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1. 发明专利

IL243623A Detection of target nucleic acid sequences by pto cleavage and extension assay 未知
公开(公告)号：IL243623A
公开(公告)日：2017-06-29
申请号：IL24362316
申请日：2016-01-14
申请人： SEEGENE INC , JONG YOON CHUN , YOUNG JO LEE
发明人： JONG YOON CHUN , YOUNG JO LEE
IPC分类号： C12Q20060101
摘要： The present invention relates to the detection of a target nucleic acid sequence by a PTOCE (PTO Cleavage and Extension) assay. The present invention detects a target nucleic acid sequence in which the PTO (Probing and Tagging Oligonucleotide) hybridized with the target nucleic acid sequence is cleaved to release a fragment and the fragment is hybridized with the CTO (Capturing and Templating Oligonucleotide) to form an extended duplex, followed by detecting the presence of the extended duplex. The extended duplex provides signals (generation, increase, extinguishment or decrease of signals) from labels indicating the presence of the extended duplex and has adjustable T m value, which are well adoptable for detection of the presence of the target nucleic acid sequence.

2. 发明专利

IL229132A Detection of target nucleic acid sequences by po cleavage and hybridization 未知
公开(公告)号：IL229132A
公开(公告)日：2018-03-29
申请号：IL22913213
申请日：2013-10-29
申请人： SEEGENE INC , JONG YOON CHUN , YOUNG JO LEE
发明人： JONG YOON CHUN , YOUNG JO LEE
摘要： The present invention relates to the detection of a target nucleic acid sequence by a POCH (PO Cleavage and Hybridization) assay on a solid substrate. The present invention detects the target nucleic acid sequence by use of in which the PO (Probing Oligonucleotide) hybridized with the target nucleic acid sequence is cleaved and the cleavage of the PO is detected by hybridization with the CO (Capturing Oligonucleotide). In the present invention, an uncleaved PO is hybridized with the CO immobilized onto the solid substrate. The designs of the PO and the CO are convenient and the optimization of reaction conditions is routinely easy in the present invention. Where the detection of signal on the solid substrate is continuously performed along with repetition of cleavage of the POs in the present invention, the number of the POs cleaved is increased upon the repetition number of the cleavage reaction and the signal is changed in parallel with the number of the POs cleaved. Then, the target nucleic acid sequence can be detected in a real-time manner. In contrast, the change of the signal is not observed in the absence of the target nucleic acid sequence.

3. 发明专利

IL223608A Detection of target nucleic acid sequences by pto cleavage and extension assay 未知
公开(公告)号：IL223608A
公开(公告)日：2016-08-31
申请号：IL22360812
申请日：2012-12-12
申请人： SEEGENE INC , JONG YOON CHUN , YOUNG JO LEE
发明人： JONG YOON CHUN , YOUNG JO LEE
IPC分类号： C12Q20060101
摘要： The present invention relates to the detection of a target nucleic acid sequence by a PTOCE (PTO Cleavage and Extension) assay. The present invention detects a target nucleic acid sequence in which the PTO (Probing and Tagging Oligonucleotide) hybridized with the target nucleic acid sequence is cleaved to release a fragment and the fragment is hybridized with the CTO (Capturing and Templating Oligonucleotide) to form an extended duplex, followed by detecting the presence of the extended duplex. The extended duplex provides signals (generation, increase, extinguishment or decrease of signals) from labels indicating the presence of the extended duplex and has adjustable T m value, which are well adoptable for detection of the presence of the target nucleic acid sequence.

4. 发明授权

US10752938B2 Detection of a target nucleic acid sequence using two different detection temperatures 有权
公开(公告)号：US10752938B2
公开(公告)日：2020-08-25
申请号：US15124700
申请日：2014-06-17
申请人： SEEGENE, INC. , Jong Yoon Chun , Young Jo Lee
发明人： Jong Yoon Chun , Young Jo Lee
IPC分类号： C12Q1/68 , G01N25/04 , C12Q1/6816 , C12Q1/6827 , C12Q1/6858
摘要： The present invention relates to detection of a target nucleic acid sequence in a sample using two different detection temperatures. The present invention using difference between signals detected at two detection temperatures enables to decrease well-to-well variation or sample-to-sample variation generated in real-time PCR processes in more convenient and effective manner.

