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1. 发明专利

JP2005194244A Zinc ion fluorescence sensor 审中-公开
标题翻译： ZINC离子荧光传感器
公开(公告)号：JP2005194244A
公开(公告)日：2005-07-21
申请号：JP2004003707
申请日：2004-01-09
申请人： Dai Ichi Pure Chem Co Ltd , Yuji Mikata , Shigenobu Yano , 裕司三方 , 重信矢野 , 第一化学薬品株式会社
发明人： YANO SHIGENOBU , MIKATA YUJI
IPC分类号： G01N21/78 , C07C229/00 , C07D215/12 , C07D215/20 , C07D217/14 , C07D257/02 , C07F3/06 , C09K11/06
CPC分类号： C07D215/12 , C07D215/20
摘要： PROBLEM TO BE SOLVED: To provide a compound that is useful as a zinc ion fluorescence sensor.
SOLUTION: This compound is represented by general formula (I) [wherein R
1 , R
2 , R
3 and R
4 are each independently 2-quinolyl which may bear substituent, 1-isoquinolyl which may bear substituent or 3-isoquinolyl which may bear substituent; m, n, p, and q are each independently 1 or 2; L is a single bond or an alkylene of 1-5 carbon atoms (the alkylene group may include hetero atoms and may have substituent on the main chain)].
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供可用作锌离子荧光传感器的化合物。解决方案：该化合物由通式（I）[其中R 1，R 2，R 2，R 3，R 3和R SP > 4 各自独立为可带有取代基的2-喹啉基，可带有取代基的1-异喹啉基或可带有取代基的3-异喹啉基; m，n，p和q各自独立地为1或2; L是单键或1-5个碳原子的亚烷基（亚烷基可以包括杂原子并且可以在主链上具有取代基）]。版权所有（C）2005，JPO＆NCIPI

2. 发明授权

US06958389B2 Tetraphenylbacteriochlorin derivatives and compositions containing the same 失效
标题翻译：四苯基细菌二氢卟吩衍生物和含有它们的组合物
公开(公告)号：US06958389B2
公开(公告)日：2005-10-25
申请号：US10363824
申请日：2001-09-06
申请人： Shigenobu Yano , Toyoji Kakuchi , Yuji Mikata
发明人： Shigenobu Yano , Toyoji Kakuchi , Yuji Mikata
IPC分类号： A61P35/00 , A61P43/00 , C07H15/203 , C07H15/26 , C07H1/00
CPC分类号： C07H15/203 , C07H15/26 , Y02P20/55
摘要： Provided is a tetraphenylbacteriochlorin derivative represented by the formula (I): [wherein R1, R2, R3 and R4, independently from each other, are a residue of a monosaccharide represented by the formulae: (wherein, R is a hydrogen or a protecting group)], or its salt. The tetraphenylbacteriochlorin derivative or its salt has a large molar extinction coefficient at long wavelengths which are expected to have a high tissue-penetrating property, and exhibits high selectivity to tumor cells and hydrophilicity.
摘要翻译：本发明提供由式（I）表示的四苯基细菌二氢卟酚衍生物：其中R 1，R 2，R 3和R 4 彼此独立地是由下式表示的单糖的残基：（其中，R是氢或保护基）]或其盐。四苯基细菌二氢卟酚衍生物或其盐在长波长处具有大的摩尔消光系数，其预期具有高的组织穿透性，并且对肿瘤细胞和亲水性显示出高选择性。

3. 发明授权

US07541467B2 Fluorescent zinc ion sensor 失效
标题翻译：荧光锌离子传感器
公开(公告)号：US07541467B2
公开(公告)日：2009-06-02
申请号：US10902432
申请日：2004-07-30
申请人： Shigenobu Yano , Yuji Mikata
发明人： Shigenobu Yano , Yuji Mikata
IPC分类号： C07D215/20 , C07F3/06 , C09K11/54
CPC分类号： C07D215/12 , C07D215/20
摘要： A compound represented by the following general formula (I) or a salt thereof: wherein R1, R2, R3, and R4 independently represent 2-quinolyl group which may be substituted, 1-isoquinolyl group which may be substituted, or 3-isoquinolyl group which may be substituted; m, n, p, and q independently represent 1 or 2; and L represents a single bond, or an alkylene group having 1 to 5 carbon atoms wherein said alkylene group may contain one or more heteroatoms in the main chain, and may have one or more substituents on the main chain, which is useful as a fluorescent zinc ion sensor.
摘要翻译：由以下通式（I）表示的化合物或其盐：其中R1，R2，R3和R4独立地表示可以被取代的2-喹啉基，可以被取代的1-异喹啉基或3-异喹啉基可以替代; m，n，p和q独立地表示1或2; L表示单键或碳原子数为1〜5的亚烷基，其中所述亚烷基可以在主链中含有一个或多个杂原子，并且可以在主链上具有一个或多个取代基，其可用作荧光锌离子传感器

