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1. 发明授权

US07245124B2 Under-sampled 3D MRI using a shells k-space sampling trajectory 有权
标题翻译：未采样的3D MRI使用壳k空间采样轨迹
公开(公告)号：US07245124B2
公开(公告)日：2007-07-17
申请号：US11341242
申请日：2006-01-27
申请人： Yunhong Shu , Matthew A. Bernstein
发明人： Yunhong Shu , Matthew A. Bernstein
IPC分类号： G01V3/00
CPC分类号： G01R33/54 , G01R33/56509
摘要： A 3D MRI image is acquired as a series of spherical shells of increasing radius. Each shell is sampled by one or more interleaved spiral sampling trajectories and to shorten the scan time one or more spiral sampling trajectories are skipped in the larger shells that sample the periphery of k-space. Motion correction of the acquired k-space data is accomplished by reconstructing tracking images from each of the shells and locating markers therein which indicate object movement from a reference position. The k-space data is corrected using this movement information.
摘要翻译：获取3D MRI图像作为一系列增加半径的球形壳体。每个壳体被一个或多个交错螺旋采样轨迹采样，并缩短扫描时间，在较大的壳中跳过一个或多个螺旋取样轨迹，该较大的壳体对k空间的外围进行采样。所获取的k空间数据的运动校正通过从每个壳体和其中定位标记重建跟踪图像来实现，其中指示物体从参考位置移动。使用该移动信息来校正k空间数据。

2. 发明申请

US20150309136A1 Systems and Methods for Efficiently Generating Magnetic Resonance Images from Incomplete Data 审中-公开
标题翻译：从不完整的数据有效地产生磁共振图像的系统和方法
公开(公告)号：US20150309136A1
公开(公告)日：2015-10-29
申请号：US14694621
申请日：2015-04-23
申请人： Yunhong Shu , Armando Manduca , Joshua D. Trzasko , Matthew A. Bernstein
发明人： Yunhong Shu , Armando Manduca , Joshua D. Trzasko , Matthew A. Bernstein
IPC分类号： G01R33/48 , G01R33/36 , G01R33/561 , G01R33/385 , G01R33/56
CPC分类号： G01R33/4826 , G01R33/5611
摘要： Systems and methods for efficiently generating MR images are provided. The method comprises acquiring k-space MR data, reconstructing an MR image from the k-space MR data, and generating the MR image. The MR image is reconstructed using an alternative-direction-method-of-multiplier (ADMM) strategy that decomposes an optimization problem into subproblems, and at least one of the subproblems is further decomposed into small problems. The further decomposition is based on Woodbury matrix identity and uses a diagonal preconditioner based on non-Toeplitz models.
摘要翻译：提供了有效产生MR图像的系统和方法。该方法包括获取k空间MR数据，从k空间MR数据重建MR图像，以及生成MR图像。使用将优化问题分解为子问题的替代方向乘法器（ADMM）策略重构MR图像，并且至少一个子问题进一步分解为小问题。进一步分解是基于Woodbury矩阵身份，并使用基于非Toeplitz模型的对角预处理器。

3. 发明授权

US08095202B2 Accelerated shells trajectory MRI acquisition 有权
标题翻译：加速炮弹弹道MRI采集
公开(公告)号：US08095202B2
公开(公告)日：2012-01-10
申请号：US11780126
申请日：2007-07-19
申请人： Yunhong Shu , Matthew Bernstein
发明人： Yunhong Shu , Matthew Bernstein
IPC分类号： A61B5/055
CPC分类号： G01R33/561 , G01R33/4824 , G01R33/5635
摘要： An MRI k-space data set is acquired using a series of shell k-space sampling trajectories of different radii. Off-resonance effects are reduced and fat-suppression can be improved by using a shorter TR for pulse sequences that sample at smaller radii. At larger radii sampling is repeated with the central axis of the shell sampling trajectory tilted such that the polar regions of shells acquired at the same radii are sampled by the other shell.
摘要翻译：使用不同半径的一系列壳k空间采样轨迹获取MRI k空间数据集。通过对较小半径进行采样的脉冲序列使用较短的TR，可以降低非共振效应，从而可以提高脂肪抑制。在较大的半径处重复采样，壳体采样轨迹的中心轴线倾斜，使得在相同半径处获取的壳的极区域被另一个壳体采样。

