050250111A1
公开(公告)日：2005-11-10
申请号：US10840208
申请日：2004-05-05
申请人： Zhiyi Xie , Soonkap Hahn , Tim Watanaskul
发明人： Zhiyi Xie , Soonkap Hahn , Tim Watanaskul
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6837 , C12Q2537/143 , C12Q2531/113
摘要： Methods for detecting in a single assay any one of multiple chromosomal disorders that result from aneuploidy or certain mutations, particularly microdeletions, and kits for use therein. A polymerase chain reaction (PCR) is carried out to amplify eukaryotic genomic DNA using a plurality of primer oligonucleotide pairs wherein one primer of each pair has a detectable label attached 5′ thereto. A plurality of the primer pairs are targeted to DNA segments of different chromosomes of interest which are indicative of potential chromosomal disorders, and one pair is targeted for a control gene. The amplified PCR products are purified, and single-stranded DNA having the detectable labels is obtained therefrom and hybridized with spots on a microarray that each contain DNA oligonucleotide probes having nucleotide sequences complementary to a nucleotide sequence of one strand of each segment. The microarray is imaged for presence of labels on its respective spots, and the absence or presence of chromosomal disorders as indicated by one or more of the targeted DNA segments of interest is diagnosed by first comparing the imaging results to the imaging of spots specific to the control gene and then to results obtained from imaging normal DNA.
摘要翻译：在单次测定中检测由非整倍体或某些突变，特别是微缺失引起的多种染色体紊乱中的任何一种以及用于其中的试剂盒的方法。进行聚合酶链反应（PCR）以使用多个引物寡核苷酸对扩增真核基因组DNA，其中每对的一个引物具有附着5'的可检测标记。多个引物对靶向不同染色体的DNA片段，其指示潜在的染色体病症，一对靶向对照基因。纯化扩增的PCR产物，从其中获得具有可检测标记的单链DNA，并与微阵列上的斑点杂交，每个点均含有具有与每个片段的一条链的核苷酸序列互补的核苷酸序列的DNA寡核苷酸探针。成像微阵列以在其各自的斑点上存在标记，并且通过首先将成像结果与成像特异性的斑点的成像进行比较来诊断由一个或多个目标DNA片段指示的染色体病症的不存在或存在控制基因，然后从成像正常DNA获得的结果。

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