专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

MA27713A1 COMPOSES AMINOHETEROARYLIQUES SERVANT D'INHIBITEURS DE PROTEINE-KINASES 未知
公开(公告)号：MA27713A1
公开(公告)日：2006-01-02
申请号：MA28457
申请日：2005-08-26
申请人： ZHANG FANG-JIE , ZHANG JENNIFER
发明人： CUI JINGJONG JEAN , BHUMRALKAR DILIP , BOTROUS IRINY , CHU JI YU , FUNK LEE A , HANAU CATHLEEN ELIZABETH , HARRIS JR G DAVIS , JIA LEI , JOHNSON JOANNE , KUNG PEI-PEI , KOLODZIEJ STEPHEN A , LI XIAOYUAN SHARON , LIN JASON QISHEN , MENG JERRY JIALUN , NAMBU MITCHELL DAVID , NELSON CHRISTOPHER G , PAIRISH MASON ALAN , SHEN HONG , TRAN-DUBE MICHELLE , WALTER ALLISON , ZHANG FANG-JIE , ZHANG JENNIFER
IPC分类号： A61K20060101 , A61K31/44 , A61K31/496 , A61K31/4965 , A61K31/497 , C07D20060101 , C07D211/72 , C07D213/73 , C07D401/00 , C07D401/12 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D413/12 , C07D417/00 , C07D419/00 , A61K321/4965
摘要： DEPOSANT Société dite : SUGEN, INC. REVENDICATION DE PRIORITES US 26 Février 2003 60/449,588 US 29 Janvier 2004 60/540,229 Composés aminohétéroaryliques servant d'inhibiteurs de protéine-kinases Des aminopyridines et aminopyrazines de formule (I), des compositions comprenant ces composés et des méthodes d'utilisation sont proposés. Les composés préférés de formule (I) ont une activité d'inhibiteurs de protéine-kinases, y compris comme inhibiteurs de c-MET.

2. 发明申请

WO2005016875A2 GEOMETRICALLY RESTRICTED 3-CYCLOPENTYLIDENE-1,3-DIHYDROINDOL-2-ONES AS POTENT PROTEIN KINASE INHIBITORS 审中-公开
标题翻译：几何限制性3-环丙基-1,3-二氢吲哚-2-酮作为蛋白激酶激酶抑制剂
公开(公告)号：WO2005016875A2
公开(公告)日：2005-02-24
申请号：PCT/US2004/022310
申请日：2004-08-05
申请人： SUGEN, INC. , ZHANG, Fang-Jie , CUI, Jingrong , WEI, Chung, Chen , TANG, Peng, Cho
发明人： ZHANG, Fang-Jie , CUI, Jingrong , WEI, Chung, Chen , TANG, Peng, Cho
IPC分类号： C07D
CPC分类号： C07D209/34 , C07D209/42 , C07D403/06 , C07D403/14 , C07D471/04
摘要： The present invention relates to certain sulfonamido-substituted geometrically restricted indolinones of the formula (I): wherein R 1 - R 12 and X are variables defined herein. The sulfonamido-substituted geometrically restricted indolinones of the preferred embodiments of the present invention modulate the activity of protein kinases ("PKs"). The compounds of this invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical compositions comprising these compounds, methods of treating diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
摘要翻译：本发明涉及式（I）的某些亚磺酰氨基取代的几何限制的二氢吲哚酮：其中R1-R12和X是本文定义的变量。本发明优选实施方案的亚磺酰氨基取代的几何限制性二氢吲哚酮调节蛋白激酶（“PKs”）的活性。因此，本发明的化合物可用于治疗与异常PK活性相关的疾病。还公开了包含这些化合物的药物组合物，利用包含这些化合物的药物组合物治疗疾病的方法及其制备方法。