4. 发明申请

US20080183067A1 Accelerated Shells Trajectory MRI Acquisition 有权
标题翻译：加速壳体轨迹MRI采集
公开(公告)号：US20080183067A1
公开(公告)日：2008-07-31
申请号：US12018899
申请日：2008-01-24
申请人： Yunhong Shu , Matthew A. Bernstein
发明人： Yunhong Shu , Matthew A. Bernstein
IPC分类号： A61B5/055
CPC分类号： G01R33/561 , G01R33/4824 , G01R33/5635
摘要： A method for prescribing a scan on an MRI system includes selecting a general pulse sequence to be used during a time-resolved imaging process of a subject using an MRI system. The method also includes setting a first set of scan parameters to more specifically prescribe the general pulse sequence and setting a second set of scan parameters using a formula that relates time resolution and spatial resolution resulting from the first set of scan parameters. The method then includes performing the time-resolved imaging process using the general pulse sequence, the first set of scan parameters, and the second set of scan parameters.
摘要翻译：用于在MRI系统上规定扫描的方法包括选择将在使用MRI系统的对象的时间分辨成像处理期间使用的一般脉冲序列。该方法还包括设置第一组扫描参数以更具体地规定通用脉冲序列，并使用涉及由第一组扫描参数产生的时间分辨率和空间分辨率的公式来设置第二组扫描参数。该方法然后包括使用通用脉冲序列，第一组扫描参数和第二组扫描参数执行时间分辨成像处理。

5. 发明授权

US08214013B2 Accelerated shells trajectory MRI acquisition 有权
标题翻译：加速炮弹弹道MRI采集
公开(公告)号：US08214013B2
公开(公告)日：2012-07-03
申请号：US12018899
申请日：2008-01-24
申请人： Yunhong Shu , Matthew A. Bernstein
发明人： Yunhong Shu , Matthew A. Bernstein
IPC分类号： A61B5/055
CPC分类号： G01R33/561 , G01R33/4824 , G01R33/5635
摘要： A method for prescribing a scan on an MRI system includes selecting a general pulse sequence to be used during a time-resolved imaging process of a subject using an MRI system. The method also includes setting a first set of scan parameters to more specifically prescribe the general pulse sequence and setting a second set of scan parameters using a formula that relates time resolution and spatial resolution resulting from the first set of scan parameters. The method then includes performing the time-resolved imaging process using the general pulse sequence, the first set of scan parameters, and the second set of scan parameters.
摘要翻译：用于在MRI系统上规定扫描的方法包括选择将在使用MRI系统的对象的时间分辨成像处理期间使用的一般脉冲序列。该方法还包括设置第一组扫描参数以更具体地规定通用脉冲序列，并使用涉及由第一组扫描参数产生的时间分辨率和空间分辨率的公式来设置第二组扫描参数。该方法然后包括使用通用脉冲序列，第一组扫描参数和第二组扫描参数执行时间分辨成像处理。

6. 发明申请

US20060226836A1 Under-sampled 3D MRI using a shells k-space sampling trajectory 有权
标题翻译：未采样的3D MRI使用壳k空间采样轨迹
公开(公告)号：US20060226836A1
公开(公告)日：2006-10-12
申请号：US11341242
申请日：2006-01-27
申请人： Yunhong Shu , Matthew Bernstein
发明人： Yunhong Shu , Matthew Bernstein
IPC分类号： G01V3/00
CPC分类号： G01R33/54 , G01R33/56509
摘要： A 3D MRI image is acquired as a series of spherical shells of increasing radius. Each shell is sampled by one or more interleaved spiral sampling trajectories and to shorten the scan time one or more spiral sampling trajectories are skipped in the larger shells that sample the periphery of k-space. Motion correction of the acquired k-space data is accomplished by reconstructing tracking images from each of the shells and locating markers therein which indicate object movement from a reference position. The k-space data is corrected using this movement information.
摘要翻译：获取3D MRI图像作为一系列增加半径的球形壳体。每个壳体被一个或多个交错螺旋采样轨迹采样，并缩短扫描时间，在较大的壳中跳过一个或多个螺旋取样轨迹，该较大的壳体对k空间的外围进行采样。所获取的k空间数据的运动校正通过从每个壳体和其中定位标记重建跟踪图像来实现，其中指示物体从参考位置移动。使用该移动信息来校正k空间数据。

7. 发明授权

US10048338B2 Systems and methods for efficiently generating magnetic resonance images from incomplete data 有权
公开(公告)号：US10048338B2
公开(公告)日：2018-08-14
申请号：US14694621
申请日：2015-04-23
申请人： Yunhong Shu , Armando Manduca , Joshua D. Trzasko , Matthew A. Bernstein
发明人： Yunhong Shu , Armando Manduca , Joshua D. Trzasko , Matthew A. Bernstein
IPC分类号： G01R33/48 , G01R33/561
摘要： Systems and methods for efficiently generating MR images are provided. The method comprises acquiring k-space MR data, reconstructing an MR image from the k-space MR data, and generating the MR image. The MR image is reconstructed using an alternative-direction-method-of-multiplier (ADMM) strategy that decomposes an optimization problem into subproblems, and at least one of the subproblems is further decomposed into small problems. The further decomposition is based on Woodbury matrix identity and uses a diagonal preconditioner based on non-Toeplitz models.

