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1. 发明授权

US09006460B2 Process for preparing aminocyclohexyl ether compounds 有权
标题翻译：制备氨基环己基醚化合物的方法
公开(公告)号：US09006460B2
公开(公告)日：2015-04-14
申请号：US13817274
申请日：2011-08-08
申请人： John Limanto , Gregory L. Beutner , Jingjun Yin , Artis Klapars , Eric R. Ashley , Hallena R. Strotman , Matthew D. Truppo , Cheol K. Chung , Gregory Hughes , Zhijian Liu , Brendan Grau , Jacob Janey
发明人： John Limanto , Gregory L. Beutner , Jingjun Yin , Artis Klapars , Eric R. Ashley , Hallena R. Strotman , Matthew D. Truppo , Cheol K. Chung , Gregory Hughes , Zhijian Liu , Brendan Grau , Jacob Janey
IPC分类号： C07D207/12 , C12P17/10
CPC分类号： C07D207/12 , C07C217/52 , C07D207/416 , C12P17/10
摘要： The present invention relates to a process for preparing aminocyclohexyl ether compounds of Formula I: or the pharmaceutically acceptable salts and esters thereof. In particular, the instant invention is directed towards a process for preparing (1R,2R)-2-[(3R)-Hydroxypyrrolidinyl]-1-(3,4-dimethoxyphenethoxy)-cyclohexane as well as various intermediates.
摘要翻译：本发明涉及制备式I的氨基环己基醚化合物或其药学上可接受的盐和酯的方法。特别地，本发明涉及制备（1R，2R）-2 - [（3R） - 羟基吡咯烷基] -1-（3,4-二甲氧基苯乙氧基） - 环己烷以及各种中间体的方法。

2. 发明申请

US20130141048A1 BATTERY MANAGEMENT SYSTEM 审中-公开
标题翻译：电池管理系统
公开(公告)号：US20130141048A1
公开(公告)日：2013-06-06
申请号：US13363925
申请日：2012-02-01
申请人： Jen-Chin Huang , Zhijian Liu
发明人： Jen-Chin Huang , Zhijian Liu
IPC分类号： H02J7/00
CPC分类号： H02J7/0021 , H02J7/0018
摘要： In one aspect of the invention, a battery management system includes a plurality of battery units, a voltage sensing module for detecting a voltage of each battery unit, an active balancing module for reducing a total voltage of the battery units and transmitting the reduced total voltage to a given battery unit needed to be charged, a controller electrically connected with the voltage sensing module and the active balancing module, and signal buses electrically connected with the voltage sensing module and the active balancing module. The signal buses are controlled by the controller to selectively electrically connect with the positive pole and the negative pole of one of the battery units. The controller is adapted for obtaining voltage signals from the voltage sensing module, determining the given battery unit according to the obtained voltage signals, and controlling power provided by the active balancing module for charging the given battery unit.
摘要翻译：在本发明的一个方面，电池管理系统包括多个电池单元，用于检测每个电池单元的电压的电压感测模块，用于降低电池单元的总电压并传送降低的总电压的主动平衡模块对于需要充电的给定电池单元，与电压感测模块和主动平衡模块电连接的控制器以及与电压感测模块和主动平衡模块电连接的信号总线。信号总线由控制器控制，以选择性地电连接一个电池单元的正极和负极。控制器适于从电压感测模块获得电压信号，根据获得的电压信号确定给定的电池单元，以及控制由主动平衡模块提供的用于对给定电池单元充电的电力。

