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1. 发明申请

WO2011100604A2 DIGITAL ANALYTE ANALYSIS 审中-公开
标题翻译：数字分析分析
公开(公告)号：WO2011100604A2
公开(公告)日：2011-08-18
申请号：PCT/US2011/024615
申请日：2011-02-11
申请人： RAINDANCE TECHNOLOGIES, INC. , LARSON, Jonathan, William , ZHONG, Qun , LINK, Darren, Roy
发明人： LARSON, Jonathan, William , ZHONG, Qun , LINK, Darren, Roy
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , C12Q1/6827 , C12Q1/686 , C12Q1/6883 , C12Q1/6886 , C12Q2600/172 , C12Q2563/159 , C12Q2565/629 , C12Q2537/143 , C12Q2531/113 , C12Q2535/131
摘要： The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.
摘要翻译：本发明一般涉及基于液滴的数字PCR和使用其进行目标核酸分析的方法。在某些实施方案中，本发明的方法包括形成含有平均单个靶核酸的样品液滴，扩增液滴中的靶，不包括来自靶的扩增子的液滴和来自靶的变体的扩增子，并分析靶扩增子。

2. 发明申请

WO2011075117A1 MODIFYING COMPUTER MANAGEMENT REQUEST 审中-公开
标题翻译：修改计算机管理要求
公开(公告)号：WO2011075117A1
公开(公告)日：2011-06-23
申请号：PCT/US2009/067946
申请日：2009-12-14
申请人： HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. , ZHONG, Qun
发明人： ZHONG, Qun
IPC分类号： G06F9/44 , G06F9/06 , G09F3/00 , G06F15/00
CPC分类号： G06F9/4445 , G06F9/452
摘要： A computer-implemented process provides for intercepting a request from a management tool running on a management system. The request can be for a management tool to run on a managed system. Plural virtual consoles are created for the managed system. The original request is modified to generate a modified request that specifies that plural data types generated by said management tool are to be directed to different respective ones of said virtual consoles.
摘要翻译：计算机实现的过程提供了从管理系统上运行的管理工具拦截请求。该请求可以用于管理工具在受管系统上运行。为受管系统创建了多个虚拟控制台。原始请求被修改以生成修改的请求，其指定由所述管理工具生成的多个数据类型将被引导到所述虚拟控制台的不同的相应的一个。

3. 发明申请

WO2011100604A3 DIGITAL ANALYTE ANALYSIS 审中-公开
标题翻译：数字分析分析
公开(公告)号：WO2011100604A3
公开(公告)日：2014-03-27
申请号：PCT/US2011024615
申请日：2011-02-11
申请人： RAINDANCE TECHNOLOGIES INC , LARSON JONATHAN WILLIAM , ZHONG QUN , LINK DARREN ROY
发明人： LARSON JONATHAN WILLIAM , ZHONG QUN , LINK DARREN ROY
IPC分类号： C12P19/34 , C12Q1/68
CPC分类号： C12Q1/6816 , C12Q1/6827 , C12Q1/686 , C12Q2563/159 , C12Q2565/629 , C12Q2537/143 , C12Q2531/113 , C12Q2535/131
摘要： The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.
摘要翻译：本发明总体上涉及基于微滴的数字PCR和使用其分析靶核酸的方法。在某些实施方案中，本发明的方法涉及形成平均含有单个靶核酸的样品液滴，扩增液滴中的靶，排除含有来自靶的扩增子的微滴和来自靶变体的扩增子，并分析靶扩增子。

