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1. 发明授权

US06596706B1 Piperazine-cyclodextrin complexes 失效
标题翻译：哌嗪 - 环糊精复合物
公开(公告)号：US06596706B1
公开(公告)日：2003-07-22
申请号：US09530592
申请日：2000-05-08
申请人： Masahiko Kikuchi , Yukihiko Nagase , Kaneto Uekama
发明人： Masahiko Kikuchi , Yukihiko Nagase , Kaneto Uekama
IPC分类号： A61K31724
CPC分类号： B82Y5/00 , A61K47/6951 , C08B37/0015
摘要： The present invention relates to a compound represented by formula (1): wherein Q, which may have a substituent, represents an aryl group, a heterocyclic group, a diarylmethyl group, or an aralkyl group; R, which may have a substituent, represents a bicyclic nitrogen-containing heterocyclic group or a phenyl group; and Z represents a C1-C3 alkylene group, a C2-C4 alkenylene group, a C1-C3 alkylene group having one hydroxyl group, a carbonyl moiety, a C1-C2 alkylene group containing one carbonyl moiety at one end or an intermediate position of the carbon chain, or an oxalyl group; or salts thereof and a piperazine-cyclodextrin complex combined with a water-soluble cyclodextrin derivative. The complex exhibits enhanced water solubility, excellent stability, and low topical stimulation and is useful as a therapeutic agent for circulatory diseases and diseases of the brain region.
摘要翻译：本发明涉及由式（1）表示的化合物：其中可具有取代基的Q表示芳基，杂环基，二芳基甲基或芳烷基; R可以具有取代基，表示双环含氮杂环基或苯基; Z表示C1-C3亚烷基，C2-C4亚链烯基，具有一个羟基的C1-C3亚烷基，羰基部分，在一端或中间位置含有一个羰基部分的C1-C2亚烷基碳链或草酰基; 或其盐和与水溶性环糊精衍生物组合的哌嗪 - 环糊精复合物。复合物表现出增强的水溶性，优异的稳定性和低的局部刺激，并且可用作循环系统疾病和脑区疾病的治疗剂。

2. 发明授权

US4481867A Axial plunger pump or motor 失效
标题翻译：推力柱塞泵或电机
公开(公告)号：US4481867A
公开(公告)日：1984-11-13
申请号：US401979
申请日：1982-07-26
申请人： Yukihiko Nagase , Tetsuo Kawasaki , Masato Hiromatsu , Sadao Asanabe , Kunio Saki
发明人： Yukihiko Nagase , Tetsuo Kawasaki , Masato Hiromatsu , Sadao Asanabe , Kunio Saki
IPC分类号： F03C1/06 , F03C1/253 , F04B1/20 , F01B13/04
CPC分类号： F04B1/2021 , F04B1/2035
摘要： An axial plunger pump or motor of the type such that a valve plate having a suction port and a discharge port drilled therein is fixed to a casing in which a rotary shaft is mounted. A cylinder block having one end surface opposed to the valve plate is coupled to the rotary shaft. A plurality of bores whose one ends can be communicated with the suction port and the discharge port are drilled in the cylinder block in parallel to the rotary shaft. A plurality of plungers, which can reciprocate within the respective bores in accordance with rotation of the rotary shaft are slidably fitted in the bores on the side of the other ends. A seal plate positioned between the valve plate and the cylinder block and making slide contact with the valve plate is coupled to the rotary shaft. A plurality of bushes or bushings, each consisting of a thin-walled cylinder portion fitted in one end portion of the bore and capable of making tight contact with an inner wall surface of the bore as expanded in diameter by a high-pressure liquid within the bore and a flange portion butting against the seal plate, are interposed between the seal plate and the cylinder block. An urging member for bringing the flange portion of the bush into tight contact with the seal plate in cooperation with the high-pressure liquid is provided between the flange portion of the bush and the one end surface of the cylinder block.
摘要翻译：这种类型的轴向柱塞泵或马达，使得具有吸入口和排出口钻出的阀板固定到安装旋转轴的壳体中。具有与阀板相对的一个端面的气缸体联接到旋转轴。一端与吸入口和排出口连通的多个孔平行于旋转轴在气缸体中钻孔。可以根据旋转轴的旋转在各孔内往复运动的多个柱塞可滑动地装配在另一端侧的孔中。定位在阀板和气缸体之间并与阀板滑动接触的密封板联接到旋转轴。多个衬套或衬套，每个衬套或衬套均由安装在孔的一个端部中的薄壁圆筒部分组成，并且能够通过内部的高压液体直径扩大而与孔的内壁表面紧密接触孔和与密封板对接的凸缘部分插入在密封板和气缸体之间。在衬套的凸缘部和气缸体的一个端面之间设置有用于使衬套的凸缘部与密封板紧密接触的推压构件，与该高压液体配合。

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