3. 发明申请

WO2023028942A1 SUPERIOR SEALING PERFORMANCE POLYETHYLENE FILMS 审中-公开
公开(公告)号：WO2023028942A1
公开(公告)日：2023-03-09
申请号：PCT/CN2021/116206
申请日：2021-09-02
申请人： BOREALIS AG , ABU DHABI POLYMERS CO. LTD (BOROUGE) L.L.C. , ZHANG, Fang
发明人： GITSAS, Antonios , BERTHELIER, Anthony , SEMAAN, Chantal , BURYAK, Andrey , SUBRATA, Kumar Das , SINGH, Raghvendra , TALAFHA, Mohammad Al
IPC分类号： B32B27/32 , B32B27/08 , B32B27/18 , C08J5/18 , C08L23/06 , C08L23/08
摘要： The invention relates to a polyethylene sealant film comprising an outer layer O, a core layer C and an inner layer I, wherein the inner layer I is made of an inner layer composition comprising a component AI, which is a linear low density eth-ylene polymer having a density of from 910 to 925 kg/m 3 and an MFR 2 of from 0.5 to 2.0 g/10 min, determined according to ISO 1133, a component BI, which is an ethylene-based plastomer, preferably is a copolymer of ethylene and a C3 to C10 alpha-olefin, preferably 1-octene, and which has an MFR 2 of from 0.5 to 2.0 g/10 min, determined according to ISO 1133, and a density of from 880 to 912 kg/m 3, in an amount of 30 to 80 wt. %, based on the total weight of the inner layer composition, and a slip agent. The invention further relates to a laminated polyethylene film and article com-prising this polyethylene sealant film. The invention further relates to the use of the laminated polyethylene film and/or the polyethylene sealant film for packag-ing of an article; and the use of the respective composition in a sealant film.

4. 发明申请

WO2012159245A1 DISPLAYING KEY PINYINS 审中-公开
标题翻译：显示关键的PINYINS
公开(公告)号：WO2012159245A1
公开(公告)日：2012-11-29
申请号：PCT/CN2011/074394
申请日：2011-05-20
申请人： MICROSOFT CORPORATION , ZHANG, Fang , LI, Mingqin
发明人： ZHANG, Fang , LI, Mingqin
IPC分类号： G06F3/023
CPC分类号： G06F3/0236 , G06F3/018 , G06F3/0237 , G06F17/2223 , G06F17/276
摘要： Methods, systems, devices, and computer-storage media having computer-usable instructions embodied thereon, for displaying key pinyins are provided. Pinyins are words and/or symbols that represent a pronunciation of a character. The character may be a Chinese character. A single page of a user interface of a device may display dynamic updates of key pinyins that are associated with a desired pinyin and dynamic updates of one or more characters that are associated with a desired pinyin. Additional embodiments may provide the associated pinyins and/or characters in a single page that is scrollable at varying speeds depending on a received gesture.
摘要翻译：提供了具有其上实施的计算机可用指令的用于显示关键拼音的方法，系统，设备和计算机存储介质。拼音是表示字符发音的单词和/或符号。角色可能是汉字。设备的用户界面的单页可以显示与期望的拼音相关联的关键拼音的动态更新以及与期望的拼音相关联的一个或多个字符的动态更新。另外的实施例可以在单个页面中提供相关联的拼音和/或字符，其可以根据所接收的手势以可变速度滚动。

5. 发明申请

WO2006010051A3 METHODS OF DIAGNOSING & TREATING DIABETES AND INSULIN RESISTANCE 审中-公开
标题翻译：诊断和治疗糖尿病和胰岛素抵抗的方法
公开(公告)号：WO2006010051A3
公开(公告)日：2007-02-22
申请号：PCT/US2005024365
申请日：2005-07-07
申请人： METABOLEX INC , MOODIE SHONNA A , PEREZ GRACE , ZHANG FANG
发明人： MOODIE SHONNA A , PEREZ GRACE , ZHANG FANG
IPC分类号： G09B9/00 , G09B9/56
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： The present invention provides compositions and methods for diagnosing and treating diabetes and insulin resistance. In particular, the invention provides methods of identifying modulators of the polynucleotides or polypeptides of the invention and using those modulators to treat diabetes, as well as methods of diagnosing diabetes by measuring the levels of the polynucleotides or polypeptides of the invention in a patient.
摘要翻译：本发明提供用于诊断和治疗糖尿病和胰岛素抵抗的组合物和方法。特别地，本发明提供鉴定本发明的多核苷酸或多肽的调节剂并使用这些调节剂治疗糖尿病的方法，以及通过测量患者体内本发明的多核苷酸或多肽的水平来诊断糖尿病的方法。