4. 发明申请

WO2011025493A1 PIPE CUTTER 审中-公开
标题翻译：管道切割机
公开(公告)号：WO2011025493A1
公开(公告)日：2011-03-03
申请号：PCT/US2009/055353
申请日：2009-08-28
申请人： MILWAUKEE ELECTRIC TOOL CORPORATION , LUO, Hua, Tian , LIU, Zhong, Qun , LI, Shui, Ming , NAUGHTON, Michael , SCOTT, John, S.
发明人： LUO, Hua, Tian , LIU, Zhong, Qun , LI, Shui, Ming , NAUGHTON, Michael , SCOTT, John, S.
IPC分类号： B23D21/06
CPC分类号： B23D21/06 , B23D17/02 , B23D21/00 , B26B15/00 , B26D3/16 , B26D5/00
摘要： A power tool that includes a pipe holder, a knife pivotally coupled to the pipe holder, and a drive mechanism coupled to at least one of the pipe holder and the knife. The power tool also includes a motor coupled to a drive mechanism, and a removable and rechargeable battery pack coupled to the motor to selectively provide power signals to the motor. The power tool also includes a controller configured to monitor a plurality of conditions of the power tool, such as battery pack voltage, battery pack temperature, operational current, and the like. The controller is also configured to detect one or more events related to the plurality of conditions of the power tool. For example, the controller is configured to monitor the operational current of the power tool. If the operational current of the power tool exceeds a first threshold value, a power signal duty cycle is reduced from a first duty cycle value to a second duty cycle value to limit the amount of torque the power tool is able to generate.
摘要翻译：一种电动工具，其包括管支架，可枢转地联接到管保持器的刀和联接到管支架和刀的至少一个的驱动机构。电动工具还包括耦合到驱动机构的电动机，以及耦合到电动机的可移除和可再充电电池组，以选择性地向电动机提供电力信号。电动工具还包括被配置为监视电动工具的多个状态的控制器，例如电池组电压，电池组温度，工作电流等。控制器还被配置为检测与电动工具的多个条件相关的一个或多个事件。例如，控制器被配置为监视电动工具的工作电流。如果电动工具的工作电流超过第一阈值，则功率信号占空比从第一占空比值减小到第二占空比值，以限制电动工具能产生的转矩量。

5. 发明申请

WO2010111231A1 MANIPULATION OF MICROFLUIDIC DROPLETS 审中-公开
标题翻译：微流控液滴的操作
公开(公告)号：WO2010111231A1
公开(公告)日：2010-09-30
申请号：PCT/US2010/028252
申请日：2010-03-23
申请人： RAINDANCE TECHNOLOGIES, INC. , MILLER, Benjamin , HUTCHISON, Brian , WILSON, Andrew , LARSON, Jonathan , ZHONG, Qun , YURKOVETSKY, Yevgeny , LINK, Darren , WEARY, Mark
发明人： MILLER, Benjamin , HUTCHISON, Brian , WILSON, Andrew , LARSON, Jonathan , ZHONG, Qun , YURKOVETSKY, Yevgeny , LINK, Darren , WEARY, Mark
IPC分类号： B01L3/00 , B01L3/02 , G01N21/00
CPC分类号： G01N1/38 , B01L3/0241 , B01L3/502715 , B01L3/502784 , B01L2200/061 , B01L2200/0673 , B01L2200/143 , B01L2300/0877 , F16K99/0001 , F16K2099/0084 , F17D3/01 , G01N27/44791 , G01N2021/0353 , Y10T137/2185 , Y10T137/7761 , Y10T137/8158 , Y10T137/8593 , Y10T436/118339
摘要： The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control. The assessment of the characteristics can be made using an image sensor.
摘要翻译：本发明提供了用于评估微流体通道内的微流体液滴的一个或多个预定特征或性质的方法，以及调节该通道内的一个或多个流体流速以使用反馈控制选择性地改变预定微滴特性或特性。可以使用图像传感器来评估特性。

6. 发明申请

WO2009009127A3 METHOD AND SYSTEM FOR TRANSFERRING AND/OR CONCENTRATING A SAMPLE 审中-公开
标题翻译：用于传送和/或浓缩样品的方法和系统
公开(公告)号：WO2009009127A3
公开(公告)日：2009-04-09
申请号：PCT/US2008008530
申请日：2008-07-11
申请人： US GENOMICS INC , ALLEN RICHARD , BURTON RANDALL E , CRANE BRYAN , KROGMEIER JEFFREY R , LARSON JONATHAN W , PAPKOV VYACHESLAV , SABOURIN NICAULAS , ZHONG QUN , ZHOU YI
发明人： ALLEN RICHARD , BURTON RANDALL E , CRANE BRYAN , KROGMEIER JEFFREY R , LARSON JONATHAN W , PAPKOV VYACHESLAV , SABOURIN NICAULAS , ZHONG QUN , ZHOU YI
IPC分类号： G01N27/26 , C07H21/04 , C12Q1/68
CPC分类号： G01N1/40 , B01L3/502753 , B01L3/502761 , B01L2300/0816 , B01L2300/0864 , B01L2400/0415 , G01N2001/4038 , G01N2001/4088
摘要： A system for transferring and/or concentrating a sample is provided. The system includes a chamber with a membrane positioned within the chamber. An electrode assembly is configured to create an electric field across the membrane to move a charged sample through the chamber such that the sample collects and may concentrate on the membrane. The system may include a plurality of membranes. The system may also include a plurality of microchannels outwardly extending from the channel, where the membrane extends along the plurality of microchannels. Aspects of the invention are also directed to a pipette which may be used to transfer and concentrate a sample on a membrane. Certain embodiments are directed to methods and systems for concentrating a nucleic acid sample.
摘要翻译：提供了用于转移和/或浓缩样品的系统。该系统包括具有位于腔室内的膜的腔室。电极组件被配置为在膜上产生电场以使带电样品移动通过室，使得样品收集并且可以集中在膜上。该系统可以包括多个膜。系统还可以包括从通道向外延伸的多个微通道，其中膜沿着多个微通道延伸。本发明的方面还涉及可用于将样品转移并浓缩在膜上的移液管。某些实施方案涉及用于浓缩核酸样品的方法和系统。

