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1. 发明申请

US20050288254A1 Novel therapeutical use of agonist ligands specific to g2a receptor 有权
标题翻译：对g2a受体特异性的激动剂配体的新型治疗用途
公开(公告)号：US20050288254A1
公开(公告)日：2005-12-29
申请号：US10509300
申请日：2003-03-25
申请人： Yung-Hi Kim , Dong-Keun Song , Hong-Won Suh , Sung-Oh Huh
发明人： Yung-Hi Kim , Dong-Keun Song , Hong-Won Suh , Sung-Oh Huh
IPC分类号： A61K45/00 , A61K31/00 , A61K31/685 , A61K31/688 , A61P1/04 , A61P3/06 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P17/06 , A61P19/02 , A61P19/06 , A61P25/00 , A61P29/00 , A61P31/04 , A61P37/08 , A61P43/00
CPC分类号： A61K31/685 , A61K31/00 , Y02A50/40 , Y02A50/401
摘要： The present invention relates to novel therapeutical use of agonist ligands specific to G2A receptor. More particularly, the present invention relates to methods for treating a disease or disorder associated with neutrophil accumulation and hyperactivity and/or excessive release of IL-8, or with microbial infection, in a subject, comprising administering LPC (lysophosphatidylcholine), SPC(sphingophosphorylcholine) or derivatives thereof to the subject. The agonist ligands for G2A receptor according hours after CLP according to the present invention and pharmaceutical or therapeutical composition comprising said ligands can be used effectively in treatment of a disease or disorder associated with neutrophil accumulation and hyperactivity and/or excessive release of IL-8, specifically inflammatory diseases and diseases associated with ischemia-reperfusion injury as well as microbial infection.
摘要翻译：本发明涉及对G2A受体特异性的激动剂配体的新型治疗用途。更具体地说，本发明涉及用于治疗受试者中嗜中性粒细胞积聚和多动症和/或IL-8或微生物感染过度释放的疾病或病症的方法，包括给予LPC（溶血磷脂酰胆碱），SPC（鞘磷脂酰胆碱）或其衍生物。根据本发明的CLP后小时的G2A受体的激动剂配体和包含所述配体的药物或治疗组合物可以有效地用于治疗与嗜中性粒细胞积聚和多动症和/或IL-8的过量释放相关的疾病或病症，特别是与缺血再灌注损伤相关的炎性疾病和疾病以及微生物感染。

2. 发明授权

US07410955B2 Therapeutic use of agonist ligands specific to G2A receptor 有权
标题翻译：治疗性使用对G2A受体特异性的激动剂配体
公开(公告)号：US07410955B2
公开(公告)日：2008-08-12
申请号：US10509300
申请日：2003-03-25
申请人： Yung-Hi Kim , Dong-Keun Song , Hong-Won Suh , Sung-Oh Huh
发明人： Yung-Hi Kim , Dong-Keun Song , Hong-Won Suh , Sung-Oh Huh
IPC分类号： A61K31/665
CPC分类号： A61K31/685 , A61K31/00 , Y02A50/40 , Y02A50/401
摘要： The present invention relates to novel therapeutical use of agonist ligands specific to G2A receptor. More particularly, the present invention relates to methods for treating a disease or disorder associated with neutrophil accumulation and hyperactivity and/or excessive release of IL-8, or with microbial infection, in a subject, comprising administering LPC (lysophosphatidylcholine), SPC(sphingophosphorylcholine) or derivatives thereof to the subject. The agonist ligands for G2A receptor according to the present invention and pharmaceutical- or therapeutical composition comprising said ligands can be used effectively in treatment of a disease or disorder associated with neutrophil accumulation and hyperactivity and/or excessive release of IL-8, specifically inflammatory diseases and diseases associated with ischemia-reperfusion injury as well as microbial infection.
摘要翻译：本发明涉及对G2A受体特异性的激动剂配体的新型治疗用途。更具体地说，本发明涉及用于治疗受试者中嗜中性粒细胞积聚和多动症和/或IL-8或微生物感染过度释放的疾病或病症的方法，包括给予LPC（溶血磷脂酰胆碱），SPC（鞘磷脂酰胆碱）或其衍生物。根据本发明的用于G2A受体的激动剂配体和包含所述配体的药物或治疗组合物可以有效地用于治疗与嗜中性粒细胞积聚和多动症相关的疾病或病症和/或过度释放IL-8，特别是炎性疾病以及与缺血再灌注损伤相关的疾病以及微生物感染。

3. 发明申请

US20050163879A1 Composition for preventing or treating dementia comprising a hydroxycinnamic acid derivative or an extract of a plant of genus Angelicae containing same 审中-公开
标题翻译：用于预防或治疗痴呆的组合物，其包含羟基肉桂酸衍生物或含有其的当归植物提取物
公开(公告)号：US20050163879A1
公开(公告)日：2005-07-28
申请号：US11023986
申请日：2004-12-29
申请人： Yung-Hi Kim , Dong-Keun Song , Hong-Won Suh , Sung-Oh Huh
发明人： Yung-Hi Kim , Dong-Keun Song , Hong-Won Suh , Sung-Oh Huh
IPC分类号： A61K36/232 , A23L1/30 , A61K31/192 , A61K31/216 , A61K36/23 , A61P25/28 , A61K35/78 , A61K31/235
CPC分类号： A61K31/216 , A61K31/192 , A61K31/235 , A61K36/232
摘要： A composition for preventing or treating dementia comprising a hydroxycinnamic acid derivative of formula (I), decursinol, a pharmaceutically acceptable salt thereof or an extract of a plant of genus Angelicae containing same, wherein, R1 is H or CH3, R2 is —CH═CHCOOH or formula (a).
摘要翻译：用于预防或治疗痴呆的组合物，其包含式（I）的羟基肉桂酸衍生物，前胡椒醇，其药学上可接受的盐或含有其的当归植物提取物，其中R 1为H 或CH 3，R 2是-CH-CHCOOH或式（a）。

4. 发明申请

US20060159790A1 Composition for preventing or treating dementia comprising a hydroxycinnamic acid derivative or an extract of a plant of genus angelicae containing same 审中-公开
标题翻译：用于预防或治疗痴呆的组合物，其包含羟基肉桂酸衍生物或含有其的当归植物提取物
公开(公告)号：US20060159790A1
公开(公告)日：2006-07-20
申请号：US11376196
申请日：2006-03-16
申请人： Yung-Hi Kim , Dong-Keun Song , Hong-Won Suh , Sung-Oh Huh
发明人： Yung-Hi Kim , Dong-Keun Song , Hong-Won Suh , Sung-Oh Huh
IPC分类号： A61K36/232 , A61K31/235 , A61K31/192
CPC分类号： A61K31/216 , A61K31/192 , A61K31/235 , A61K36/232
摘要： A composition for preventing or treating dementia comprising a hydroxycinnamic acid derivative of formula (I), decursinol, a pharmaceutically acceptable salt thereof or an extract of a plant of genus Angelicae containing same, wherein, R1 is H or CH3, R2 is —CH═CHCOOH or formula (a).
摘要翻译：用于预防或治疗痴呆的组合物，其包含式（I）的羟基肉桂酸衍生物，前胡椒醇，其药学上可接受的盐或含有其的当归植物提取物，其中R 1为H 或CH 3，R 2是-CH-CHCOOH或式（a）。

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