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1. 发明申请

WO2011042463A3 PHARMACEUTICAL COMPOSITION COMPRISING POORLY SOLUBLE ACTIVE INGREDIENT AND HYPERBRANCHED POLYMER 审中-公开
标题翻译：包含不溶性活性成分和超分子聚合物的药物组合物
公开(公告)号：WO2011042463A3
公开(公告)日：2012-02-23
申请号：PCT/EP2010064916
申请日：2010-10-06
申请人： LEK PHARMACEUTICALS , REVEN SEBASTJAN , ZAGAR EMA
发明人： REVEN SEBASTJAN , ZAGAR EMA
IPC分类号： A61K9/14 , A61K9/16 , A61K9/20 , A61K31/64 , A61K47/34
CPC分类号： A61K31/00 , A61K9/1647 , A61K9/1676 , A61K9/204 , A61K31/122 , A61K31/404 , A61K31/4985 , A61K31/501 , A61K31/64
摘要： The present invention belongs to the field of pharmaceutical industry and relates to a pharmaceutical composition comprising at least one hyperbranched polymer and at least one pharmaceutically active ingredient, wherein the polymer and the pharmaceutically active ingredient are present in a specific weight ratio, and to a process for the preparation of said pharmaceutical composition. The present invention is also directed to a powder or granulate comprising at least one hyperbranched polymer and at least one pharmaceutically active ingredient in a specific weight ratio, to a process for the preparation of said powder or granulate, and to a pharmaceutical dosage form comprising the pharmaceutical composition, powder or granulate. Furthermore, the present invention relates to a process for preparing a solid dispersion of a hyperbranched polymer and at least one API. Moreover, it relates to the use of a crystalline carrier for the preparation of a mixture of hyperbranched polymer and a pharmaceutically active ingredient, as well as to the use of polyesteramide hyperbranched polymers for the preparation of a pharmaceutical composition, to the use of a hydrophilic or hydrophobic carrier for the preparation of said composition comprising a specific group of API, and to the use of a specific API and at least one hyperbranched polymer for the preparation of a pharmaceutical composition.
摘要翻译：本发明属于制药工业领域，涉及包含至少一种超支化聚合物和至少一种药物活性成分的药物组合物，其中聚合物和药物活性成分以特定重量比存在，并且涉及一种方法用于制备所述药物组合物。本发明还涉及包含至少一种超支化聚合物和至少一种特定重量比的药物活性成分的粉末或颗粒与制备所述粉末或颗粒的方法，以及包含药物组合物，粉剂或颗粒剂。此外，本发明涉及一种制备超支化聚合物和至少一种API的固体分散体的方法。此外，它涉及结晶载体用于制备超支化聚合物和药物活性成分的混合物的用途，以及使用聚酯酰胺超支化聚合物制备药物组合物以使用亲水性或疏水性载体，用于制备包含特定API组的所述组合物，以及使用特定的API和至少一种超支化聚合物来制备药物组合物。

2. 发明申请

WO2011042463A2 PHARMACEUTICAL COMPOSITION COMPRISING POORLY SOLUBLE ACTIVE INGREDIENT AND HYPERBRANCHED POLYMER 审中-公开
标题翻译：包含不溶性活性成分和高分子聚合物的药物组合物
公开(公告)号：WO2011042463A2
公开(公告)日：2011-04-14
申请号：PCT/EP2010/064916
申请日：2010-10-06
申请人： LEK PHARMACEUTICALS D.D. , REVEN, Sebastjan , ZAGAR, Ema
发明人： REVEN, Sebastjan , ZAGAR, Ema
IPC分类号： A61K9/14 , A61K9/16 , A61K9/20 , A61K47/34 , A61K31/64
CPC分类号： A61K31/00 , A61K9/1647 , A61K9/1676 , A61K9/204 , A61K31/122 , A61K31/404 , A61K31/4985 , A61K31/501 , A61K31/64
摘要： The present invention belongs to the field of pharmaceutical industry and relates to a pharmaceutical composition comprising at least one hyperbranched polymer and at least one pharmaceutically active ingredient, wherein the polymer and the pharmaceutically active ingredient are present in a specific weight ratio, and to a process for the preparation of said pharmaceutical composition. The present invention is also directed to a powder or granulate comprising at least one hyperbranched polymer and at least one pharmaceutically active ingredient in a specific weight ratio, to a process for the preparation of said powder or granulate, and to a pharmaceutical dosage form comprising the pharmaceutical composition, powder or granulate. Furthermore, the present invention relates to a process for preparing a solid dispersion of a hyperbranched polymer and at least one API. Moreover, it relates to the use of a crystalline carrier for the preparation of a mixture of hyperbranched polymer and a pharmaceutically active ingredient, as well as to the use of polyesteramide hyperbranched polymers for the preparation of a pharmaceutical composition, to the use of a hydrophilic or hydrophobic carrier for the preparation of said composition comprising a specific group of API, and to the use of a specific API and at least one hyperbranched polymer for the preparation of a pharmaceutical composition.
摘要翻译：本发明属于制药工业领域，涉及包含至少一种超支化聚合物和至少一种药物活性成分的药物组合物，其中聚合物和药物活性成分以特定重量比存在，并且涉及一种方法用于制备所述药物组合物。本发明还涉及包含至少一种超支化聚合物和至少一种特定重量比的药物活性成分的粉末或颗粒，与制备所述粉末或颗粒的方法，以及药物剂型，其包含药物组合物，粉剂或颗粒剂。此外，本发明涉及制备超支化聚合物和至少一种API的固体分散体的方法。此外，它涉及使用结晶载体制备超支化聚合物和药物活性成分的混合物，以及使用聚酯酰胺超支化聚合物制备药物组合物，使用亲水性或疏水载体，用于制备包含特定API组的所述组合物，以及使用特定的API和至少一种超支化聚合物来制备药物组合物。

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