7. 发明申请

WO2009127086A1 AUDIO SIGNAL AMPLIFIER FOR KARAOKE PLAYER 审中-公开
标题翻译：卡拉OK播放器的音频信号放大器
公开(公告)号：WO2009127086A1
公开(公告)日：2009-10-22
申请号：PCT/CN2008/000807
申请日：2008-04-18
申请人： ZORAN CORPORATION , LIN, Gaile , GUAN, Hong , ZHONG, Qun
发明人： LIN, Gaile , GUAN, Hong , ZHONG, Qun
IPC分类号： G10K15/04
CPC分类号： H03G1/0082
摘要： A configurable amplifier circuit for a karaoke player is described. In one embodiment, a karaoke player includes: a DVD/CD reader port for coupling to a DVD/CD reader, a microphone input to receive audio signals from an external microphone, an MPEG decoder coupled to the DVD/CD reader port and the microphone input, the MPEG decoder having first and second output terminals, a processor coupled to the MPEG decoder, the processor to control the MPEG decoder, and a configurable amplifier coupled to the first and second output terminals, wherein a first audio signal originating from the first output terminal is selectively amplified by the configurable amplifier circuit in accordance with a second signal originating from the second output terminal.
摘要翻译：描述了用于卡拉OK播放器的可配置放大器电路。在一个实施例中，卡拉OK播放器包括：用于耦合到DVD / CD读取器的DVD / CD读取器端口，用于从外部麦克风接收音频信号的麦克风输入端，耦合到DVD / CD读取器端口的MPEG解码器和麦克风输入，具有第一和第二输出端的MPEG解码器，耦合到MPEG解码器的处理器，用于控制MPEG解码器的处理器以及耦合到第一和第二输出端的可配置放大器，其中源自第一和第二输出端的第一音频信号输出端子由可配置放大器电路根据源自第二输出端子的第二信号选择放大。

8. 发明申请

WO2009009127A2 METHOD AND SYSTEM FOR TRANSFERRING AND/OR CONCENTRATING A SAMPLE 审中-公开
标题翻译：用于传送和/或浓缩样本的方法和系统
公开(公告)号：WO2009009127A2
公开(公告)日：2009-01-15
申请号：PCT/US2008/008530
申请日：2008-07-11
申请人： U.S. GENOMICS, INC. , ALLEN, Richard , BURTON, Randall, E. , CRANE, Bryan , KROGMEIER, Jeffrey, R. , LARSON, Jonathan, W. , PAPKOV, Vyacheslav , SABOURIN, Nicaulas , ZHONG, Qun , ZHOU, Yi
发明人： ALLEN, Richard , BURTON, Randall, E. , CRANE, Bryan , KROGMEIER, Jeffrey, R. , LARSON, Jonathan, W. , PAPKOV, Vyacheslav , SABOURIN, Nicaulas , ZHONG, Qun , ZHOU, Yi
IPC分类号： G01N27/26 , C12Q1/68 , C07H21/04
CPC分类号： G01N1/40 , B01L3/502753 , B01L3/502761 , B01L2300/0816 , B01L2300/0864 , B01L2400/0415 , G01N2001/4038 , G01N2001/4088
摘要： A system for transferring and/or concentrating a sample is provided. The system includes a chamber with a membrane positioned within the chamber. An electrode assembly is configured to create an electric field across the membrane to move a charged sample through the chamber such that the sample collects and may concentrate on the membrane. The system may include a plurality of membranes. The system may also include a plurality of microchannels outwardly extending from the channel, where the membrane extends along the plurality of microchannels. Aspects of the invention are also directed to a pipette which may be used to transfer and concentrate a sample on a membrane. Certain embodiments are directed to methods and systems for concentrating a nucleic acid sample.
摘要翻译：提供了用于转移和/或浓缩样品的系统。该系统包括具有位于腔室内的隔膜的腔室。电极组件被配置成跨越膜产生电场以使带电样本移动通过腔室，使得样本收集并且可以集中在膜上。该系统可以包括多个膜。该系统还可以包括从通道向外延伸的多个微通道，其中膜沿着多个微通道延伸。本发明的方面还涉及可用于将样品转移和浓缩在膜上的移液管。某些实施方案涉及浓缩核酸样品的方法和系统。

