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1. 发明专利

SG11201906699WA SYSTEMS AND METHODS FOR SUPPORTING MULTIPLE AUTOMATED WORKFLOWS 未知
公开(公告)号：SG11201906699WA
公开(公告)日：2019-08-27
申请号：SG11201906699W
申请日：2018-01-22
申请人： LIFEFOUNDRY INC , CHAO RAN , JIANG JING , MENG SHAOYU , ZHAO HUIMIN
发明人： CHAO RAN , JIANG JING , MENG SHAOYU , ZHAO HUIMIN
IPC分类号： G06F9/38 , C04B30/02
摘要： WO 18/ 136903 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 26 July 2018 (26.07.2018) WIP0 I PCT omit IIl °nolo mom oimIE (10) International Publication Number WO 2018/136903 Al (51) International Patent Classification: G06F 9 / 3 8 (2018.01) C04B 30/02 (2006.01) G06F 19/24 (2011.01) (21) International Application Number: PCT/US2018/014751 (22) International Filing Date: 22 January 2018 (22.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/448,948 20 January 2017 (20.01.2017) US (71) Applicant: LIFEFOUNDRY, INC. [US/US]; 60 Hazel- wood Drive, Champaign, IL 61822 (US). (72) Inventors; and (71) Applicants: CHAO, Ran [IL/IL]; 60 Hazelwood Drive, Champaign, IL 61822 (US). JIANG, Jing [IL/IL]; 60 Hazelwood Drive, Champaign, IL 61822 (US). MENG, Shaoyu [IL/IL]; 60 Hazelwood Drive, Champaign, IL 61822 (US). ZHAO, Huimin [IL/IL]; 60 Hazelwood Drive, Champaign, IL 61822 (US). (74) Agent: LOVEJOY, Brett, A. et al.; Morgan, Lewis & Bockius LLP, One Market, Spear Street Tower, San Fran- cisco, CA 94105 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: SYSTEMS AND METHODS FOR SUPPORTING MULTIPLE AUTOMATED WORKFLOWS (57) : Systems and methods for automated workflow comprise assigning a set of first targets to an uncompiled first workflow. The un- compiled first workflow specifies a first set of process modules. Each such module is associated with a subset of unit operations. Each unit O Communications Circuit, operation includes a time interval and specifies an instrument. For each target in the set of first targets, the uncompiled workflow is translated into an instance of a compiled first workflow comprising a linear tempo- 3 ral order of unit operations, each including execution instructions for an addressed instrument. A set of second targets is obtained and assigned a second uncompiled workflow. Compilation of the second uncompiled workflow for each second target produces a different instance of a com- piled second workflow. Each second compiled workflow comprises a Scheduler linear temporal order of unit operations, with each unit operation includ- ing execution instructions for an addressed instrument and specifying a time interval. 12 Cont olle FIG. IA [Continued on next page] Wide area nctwor . 10 ,2 1 1; Ti 26 Power Source 28 24 22- 4' Instruments Engineering target library Process module lib Operating Systen laboratory infomsation management syste Co led workflows Unit operationdefinitions Na rktlaw library e syste 1 J -40 x 42 x 44 J -4( J -48 54 y-56 y58 WO 2018/136903 Al MIDEDIMOHNOBEIEDEMEMEDIMOIMMOVON Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a))

2. 发明专利

CA3061128A1 SYSTEMS AND METHODS FOR SUPPORTING MULTIPLE AUTOMATED WORKFLOWS 未知
公开(公告)号：CA3061128A1
公开(公告)日：2018-07-26
申请号：CA3061128
申请日：2018-01-22
申请人： LIFEFOUNDRY INC , CHAO RAN , JIANG JING , MENG SHAOYU , ZHAO HUIMIN
发明人： CHAO RAN , JIANG JING , MENG SHAOYU , ZHAO HUIMIN
IPC分类号： G06F9/38 , C04B30/02
摘要： Systems and methods for automated workflow comprise assigning a set of first targets to an uncompiled first workflow. The uncompiled first workflow specifies a first set of process modules. Each such module is associated with a subset of unit operations. Each unit operation includes a time interval and specifies an instrument. For each target in the set of first targets, the uncompiled workflow is translated into an instance of a compiled first workflow comprising a linear temporal order of unit operations, each including execution instructions for an addressed instrument. A set of second targets is obtained and assigned a second uncompiled workflow. Compilation of the second uncompiled workflow for each second target produces a different instance of a compiled second workflow. Each second compiled workflow comprises a linear temporal order of unit operations, with each unit operation including execution instructions for an addressed instrument and specifying a time interval.