5. 发明授权

US09328377B2 Detection of target nucleic acid using a target hybridization and detection primer 有权
标题翻译：使用靶杂交和检测引物检测靶核酸
公开(公告)号：US09328377B2
公开(公告)日：2016-05-03
申请号：US13508086
申请日：2009-11-28
申请人： Jong Yoon Chun , In Taek Hwang , Young Jo Lee
发明人： Jong Yoon Chun , In Taek Hwang , Young Jo Lee
IPC分类号： C12P19/34 , C12Q1/68
CPC分类号： C12Q1/6823 , C12Q1/6818 , C12Q1/6851 , C12Q1/6853 , C12Q2565/1015 , C12Q2561/113 , C12Q2561/101
摘要： The present invention relates to the detection of a target nucleic acid sequence using a target hybridization and detection primer (THD primer). The present invention allows for both a target amplification and a signal amplification by introducing a label into a primer used in PCR reactions, ensuring a real-time target detection by PCR reaction by no use of complicated oligonucleotides. The present invention could completely be free from the troublesome matters and shortcomings associated with conventional real-time PCR methods. The present invention allows for successful real-time target detection by using only a labeled primer. This feature makes it possible that the present invention exhibits excellent real-time target detection in multiplex manner.
摘要翻译：本发明涉及使用靶杂交和检测引物（THD引物）检测靶核酸序列。本发明通过在PCR反应中使用的引物中引入标记物来允许目标扩增和信号扩增两者，通过不使用复杂的寡核苷酸来确保PCR反应的实时目标检测。本发明可以完全免除与常规实时PCR方法相关的麻烦的问题和缺点。本发明允许仅使用标记的引物成功实现目标检测。该特征使得本发明可以以多路复用方式显示出优异的实时目标检测。

6. 发明授权

US08767635B2 Method of scheduling shared channels and a scheduler therefor in a wireless packet communication system 有权
标题翻译：在无线分组通信系统中调度共享信道的方法及其调度器
公开(公告)号：US08767635B2
公开(公告)日：2014-07-01
申请号：US12631973
申请日：2009-12-07
申请人： Ki Jun Kim , Young Jo Lee , Young Woo Yun , Suk Hyon Yoon , Soon Yil Kwon
发明人： Ki Jun Kim , Young Jo Lee , Young Woo Yun , Suk Hyon Yoon , Soon Yil Kwon
IPC分类号： G01R31/08 , H04H20/71 , H04W4/00 , H04J3/00 , H04B7/00 , H04B7/14 , H04W72/00 , H04W36/00
CPC分类号： H04W72/1242 , H04L47/10 , H04L47/14 , H04L47/20 , H04W72/1273
摘要： The present invention relates to a method of scheduling a shared channel of a wireless packet communication system, and more particularly, to a shared scheduler of a wireless packet communication. The present invention includes determining priorities of provided services for target terminals of cellular phones and ratios of carrier signal to interference from multiple target terminals; and based on the determined priorities, transmitting packet data to each the target terminal of cellular phones.
摘要翻译：本发明涉及一种调度无线分组通信系统的共享信道的方法，更具体地说，涉及一种无线分组通信的共享调度器。本发明包括确定蜂窝电话目标终端提供的服务的优先级和来自多个目标终端的载波信号与干扰的比率; 并且基于确定的优先级，将分组数据发送到蜂窝电话的每个目标终端。

7. 发明申请

US20140073534A1 DETECTION OF TARGET NUCLEIC ACID SEQUENCES BY PO CLEAVAGE AND HYBRIDIZATION 有权
标题翻译：通过PO CLEAVAGE和杂交检测目标核酸序列
公开(公告)号：US20140073534A1
公开(公告)日：2014-03-13
申请号：US14114253
申请日：2012-05-03
申请人： Jong Yoon Chun , Young Jo Lee
发明人： Jong Yoon Chun , Young Jo Lee
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6823 , C12Q2521/319 , C12Q2565/519
摘要： The present invention relates to the detection of a target nucleic acid sequence by a POCH (PO Cleavage and Hybridization) assay on a solid substrate. The present invention detects the target nucleic acid sequence by use of in which the PO (Probing Oligonucleotide) hybridized with the target nucleic acid sequence is cleaved and the cleavage of the PO is detected by hybridization with the CO (Capturing Oligonucleotide). In the present invention, an uncleaved PO is hybridized with the CO immobilized onto the solid substrate. The designs of the PO and the CO are convenient and the optimization of reaction conditions is routinely easy in the present invention. Where the detection of signal on the solid substrate is continuously performed along with repetition of cleavage of the POs in the present invention, the number of the POs cleaved is increased upon the repetition number of the cleavage reaction and the signal is changed in parallel with the number of the POs cleaved. Then, the target nucleic acid sequence can be detected in a real-time manner. In contrast, the change of the signal is not observed in the absence of the target nucleic acid sequence.
摘要翻译：本发明涉及通过在固体基质上的POCH（PO切割和杂交）测定法检测靶核酸序列。本发明通过使用其中与靶核酸序列杂交的PO（探针寡核苷酸）被切割并通过与CO（捕获寡核苷酸）杂交来检测PO的切割来检测靶核酸序列。在本发明中，未切割的PO与固定在固体基质上的CO杂交。 PO和CO的设计是方便的，并且在本发明中反应条件的优化通常很容易。在本发明中连续进行PO的切割的情况下连续进行固体基板上的信号检测的情况下，切割反应的次数随着切割反应的重复次数而增加，信号与 PO的数量劈开。然后，可以以实时的方式检测靶核酸序列。相比之下，在没有靶核酸序列的情况下，没有观察到信号的变化。