4. 发明申请

US20060003946A1 Tetraphenylbacteriochlorin derivatives and compositions containing the same 失效
标题翻译：四苯基细菌二氢卟吩衍生物和含有它们的组合物
公开(公告)号：US20060003946A1
公开(公告)日：2006-01-05
申请号：US11219853
申请日：2005-09-07
申请人： Shigenobu Yano , Toyoji Kakuchi , Yuji Mikata
发明人： Shigenobu Yano , Toyoji Kakuchi , Yuji Mikata
IPC分类号： A61K31/7052 , C07H17/02
CPC分类号： C07H15/203 , C07H15/26 , Y02P20/55
摘要： Provided is a tetraphenylbacteriochlorin derivative represented by the formula (I): [wherein R1, R2, R3 and R4, independently from each other, are a residue of a monosaccharide represented by the formulae: (wherein, R is a hydrogen or a protecting group)], or its salt. The tetraphenylbacteriochlorin derivative or its salt has a large molar extinction coefficient at long wavelengths which are expected to have a high tissue-penetrating property, and exhibits high selectivity to tumor cells and hydrophilicity.
摘要翻译：本发明提供由式（I）表示的四苯基细菌二氢卟酚衍生物：其中R 1，R 2，R 3和R 4 彼此独立地是由下式表示的单糖的残基：（其中，R是氢或保护基）]或其盐。四苯基细菌二氢卟酚衍生物或其盐在长波长处具有大的摩尔消光系数，其预期具有高的组织穿透性，并且对肿瘤细胞和亲水性显示出高选择性。

5. 发明授权

US07157432B2 Tetraphenylbacteriochlorin derivatives and compositions containing the same 失效
标题翻译：四苯基细菌二氢卟吩衍生物和含有它们的组合物
公开(公告)号：US07157432B2
公开(公告)日：2007-01-02
申请号：US11219853
申请日：2005-09-07
申请人： Shigenobu Yano , Toyoji Kakuchi , Yuji Mikata
发明人： Shigenobu Yano , Toyoji Kakuchi , Yuji Mikata
IPC分类号： A61K31/70 , C07H1/00 , C07H17/00
CPC分类号： C07H15/203 , C07H15/26 , Y02P20/55
摘要： Provided is a tetraphenylbacteriochlorin derivative represented by the formula (I): [wherein R1, R2, R3 and R4, independently from each other, are a residue of a monosaccharide represented by the formulae: (wherein, R is a hydrogen or a protecting group)], or its salt. The tetraphenylbacteriochlorin derivative or its salt has a large molar extinction coefficient at long wavelengths which are expected to have a high tissue-penetrating property, and exhibits high selectivity to tumor cells and hydrophilicity.
摘要翻译：本发明提供由式（I）表示的四苯基细菌二氢卟酚衍生物：其中R 1，R 2，R 3和R 4 彼此独立地是由下式表示的单糖的残基：（其中，R是氢或保护基）]或其盐。四苯基细菌二氢卟酚衍生物或其盐在长波长处具有大的摩尔消光系数，其预期具有高的组织穿透性，并且对肿瘤细胞和亲水性显示出高选择性。

6. 发明申请

US20050182253A1 Fluorescent zinc ion sensor 失效
标题翻译：荧光锌离子传感器
公开(公告)号：US20050182253A1
公开(公告)日：2005-08-18
申请号：US10902432
申请日：2004-07-30
申请人： Shigenobu Yano , Yuji Mikata
发明人： Shigenobu Yano , Yuji Mikata
IPC分类号： G01N21/78 , C07C229/00 , C07D215/12 , C07D215/20 , C07D217/14 , C07D257/02 , C07F3/06 , C09K11/06
CPC分类号： C07D215/12 , C07D215/20
摘要： A compound represented by the following general formula (I) or a salt thereof: wherein R1, R2, R3, and R4 independently represent 2-quinolyl group which may be substituted, 1-isoquinolyl group which may be substituted, or 3-isoquinolyl group which may be substituted; m, n, p, and q independently represent 1 or 2; and L represents a single bond, or an alkylene group having 1 to 5 carbon atoms wherein said alkylene group may contain one or more heteroatoms in the main chain, and may have one or more substituents on the main chain, which is useful as a fluorescent zinc ion sensor.
摘要翻译：由以下通式（I）表示的化合物或其盐：其中R 1，R 2，R 3和R 3，独立地代表可被取代的2-喹啉基，可被取代的1-异喹啉基或可被取代的3-异喹啉基; m，n，p和q独立地表示1或2; L表示单键或碳原子数为1〜5的亚烷基，其中所述亚烷基可以在主链中含有一个或多个杂原子，并且可以在主链上具有一个或多个取代基，其可用作荧光锌离子传感器

7. 发明授权

US06844429B2 Fullerene derivative and composition comprising the same 失效
标题翻译：富勒烯衍生物及其组合物
公开(公告)号：US06844429B2
公开(公告)日：2005-01-18
申请号：US10466870
申请日：2002-07-18
申请人： Yuji Mikata , Toyoji Kakuchi , Shigenobu Yano
发明人： Yuji Mikata , Toyoji Kakuchi , Shigenobu Yano
IPC分类号： C07H15/26 , A61K31/70 , A61K41/00 , A61P35/00 , A61P43/00 , C07H15/18 , C07H17/02 , C09K3/00 , C07H15/00
CPC分类号： C07H15/18 , A61K31/70 , C07H17/02 , Y10S977/734
摘要： A fullerene derivative represented by the formula (I): [wherein, A is a residue of monosaccharides or disaccharides, and Alk is a lower alkylene group, the group represented by the formula (X): is a fullerene residual skeleton, and n is an integral number of 1 or 2] or its salt produces a formulation usable for PDT which has more hydrophilicity and lipophilicity, is expected to have selectivity to tumor cells by cell recognition, shows no toxicity to the cells in a dark place and has a cytocidal effect by light irradiation.
摘要翻译：由式（I）表示的富勒烯衍生物：[其中，A是单糖或二糖的残基，Alk是低级亚烷基，由式（X）表示的基团是富勒烯残基骨架，n为整数为1或2]或其盐产生可用于具有更高亲水性和亲油性的PDT的制剂，预期通过细胞识别对肿瘤细胞具有选择性，对黑暗中的细胞没有毒性并具有杀细胞活性光照射效果。

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