3. 发明公开

EP3571582A1 SYSTEMS AND METHODS FOR SUPPORTING MULTIPLE AUTOMATED WORKFLOWS 审中-实审转让
公开(公告)号：EP3571582A1
公开(公告)日：2019-11-27
申请号：EP18741948.6
申请日：2018-01-22
申请人： Lifefoundry, Inc. , Chao, Ran , Jiang, Jing , Meng, Shaoyu , Zhao, Huimin
发明人： CHAO, Ran , JIANG, Jing , MENG, Shaoyu , ZHAO, Huimin
IPC分类号： G06F9/38 , G06F19/24 , C04B30/02

4. 发明申请

WO2020033162A1 SYSTEMS AND METHODS FOR SUPPORTING MULTIPLE AUTOMATED WORKFLOWS 审中-公开
公开(公告)号：WO2020033162A1
公开(公告)日：2020-02-13
申请号：PCT/US2019/043512
申请日：2019-07-25
申请人： LIFEFOUNDRY, INC. , CHAO, Ran , JIANG, Jing , MENG, Shaoyu , ZHAO, Huimin
发明人： CHAO, Ran , JIANG, Jing , MENG, Shaoyu , ZHAO, Huimin
IPC分类号： G06Q10/06 , G05B19/18
摘要： Systems and methods for automated workflow comprise assigning a set of first targets to an uncompiled first workflow. The uncompiled first workflow specifies a first set of process modules. Each such module is associated with a subset of unit operations. Each unit operation includes a time interval and specifies an instrument. For each target in the set of first targets, the uncompiled workflow is translated into an instance of a compiled first workflow comprising a linear temporal order of unit operations, each including execution instructions for an addressed instrument. A set of second targets is obtained and assigned a second uncompiled workflow. Compilation of the second uncompiled workflow for each second target produces a different instance of a compiled second workflow. Each second compiled workflow comprises a linear temporal order of unit operations, with each unit operation including execution instructions for an addressed instrument and specifying a time interval.

5. 发明申请

WO2012045088A9 COMBINATORIAL DESIGN OF HIGHLY EFFICIENT HETEROLOGOUS PATHWAYS 审中-公开
标题翻译：高效率异常路径的组合设计
公开(公告)号：WO2012045088A9
公开(公告)日：2012-07-26
申请号：PCT/US2011054650
申请日：2011-10-03
申请人： UNIV ILLINOIS , ZHAO HUIMIN , KIM BYOUNGJIN , DU JING , YUAN YONGBO , ERIKSEN DAWN , SI TONG
发明人： ZHAO HUIMIN , KIM BYOUNGJIN , DU JING , YUAN YONGBO , ERIKSEN DAWN , SI TONG
IPC分类号： C12N15/52
CPC分类号： C12P7/06 , C07K14/39 , C12N9/0006 , C12N9/1205 , C12N9/2445 , C12N15/1093 , C12N15/52 , C12N15/81 , C12P7/10 , C12Y101/01009 , C12Y101/0101 , C12Y101/01307 , C12Y207/01017 , C12Y302/01021 , Y02E50/16 , Y02E50/17
摘要： The present disclosure relates to the production of highly efficient heterologous pathways in host cells by identifying favorable enzyme and/or promoter combinations. In particular the present disclosure provides methods for assembly and selection of multi-step xylose and arabinose/xylose utilization pathways from a library of fungal enzymes. The present disclosure further provides compositions containing favorable enzyme combinations, as well as recombinant yeast expressing such combinations, and methods of use for bioconversion of pentose sugars. Also provided are compositions and methods involving favorable expression patterns identified by utilization of combinations of promoters of varying strengths. Provided herein are methods for assembly and selection of multi-step xylose, arabinose/xylose, and cellobiose utilization pathways from a library of promoters of varying strengths. The present disclosure further provides compositions containing heterologous enzyme-coding polynucleotides under the control of favorable promoters, as well as recombinant yeast expressing such enzymes, and methods of their use for bioconversion of pentose and/or hexose sugars.
摘要翻译：本公开涉及通过鉴定有利的酶和/或启动子组合在宿主细胞中产生高效的异源途径。特别地，本公开提供了从真菌酶文库中组装和选择多步木糖和阿拉伯糖/木糖利用途径的方法。本公开进一步提供含有有利的酶组合的组合物，以及表达这种组合的重组酵母以及用于戊糖的生物转化的方法。还提供了包括通过利用不同强度的启动子的组合鉴定的有利的表达模式的组合物和方法。本文提供了用于从不同强度的启动子文库中组装和选择多步木糖，阿拉伯糖/木糖和纤维二糖利用途径的方法。本公开进一步提供了含有有利启动子控制的异源酶编码多核苷酸的组合物，以及表达这些酶的重组酵母，以及它们用于戊糖和/或己糖的生物转化的方法。