3. 发明申请

US20130141047A1 BATTERY MANAGEMENT SYSTEM AND METHOD THEREOF 审中-公开
标题翻译：电池管理系统及其方法
公开(公告)号：US20130141047A1
公开(公告)日：2013-06-06
申请号：US13364154
申请日：2012-02-01
申请人： Jen-Chin HUANG , Zhijian LIU
发明人： Jen-Chin HUANG , Zhijian LIU
IPC分类号： H02J7/00
CPC分类号： H02J7/0018
摘要： The present invention relates to a battery management system and a method thereof. The system includes a number of battery units connected in series, a DC/DC converter module and a controller controlling the DC/DC converter module to operate under one of at least two operation modes. The battery units include a given battery unit needed to be charged. When the DC/DC converter module operates in a first operation mode, the DC/DC converter module receives and reduces a total voltage of all the battery units and transmits the reduced voltage to charge the given battery unit. When the DC/DC converter module operates in a second operation mode, the DC/DC converter module receives and converts a cumulated voltage of part of the battery units and transmits the converted voltage to charge the given battery unit.
摘要翻译：电池管理系统及其方法技术领域本发明涉及电池管理系统及其方法。该系统包括串联连接的多个电池单元，DC / DC转换器模块和控制DC / DC转换器模块以在至少两种操作模式之一下操作的控制器。电池单元包括需要充电的给定电池单元。当DC / DC转换器模块在第一操作模式下工作时，DC / DC转换器模块接收并降低所有电池单元的总电压，并发送降低的电压以对给定的电池单元充电。当DC / DC转换器模块在第二操作模式下工作时，DC / DC转换器模块接收并转换部分电池单元的累积电压并传送转换的电压以对给定的电池单元充电。

4. 发明申请

US20130141034A1 CHARGING MANAGEMENT SYSTEM AND CHARGER WITH THE SAME 有权
标题翻译：充电管理系统和充电器
公开(公告)号：US20130141034A1
公开(公告)日：2013-06-06
申请号：US13362853
申请日：2012-01-31
申请人： Jen-Chin Huang , Zhijian Liu
发明人： Jen-Chin Huang , Zhijian Liu
IPC分类号： H02J7/00
CPC分类号： H02J7/045 , H02J2007/0098 , Y02B40/90
摘要： The present invention discloses a charging management system and a charger with such charging management system. The charging management system includes a first signal-output port, a second signal-output port, a third signal-output port and a controller electrically connected with the first, second and third signal-output ports. The first and second signal-output ports are adapted for outputting first and second control signals representing first and second charging currents, respectively, to a charging circuit. The third signal-output port is adapted for outputting a third control signal representing a variable third charging current to the charging circuit. The controller controls the charging management system to operate under at least one of two modes. In the first mode, the controller alternately controls the first and second signal-output ports to output the first and second control signals. In the second mode, the controller only controls the third signal-output port to output the third control signal.
摘要翻译：本发明公开了一种带充电管理系统的充电管理系统和充电器。充电管理系统包括第一信号输出端口，第二信号输出端口，第三信号输出端口和与第一，第二和第三信号输出端口电连接的控制器。第一和第二信号输出端口分别用于将表示第一和第二充电电流的第一和第二控制信号分别输出到充电电路。第三信号输出端口用于向充电电路输出表示可变的第三充电电流的第三控制信号。控制器控制充电管理系统在两种模式中的至少一种下工作。在第一模式中，控制器交替地控制第一和第二信号输出端口以输出第一和第二控制信号。在第二模式中，控制器仅控制第三信号输出端口输出第三控制信号。

5. 发明申请

US20090156824A1 Hydroamination of Alkenes 有权
标题翻译：烯烃的水分
公开(公告)号：US20090156824A1
公开(公告)日：2009-06-18
申请号：US12251062
申请日：2008-10-14
申请人： Akihiro Takemiya , Zhijian Liu , John F. Hartwig
发明人： Akihiro Takemiya , Zhijian Liu , John F. Hartwig
IPC分类号： C07C209/60 , B01J31/02 , C07D295/02 , C07D209/54 , C07D211/06
CPC分类号： C07D207/06 , B01J31/1805 , B01J31/2404 , B01J31/2409 , B01J31/2452 , B01J2231/324 , B01J2531/822 , C07C209/60 , C07D207/09 , C07D207/12 , C07D209/96 , C07D211/12 , C07D211/14
摘要： A method includes reacting an amino group, a composition including rhodium and an organic ligand, and a substrate having structural formula (I) in a reaction mixture. R1 is an organic group including a sp3 carbon atom bonded to CA. R2 is selected from the group consisting of hydrogen, methyl, and an organic group including a sp3 carbon atom bonded to CA. R3 and R4 independently are selected from the group consisting of hydrogen, methyl, and an organic group including a sp3 carbon atom bonded to CB. The method further includes forming a hydroaminated product in the reaction mixture.
摘要翻译：一种方法包括在反应混合物中使氨基，包含铑和有机配体的组合物和具有结构式（I）的底物反应。 R1是包含与CA键合的sp3碳原子的有机基团。 R2选自氢，甲基和包括与CA结合的sp 3碳原子的有机基团。 R 3和R 4独立地选自氢，甲基和包含与CB结合的sp 3碳原子的有机基团。所述方法还包括在所述反应混合物中形成聚氨酯产物。