6. 发明申请

WO2006010051A2 METHODS OF DIAGNOSING & TREATING DIABETES AND INSULIN RESISTANCE 审中-公开
标题翻译：诊断和治疗糖尿病和胰岛素抵抗的方法
公开(公告)号：WO2006010051A2
公开(公告)日：2006-01-26
申请号：PCT/US2005/024365
申请日：2005-07-07
申请人： METABOLEX, INC. , MOODIE, Shonna, A. , PEREZ, Grace , ZHANG, Fang
发明人： MOODIE, Shonna, A. , PEREZ, Grace , ZHANG, Fang
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： The present invention provides compositions and methods for diagnosing and treating diabetes and insulin resistance. In particular, the invention provides methods of identifying modulators of the polynucleotides or polypeptides of the invention and using those modulators to treat diabetes, as well as methods of diagnosing diabetes by measuring the levels of the polynucleotides or polypeptides of the invention in a patient.
摘要翻译：本发明提供用于诊断和治疗糖尿病和胰岛素抵抗的组合物和方法。特别地，本发明提供鉴定本发明的多核苷酸或多肽的调节剂并使用这些调节剂治疗糖尿病的方法，以及通过测量患者体内本发明的多核苷酸或多肽的水平来诊断糖尿病的方法。

7. 发明申请

WO2006007400A2 METHODS OF DIAGNOSING AND TREATING OBESITY, DIABETES AND INSULIN RESISTANCE 审中-公开
标题翻译：诊断和治疗肥胖，糖尿病和胰岛素抵抗的方法
公开(公告)号：WO2006007400A2
公开(公告)日：2006-01-19
申请号：PCT/US2005021297
申请日：2005-06-15
申请人： METABOLEX INC , MOODIE SHONNA A , ZHANG FANG , RACK PAUL G , SHANG JIN , LAVAN BRIAN E , ALLAN BERNARD , WONG CHI-WAI , GREGOIRE FRANCINE , PEREZ GRACE , WATERS STEVE
发明人： MOODIE SHONNA A , ZHANG FANG , RACK PAUL G , SHANG JIN , LAVAN BRIAN E , ALLAN BERNARD , WONG CHI-WAI , GREGOIRE FRANCINE , PEREZ GRACE , WATERS STEVE
IPC分类号： C12N1/00
CPC分类号： C12Q1/6883 , C07K14/47 , C12Q2600/158
摘要： The present invention provides compositions and methods for diagnosing and treating obesity, diabetes and insulin resistance. In particular, the invention provides methods of identifying modulators of the polynucleotides or polypeptides of the invention and using those modulators to treat obesity and/or diabetes, as well as methods of diagnosing obesity and/or diabetes by measuring the levels of the polynucleotides or polypeptides of the invention in a patient.
摘要翻译：本发明提供了用于诊断和治疗肥胖，糖尿病和胰岛素抵抗的组合物和方法。特别地，本发明提供鉴定本发明的多核苷酸或多肽的调节剂并使用这些调节剂治疗肥胖症和/或糖尿病的方法，以及通过测量多核苷酸或多肽的水平来诊断肥胖症和/或糖尿病的方法的发明。