6. 发明申请

WO2008131215A3 ENGINEERED PHOSPHITE DEHYDROGENASE MUTANTS 审中-公开
公开(公告)号：WO2008131215A3
公开(公告)日：2008-10-30
申请号：PCT/US2008/060814
申请日：2008-04-18
申请人： BIOTECHNOLOGY RESEARCH AND DEVELOPMENT CORPORATION , THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , ZHAO, Huimin , MCLACHLAN, Michael , JOHANNES, Tyler
发明人： ZHAO, Huimin , MCLACHLAN, Michael , JOHANNES, Tyler
IPC分类号： C12N9/04 , C12N1/20 , C12N15/00 , C12Q1/00 , C12Q1/34 , C12Q1/68 , C12P21/06 , C12P21/04 , A61K38/44 , C07H21/04 , C07K1/00 , C07K16/00
摘要： Phosphite dehydrogenase mutant enzymes provide relaxed cofactor specificity, increased thermostability, increased activity, solubility, and expression over the wild-type enzyme. The mutant enzymes are useful for nicotinamide cofactor regeneration.

7. 发明申请

WO2006074194A3 ENGINEERED PHOSPHITE DEHYDROGENASE MUTANTS FOR NICOTINAMIDE COFACTOR REGENERATION 审中-公开
标题翻译：工程磷酸脱氢酶突变体用于烟酰胺类辅酶再生
公开(公告)号：WO2006074194A3
公开(公告)日：2006-10-19
申请号：PCT/US2006000135
申请日：2006-01-03
申请人： BIOTECHNOLOGY RES & DEV , UNIV ILLINOIS , ZHAO HUIMIN , WOODYER RYAN , METCALF WILLIAM , VAN DER DONK WILFRED A , JOHANNES TYLER
发明人： ZHAO HUIMIN , WOODYER RYAN , METCALF WILLIAM , VAN DER DONK WILFRED A , JOHANNES TYLER
IPC分类号： C07H21/04 , C12N9/00 , C12N9/02 , C12P19/30 , C12P21/02
CPC分类号： C12P19/36 , C12N9/0004 , C12N9/0036
摘要： Phosphite dehydrogenase mutant enzymes provide relaxed cofactor specificity, increased thermostability, increased activity, solubility, and expression over the wild-type enzyme. The mutant enzymes are useful for nicotinamide cofactor regeneration.
摘要翻译：亚磷酸盐脱氢酶突变酶与野生型酶相比提供了松弛的辅因子特异性，增加的热稳定性，增加的活性，溶解性和表达。突变酶可用于烟酰胺辅因子再生。