8. 发明申请

US20130190208A1 DETECTION OF TARGET NUCLEIC ACID SEQUENCES BY EXONUCLEOLYTIC ACTIVITY USING SINGLE-LABELED IMMOBILIZED PROBES ON SOLID PHASE 有权
标题翻译：通过使用固体相位上的单标记固定化探针检测非离子表面活性剂的目标核酸序列
公开(公告)号：US20130190208A1
公开(公告)日：2013-07-25
申请号：US13824688
申请日：2010-12-23
申请人： Jong Yoon Chun , Young Jo Lee
发明人： Jong Yoon Chun , Young Jo Lee
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6834 , C12Q1/6816 , C12Q1/6823 , C12Q1/6876 , C12Q2521/319 , C12Q2563/107 , C12Q2565/30 , C12Q2565/519
摘要： The present invention relates to a novel method for detection of target nucleic acid sequences by cyclic exonucleolytic reactions (CER) or exonucleolytic reactions (ER) using single-labeled immobilized probes on a solid phase. The present invention enables to detect target nucleic acid sequences on a solid phase using single-labeled systems. Comparing with multiple-labeled systems such as dual labeling, the present invention using single-labeled probes has excellent advantages in light of convenience and cost effectiveness in probe design and preparation. Furthermore, the measurement of changes of the signal decrease during reactions is responsible for more accurate qualitative and quantitative analysis of target nucleic acid sequences.
摘要翻译：本发明涉及通过使用固相上的单标记固定化探针的循环外源核解决反应（CER）或核酸外解反应（ER）检测靶核酸序列的新方法。本发明能够使用单标记系统检测固相上的靶核酸序列。与双标记等多标记体系相比，使用单标记探针的本发明在探针设计和制备中的便利性和成本效益方面具有优异的优点。此外，反应期间信号变化的测量的测量负责更准确地定性和定量分析靶核酸序列。

9. 发明授权

US08418024B2 Error detection code generating method and error detection code generator 有权
公开(公告)号：US08418024B2
公开(公告)日：2013-04-09
申请号：US12178115
申请日：2008-07-23
申请人： Cheolwoo You , Young Jo Lee , Young Woo Yun , Suk Hyon Yoon , Soon yil Kwon , Ki-Jun Kim
发明人： Cheolwoo You , Young Jo Lee , Young Woo Yun , Suk Hyon Yoon , Soon yil Kwon , Ki-Jun Kim
IPC分类号： H03M13/09
CPC分类号： H03M13/29 , H04L1/0041 , H04L1/0059 , H04L1/0061 , H04L1/0065 , H04L1/0068 , H04L1/0071 , H04L1/0083 , H04L1/08 , H04L1/18
摘要： In a mobile communication system, an error detection code or a quality frame indicator (e.g., CRC) is generated using selectively frame information, and at least one of a WCA identifier of another terminal, and a corresponding terminal identifier. And the terminal identifier can be implicitly transmitted to the receiver.

10. 发明授权

US08111071B2 Battery management system and driving method thereof 有权
标题翻译：电池管理系统及其驱动方法
公开(公告)号：US08111071B2
公开(公告)日：2012-02-07
申请号：US11858798
申请日：2007-09-20
申请人： Gye-Jong Lim , Soo-Seok Choi , Young-Jo Lee , Yong-Jun Tae , Han-Seok Yun , Se-Wook Seo , Beom-Gyu Kim , Ho-Young Park
发明人： Gye-Jong Lim , Soo-Seok Choi , Young-Jo Lee , Yong-Jun Tae , Han-Seok Yun , Se-Wook Seo , Beom-Gyu Kim , Ho-Young Park
IPC分类号： G01N27/416 , H02J7/00
CPC分类号： H02J7/0016 , G01R19/16542 , G01R31/3658 , Y02T10/7055
摘要： A sensing and control apparatus for a battery management system is provided. The sensing and control apparatus includes: a sensing unit and a main control unit. The sensing unit includes: a cell relay of a plurality of cell relays and a voltage detection unit. The cell relay is configured to be coupled to at least one of a plurality of cells. The voltage detection unit is coupled to a cell relay. The voltage detection unit is configured to: receive a reference voltage when each of the plurality of cell relays is turned off; and generate a second voltage by amplifying by a gain a first voltage that corresponds to the reference voltage. The main control unit is configured to calculate a valid gain corresponding to a ratio of the second voltage to the reference voltage when the temperature of the voltage detection unit is within a threshold temperature range.
摘要翻译：提供了一种用于电池管理系统的感测和控制装置。感测和控制装置包括：感测单元和主控制单元。感测单元包括：多个单元继电器的单元继电器和电压检测单元。小区中继被配置为耦合到多个小区中的至少一个小区。电压检测单元耦合到电池继电器。电压检测单元被配置为：当多个单电池继电器中的每一个被关闭时，接收参考电压; 并且通过增益放大对应于参考电压的第一电压来产生第二电压。主控制单元被配置为当电压检测单元的温度在阈值温度范围内时，计算对应于第二电压与参考电压的比率的有效增益。

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