6. 发明公开

US20230287032A1 SYNTHESIS OF FLUORINATED NUCLEOTIDES 审中-公开
公开(公告)号：US20230287032A1
公开(公告)日：2023-09-14
申请号：US18040679
申请日：2021-08-11
申请人： Cheol Keun CHUNG , Zhijian LIU , Peter E. MALIGRES , Edna MAO , Jennifer V. OBLIGACION , Eric M. PHILLIPS , Michael PIRNOT , Marc POIRIER , Zhiguo Jake SONG , Tao WANG , Merck Sharp & Dohme LLC
发明人： Cheol Keun Chung , Zhijian Liu , Peter E. Maligres , Edna Mao , Jennifer V. Obligacion , Eric M. Phillips , Michael Pirnot , Marc Poirier , Zhiguo Jake Song , Tao Wang
IPC分类号： C07H19/16
CPC分类号： C07H19/16
摘要： The present invention relates to efficient processes useful in the preparation of fluorinated nucleosides, such as (O—{[(2R,3R,4S,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-3-hydroxyoxolan-2-yl]methyl}O,O-dihydrogen phosphorothioate, also known as 2′-(S)-fluoro-thio-adenosine monophosphate or 2′-F-thio-AMP. Such fluorinated nucleosides may be useful as a biologically active compound and or as an intermediate for the synthesis of more complex biologically active compounds. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.

7. 发明申请

US20160122350A1 PROCESS FOR THE PREPARATION OF CHIRAL TERT-BUTYL 4-((1R,2S,5R)-6-(BENZYLOXY)-7-OXO-1,6-DIAZABICYCLO[3.2.1]OCTANE-2-CARBOXAMIDO)PIPERIDINE-1-CARBOXYLATE DERIVATIVES AND (2S,5R)-7-OXO-N-PIPERIDIN-4-YL-6-(SULFOXY)-1,6-DIAZABICYCLO[3.2.1]OCTANE-2-CARBOXAMIDE 有权
标题翻译：制备叔丁基叔丁基-4 - （（1R，2S，5R）-6-（苯甲酰基）-7-氧代-1,6-二氮杂双环[3.2.1]十二碳二羧酸的制备方法）羧酸酯衍生物和（2S，5R）-7-氧代-N-哌啶-4-基-6-（磺酰基）-1,6-二氮杂双环〔3.2.1〕十二碳二羧酸
公开(公告)号：US20160122350A1
公开(公告)日：2016-05-05
申请号：US14897290
申请日：2014-06-05
申请人： Steven P. MILLER , John LIMANTO , Yong-Li ZHONG , Nobuyoshi YASUDA , Zhijian LIU , MERCK SHARP & DOHME CORP.
发明人： Steven P. Miller , John Limanto , Yong-Li Zhong , Nobuyoshi Yasuda , Zhijian Liu
IPC分类号： C07D471/08 , C07D401/12
CPC分类号： C07D471/08 , C07D211/62 , C07D401/12 , C07D491/08 , Y02P20/55
摘要： A process for the preparation of N-protected 6-(piperidin-4-ylcarbamoyl)piperidin-3-yl sulfonates of Formula (III): which comprises contacting a lactone of Formula (II): with an azacycloalkylamine of formula (II-Am): followed by contact with a sulfonyl halide of formula (II-Su): R4—SO2W (II-Su) in the presence of tertiary amine base, wherein PG1 and PG2 are amine protective groups; k, p and q are 0, 1, or 2, and W, R2, R3, R4, R5, R6, R7, R8, and R9 are defined herein. Additional embodiments add a series of process steps leading to the synthesis of 7-oxo-1,6-diazabicyclo[3.2.1]octanes suitable for use as β-lactamase inhibitors.
摘要翻译：制备式（III）的N-保护的6-（哌啶-4-基氨基甲酰基）哌啶-3-基磺酸盐的方法：其包括使式（II）的内酯与式（II-Am）的氮杂环烷基胺）：然后在叔胺碱存在下与式（II-Su）的磺酰卤接触：R4-SO2W（II-Su），其中PG1和PG2是胺保护基; k，p和q分别为0,1或2，W，R2，R3，R4，R5，R6，R7，R8和R9如本文所定义。另外的实施方案添加了一系列方法步骤，导致合成适合用作β-内酰胺酶抑制剂的7-氧代-1,6-二氮杂双环[3.2.1]辛烷。