8. 发明申请

US20160220168A1 SYSTEMS AND METHODS FOR PRODUCING IMAGING BIOMARKERS INDICATIVE OF A NEUROLOGICAL DISEASE STATE USING GRAY MATTER SUPPRESSIONS VIA DOUBLE INVERSION-RECOVERY MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：使用双重反向恢复磁共振成像的灰度事件抑制表示神经病学疾病状态的成像生物标志物的生产系统和方法
公开(公告)号：US20160220168A1
公开(公告)日：2016-08-04
申请号：US15022404
申请日：2014-09-22
申请人： John D. PORT , Istvan PIRKO , Jan-Mendelt TILLEMA , Yunhong SHU , Claudia F. LUCCHINETTI
发明人： John D. Port , Istvan Pirko , Jan-Mendelt Tillema , Yunhong Shu , Claudia F. Lucchinetti
IPC分类号： A61B5/00 , G01R33/56 , G01R33/563 , A61B5/055
CPC分类号： A61B5/4076 , A61B5/0042 , A61B5/055 , A61B2576/026 , G01R33/5602 , G01R33/5608 , G01R33/56341
摘要： Systems and methods related to imaging biomarkers for determining neurological disease states of a subject are provided. In one embodiment, a method for producing an image indicative of a neurological disease using a magnetic resonance imaging (“MRI”) system is provided. The method includes directing the MRI system to perform a double inversion-recovery (“DIR”) pulse sequence to generate data where signals from gray matter and cerebral spinal fluid are substantially suppressed. The method also includes analyzing the DIR images, reconstructed from the acquired data, to identify cortical and white matter lesions. This includes identifying imaging biomarkers based on visual signatures of brain tissue, including white matter tissue. In some aspects, diffusion-weighted data may also be obtained using the MRI system. Diffusion-weighted data may be used in a tractography process to determine connectivities, or connectivity patterns between the identified lesions, including cortical lesions, to determine neurological disease states of the subject.
摘要翻译：提供了与成像生物标志物相关的用于确定受试者的神经疾病状态的系统和方法。在一个实施例中，提供了使用磁共振成像（“MRI”）系统产生指示神经疾病的图像的方法。该方法包括引导MRI系统执行双反转恢复（“DIR”）脉冲序列以产生其中来自灰质和脑脊液的信号被基本上抑制的数据。该方法还包括分析从获取的数据重建的DIR图像，以鉴定皮层和白质病变。这包括基于脑组织的视觉特征（包括白质组织）识别成像生物标志物。在某些方面，也可以使用MRI系统获得扩散加权数据。扩散加权数据可用于牵引成像过程中以确定所识别的病变（包括皮质损伤）之间的连接性或连接性模式，以确定受试者的神经疾病状态。

9. 发明申请

US20080045828A1 Accelerated Shells Trajectory MRI Acquisition 有权
标题翻译：加速壳体轨迹MRI采集
公开(公告)号：US20080045828A1
公开(公告)日：2008-02-21
申请号：US11780126
申请日：2007-07-19
申请人： Yunhong Shu , Matthew Bernstein
发明人： Yunhong Shu , Matthew Bernstein
IPC分类号： A61B5/055
CPC分类号： G01R33/561 , G01R33/4824 , G01R33/5635
摘要： An MRI k-space data set is acquired using a series of shell k-space sampling trajectories of different radii. Off-resonance effects are reduced and fat-suppression can be improved by using a shorter TR for pulse sequences that sample at smaller radii. At larger radii sampling is repeated with the central axis of the shell sampling trajectory tilted such that the polar regions of shells acquired at the same radii are sampled by the other shell.
摘要翻译：使用不同半径的一系列壳k空间采样轨迹获取MRI k空间数据集。通过对较小半径进行采样的脉冲序列使用较短的TR，可以降低非共振效应，从而可以提高脂肪抑制。在较大的半径处重复采样，壳体采样轨迹的中心轴线倾斜，使得在相同半径处获取的壳的极区域被另一个壳体采样。

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