9. 发明申请

US20130097873A1 PIPE CUTTER 有权
标题翻译：管道切割机
公开(公告)号：US20130097873A1
公开(公告)日：2013-04-25
申请号：US13393131
申请日：2009-08-28
申请人： Hua Tian Luo , Shui Ming Li , Zhong Qun Liu , Michael Naughton , John S. Scott
发明人： Hua Tian Luo , Shui Ming Li , Zhong Qun Liu , Michael Naughton , John S. Scott
IPC分类号： B23D21/06 , B26B15/00
CPC分类号： B23D21/06 , B23D17/02 , B23D21/00 , B26B15/00 , B26D3/16 , B26D5/00
摘要： A power tool that includes a pipe holder, a knife pivotally coupled to the pipe holder, and a drive mechanism coupled to at least one of the pipe holder and the knife. The power tool also includes a motor coupled to a drive mechanism, and a removable and rechargeable battery pack coupled to the motor to selectively provide power signals to the motor. The power tool also includes a controller configured to monitor a plurality of conditions of the power tool, such as battery pack voltage, battery pack temperature, operational current, and the like. The controller is also configured to detect one or more events related to the plurality of conditions of the power tool. For example, the controller is configured to monitor the operational current of the power tool. If the operational current of the power tool exceeds a first threshold value, a power signal duty cycle is reduced from a first duty cycle value to a second duty cycle value to limit the amount of torque the power tool is able to generate.
摘要翻译：一种电动工具，其包括管支架，可枢转地联接到管保持器的刀和联接到管支架和刀的至少一个的驱动机构。电动工具还包括耦合到驱动机构的电动机，以及耦合到电动机的可移除和可充电电池组，以选择性地向电动机提供电力信号。电动工具还包括被配置为监视电动工具的多个状态的控制器，例如电池组电压，电池组件温度，工作电流等。控制器还被配置为检测与电动工具的多个条件相关的一个或多个事件。例如，控制器被配置为监视电动工具的工作电流。如果电动工具的工作电流超过第一阈值，则功率信号占空比从第一占空比值减小到第二占空比值，以限制电动工具能产生的转矩量。

10. 发明申请

US20130041421A1 ELECTROCARDIOGRAM MONITORING 有权
标题翻译：电子监控
公开(公告)号：US20130041421A1
公开(公告)日：2013-02-14
申请号：US13650570
申请日：2012-10-12
申请人： Zhong Qun Lu , Richard C. Nova , Paul S. Tamura , Gary A. DeBardi , David W. Tecklenburg , Tyler R. Hart , James S. Neumiller , Richard J. Cardin
发明人： Zhong Qun Lu , Richard C. Nova , Paul S. Tamura , Gary A. DeBardi , David W. Tecklenburg , Tyler R. Hart , James S. Neumiller , Richard J. Cardin
IPC分类号： A61N1/39 , A61B5/0402
CPC分类号： A61N1/3925 , A61B5/0424 , A61B5/6843 , A61B5/7242 , A61N1/046 , A61N1/3931 , A61N1/3993
摘要： Techniques for determining whether one or more leads are not adequately connected to a patient, e.g., for ECG monitoring, are described. The techniques involve injection of an integrated signal (which includes a test signal) into one lead, and monitoring the driven lead and the response at the other leads, including the common mode and the difference between the other leads. These “lead-off” detection techniques may be provided by an external defibrillator that provides three-wire ECG monitoring. Techniques for determining a type of a cable coupled to a defibrillator are also described. The cable-type identification may allow a defibrillator to, for example, operate in either a three-wire ECG monitoring mode or a therapy mode, based on whether a three-wire ECG cable or a defibrillation cable is coupled to the defibrillator.
摘要翻译：描述了用于确定一个或多个引线是否不能充分地连接到患者的技术，例如用于ECG监测。这些技术涉及将一个积分信号（包括一个测试信号）注入到一个引线中，并监视其它引线的驱动引线和响应，包括共模和其它引线之间的差异。这些引线检测技术可以由提供三线ECG监测的外部除颤器提供。还描述了用于确定耦合到去纤颤器的电缆的类型的技术。基于三线ECG电缆或除颤电缆是否耦合到除颤器，电缆型识别可以允许除颤器例如以三线ECG监测模式或治疗模式操作。

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