8. 发明申请

WO2005016875A3 GEOMETRICALLY RESTRICTED 3-CYCLOPENTYLIDENE-1,3-DIHYDROINDOL-2-ONES AS POTENT PROTEIN KINASE INHIBITORS 审中-公开
标题翻译：几何限制的3-环亚戊基-1,3-二氢吲哚-2-酮作为蛋白激酶抑制剂
公开(公告)号：WO2005016875A3
公开(公告)日：2005-07-28
申请号：PCT/US2004022310
申请日：2004-08-05
申请人： SUGEN INC , ZHANG FANG-JIE , CUI JINGRONG , WEI CHUNG CHEN , TANG PENG CHO
发明人： ZHANG FANG-JIE , CUI JINGRONG , WEI CHUNG CHEN , TANG PENG CHO
IPC分类号： A61K31/404 , A61K31/4745 , C07D20060101 , C07D209/34 , C07D209/42 , C07D403/04 , C07D403/06 , C07D403/14 , C07D471/02 , C07D471/04
CPC分类号： C07D209/34 , C07D209/42 , C07D403/06 , C07D403/14 , C07D471/04
摘要： The present invention relates to certain sulfonamido-substituted geometrically restricted indolinones of the formula (I): wherein R1 - R12 and X are variables defined herein. The sulfonamido-substituted geometrically restricted indolinones of the preferred embodiments of the present invention modulate the activity of protein kinases ("PKs"). The compounds of this invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical compositions comprising these compounds, methods of treating diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
摘要翻译：本发明涉及式（I）的某些亚磺酰氨基取代的几何限制吲哚啉酮：其中R 1 -R 12和X是本文定义的变量。本发明优选实施方案的亚磺酰氨基取代的几何限制的吲哚满酮调节蛋白激酶（“PK”）的活性。因此本发明化合物可用于治疗与PK异常活性有关的疾病。还公开了包含这些化合物的药物组合物，利用包含这些化合物的药物组合物治疗疾病的方法以及制备它们的方法。

9. 发明申请

WO2005005378A3 INDOLINONE HYDRAZIDES AS C-MET INHIBITORS 审中-公开
标题翻译：吲哚啉酮水合物作为C-MET抑制剂
公开(公告)号：WO2005005378A3
公开(公告)日：2005-03-03
申请号：PCT/US2004017423
申请日：2004-06-25
申请人： SUGEN INC , KOENIG MARCEL , CUI JINGRONG , WEI CHUNG CHEN , DO STEVEN HUY , ZHANG FANG-JIE , VOJKOVSKY TOMAS , RAMPHAL JOHN , YANG GUANG , MATTSON MATTHEW , NELSON CHRISTOPHER , TANG PENG CHO
发明人： KOENIG MARCEL , CUI JINGRONG , WEI CHUNG CHEN , DO STEVEN HUY , ZHANG FANG-JIE , VOJKOVSKY TOMAS , RAMPHAL JOHN , YANG GUANG , MATTSON MATTHEW , NELSON CHRISTOPHER , TANG PENG CHO
IPC分类号： C07D20060101 , C07D403/12
CPC分类号： C07D209/40 , C07D209/34 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D471/04
摘要： The present invention relates to compounds of the formulae (I) - (XII), wherein R1 - R71, A, B, X, Y, G, L and Z are defined herein, and their pharmaceutically acceptable salts. These compounds modulate the activity of c-Met and are therefore expected to be useful in the prevention and treatment of c-Met related disorders such as cancer.
摘要翻译：本发明涉及式（I） - （XII）化合物，其中R1-R71，A，B，X，Y，G，L和Z如本文所定义，及其药学上可接受的盐。这些化合物调节c-Met的活性，因此预期可用于预防和治疗c-Met相关疾病如癌症。

10. 发明申请

WO2005004808A2 TETRACYCLIC COMPOUNDS AS c-MET INHIBITORS 审中-公开
标题翻译：四环化合物作为c-MET抑制剂
公开(公告)号：WO2005004808A2
公开(公告)日：2005-01-20
申请号：PCT/US2004/020929
申请日：2004-06-30
申请人： SUGEN, INC. , VOJKOVSKY, Tomas , KOENIG, Marcel , ZHANG, Fang-Jie , CUI, Jingrong
发明人： VOJKOVSKY, Tomas , KOENIG, Marcel , ZHANG, Fang-Jie , CUI, Jingrong
IPC分类号： A61K
CPC分类号： C07D487/14
摘要： The present invention relates to compounds of the Formulae (I) and (II), wherein R 1 - R 10 and G are defined herein, and their pharmaceutically acceptable salts. These compounds modulate the activity of c-Met and are therefore expected to be useful in the prevention and treatment of c-Met related disorders such as cancer.
摘要翻译：本发明涉及式（I）和（II）的化合物，其中R 1 -R 10和G在本文中定义及其药学上可接受的盐。这些化合物调节c-Met的活性，因此预计可用于预防和治疗与c-Met有关的疾病，例如癌症。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式