8. 发明申请

WO2018136903A1 SYSTEMS AND METHODS FOR SUPPORTING MULTIPLE AUTOMATED WORKFLOWS 审中-公开
公开(公告)号：WO2018136903A1
公开(公告)日：2018-07-26
申请号：PCT/US2018/014751
申请日：2018-01-22
申请人： LIFEFOUNDRY, INC. , CHAO, Ran , JIANG, Jing , MENG, Shaoyu , ZHAO, Huimin
发明人： CHAO, Ran , JIANG, Jing , MENG, Shaoyu , ZHAO, Huimin
IPC分类号： G06F9/38 , G06F19/24 , C04B30/02
摘要： Systems and methods for automated workflow comprise assigning a set of first targets to an uncompiled first workflow. The uncompiled first workflow specifies a first set of process modules. Each such module is associated with a subset of unit operations. Each unit operation includes a time interval and specifies an instrument. For each target in the set of first targets, the uncompiled workflow is translated into an instance of a compiled first workflow comprising a linear temporal order of unit operations, each including execution instructions for an addressed instrument. A set of second targets is obtained and assigned a second uncompiled workflow. Compilation of the second uncompiled workflow for each second target produces a different instance of a compiled second workflow. Each second compiled workflow comprises a linear temporal order of unit operations, with each unit operation including execution instructions for an addressed instrument and specifying a time interval.

9. 发明申请

WO2012100196A1 ENHANCED FERMENTATION OF CELLODEXTRINS AND β-D-GLUCOSE 审中-公开
标题翻译：增强CELLODEXTRINS和β-D-葡萄糖的发酵
公开(公告)号：WO2012100196A1
公开(公告)日：2012-07-26
申请号：PCT/US2012/022079
申请日：2012-01-20
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , DOUDNA CATE, James, H. , BEESON, William, T. , GALAZKA, Jonathan, M. , ZHAO, Huimin , LI, Sijin , JIN, Yong-Su , HA, Suk-Jin
发明人： DOUDNA CATE, James, H. , BEESON, William, T. , GALAZKA, Jonathan, M. , ZHAO, Huimin , LI, Sijin , JIN, Yong-Su , HA, Suk-Jin
IPC分类号： C07K14/195 , C07K14/37 , C12N9/00 , C12N9/90 , C12P5/00
CPC分类号： C12P19/12 , C07K14/195 , C07K14/37 , C12N9/2445 , C12N9/90 , C12P7/10 , C12P19/14 , C12P19/16 , C12P19/24 , Y02E50/16 , Y02E50/17
摘要： The present disclosure provides compositions and methods for the fermentation of cellodextrins and β-D-glucose. Host cells and recombinant polypeptides having glucose mutarotase activity are provided. Additionally, methods for improving cell growth, production of chemicals, and consumption of cellodextrins and β-D-glucose during fermentation of mixtures containing cellodextrins and β-D-glucose are provided.
摘要翻译：本公开提供了用于发酵纤维糊精和β-D-葡萄糖的组合物和方法。提供具有葡萄糖变异酶活性的宿主细胞和重组多肽。另外，提供了用于在含有纤维糊精和β-D-葡萄糖的混合物的发酵期间改善细胞生长，化学品生产和消耗纤维糊精和β-D-葡萄糖的方法。

10. 发明申请

WO2011130509A1 MUTANTS OF L-ARABINITOL 4-DEHYDROGENASE FROM NEUROSPORA CRASSA 审中-公开
标题翻译：来自神经细胞的L-阿拉伯糖醇4脱氢酶的突变体
公开(公告)号：WO2011130509A1
公开(公告)日：2011-10-20
申请号：PCT/US2011/032486
申请日：2011-04-14
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , ZHAO, Huimin , SULLIVAN, Ryan, P. , BAE, Brian , NAIR, Satish
发明人： ZHAO, Huimin , SULLIVAN, Ryan, P. , BAE, Brian , NAIR, Satish
IPC分类号： C12N9/06
CPC分类号： C12Y101/01012 , C12N9/0006
摘要： To elucidate the determinants of substrate and cofactor recognition on LAD, the first high-resolution X-ray crystallographic structure of an LAD was determined to a resolution of 2.6. The crystal structure of the ncLAD-NAD+ complex was successfully utilized for the engineering of variants with altered cofactor specificity towards NADP+. These results provide the framework for engineering of variants with increased activity that can overcome the bottleneck in pentose catabolism in yeast.
摘要翻译：为了阐明LAD上底物和辅因子识别的决定因素，确定LAD的第一个高分辨率X射线晶体结构为2.6的分辨率。 ncLAD-NAD +复合物的晶体结构成功地用于对NADP +具有改变的辅因子特异性的变体的工程化。这些结果提供了具有增加活性的变体工程的框架，可以克服酵母中戊糖分解代谢的瓶颈。

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