8. 发明授权

US10392353B2 Processes for making substituted quinazoline compounds using hydrogen bonding catalysts 有权
公开(公告)号：US10392353B2
公开(公告)日：2019-08-27
申请号：US15778505
申请日：2016-11-18
申请人： Merck Sharp & Dohme Corp. , Cheol K. Chung , Guy R. Humphrey , Zhijian Liu , Mark McLaughlin , Yingju Xu , Younong Yu
发明人： Cheol K. Chung , Guy R. Humphrey , Zhijian Liu , Mark McLaughlin , Yingju Xu , Younong Yu
IPC分类号： C07D239/84
摘要： Disclosed herein is a novel process for preparing substituted quinazoline compounds of formula (I) using a hydrogen bonding catalyst.

9. 发明申请

US20180346429A1 NOVEL PROCESSES FOR MAKING SUBSTITUTED QUINAZOLINE COMPOUNDS USING HYDROGEN BONDING CATALYSTS 审中-公开
公开(公告)号：US20180346429A1
公开(公告)日：2018-12-06
申请号：US15778505
申请日：2016-11-18
申请人： Cheol K. CHUNG , Guy R. HUMPHREY , Zhijian LIU , Mark MCLAUGHLIN , Yingju XU , Younong YU , Merck Sharp & Dohme Corp.
发明人： Cheol K. Chung , Guy R. Humphrey , Zhijian Liu , Mark McLaughlin , Yingju Xu , Younong Yu
IPC分类号： C07D239/84
CPC分类号： C07D239/84
摘要： Disclosed herein is a novel process for preparing substituted quinazoline compounds of formula (I) using a hydrogen bonding catalyst.

10. 发明申请

US20120190854A1 Hydroamination of Alkenes 审中-公开
标题翻译：烯烃的水分
公开(公告)号：US20120190854A1
公开(公告)日：2012-07-26
申请号：US13440465
申请日：2012-04-05
申请人： Akihiro Takemiya , Zhijian Liu , John F. Hartwig
发明人： Akihiro Takemiya , Zhijian Liu , John F. Hartwig
IPC分类号： C07D207/06 , C07D207/08 , C07D403/10 , C07D209/54 , C07D211/14 , C07D207/04 , C07D207/09
CPC分类号： C07D207/06 , B01J31/1805 , B01J31/2404 , B01J31/2409 , B01J31/2452 , B01J2231/324 , B01J2531/822 , C07C209/60 , C07D207/09 , C07D207/12 , C07D209/96 , C07D211/12 , C07D211/14
摘要： A method includes reacting an amino group, a composition including rhodium and an organic ligand, and a substrate having structural formula (I) in a reaction mixture. R1 is an organic group including a sp3 carbon atom bonded to CA. R2 is selected from the group consisting of hydrogen, methyl, and an organic group including a sp3 carbon atom bonded to CA. R3 and R4 independently are selected from the group consisting of hydrogen, methyl, and an organic group including a sp3 carbon atom bonded to CB. The method further includes forming a hydroaminated product in the reaction mixture.
摘要翻译：一种方法包括在反应混合物中使氨基，包含铑和有机配体的组合物和具有结构式（I）的底物反应。 R1是包含与CA键合的sp3碳原子的有机基团。 R2选自氢，甲基和包括与CA结合的sp 3碳原子的有机基团。 R 3和R 4独立地选自氢，甲基和包含与CB结合的sp 3碳原子的有机基团。所述方法还包括在所述反应混合物中形成聚氨酯产物。

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